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INDIANAPOLIS (AP) — The Indianapolis Colts defense started this season struggling. It couldn't stop the run, couldn't keep teams out of the end zone, couldn't get off the field. Now the script has flipped. Defensive coordinator Gus Bradley's group is playing stouter, holding teams — even the high-scoring Detroit Lions — largely in check long enough to give Indy a chance to win, and it's the Colts offense that has struggled. “They are playing their tails off. You don’t want them on the field a bunch and as an offense you want to be able to play complementary football,” running back Jonathan Taylor said after Sunday's 24-6 loss. “I would say specifically on offense, it sucks when you can’t help your defense out when they are fighting their tails off all game.” Indy's defense held up its end of the bargain by limiting the Lions (10-1) to 14 first-half points and allowing just 24, matching Detroit's lowest output since Week 3. The problem: Even when the Colts (5-7) did get Detroit off the field, they couldn't sustain drives or score touchdowns. Again. Anthony Richardson provided the bulk of the ground game by rushing 10 times for 61 yards, mostly early. Taylor managed just 35 yards on 11 carries and a season-high 10 penalties constantly forced the Colts to dig out from deep deficits. Part of that was by design. “We knew Jonathan Taylor was going to be the guy we needed to shut down,” Lions coach Dan Campbell said. “We did that. The quarterback runs. It got us on a couple but overall, we did what we needed to do, and we kept them out of that game." Part of it could be because of an injury-battered offensive line that has started three rookies each of the past two weeks and finished the previous game with the same three rookies. Whatever the fix, Indy needs a good solution. There is good news for Indy is that its schedule now gets substantially more manageable. After losing four of five, all to teams in playoff position and three to division leaders, Indy faces only one team with a winning record in its final five games. The most recent time the Colts played a team with a losing mark, Richardson rallied them past the New York Jets 28-27. But Colts coach Shane Steichen knows that's not the answer. The Colts must get this offense righted now. “We’ve got to get that figured out. We’ve got to get him going on the ground,” Steichen said when asked about Taylor, who has 92 yards on his past 35 carries. “We’ll look at the offensive line. We’ll look at everything." What’s working Pass rush. Pro Bowl DT DeForest Buckner's presence certainly has been felt since he returned from a sprained ankle Oct. 27. In those past five games, the Colts have had 14 sacks, including three of Jared Goff on Sunday. What needs work Penalties. The Colts have had one of the cleanest operations in the league most of this season. Sunday was an anomaly, but one that can't merely be written off. Stock up WR Michael Pittman Jr. The five-year veteran is one of the league's toughest guys, but playing through a back injury appeared to take its toll on Pittman's productivity. Since sitting out in Week 10, Pittman has 11 receptions for 142 yards including six for 96 yards, his second-highest total of the season, Sunday. Stock down Tight ends. Each week the Colts want their tight ends to make an impact. And each week, they seem to fail. It happened again Sunday when Drew Ogletree dropped a TD pass that would have given Indy a 10-7 lead. Instead, Indy settled for a field goal and a 7-6 deficit. Through 12 games, Indy's tight ends have a total of 26 catches, 299 yards and two TDs. That's just not good enough in a league where versatile, productive tight ends increasingly signal success. Injuries Pittman and WR Josh Downs both returned to the game after leaving briefly with shoulder injuries. WR Ashton Dulin did not return after hurting his foot in the second half. But the bigger questions come on the offensive line. LT Bernhard Raimann (knee) was inactive Sunday, and rookie center Tanor Bortolini entered the concussion protocol Monday. Bortolini was one of three rookie starters the past two weeks, replacing Pro Bowler Ryan Kelly who is on injured reserve. Key number 55.88 — Indy has scored touchdowns on 55.88% of its red zone trips this season. While it puts it near the middle of the NFL, it's cost the Colts multiple wins. Next steps Richardson needs to rebound from this latest 11 of 28 performance and show he can lead the Colts to victories week after week. He'll get plenty of chances over the season's final month, starting with next week's game at the New England Patriots. ___ AP NFL: https://apnews.com/hub/nfl Michael Marot, The Associated PressNHS weight loss waiting lists blamed for risky jab purchases

