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niceph cc ——Introducing Sanyou Mrna Mab innovative antibody generation technology platform SHANGHAI, Dec. 6, 2024 /PRNewswire/ -- With the announcement of the 2024 Nobel Prize in Physiology or Medicine, microRNA has once again become the focus of global attention. In the past 20 years, three Nobel Prizes have been awarded to the field of RNA molecular research, namely "RNA interference mechanism - double-stranded RNA gene silencing (RNAi)" in 2006, "mRNA vaccines based on modified bases" in 2023, and "microRNA in post-transcriptional gene regulation" in 2024. By studying different types of RNA, scientists have subverted people's previous understanding of the role of RNA in the regulation of gene expression, unveiled the mystery of RNA as the engine of evolution of organisms, and as the control of genetic information flow. This opens a new window for us to understand the basic mechanisms of life sciences, and also opens up new ideas for the diagnosis and treatment of diseases. The Mrna Mab innovative monoclonal antibody technology platform is launched following this trend, which covers mRNA sequence design, mRNA in vitro transcription and purification, mRNA-LNP packaging, mRNA-LNP animal immunization, STAL phage display antibody library construction, automated antibody library screening, Bac-to-Mammalian full-length antibody production, integrated antibody screening and other technologies, which can provide one-stop innovative antibody research and development from target to high-quality monoclonal antibody. This platform from Sanyou Bio has a number of advantages: 1) AI-assisted design of the mRNA non-coding region (UTR) sequence to enhance the mRNA stability; 2) Optimization of the mRNA coding region (CDS) sequence based on the sequence analysis software independently developed by the company, which can enhance the mRNA stability and improve the translation efficiency; 3) mRNA animal immunization which can obtain equivalent serum titers, and reduce the preparation cost and time of difficult-to-express antigens. In addition, Sanyou Bio has established a complete mRNA supply chain, which ensures the stability, efficacy and integrity of mRNA from preparation to LNP packaging. Sanyou Bio's mRNA platform jumps out of the limitations of protein targets, further expands its one-stop service for antigen preparation and antibody discovery, and develops customized plans according to different target types to meet customers' needs. For proteins that are difficult to prepare in vitro, such as multi-transmembrane proteins (e.g., CD20) and GPCR proteins (e.g., CCR8), mRNA immunization can not only reduce the cost and time of antigen preparation, but also maintains comparable serum titer compared to conventional VLP and cell line immunization. About Sanyou Bio Sanyou Biopharmaceuticals Co., Ltd. is a high-tech biopharmaceutical company with the vision of "improving the quality of human life through innovative biologics" and the mission of " to make the R&D easy for innovative biologics". The company is headquartered in Shanghai, China, with subsidiaries in the United States, Europe, and other regions. It has over 20,000 square meters of R&D and GMP facilities that are currently in operation or under planning. The company has established a world-leading preclinical intelligent and integrated R&D platform for innovative biologics, centered around an innovative platform of super-trillion antibody library. This platform accelerates the development of innovative biologics across four dimensions: new drug discovery, preclinical research, AI-assisted drug development, and frontier scientific research. Sanyou provides a comprehensive "4C" business model for innovative biologics, combining differentiated CRO, integrated CDO, collaborative CPO, and specialized CRS. The company has built a global marketing network and established business with over 1,200 pharmaceutical and biotech companies worldwide. It has completed more than 1,200 new drug discovery and development service projects, with over 50 collaborative R&D projects, including 9 that have obtained IND approval. The company has also developed thousands of RUO reagents. Sanyou has also received a number of nationwide and Shanghai recognitions and awards. View original content: https://www.prnewswire.com/news-releases/another-star-technology-platform-of-the-sanyou-ai-stal-family-302323327.html SOURCE Sanyou Bio

3 Dividend Powerhouses Offering Yields Up To 9.4%NEW ORLEANS — A scruffy little fugitive is on the lam again in New Orleans, gaining fame as he outwits a tenacious band of citizens armed with night-vision binoculars, nets and a tranquilizer rifle. Scrim, a 17-pound mutt that's mostly terrier, has become a folk hero, inspiring tattoos, T-shirts and even a ballad as he eludes capture from the posse of volunteers. And like any antihero, Scrim has a backstory: Rescued from semi-feral life at a trailer park and adopted from a shelter, the dog broke loose in April and scurried around the city until he was cornered in October and brought to a new home. Weeks later, he'd had enough. Scrim leaped out of a second-story window, a desperate act recorded in a now-viral video. Since then, despite a stream of daily sightings, he's roamed free. The dog’s fans include Myra and Steve Foster, who wrote “Ode to Scrim” to the tune of Ricky Nelson’s 1961 hit, “I’m a Travelin’ Man.” Michelle Cheramie, founder of Zeus' Rescues, at her office in New Orleans on Dec. 9 with a whiteboard index of sheltered cats and dogs and a Scrim look-alike recuperating in the background. 