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m.fb.777 By DAVID BAUDER Time magazine gave Donald Trump something it has never done for a Person of the Year designee: a lengthy fact-check of claims he made in an accompanying interview. Related Articles National Politics | Trump’s lawyers rebuff DA’s idea for upholding his hush money conviction, calling it ‘absurd’ National Politics | Trump wants to turn the clock on daylight saving time National Politics | Ruling by a conservative Supreme Court could help blue states resist Trump policies National Politics | A nonprofit leader, a social worker: Here are the stories of the people on Biden’s clemency list National Politics | Nancy Pelosi hospitalized after she ‘sustained an injury’ on official trip to Luxembourg The fact-check accompanies a transcript of what the president-elect told the newsmagazine’s journalists. Described as a “12 minute read,” it calls into question 15 separate statements that Trump made. It was the second time Trump earned the Time accolade; he also won in 2016, the first year he was elected president. Time editors said it wasn’t a particularly hard choice over other finalists Kamala Harris, Elon Musk, Benjamin Netanyahu and Kate Middleton. Time said Friday that no other Person of the Year has been fact-checked in the near-century that the magazine has annually written about the figure that has had the greatest impact on the news. But it has done the same for past interviews with the likes of Joe Biden, Netanyahu and Trump. Such corrections have been a sticking point for Trump and his team in the past, most notably when ABC News did it during his only debate with Democrat Kamala Harris this fall. There was no immediate response to a request for comment on Friday. In the piece, Time called into question statements Trump made about border security, autism and the size of a crowd at one of his rallies. When the president-elect talked about the “massive” mandate he had received from voters, Time pointed out that former President Barack Obama won more electoral votes the two times he had run for president. The magazine also questioned Trump’s claim that he would do interviews with anyone who asked during the campaign, if he had the time. The candidate rejected a request to speak to CBS’ “60 Minutes,” the magazine said. “In the final months of his campaign, Trump prioritized interviews with podcasts over mainstream media,” reporters Simmone Shah and Leslie Dickstein wrote. David Bauder writes about media for the AP. Follow him at http://x.com/dbauder and https://bsky.app/profile/dbauder.bsky.social.Qatar tribune Tribune News Network Doha Al Jazeera Digital is set to launch ‘True Crime Reports’, the first true crime video podcast created by Al Jazeera and the first from a major news organisation to utilise AI in visual storytelling. Hosted by renowned journalist Halla Mohieddeen, the show aims to broaden the scope of true crime narratives by focusing on under-reported stories from the Global South and beyond. ‘True Crime Reports’ innovative format combines AI-generated visuals to re-enact aspects of the cases, motion graphics, and interviews with individuals at the heart of these stories, offering a unique and immersive experience for viewers and listeners. “We’re taking the popular true crime genre but widening our focus to the Global South and beyond because crime affects all kinds of people worldwide,” says Halla Mohieddeen, host of True Crime Reports. “We want to spotlight countries and topics often under-reported in this genre, which Al Jazeera is best placed to do. Too often, the ‘missing white woman’ syndrome plagues news media, and this genre isn’t exempt. The way we talk about crime matters, and this new project will help provide a new perspective and make a difference in how true crime is reported.” Ney Alvarez, Al Jazeera’s Head of Audio, emphasises the show’s pioneering nature: “We are immensely proud to be at the forefront of innovation in video podcasting. By creating a show that seamlessly blends AI technology with fact-checked storytelling, we’re not just telling stories—we’re bringing them to life in a way that’s never been done before in the true crime genre.” The show is a co-production between Al Jazeera and Message Heard, a podcast production company known for creating compelling, purpose-driven content. Jake Warren, founder and CEO of Message Heard, said: “There’s no dimming in the appetite for true crime podcasts, but we are happy to be shining a light on gripping, human stories that podcast audiences have never heard of before outside of the traditional true crime heartlands of rural North America and the Anglosphere. These are simply great stories which respect the dignity of the people at their heart.” True Crime Reports will cover a diverse range of cases, from a prison break in South Africa to the murder of a game show contestant in Peru, offering exclusive archive access and contributions from those affected by these stories and moving beyond the typical focus on English-speaking countries. The podcast will be available on Al Jazeera’s YouTube Podcast tab, all major streaming platforms, and Al Jazeera’s digital platforms starting on January 5. Copy 27/12/2024 10