Arsenal player ratings: Havertz shines in different role but Jesus can’t keep up hot streak against IpswichPresident-elect Donald Trump has chosen health economist Dr. Jay Bhattacharya, a critic of pandemic lockdowns and vaccine mandates, to lead the National Institutes of Health, the nation's leading medical research agency. Trump, in a statement Tuesday evening, said Bhattacharya, a 56-year-old physician and professor at Stanford University School of Medicine, will work in cooperation with Robert F. Kennedy Jr., his pick to lead the Department of Health and Human Services, "to direct the Nation’s Medical Research, and to make important discoveries that will improve Health, and save lives.” “Together, Jay and RFK Jr. will restore the NIH to a Gold Standard of Medical Research as they examine the underlying causes of, and solutions to, America’s biggest Health challenges, including our Crisis of Chronic Illness and Disease," he wrote. The decision to choose Bhattacharya for the post is yet another reminder of the ongoing impact of the COVID pandemic on the politics on public health. Bhattacharya was one of three authors of the Great Barrington Declaration, an October 2020 open letter maintaining that lockdowns were causing irreparable harm. Get the latest breaking news as it happens. By clicking Sign up, you agree to our privacy policy . The document — which came before the availability of COVID-19 vaccines and during the first Trump administration — promoted “herd immunity,” the idea that people at low risk should live normally while building up immunity to COVID-19 through infection. Protection should focus instead on people at higher risk, the document said. “I think the lockdowns were the single biggest public health mistake,” Bhattacharya said in March 2021 during a panel discussion convened by Florida Gov. Ron DeSantis. The Great Barrington Declaration was embraced by some in the first Trump administration, even as it was widely denounced by disease experts. Then- NIH director Dr. Francis Collins called it dangerous and “not mainstream science.” His nomination would need to be approved by the Senate. Trump on Tuesday also announced that Jim O’Neill, a former HHS official, will serve as deputy secretary of the sprawling agency. Trump said O’Neill “will oversee all operations and improve Management, Transparency, and Accountability to, Make America Healthy Again,” the president-elect announced. O’Neill is the only one of Trump’s health picks so far who brings previous experience working inside the bureaucracy to the job. Trump’s previous choices to lead public health agencies — including Kennedy, Dr. Mehmet Oz for Centers for Medicare and Medicaid Services administrator and Dr. Marty Makary for Food and Drug Administration commissioner — have all been Washington outsiders who are vowing to shake up the agencies. Bhattacharya, who faced restrictions on social media platforms because of his views, was also a plaintiff in Murthy v. Missouri, a Supreme Court case contending that federal officials improperly suppressed conservative views on social media as part of their efforts to combat misinformation. The Supreme Court sided with the Biden administration in that case. After Elon Musk acquired Twitter in 2022, he invited Bhattacharya to the company's headquarters to learn more about how his views had been restricted on the platform, which Musk renamed X. More recently, Bhattacharya has posted on X about scientists leaving the site and joining the alternative site Bluesky, mocking Bluesky as "their own little echo chamber.” Bhattacharya has argued that vaccine mandates that barred unvaccinated people from activities and workplaces undermined Americans' trust in the public health system. He is a former research fellow at the Hoover Institution and an economist at the RAND Corporation. The National Institutes of Health falls under HHS, which Trump has nominated Kennedy to oversee. The NIH's $48 billion budget funds medical research on vaccines, cancer and other diseases through competitive grants to researchers at institutions across the nation. The agency also conducts its own research with thousands of scientists working at NIH labs in Bethesda, Maryland. Among advances that were supported by NIH money are a medication for opioid addiction, a vaccine to prevent cervical cancer, many new cancer drugs and the speedy development of mRNA COVID-19 vaccines.