'I'm a travelin' dog and I've made a lot of stops/All over this town...' Leading the recapture effort is Michelle Cheramie, a 55-year-old former information technology professional. She lost everything — home, car, possessions — in Hurricane Katrina in 2005, and in the aftermath, found her calling rescuing pets. “I was like, ‘This is what I should be doing,’” Cheramie said. “I was born to rescue.” She launched Zeus’ Rescues, a nonprofit shelter that now averages 600 cat and dog adoptions a year and offers free pet food to anyone who needs it. She helped Scrim find the home he first escaped from. It was Cheramie's window Scrim leaped from in November. She's resumed her relentless mission since then, posting flyers on telephone poles and logging social media updates on his reported whereabouts. She's invested thousands of dollars on wildlife cameras, thermal sensors and other gear. She took a course offered by the San Diego Zoo on the finer points of tranquilizing animals. And she's developed a network of volunteers — the kind of neighbors who are willing to grid-search a city at 3 a.m. Scrim on Oct. 24 at the Metairie Small Animal Hospital in Metairie, La. '...And at every stop I own the heart, of at least one lovely...' People like writer David W. Brown, who manages a crowd-sourced Google Map of all known Scrim sightings. He says the search galvanized residents from all walks of life to come together. As they search for Scrim, they hand out supplies to people in need. “Being a member of the community is seeing problems and doing what you can to make life a little better for the people around here and the animals around you,” Brown said. Neighbor Tammy Murray had to close her furniture store and lost her father to Parkinson's disease. This search, she says, got her mojo back. “Literally, for months, I’ve done nothing but hunt this dog,” said Murray, 53. “I feel like Wile E. Coyote on a daily basis with him.” Murray drives the Zeus' Rescues van toward reported Scrim sightings. She also handles a tactical net launcher, which looks like an oversized flashlight and once misfired, shattering the van's window as Scrim sped away. After realizing Scrim came to recognize the sound of the van's diesel engine, Murray switched to a Vespa scooter for stealth. Michelle Cheramie, director of Zeus' Rescues, left, walks with Scrim on Oct. 24 at the Metairie Small Animal Hospital in Metairie, La. '...If you're ever in the 9th Ward stop and see/My cute little mini poodle...' Near-misses have been tantalizing. The search party spotted Scrim napping beneath an elevated house, and wrapped construction netting around the perimeter, but an over-eager volunteer broke ranks and dashed forward, leaving an opening Scrim slipped through. Scrim's repeated escapades prompted near-daily local media coverage and a devoted online following. Cheramie can relate. “We’re all running from something or to something," she said. "He's doing that, too.” Cheramie's team dreams of placing the pooch in a safe and loving environment. But a social media chorus growing under the hashtag #FreeScrim has other ideas — they say the runaway should be allowed a life of self-determination. The animal rescue volunteers consider that misguided. “The streets of New Orleans are not the place for a dog to be free,” Cheramie said. “It’s too dangerous.” Scrim rests in a kennel Oct. 24 at the Metairie Small Animal Hospital in Metairie, La. '...and my Shar-Pei doll down in old Treme/Waits for my return...' Scrim was a mess when Cheramie briefly recaptured him in October, with matted fur, missing teeth and a tattered ear. His trembling body was scraped and bruised, and punctured by projectiles. A vet removed one, but decided against operating to take out a possible bullet. The dog initially appeared content indoors, sitting in Cheramie's lap or napping beside her bed. Then while she was out one day, Scrim chewed through a mesh screen, dropped 13 feet to the ground and squeezed through a gap in the fence, trotting away. Murray said Cheramie's four cats probably spooked him. Cheramie thinks they may have gotten territorial. Devastated but undeterred, the pair is reassessing where Scrim might fit best — maybe a secure animal sanctuary with big outdoor spaces where other dogs can keep him company. Somewhere, Murray says, “where he can just breathe and be.” Scrim sits in the arms of Zoey Ponder on Oct. 24 at Metairie Small Animal Hospital in Metairie. A Scrim sticker for sale Dec. 9 at Zeus' Rescues office to raise money for the shelter in New Orleans. A homemade portrait of Scrim hangs Dec. 9 in the Zeus' Rescues shelter in New Orleans. Scrim spends some time outside Oct. 24 with Michelle Cheramie, director of Zeus' Rescues, in a fenced-in area at Metairie Small Animal Hospital in Metairie. Scrim at the Terrebonne Parish Animal Shelter in Louisiana. Stay up-to-date on what's happening Receive the latest in local entertainment news in your inbox weekly!