European Auto Industry Turmoil At Volkswagen & Stellantis Likely To Accelerate In 2025TRADITIONAL CRAFT A Tboli weaver showcases her craft at Winaca Village in Tublay, Benguet, as part of activities for the World Ikat Textiles Symposium held in Baguio City early this month. —Joel Arthur Tibaldo/Contributor BAGUIO CITY, Philippines — Domestic silk production is undergoing a revival in the provinces as international demand rises for natural dyes and indigenous fabric, experts said at this year’s World Ikat Textiles Symposium which was hosted by the Philippines for the first time in Baguio early this month. Piloted 42 years ago in Benguet province, sericulture hubs have been put up in the Cordillera, Cagayan Valley, southern Luzon and Northern Mindanao where mulberry plantations again flourish, said Julius Leaño, director of the Philippine Textile Research Institute (PTRI), in a talk he gave at the symposium. READ: Narda’s legacy: Reviving Cordillera ‘ikat’ Sericulture or silk farming is a technology that cultivates silk from the cocoons of silk moth caterpillars which latch onto mulberry branches. If the progress of mulberry silk farms continues as planned, the Philippines will be “silk sufficient” by the year 2030, employing 980 workers and earning P50 million in combined revenue, said Leaño, a published researcher specializing in textile chemistry. But technology has afforded Filipino scientists the means to harvest weaving fiber from other plants as part of a government-led textile innovation drive, he said, with the development of yarns from bamboo, or “kawayarn,” water hyacinth, bakong (Hanguana malayana in Cagayan province) and the common “saluyot” (jute). Some of these plants share the antimicrobial properties of yarn produced from pineapple, Leaño said. Research into the potentially new plant sources for yarn coincides with new product lines using domestic woven fabric, such as ikat shoes, he said. Ikat is a method of dyeing or coloring fabric in patterns before it is woven. Leading textile scholars like Joseph Lo of Singapore, Maria do Ceu Lopes da Silva of Timor Leste, Bina Rao of India and Mexican artisan Arturo Estrada Hernandez outlined ikat’s market growth and subsequent debates about authenticity among weaving cultures throughout the world. National Living Treasures Samporonia Madanlo and Barbara Ofonga, who champion traditional Tboli weaving, and Rosie Sula for Tboli chant were vocal about the way commerce has upended efforts to preserve their ikat traditions, which are tied to the culture’s spiritual roots. Indigenous ikat is generally woven by hand using handlooms, footlooms or backstrap looms and may take weeks or months to complete. But one of the biggest obstacles being solved by government sericulture initiatives is the supply of indigenous dyes and textiles, which has not helped efforts to keep the weaving knowledge alive among present-day indigenous Filipinos, according to University of the Philippines (UP) Baguio anthropology professor Analyn Salvador Amores. Amores heads the multidisciplinary program Cordillera Textiles Research Project (Corditex) of UP Baguio which has discovered and analyzed extant weaving techniques that are being reintroduced to Cordillera weavers who have long forgotten them. Corditex identified the chemical makeup of dyes used by Itneg weavers in Abra, tracked down the original plants and other botanical resources used to produce woven Cordillera garments, and even studied the music, diagrams and mythology associated with the old handloom weaving traditions. Amores said Corditex was also studying the region’s “textile value chain,” focusing on how the market, the local economy and the dwindling supply of raw materials had affected livelihoods and the protection of indigenous traditions when she first discussed the matter at the Cordillera Regional Handloom Conference in July. The full revival of the government’s sericulture program was institutionalized in Benguet back in 2015, alongside mulberry farms in Kalinga and Misamis Oriental provinces, according to PTRI senior researcher Cheryl Lopez at the July forum. Subscribe to our daily newsletter By providing an email address. I agree to the Terms of Use and acknowledge that I have read the Privacy Policy . Between 2017 and 2023, mulberry plantations had expanded by 1,563 percent, with silk cocoon production rising by 278.67 percent and raw silk production hiking by 760 percent, PTRI had said.