College playoff bracket offers last dress rehearsal and one more chance to see where the SEC stands

When the Fortnite Chapter 5 and Remix Finale event takes the stage in-game on November 30, it will feature a pack of four iconic musical artists: Snoop Dogg, Eminem, Ice Spice, and Juice WRLD. Like previous in-game concerts, such as those starring Travis Scott and Ariana Grande, the event is likely to be a kaleidoscopic audiovisual roller coaster. Still, by including the late Juice WRLD, who passed away in 2019, this in-game concert will also be decidedly different from any before seen in Fortnite: It will be the first to use an artist's likeness posthumously, something that Hollywood is also grappling with as of late . GameSpot recently spoke to Nate Nanzer, Epic's head of global partnerships, in a music-focused interview that hit on the developer-publisher's decision to bring Juice WRLD, whose real name is Jarad Anthony Higgins, to Fortnite. Nanzer told me Epic had long hoped to do something like this with the late artist and explained why the company feels now is the right time. "It's something that our players have been asking for for years and years and years, and we've wanted to do it, but we wanted to find the right moment," Nanzer said. "We obviously want to do it in the most respectful way possible. We worked very closely with his mom and his label, and we were able to find the right moment where it felt right, around this event, and he has new music coming out, so all the stars kind of aligned around this moment." Nanzer mentioned that Juice WRLD himself was "a big Fortnite player," and though the Epic executive didn't say this, it stands to reason that Juice WRLD would want to be in the game if he could say so today. Still, even with the involvement of his family and his music label, for some, the inclusion of a deceased artist's likeness in this manner may always cross a line. In the movie world, Robert Downey Jr. recently said he plans to sue anyone who tries to create an AI replica of his likeness , and that even if it were to occur after he has died, his "law firm will still be very active." Events in 2012 surely predate many of Fortnite's biggest fans, but the Juice WRLD concert also recalls the Tupac "hologram" that once performed at Coachella . In the Fortnite world, I haven't personally seen a lot of pushback to Juice WRLD's involvement in next weekend's event. Certainly, there have been some feelings of ethics-based squeamishness, but the prevailing sentiment on places like the game's subreddit and popular Discord servers is one of excitement, perhaps owing to the often younger player pool in Fortnite. Whereas older players and onlookers may see this as a line being crossed, younger players who have already spent years growing up within Fortnite may more quickly accept this as a marvel of modern technology, and they may be excited to finally have the Fortnite Juice WRLD event Nanzer says has been one of the community's most requested. "Our community loves his music. We have data [that shows he is] still extremely popular. And I would say, I can't quantify this, but when I look at Reddit threads, or Discord chats, or Twitter threads, Juice WRLD comes up over and over and over again. I mean, people have made Juice WRLD concerts in Fortnite Creative and [Unreal Engine for Fortnite]." Nanzer added that he feels fans of the late artist will come out of the event with positive feelings. "We're hopeful. We know our players have been asking for it, so there's a lot of pressure to really deliver it the right way. I think people are really gonna love what we have coming, like, I think it's done in an awesome way. I think if you're a Juice WRLD fan, you're gonna feel good about it," he said. As mentioned, Juice WRLD's mother, Carmela Wallace, was involved in this collaboration. Earlier this month, she shared remarks on the upcoming event, which you can read in full below. The debate over when it is or isn't acceptable to use a deceased person's likeness won't end when Fortnite Chapter 5 does next weekend, but Nanzer told me the company wants "music to permeate everything in Fortnite," which likely means this isn't the last time Fortnite will court controversy, even unintentionally, as it strives to fulfill its vision of a multimedia metaverse. In fact, there are already rumors that a future Fortnite collaboration will revolve around XXXTentacion, a musical artist who was murdered in 2018 at the age of 20. Fortnite is a tastemaker on a global scale. Much of the games industry over the past half-decade has been mired in chasing lucrative trends that Fortnite started or had massive success with. Once meant to be nothing more than a survival game, Fortnite is today an increasingly hard-to-define platform that doesn't merely feature pop culture; it shapes it. As Epic continues down this path of making the ultimate everything experience, it's inevitably molding what the future looks like, whether we're ready to live there or not. Editor's note: Remarks from Mrs. Wallace were added to the body of this story shortly after publishing.Ed’s Plant Shop Celebrates Black Friday with 20% Off EverythingDemocrats push possible Trump response, other state legislative matters to New Year