Samsung Biologics listed among top most sustainable companies in Dow Jones Sustainability World Index

The Liberal government is pulling out the federal wallet to put more money into people’s pockets over the holidays, but its recently announced affordability measures create winners and losers. Prime Minister Justin Trudeau announced on Thursday that the federal government will remove the goods and services tax on a slew of items for two months, starting Dec. 14. But in provinces where the provincial and federal sales taxes are blended together into a harmonized sales tax, Canadians will get a larger break. The federal government also plans to send $250 cheques to Canadians who were working in 2023 and earned up to $150,000. That means Canadians who were not working in 2023, including those who were receiving social assistance or were in retirement, will not be sent a cheque in April. In the House of Commons on Friday, NDP MP Peter Julian called the government out for not including Canadians with fixed incomes. “Why are Liberals excluding seniors and people with disabilities from the real help they need this holiday season? Why won’t Liberals help them, too?” Julian asked during question period. At a news conference on Friday, Trudeau said that the federal government has already stepped up to help the most vulnerable Canadians and that it is now time to give a hand to workers. “Over the past number of years, we have been extraordinarily present in helping the most vulnerable Canadians,” Trudeau said, mentioning the boost to old-age security for seniors aged 75 and older and the Canada Child Benefit. “But as I travel across the country, I do regularly hear from working Canadians who are having trouble making ends meet, but saying, ‘look, I don’t have kids. I’m not a senior yet, and I’m facing challenges.’” The GST break, which is expected to cost the federal government $1.6 billion, will apply to a number of items including children’s clothing and shoes, toys, diapers, restaurant meals and beer and wine. It also applies to Christmas trees — both natural and artificial — along with a variety of snack foods and beverages, and video game consoles. Meanwhile, 18.7 million people will receive a check this spring, costing the government about $4.7 billion.NoneHYDERABAD Working president of the Bharat Rashtra Samithi (BRS) K.T. Rama Rao has observed that by unveiling a new model of Telangana Talli statue the Congress government in the State has not only disrespected Telangana but also hurt the sentiments of people associated with the culture and prosperity of the region. Speaking after inaugurating the party office of Medchal-Malkajigiri district and also a Telangana Talli statue on the premises of the new office at Medchal on Monday in the presence of several legislators and party leaders, he compared the unveiling of a statue in the name of Telangana Talli on the Secretariat complex by Chief Minister A. Revanth Reddy as the killers holding a condolence meeting as it was who spoke against Telangana activists and martyrs during the movement for Statehood. He stated that Mr. Revanth Reddy would go into the history as the first person to change the image of mother. Stating that nobody in the State had asked for change of Telangana Talli, he sought to know whether the image of Bharata Mata or Telangana Talli would change every time a government was changed. Telangana Talli did not mean a person, a system or a party but it was an inspiration to the entire people of the region. By removing ‘Bathukamma’ from Telangana Talli, the Congress government was insulting the culture of Telangana people itself, he said and reiterated that when BRS will return to power it would send the statues of both Telangana Talli and Rajiv Gandhi statue installed in front of the Secretariat to Gandhi Bhavan, the Congress party office here. Medchal district president of BRS and MLC Shambhipur Raju, Quthbullapur MLA K.P. Vivekanand said the people of Greater Hyderabad were with BRS as proved in the last Assembly elections. Published - December 10, 2024 04:50 am IST Copy link Email Facebook Twitter Telegram LinkedIn WhatsApp Reddit Telangana / Hyderabad / politics / political parties

Samsung Biologics listed among top most sustainable companies in Dow Jones Sustainability World IndexSurface Protection Service Market to Observe Prominent CAGR of 9% by 2031, Size, Share, Trends, Demand, Growth, Challenges and Competitive Outlook