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I'm A Celeb fans in hysterics as Maura Higgins says 'she recommends sleeping with a priest' after she and Reverend Richard Coles shared a bed together in the Jungle Junkyard Have YOU got a story? Email tips@dailymail.com By LILY JOBSON FOR MAILONLINE Published: 21:07, 22 November 2024 | Updated: 21:53, 22 November 2024 e-mail 33 shares View comments I'm A Celebrity fans were in hysterics as Maura Higgins said she 'recommended sleeping with a priest' during Friday night's episode. The former Love Island star, 33, had to share a bed with Richard Reverend Coles , 62, in the Jungle Junkyard as they continue their top secret missions. After already joking 'she never thought she'd sleep with a vicar', Maura said she 'slept like a baby' while lying next to Richard. The new comers are having to convince their 10 campmates they are living in a basic camp, called Jungle Junkyard, that contains overgrown greenery and zero luxury, rather than the main camp. However, the pair have actually got luxurious double bed, a hidden large sofa, a large bathtub with bubbles, bath salts and hot water. The pair were also treated to a red chest which had a gas cooker and a hidden fridge door, stocked with fruit smoothies and a fruit platter. I'm A Celebrity fans were in hysterics as Maura Higgins said she 'recommended sleeping with a priest' during Friday night's episode The former Love Island star had to share a bed with Richard Reverend Coles in the Jungle Junkyard as they continue their top secret missions After already joking 'she never thought she'd sleep with a vicar', Maura said she 'slept like a baby' while lying next to Richard Maura and Richard have been tasked with a number of missions in order to win food at the Jungle Junkyard buffet. While the main camp sympathised with Maura and Richard having to sleep on the floor, Maura said she got plenty of beauty sleep. In main camp, GK Barry said: 'But do you know what, poor Maura and Richard. If they have to stay down there another night, Maura’s walking, 100% Maura’s walking.' Little did they know about Maura and Richard's sleeping arrangements, in Jungle Junkyard Maura said: 'I’d recommend sleeping with a priest!' Fans were in stitches of laughter over Maura's comment and wrote on X: 'Maura: “I’d recommend sleeping with a priest.', 'I’d recommend sleeping with a priest’ Maura #ImACeleb', 'I'd recommend sleeping with a priest" Oh Maura #imaceleb'. I'm A Celeb viewers branded Maura and Richard an 'iconic duo' as they gushed that they're already 'obsessed' with the 'genius' pairing. The new comers are having to convince their 10 campmates they are living in a basic camp, called Jungle Junkyard, that contains overgrown greenery and zero luxury, rather than the main camp However, the pair have actually got luxurious double bed, a hidden large sofa, a large bathtub with bubbles, bath salts and hot water The pair were also treated to a red chest which had a gas cooker and a hidden fridge door, stocked with fruit smoothies and a fruit platter While the main camp sympathised with Maura and Richard having to sleep on the floor, Maura said she got plenty of beauty sleep In main camp, GK Barry said: 'But do you know what, poor Maura and Richard. If they have to stay down there another night, Maura’s walking, 100% Maura’s walking' Little did they know about Maura and Richard's sleeping arrangements, in Jungle Junkyard Maura said: 'I’d recommend sleeping with a priest!' Fans were in stitches of laughter over Maura's comment and wrote on X: 'Maura: “I’d recommend sleeping with a priest.' After watching Maura and Richard meet for the first time and immediately begin bouncing off each other, the public already can't get enough of the pairing. Taking to X, fans quipped: 'Maura and Richard being an iconic duo I didn’t know I needed until they arrived on my tv 2 minutes ago #ImACeleb.' 'Jesus Christ. Sorry Father' 'I say Jesus Christ a lot too, it’s kinda my job' This duo are iconic already #ImACeleb.' Read More I'm A Celeb viewers are already 'obsessed' with 'iconic duo' Maura Higgins and Rev Richard Coles '#ImACeleb Maura and Reverend Richard Coles livened this show up ''Jesus Christ'' I had to laugh when she said that in front of him, the unexpected duo.' 'We've literally had five minutes of Maura and Reverend Richard Coles and already they're iconic #ImACeleb.' 'I remove all criticisms I had. The pairing of Reverend and Maura is genius #ImACeleb.' 'Richard and Maura are such partners in crime #ImACeleb #godiswatching.' 'Maura X Richard is not a duo on my 2024 bingo card but I LOOOVE THEM #ImACeleb.' 