INDIANAPOLIS (AP) — The Indianapolis Colts defense started this season struggling. It couldn't stop the run, couldn't keep teams out of the end zone, couldn't get off the field. Now the script has flipped. Defensive coordinator Gus Bradley's group is playing stouter, holding teams — even the high-scoring Detroit Lions — largely in check long enough to give Indy a chance to win, and it's the Colts offense that has struggled. “They are playing their tails off. You don’t want them on the field a bunch and as an offense you want to be able to play complementary football,” running back Jonathan Taylor said after Sunday's 24-6 loss. “I would say specifically on offense, it sucks when you can’t help your defense out when they are fighting their tails off all game.” Indy's defense held up its end of the bargain by limiting the Lions (10-1) to 14 first-half points and allowing just 24, matching Detroit's lowest output since Week 3. The problem: Even when the Colts (5-7) did get Detroit off the field, they couldn't sustain drives or score touchdowns. Again. Anthony Richardson provided the bulk of the ground game by rushing 10 times for 61 yards, mostly early. Taylor managed just 35 yards on 11 carries and a season-high 10 penalties constantly forced the Colts to dig out from deep deficits. Part of that was by design. “We knew Jonathan Taylor was going to be the guy we needed to shut down,” Lions coach Dan Campbell said. “We did that. The quarterback runs. It got us on a couple but overall, we did what we needed to do, and we kept them out of that game." Part of it could be because of an injury-battered offensive line that has started three rookies each of the past two weeks and finished the previous game with the same three rookies. Whatever the fix, Indy needs a good solution. There is good news for Indy is that its schedule now gets substantially more manageable. After losing four of five, all to teams in playoff position and three to division leaders, Indy faces only one team with a winning record in its final five games. The most recent time the Colts played a team with a losing mark, Richardson rallied them past the New York Jets 28-27. But Colts coach Shane Steichen knows that's not the answer. The Colts must get this offense righted now. “We’ve got to get that figured out. We’ve got to get him going on the ground,” Steichen said when asked about Taylor, who has 92 yards on his past 35 carries. “We’ll look at the offensive line. We’ll look at everything." Pass rush. Pro Bowl DT DeForest Buckner's presence certainly has been felt since he returned from a sprained ankle Oct. 27. In those past five games, the Colts have had 14 sacks, including three of Jared Goff on Sunday. Penalties. The Colts have had one of the cleanest operations in the league most of this season. Sunday was an anomaly, but one that can't merely be written off. WR Michael Pittman Jr. The five-year veteran is one of the league's toughest guys, but playing through a back injury appeared to take its toll on Pittman's productivity. Since sitting out in Week 10, Pittman has 11 receptions for 142 yards including six for 96 yards, his second-highest total of the season, Sunday. Tight ends. Each week the Colts want their tight ends to make an impact. And each week, they seem to fail. It happened again Sunday when Drew Ogletree dropped a TD pass that would have given Indy a 10-7 lead. Instead, Indy settled for a field goal and a 7-6 deficit. Through 12 games, Indy's tight ends have a total of 26 catches, 299 yards and two TDs. That's just not good enough in a league where versatile, productive tight ends increasingly signal success. Pittman and WR Josh Downs both returned to the game after leaving briefly with shoulder injuries. WR Ashton Dulin did not return after hurting his foot in the second half. But the bigger questions come on the offensive line. LT Bernhard Raimann (knee) was inactive Sunday, and rookie center Tanor Bortolini entered the concussion protocol Monday. Bortolini was one of three rookie starters the past two weeks, replacing Pro Bowler Ryan Kelly who is on injured reserve. 55.88 — Indy has scored touchdowns on 55.88% of its red zone trips this season. While it puts it near the middle of the NFL, it's cost the Colts multiple wins. Richardson needs to rebound from this latest 11 of 28 performance and show he can lead the Colts to victories week after week. He'll get plenty of chances over the season's final month, starting with next week's game at the New England Patriots. AP NFL: https://apnews.com/hub/nfl— BIRTH NAME: James Earl Carter, Jr. — BORN: Oct. 1, 1924, at the Wise Clinic in Plains, Georgia, the first U.S. president born in a hospital. He would become the first president to live for an entire century . — EDUCATION: Plains High School, Plains, Georgia, 1939-1941; Georgia Southwestern College, Americus, Georgia, 1941-1942; Georgia Institute of Technology, Atlanta, 1942-1943; U.S. Naval Academy, Annapolis, Maryland, 1943-1946 (class of 1947); Union College, Schenectady, New York, 1952-1953. — PRESIDENCY: Sworn-in as 39th president of the United States at the age of 52 years, 3 months and 20 days on Jan. 20, 1977, after defeating President Gerald R. Ford in the 1976 general election. Left office on Jan. 20, 1981, following 1980 general election loss to Ronald Reagan. — POST-PRESIDENCY: Launched The Carter Center in 1982. Began volunteering at Habitat for Humanity in 1984. Awarded Nobel Peace Prize in 2002. Taught for 37 years at Emory University, where he was granted tenure in 2019, at age 94. — OTHER ELECTED OFFICES: Georgia state senator, 1963-1967; Georgia governor, 1971-1975. — OTHER OCCUPATIONS: Served in U.S. Navy, achieved rank of lieutenant, 1946-53; Farmer, warehouseman, Plains, Georgia, 1953-77. — FAMILY: Wife, Rosalynn Smith Carter , married July 7, 1946 until her death Nov. 19, 2023. They had three sons, John William (Jack), James Earl III (Chip), Donnel Jeffrey (Jeff); a daughter, Amy Lynn; and 11 living grandchildren and 14 great-grandchildren. Source: Jimmy Carter Library & Museum

No. 23 Alabama women beat Alabama State 83-33 at Emerald Coast ClassicAttorneys for Donald Trump conducted an internal investigation into allegations that one of his top aides, Boris Epshteyn, has sought to gain financially from his influence with Trump and others in the president-elect’s orbit, according to multiple sources familiar with the matter. The internal investigation, which was confirmed by half a dozen sources and is not criminal in nature, has probed multiple instances of Epshteyn allegedly requesting payment in exchange for promoting candidates for administration positions or offering to connect individuals with people in the upcoming administration relevant to their industries, sources said. In one instance he requested as much as $100,000 per month in exchange for his services, according to sources familiar with the matter. Epshteyn’s alleged activities prompted those looking into the matter to make an initial recommendation that Epshteyn should be removed from Trump’s proximity and that he should not be employed or paid by Trump entities, according to two sources. As of Monday afternoon, it does not appear the transition team will heed that recommendation. “I am honored to work for President Trump and with his team,” Epshteyn said in a statement to CNN. “These fake claims are false and defamatory and will not distract us from Making America Great Again.” The alleged behavior by one of Trump’s closest advisers hints at some of the turmoil and strife behind the scenes of the transition process as the president-elect and his team staff the incoming administration. Epshteyn, long seen as one of Trump’s most loyal advisers, has played a significant role in the transition, sitting in on key meetings and candidate briefings at the president-elect’s Mar-a-Lago resort in Palm Beach, Florida. But his presence has often been a divisive one. A notorious Trump-world infighter, Epshteyn is known for his combative and loud personality, and often boasts about his close relationship with Trump, according to sources in and around the president-elect’s orbit. In recent years, Epshteyn has acted as both an attorney and an adviser to Trump and – much to the chagrin of some more experienced lawyers in Trump’s inner circle– played an influential role in organizing his criminal defense strategy after the former president was indicted four times. While Epshteyn has not been accused of illegal behavior, the decision to launch an internal investigation reflects the Trump team’s cautiousness around activity that could appear unsavory. “As is standard practice, a broad review of the campaign’s consulting agreements has been conducted and completed, including as to Boris, among others,” Trump transition spokesman Steven Cheung said in a statement to CNN. “We are now moving ahead together as a team to help President Trump Make America Great Again.” Source: ‘Very much pay-for-play’ Part of that investigation focused on claims that Epshteyn proposed that Scott Bessent, Trump’s pick for Treasury secretary, pay him to promote his name with Trump and others at Mar-a-Lago. Bessent did not make payments to Epshteyn. CNN has reached out to representatives of Bessent for comment. The back-and-forth between Epshteyn and Bessent resulted in a heated confrontation last week in the lobby of Mar-a-Lago, where Epshteyn raised his voice at Bessent, according to two sources briefed on the matter. In at least one other instance, Epshteyn asked for payment in exchange for introductions and influence with the incoming Trump administration, according to two sources. Trump’s legal team was investigating several other similar alleged incidents, according to sources familiar with the situation. The allegations concerning Epshteyn were brought to incoming White House chief of staff Susie Wiles, two sources familiar with the matter told CNN. It is unclear whether the allegations have been presented to Trump directly. At times, Epshteyn has described the services he is trying to sell as a type of consulting, but the legal team investigating the issue has struggled to pinpoint any legitimate consulting work Epshteyn has provided, according to a source familiar with the matter. “The way I see it is it’s very much a pay-for-play,” said one person who spoke to the legal team that investigated Epshteyn. This person described a separate incident in which Epshteyn allegedly tried to request payment for questionable consulting services, offering to connect the person with incoming administration officials relevant to their industry or lobbying firms that will be the most well-connected to the new administration. The investigator assured the person that their interaction with Epshteyn wasn’t an isolated incident. “It was like, ‘Hey, you’re not the only one,’” the person who spoke to investigators said. “He’s gone to everybody for it.” One person close to Epshteyn brushed off the notion that this was pay-for-play. “This is how Washington works,” the person said. Allies of Epshteyn described the internal review as the product of newer associates not understanding the dynamic between Trump and Epshteyn as well as a disdain for the power Epshteyn wields with the President-elect. Epshteyn was a constant presence on Trump’s plane through the end of the 2024 campaign, often insisting on being present for conversations and briefings that had nothing to do with legal matters, a source close to Trump told CNN. “Boris is a Trump original—loyal and effective from the very beginning,” a Trump transition official told CNN. “He works for President Trump, and nobody else, and has helped defeat the most vicious lawfare campaign in history. Boris has seen these petty skirmishes before, but he always perseveres.” Lobbied for Gaetz As the legal team’s investigation got underway, Epshteyn sent cease-and-desist-style messages to associates, claiming he had never demanded payment and threatening legal action, according to two people familiar with the matter. Epshteyn has long been a fixture of the president-elect’s inner circle and has been part of key meetings with Trump at Mar-a-Lago during the transition period. He is often spotted at Mar-a-Lago eating dinner with the president-elect on the patio and has sat in on several transition meetings and candidate briefings, particularly related to Trump’s choices for the Department of Justice. Sources described Epshteyn as responsible for pushing former Florida Rep. Matt Gaetz’s name amid discussions about who Trump should pick as his attorney general. Epshteyn lobbied for Gaetz directly to Trump on a flight just hours before Gaetz was named as the pick. The former Florida congressman later withdrew after it became clear he didn’t have the votes in the Senate amid the potential disclosure of a House Ethics Committee report detailing an investigation into Gaetz, including