'Obsessed with Maura and Richard as a duo #ImACeleb.' I'M A CELEBRITY 2024: MEET THE ALL STAR LINE UP OTI MABUSE Oti Mabuse has already two Strictly glitterballs under her belt AGE: 34 OCCUPATION: Professional dancer FAMOUS FOR: Oti is best known for being a professional dancer on the British television series Strictly Come Dancing, which she won in 2019 and 2020. DANNY JONES Danny Jones is one of the bookies' favourites to win this year's I'm A Celeb AGE : 38 OCCUPATION: McFly singer FAMOUS FOR: Danny is one of the lead vocalists and the lead guitarist for pop-rock band McFly. He is also a coach on The Voice UK. BARRY MCGUIGAN Former boxer Barry McGuigan is heading into the jungle AGE: 63 OCCUPATION: Retired professional boxer FAMOUS FOR: Barry was nicknamed The Clones Cyclone and held the WBA and lineal featherweight titles from 1985 to 1986. GK BARRY GK Barry is a TikTok star who recently joined the ITV family on Loose Women AGE: 25 OCCUPATION: TikTok star FAMOUS FOR: Grace is known for her comedic commentary on culture, lifestyle, and fashion. She has over 3.6 million followers and recently joined the Loose Women panel. DEAN MCCULLOUGH ITV bosses are hoping Dean McCullough will ruffle feathers in the camp AGE: 32 OCCUPATION: Radio 1 DJ FAMOUS FOR: Radio 1 DJ Dean has been signed by I'm A Celeb bosses, in the hope that he will ruffle feathers with his outspoken views. Earlier this year it was announced Dean would be taking over the BBC Radio 1 Early Breakfast Show, after previously fronting the afternoon slot. JANE MOORE Jane is best known as a panellist and anchor of Loose Women AGE : 62 OCCUPATION: Journalist FAMOUS FOR: Jane is best known as a panellist and anchor of Loose Women between 1999 and 2002. She returned as a regular panellist from 2013 onwards. Jane takes on the challenge following her high-profile split from husband of 20 years, Showbiz agent, Gary Farrow. MELVIN ODOOM Melvin was previously courted by I'm A Celeb bosses back in 2021 AGE: 44 OCCUPATION: DJ and TV presenter FAMOUS FOR: His work on radio. Melvin was previously courted by I'm A Celeb bosses back in 2021, but turned down the offer at the last minute. He also had a primetime stint on Strictly back in 2016. COLEEN ROONEY Reports claim that she has been offered the biggest deal in the show's history AGE: 38 OCCUPATION: WAG FAMOUS FOR: Wagatha Christie case against arch rival Rebekah Vardy. Reports claim that she has been offered the biggest deal in the show's history, exceeding Nigel Farage's £1.5million from last year. ALAN HALSALL Alan Halsall is best known for his role as Tyrone Dobbs on Coronation Street AGE: 42 OCCUPATION: Actor FAMOUS FOR: Coronation Street actor Alan Halsall was forced to withdraw from I'm A Celeb last year, after undergoing ACL Reconstruction surgery. Bosses have now convinced the actor to sign up again, and no doubt he will draw in a huge fanbase thanks to his long-running role as Tyrone Dobbs on the soap. TULISA Tulisa is making her career comeback after reuniting with N-Dubz last year AGE: 36 OCCUPATION: Singer and former X Factor judge FAMOUS FOR: Tulisa reunited with N-Dubz last year for a tour after first finding fame with the band in 2007. In 2011, she became a judge on The X Factor and went on to launch her debut solo album, The Female Boss. She released her fourth album with N-Dubz last year. REVEREND RICHARD COLES Richard is an English writer, radio presenter and Church of England priest AGE : 62 OCCUPATION : Writer, broadcaster and priest FAMOUS FOR : Richard is an English writer, radio presenter and Church of England priest. He first came to prominence as the multi-instrumentalist who partnered Jimmy Somerville in the 1980s band the Communards. MAURA HIGGINS Maura is best known for her stint on Love Island UK in 2019 AGE : 33 OCCUPATION : TV Personality FAMOUS FOR: Maura is an Irish television personality, television presenter and model. She rose to prominence in 2019, when she was a finalist on the fifth series of ITV2 reality series Love Island. Share or comment on this article: I'm A Celeb fans in hysterics as Maura Higgins says 'she recommends sleeping with a priest' after she and Reverend Richard Coles shared a bed together in the Jungle Junkyard e-mail 33 shares Add comment

California could offer electric vehicle rebates if Trump eliminates tax credit, Newsom saysNearly half of American teenagers say they are online "constantly" despite concerns about the effects of social media and smartphones on their mental health, according to a new report published Thursday by the Pew Research Center. As in past years, YouTube was the single most popular platform teenagers used — 90% said they watched videos on the site, down slightly from 95% in 2022. Nearly three-quarters said they visit YouTube every day. There was a slight downward trend in several popular apps teens used. For instance, 63% of teens said they used TikTok, down from 67% and Snapchat slipped to 55% from 59%. This small decline could be due to pandemic-era restrictions easing up and kids having more time to see friends in person, but it's not