over allegations of sexual misconduct and other alleged crimes. Confrontation with Musk Despite a seemingly more orderly and quick process than in 2016, Trump’s transition this time around is still rife with the infighting that is typically on display in Trump’s orbit, multiple sources familiar with the matter tell CNN. Sources on the transition team have expressed frustration at how many people have Trump’s ear and how quickly a day’s progress can be undone. Tensions between Epshteyn and some other members of Trump’s inner circle have escalated in recent weeks. Elon Musk, who has been by Trump’s side regularly since the election and has a growing influence on the president-elect, has questioned Epshteyn’s sway over Trump. The two also had a confrontation at Mar-a-Lago, with Musk leveling a number of accusations at Epshteyn, according to two sources familiar with the matter. This year, the Trump campaign paid Epshteyn’s firm, Georgetown Advisory, $53,500 each month for communications and legal consulting, according to campaign finance records through October, the most recent month available. Epshteyn briefly served in the first Trump administration as a special assistant to the president in 2017, but he has not been offered a formal role in the incoming administration. Epshteyn stood alongside Trump during his arraignment in his New York hush money case and traveled with him for his arraignments in Georgia and Washington, DC. Epshteyn himself faces criminal charges in a case in Arizona related to efforts to upend the results of the 2020 presidential election. He has pleaded not guilty.Scienture Holdings to Receive Funding of Up to $12 Million From Private Placement of 10% Secured Convertible Debentures and Up to $50 Million from Equity Line of Credit Tampa, FL, Nov. 26, 2024 (GLOBE NEWSWIRE) -- Scienture Holdings, Inc. (Nasdaq: SCNX) (the "Company” or "Scienture”), a pharmaceutical company with strategic capabilities across R&D, manufacturing, sales & marketing, and commercial operations, today announced it has entered into a securities purchase agreement to issue 10% secured convertible debentures in an aggregate principal amount of up to $12,222,222 million to certain affiliates of Arena Investors, LP ("Arena”) in three separate tranches that are subject to certain closing conditions. The closing of the first tranche was consummated on November 25, 2024 and the Company issued debentures in an aggregate principal amount of approximately $3.33 million. Dawson James Securities, Inc. acted as the sole placement agent for the private placement of the debentures. Concurrent with the debenture offering, Scienture also entered into an agreement with Arena Business Solutions ("ABS”), an affiliate of Arena, for a $50 million equity line of credit (ELOC). Under the terms of the agreement, the Company will have the right, but not the obligation, to issue and sell to ABS up to $50 million of shares of common stock over a period of 36 months, subject to customary conditions. The Company has no immediate plans to draw upon the ELOC. Scienture intends to use the proceeds from this strategic financing for working capital and other general corporate purposes. Scienture will determine the allocation of funds according to the Company's strategic needs. Further information regarding the Securities Purchase Agreement and the ELOC Agreement are provided in the Current Report on Form 8-K filed today with the Securities and Exchange Commission. About Arena Investors, LP Arena is an institutional asset manager founded in partnership with The Westaim Corporation. With $3.5 billion invested and committed assets under management as of June 30, 2024, and a team of over 180 employees in offices globally, Arena provides investment capital to a broad range of industries, including healthcare. The firm brings individuals with decades of experience, a track record of comfort with industry complexity, the ability to deliver within time constraints, and the flexibility to engage in transactions that cannot be addressed by banks and other conventional financial institutions. Arena Business Solutions, an affiliate of Arena, provides equity capital markets solutions for emerging public companies. For more information, please visit www.arenaco.com. About Scienture Scienture Holdings, Inc. is a NY based pharmaceutical company. We are a highly experienced team of industry professionals who are passionate about developing unique specialty product concepts and solutions that bring enhanced value to patients and healthcare systems. Our assets in development are across therapeutics areas, indications and cater to different market segments. Scienture is a fully fitted company with strategic capabilities across R&D, Manufacturing, Sales and Marketing and Commercial Operations. For more information, visit Scienture's website at www.scienture.com. Forward-Looking Statements Cautionary Statements Regarding Forward-Looking Statements This press release contains certain statements that may be deemed to be "forward-looking statements” within the federal securities laws, including the safe harbor provisions under the Private Securities Litigation Reform Act of 1995. Statements that are not historical are forward-looking statements within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. Forward-looking statements relate to future events or our future performance or future financial condition. These forward-looking statements are not historical facts, but rather are based on current expectations, estimates and projections about our company, our industry, our beliefs and our assumptions. Such forward-looking statements include, but are not limited to, statements regarding our or our management team's expectations, hopes, beliefs, intentions or strategies regarding the future. In addition, any statements that refer to projections, forecasts or other characterizations of future events or circumstances, including any underlying assumptions, are forward-looking statements. In some cases, you can identify forward-looking statements by the following words: "anticipate,” "believe,” "continue,” "could,” "estimate,” "expect,” "intend,” "may,” "ongoing,” "plan,” "potential,” "predict,” "project,” "should,” or the negative of these terms or other similar expressions, but the absence of these words does not mean that a statement is not forward-looking. Forward-looking statements are subject to a number of risks and uncertainties (some of which are beyond our control) that may cause actual results or performance to be materially different from those expressed or implied by such forward-looking statements. Accordingly, readers should not place undue reliance on any forward-looking statements. These risks include risks relating to agreements with third parties; our ability to raise funding in the future, as needed, and the terms of such funding, including potential dilution caused thereby; our ability to continue as a going concern; security interests under certain of our credit arrangements; our ability to maintain the listing of our common stock on the Nasdaq Capital Market; claims relating to alleged violations of intellectual property rights of others; the outcome of any current legal proceedings or future legal proceedings that may be instituted against us; unanticipated difficulties or expenditures relating to our business plan; and those risks detailed in our most recent Annual Report on Form 10-K and subsequent reports filed with the SEC. Forward-looking statements speak only as of the date they are made. The Company undertakes no obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise that occur after that date, except as otherwise provided by law. Contacts: Scienture Holdings, Inc. 6308 Benjamin Rd, Suite 708 Tampa, Florida 33634 Phone: (866) 468-6535 Email: [email protected] Arena Investors, LP Parag Shah Email: [email protected]

WEST PALM BEACH, Fla. (AP) — An online spat between factions of supporters over immigration and the tech industry has thrown internal divisions in his political movement into public display, previewing the fissures and contradictory views his coalition could bring to the White House. The rift laid bare the tensions between the newest flank of Trump’s movement — wealthy members of the tech world including billionaire and fellow entrepreneur and their call for more highly skilled workers in their industry — and people in Trump’s Make America Great Again base who championed his hardline immigration policies. The debate touched off this week when , a right-wing provocateur with a history of racist and conspiratorial comments, criticized Trump’s selection of as an adviser on artificial intelligence policy in his coming administration. Krishnan favors the ability to bring more skilled immigrants into the U.S. Loomer declared the stance to be “not America First policy” and said were doing so to enrich themselves. Much of the debate played out on the social media network X, which Musk owns. Loomer’s comments sparked a back-and-forth with venture capitalist and former , whom Trump has tapped to be the “White House A.I. & Crypto Czar.” Musk and Ramaswamy, , weighed in, defending the tech industry’s need to bring in foreign workers. It bloomed into a larger debate with more figures from the hard-right weighing in about the need to hire U.S. workers, whether values in American culture can produce the best engineers, free speech on the internet, the newfound influence tech figures have in Trump’s world and what his political movement stands for. Trump has not yet weighed in on the rift, and his presidential transition team did not respond to a message seeking comment. Musk, the world’s richest man who has , was a central figure in the debate, not only for his stature in Trump’s movement but his stance on the tech industry’s hiring of foreign workers. Technology companies say H-1B visas for skilled workers, used by software engineers and others in the tech industry, are critical for hard-to-fill positions. But critics have said they undercut U.S. citizens who could take those jobs. Some on the right have called for the program to be eliminated, not expanded. Born in South Africa, Musk was once on an a H-1B visa himself and defended the industry’s need to bring in foreign workers. “There is a permanent shortage of excellent engineering talent,” he said in a post. “It is the fundamental limiting factor in Silicon Valley.” Trump’s own positions over the years have reflected the divide in his movement. His tough immigration policies, including his pledge for a mass deportation, were central to his winning presidential campaign. He has focused on immigrants who come into the U.S. illegally but he has also , including family-based visas. As a presidential candidate in 2016, Trump called the H-1B visa program “very bad” and “unfair” for U.S. workers. After he became president, Trump in 2017 issued a “Buy American and Hire American” , which directed Cabinet members to suggest changes to ensure H-1B visas were awarded to the highest-paid or most-skilled applicants to protect American workers. Trump’s businesses, however, have hired foreign workers, including , and his social media company behind his Truth Social app for highly skilled workers. During his 2024 campaign for president, as he made immigration his signature issue, Trump said immigrants in the country illegally are “poisoning the blood of our country” and promised to carry out the largest deportation operation in U.S. history. But in a sharp departure from his usual alarmist message around immigration generally, Trump this year that he wants to give automatic green cards to foreign students who graduate from U.S. colleges. “I think you should get automatically, as part of your diploma, a green card to be able to stay in this country,” he told the “All-In” podcast with people from the venture capital and technology world. Those comments came on the cusp of Trump’s budding alliance with tech industry figures, but he did not make the idea a regular part of his campaign message or detail any plans to pursue such changes.