enough to be truly meaningful. X saw the biggest decline among teenage users. Only 17% of teenagers said they use X, down from 23% in 2022, the year Elon Musk bought the platform. Reddit held steady at 14%. About 6% of teenagers said they use Threads, Meta's answer to X that launched in 2023. Meta's messaging service WhatsApp was a rare exception in that it saw the number of teenage users increase, to 23% from 17% in 2022. Pew also asked kids how often they use various online platforms. Small but significant numbers said they are on them "almost constantly." For YouTube, 15% reported constant use, for TikTok, 16% and for Snapchat, 13%. As in previous surveys, girls were more likely to use TikTok almost constantly while boys gravitated to YouTube. There was no meaningful gender difference in the use of Snapchat, Instagram and Facebook. Roughly a quarter of Black and Hispanic teens said they visit TikTok almost constantly, compared with just 8% of white teenagers. The report was based on a survey of 1,391 U.S. teens ages 13 to 17 conducted from Sept. 18 to Oct. 10, 2024.

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Michael Moore reacted to the murder of UnitedHealthcare CEO Brian Thompson by saying he wants to “pour gasoline” on the “anger” people feel toward the health insurance industry. In a Friday Substack post , Moore said that while he condemns “murder” in general, he does not condemn the “anger” people feel “toward the health insurance industry.” In fact, he wants to further fuel that anger. “The anger is 1000% justified. It is long overdue for the media to cover it. It is not new. It has been boiling. And I’m not going to tamp it down or ask people to shut up. I want to pour gasoline on that anger,” Moore wrote. Moore goes on to point out that Thompson’s murder suspect, Luigi Mangione, appeared to reference his work in his manifesto. “In his manifesto, he references how I’ve ‘illuminated the corruption and greed,’ implying folks should go to my work to understand the complexity — and the power-hungry abuse — within our current system,” Moore noted. “It’s not often that my work gets a killer five-star review from an actual killer,” he added, before disclosing that he has therefore received a slew of calls and emails asking him to condemn murder. In response to those inquires, Moore wrote, “Do I condemn murder? That’s an odd question,” before noting that he has condemned murder in his films, which should be evidence that he does not condone violence. But when it comes to people condemning “anger toward the health insurance industry,” Moore said, “I am not one of them.” “Because this anger is not about the killing of a CEO. If everyone who was angry was ready to kill the CEOs, the CEOs would already be dead. That is not what this reaction is about,” Moore said. “It is about the mass death and misery — the physical pain, the mental abuse, the medical debt, the bankruptcies in the face of denied claims and denied care and bottomless deductibles on top of ballooning premiums — that this ‘health care’ industry has levied against the American people for decades,” he added, before claiming that the government has enabled the healthcare industry to “murder.” Moore continued: Yes, I condemn murder, and that’s why I condemn America’s broken, vile, rapacious, bloodthirsty, unethical, immoral health care industry and I condemn every one of the CEOs who are in charge of it and I condemn every politician who takes their money and keeps this system going instead of tearing it up, ripping it apart, and throwing it all away. We need to replace this system with something sane, something caring and loving — something that keeps people alive . “This is a moment where we can create that change,” Moore added, before attacking the “mainstream media” for refusing to publish Mangione’s manifesto. Moore concluded his lengthy post with a link to his 2007 film, Sicko , and a call for the Unites States to “throw this entire system in the trash” and implement “universal” cradle-to-grave, government-funded healthcare. Alana Mastrangelo is a reporter for Breitbart News. You can follow her on Facebook and X at @ARmastrangelo , and on Instagram .File photo MANILA, Philippines — Nearly four out of 10 jobs in the Philippines are “highly” exposed to artificial intelligence (AI) and its potential to either displace workers or support various tasks to boost the productivity of employees, the International Monetary Fund (IMF) said. In a country report dated Dec. 20, the Washington-based institution estimated that 36 percent of jobs in the Philippines are “highly exposed” to AI, which can either replace human workers or “complement“ tasks to boost the efficiency of employees. The good news is “more than half” of those highly impacted jobs were also rated as “highly complementary”—where AI can augment rather than take over the tasks performed by the worker. READ: Adopt AI or perish This means that 14 percent of the total workforce in the Philippines are at risk of being replaced by AI, the IMF warned, adding that the business process outsourcing (BPO) sector might experience shifts amid recent advances in such a technology. The IMF specifically noted the proliferation of AI-driven chatbots and virtual assistants that now handle more customer service tasks. IMF staff estimated that roles such as technicians, services and sales, and clerical support have large exposures to AI. At the same time, these positions may also see the highest risk of job displacement due to the low potential for AI to just provide support to—and not replace—the workers in these occupations. On the flip side, there are a lot of opportunities for AI to augment the tasks of managers, professionals and machine operators. Workers in craft and trades, skilled agriculture, and elementary occupations were the least impacted by AI. The IMF also said that AI exposure varies by gender in the Philippines. It estimated that approximately half of all jobs held by women were highly exposed to the disruptions, compared to a quarter by men. “It is due to more women being employed as clerical support, service, and sales workers whereas men have a higher share in trades, agriculture, machine operations, and elementary occupations which are less likely to be impacted by AI at this stage,” it added. The latest country report was a product of the IMF’s 2024 Article IV Consultation in the Philippines that wrapped up early this month. And the findings were not surprising at all considering how vibrant the local information technology and business process management (IT-BPM) sector is. For this year, the Bangko Sentral ng Pilipinas (BSP) expects BPO revenues to grow by 6 percent to $31.4 billion. This means BPO receipts would outperform the growth of other key dollar engines such as remittances, which are projected to expand by just 3 percent based on BSP forecasts. The IT and Business Process Association of the Philippines, the umbrella organization of IT-BPM firms in the country, is projecting a much better revenue haul of $37.5 billion and for the domestic workforce headcount across the industry to reach 1.82 million by year’s end. Given the Philippines’ service-based economy, the IMF said the government would need to invest in digital infrastructure and education to ensure that the gains from AI use “are widely shared.” The IMF also urged local authorities to “strengthen the social safety net” for workers that will be replaced by AI. “The authorities concur that skills gaps, including those related to Al, and the high cost of power are the biggest bottlenecks to greater private sector investment,” the fund said. “They hope that joint efforts between the private sector and government agencies to modernize education curriculums, along with greater training for teachers at all levels and use of digitalization, will improve education outcomes,” it added. The IMF said that AI will have a potential impact on the global labor market, citing many studies predicting the likelihood that jobs will be replaced by AI, but in many cases will likely complement human work. In its study, it said almost 40 percent of global employment is exposed to AI. “Historically, automation and information technology have tended to affect routine tasks, but one of the things that sets AI apart is its ability to impact high-skilled jobs. As a result, advanced economies face greater risks from AI—but also more opportunities to leverage its benefits—compared with emerging markets and developing economies,” it noted. In advanced economies, it said about 60 percent of jobs may be impacted by AI. “Roughly half the exposed jobs may benefit from AI integration, enhancing productivity. For the other half, AI applications may execute key tasks currently performed by humans, which could lower labor demand, leading to lower wages and reduced hiring. In the most extreme cases, some of these jobs may disappear,” it warned. In emerging markets and low-income countries, by contrast, AI exposure is expected to be 40 percent and 26 percent, respectively, according to the IMF. Subscribe to our daily newsletter By providing an email address. I agree to the Terms of Use and acknowledge that I have read the Privacy Policy . “These findings suggest emerging market and developing economies face fewer immediate disruptions from AI. At the same time, many of these countries don’t have the infrastructure or skilled workforces to harness the benefits of AI, raising the risk that over time the technology could worsen inequality among nations,” it noted.

Neurocrine Biosciences Announces FDA Approval of CRENESSITYTM (crinecerfont), a First-in-Class Treatment for Children and Adults With Classic Congenital Adrenal Hyperplasia