Your black plastic kitchen utensils aren’t so toxic after all. But you should still toss them, group saysWhen Jimmy and entered the White House in 1977, they became the first couple since to raise their children in the executive mansion on Pennsylvania Avenue. Over the years, their family continued to grow in size, with nearly two dozen grandchildren and great-grandchildren added to the Carter clan. “We have a big family now. We have 22 grandchildren and great-grandchildren, 38 of us in all,” Carter told CNN in 2015. “So, we try to hold our family together and just enjoy the family life.” Rosalynn passed away in November 2023. Carter became the longest-living president when he turned 98 in October 2022. He died at the age of 100 on Sunday, December 29, his son announced. An immediate cause was not given. “It’s been awe-inspiring to watch my grandfather live out his values for all these decades,” his grandson Jason Carter told in a previous interview. “My earliest memories are from his years in the White House, and I’ve grown up witnessing and learning from his faith and his belief in equal treatment and respect for all people." In February 2023, Carter entered hospice care following multiple hospital stays. He celebrated his 100th birthday on October 1, 2024, joining his loved ones in the backyard of his home to watch a military flyover in his honor. His grandson Jason said he is also looking forward to voting for Kamala Harris in the November election. John William “Jack” Carter, 77, is the eldest son of Jimmy and Rosalynn Carter. He spent his young adult years at the Georgia Institute of Technology, but later left to join the US Navy and served during the Vietnam War. He would eventually be discharged after he was caught smoking marijuana while stationed in Idaho, but he would later rejoin Georgia Tech and earn a degree in nuclear physics. Like his father, Mr Carter also had a stint in US politics, winning the Democratic primary for the US Senate in Nevada in 2006, but he lost the general election to Republican John Ensign. His top issues during the campaign were opposing the Iraq War and improving healthcare, particularly for veterans. “We took our eye off Afghanistan, which should have been the focus,” he said during a campaign stop with his father, according to the James Earl “Chip” Carter III, 74, the second eldest son, was handed down his father’s and grandfather’s name. He had a son with his first wife Caron Griffin, whom he also bestowed the name upon. He worked in the family peanut warehouse for a while before he was elected to the Plains City Council and worked on the Democratic National Committee. Jimmy Carter revealed in the documentary that Chip and singer Willie Nelson smoked marijuana on the White House roof. “When Willie Nelson wrote his autobiography, he confessed that he smoked pot in the White House one night when he was spending the night with me,” Mr Carter said in the documentary. “And he says that his companion that shared the pot with him was one of the servants in the White House. That is not exactly true — it actually was one of my sons, which he didn’t want to categorize as a pot-smoker like him.” Donnel “Jeff” Carter, 72, is the youngest of the Carter brothers. He studied geography and computer cartography and later co-founded the company Computer Mapping Consultants with his former professor the same year he graduated, he told He had three children, Joshua, Jeremy, and James, but Jeremy passed away in 2015 at the age of 28 from an . Donnel lost his wife Annette, 68, in 2021. He met her on their first day of school at Georgia Southwestern State University. Joshua Carter for his mother that “Jeff saw her across the student center while he was playing spades, and he told his friends to turn around and look at that pretty girl that just walked in. He told them he was going to marry her, and four years later he did.” They were married for 46 years. Amy Carter, 57, is the only daughter and youngest child by 15 years of the former president and first lady. Ms Carter spent her childhood years in the White House while her father was serving as president, putting her in the political and media spotlight at a young age. Born in October 1967, she was nine years old when her father became president. She later went on to become known for her political activism, such as participating in protests and sit-ins against US foreign policy in Central America and apartheid in South Africa. On one occasion in 1986, Ms Carter and several others were arrested during a protest against CIA recruitment. She was acquitted of charges of disorderly conduct and trespassing, She illustrated her father’s children’s book, , which was published in 1995. Ms Carter has two sons from two marriages. In more recent years, she has kept a low profile. She became a member of the Carter Center Board of Councilors in 2020.