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No. 11 Tennessee crushes UTEP to enhance CFP chancesSystemic Sclerosis Clinical Trials 2024: EMA, PDMA, FDA Approvals, Medication, Therapies, Mechanism of Action, Route of Administration and Companies by DelveInsight 12-26-2024 04:21 PM CET | Health & Medicine Press release from: DelveInsight Business Research Systemic Sclerosis Clinical Trials (New York, USA) DelveInsight's, "Systemic Sclerosis Pipeline Insight 2024" report provides comprehensive insights about 50+ companies and 50+ pipeline drugs in the Systemic Sclerosis pipeline landscape. It covers the Systemic Sclerosis pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space. Request a sample and discover the recent advances in Systemic Sclerosis Treatment Drugs @ Systemic Sclerosis Pipeline Report- https://www.delveinsight.com/report-store/systemic-sclerosis-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=apr In the Systemic Sclerosis pipeline report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Systemic Sclerosis collaborations, licensing, mergers and acquisition, funding, designations and other product related details. Key Takeaways from the Systemic Sclerosis Pipeline Report • DelveInsight's Systemic Sclerosis pipeline report depicts a robust space with 50+ active players working to develop 50+ pipeline therapies for Systemic Sclerosis treatment. • Leading Systemic Sclerosis companies working in the Market include Eicos Sciences, Beijing Continent Pharmaceutical, Kyowa Kirin, Cytori therapeutics, Corbus Pharmaceuticals, Zenyaku Kogyo, Sanofi, Bayer, ASKA Pharmaceutical, Emerald Health Pharmaceuticals, United Therapeutics, Cumberland Pharmaceuticals, ILTOO Pharma, Horizon Pharmaceuticals, Janssen Biotech, Gesynta Pharma, Certa Therapeutics, Pfizer, Vicore Pharma, Seagen, CSL Behring, arGentis Pharmaceuticals, Mitsubishi Tanabe Pharma, Kadmon Pharmaceuticals, GlaxoSmithKline, Bristol-Myers Squibb, Camurus, Pfizer, Regeneron Pharmaceuticals, Castle Creek Biosciences, Talaris Therapeutics, Viela Bio, Formation Biologics, Horizon Therapeutics, Chemomab therapeutics, AnaMar, Atlantic Healthcare, D&D Pharmatech, Acceleron Pharma, Riptide Bioscience, Timber Pharmaceuticals, Tvardi Therapeutics, Accuitis Pharmaceuticals, AKL Research and Development, iBio, Blade Therapeutics, Cantargia, BriaCell Therapeutics, Leadiant Biosciences, and others. • Promising Systemic Sclerosis Pipeline Therapies in the various stages of development include GS-248, KHK4827, Paquinimod, Inebilizumab, Nemolizumab, RO7303509, Treprostinil Diethanolamine, and others. • On September 2023, Horizon Pharma Ltd announced a study of phase 2 clinical trials for HZN-825 BID. All participants who complete the Double-blind Treatment Period (Week 52) will be eligible to enter a 52-week extension trial (HZNP-HZN-825-302, NCT05626751). Participants not entering the extension trial will participate in a Safety Follow-up Visit 4 weeks after the last dose of trial drug. • On September 2023, Hospital for Special Surgery, New York announced a study of phase 2 clinical trials for Belimumab, and MMF. After patients maintain a stable dose of Mycophenolate Mofetil (MMF) for at least 1 month, they will be randomized to treatment with either Belimumab & Rituximab or placebo. Patients in both groups will be on background MMF for the entirety of the study. Belimumab will be administered subcutaneously and Rituximab intravenously. Systemic Sclerosis Overview Scleroderma, also known as Systemic Sclerosis, progressive systemic sclerosis or the CREST syndrome, is a chronic skin disorder that affects the skin, connective tissues and other internal organs. The disorder takes place sin humans, when the immune system causes the body to make the protein collagen, an important component of the skin, in huge amounts. Find out more about Systemic Sclerosis Therapeutics Assessment @ Systemic Sclerosis Preclinical and Discovery Stage Products- https://www.delveinsight.com/sample-request/systemic-sclerosis-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=apr Systemic Sclerosis Emerging Drugs Profile • Iloprost: Eicos Sciences • ECCS 50: Cytori therapeutics • Lenabasum (JBT-101): Corbus Pharmaceuticals • EHP-101: Emerald Health Pharmaceuticals Systemic Sclerosis Pipeline Therapeutics Assessment There are approx. 50+ key companies which are developing the Systemic Sclerosis therapies. The Systemic Sclerosis companies which have their Systemic Sclerosis drug candidates in the most advanced stage, i.e. Phase III include, Eicos Sciences. Learn more about the emerging Systemic Sclerosis Pipeline Therapies @ Systemic Sclerosis Clinical Trials Assessment- https://www.delveinsight.com/sample-request/systemic-sclerosis-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=apr Scope of the Systemic Sclerosis Pipeline Report • Coverage- Global • Systemic Sclerosis Therapeutic Assessment by Product Type: Mono, Combination, Mono/Combination • Systemic Sclerosis Therapeutic Assessment by Clinical Stages: Discovery, Pre-clinical, Phase I, Phase II, Phase III • Systemic Sclerosis Companies- Eicos Sciences, Beijing Continent Pharmaceutical, Kyowa Kirin, Cytori therapeutics, Corbus Pharmaceuticals, Zenyaku Kogyo, Sanofi, Bayer, ASKA Pharmaceutical, Emerald Health Pharmaceuticals, United Therapeutics, Cumberland Pharmaceuticals, ILTOO Pharma, Horizon Pharmaceuticals, Janssen Biotech, Gesynta Pharma, Certa Therapeutics, Pfizer, Vicore Pharma, Seagen, CSL Behring, arGentis Pharmaceuticals, Mitsubishi Tanabe Pharma, Kadmon Pharmaceuticals, GlaxoSmithKline, Bristol-Myers Squibb, Camurus, Pfizer, Regeneron Pharmaceuticals, Castle Creek Biosciences, Talaris Therapeutics, Viela Bio, Formation Biologics, Horizon Therapeutics, Chemomab therapeutics, AnaMar, Atlantic Healthcare, D&D Pharmatech, Acceleron Pharma, Riptide Bioscience, Timber Pharmaceuticals, Tvardi Therapeutics, Accuitis Pharmaceuticals, AKL Research and Development, iBio, Blade Therapeutics, Cantargia, BriaCell Therapeutics, Leadiant Biosciences, and others. • Systemic Sclerosis Pipeline Therapies- GS-248, KHK4827, Paquinimod, Inebilizumab, Nemolizumab, RO7303509, Treprostinil Diethanolamine, and others. Dive deep into rich insights for new drugs for Systemic Sclerosis Treatment Market, Visit @ Systemic Sclerosis Market Drivers and Barriers, and Future Perspective- https://www.delveinsight.com/sample-request/systemic-sclerosis-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=apr Table of Content 1. Introduction 2. Executive Summary 3. Systemic Sclerosis: Overview 4. Pipeline Therapeutics 5. Therapeutic Assessment 6. Late Stage Products (Phase III) 7. Iloprost: Eicos Sciences 8. Drug profiles in the detailed report..... 9. Mid Stage Products (Phase II) 10. EHP-101: Emerald Health Pharmaceuticals 11. Drug profiles in the detailed report..... 12. Early stage products (Phase I) 13. VIB7734: Viela Bio 14. Drug profiles in the detailed report..... 15. Inactive Products 16. Systemic Sclerosis Key Companies 17. Systemic Sclerosis Key Products 18. Systemic Sclerosis- Unmet Needs 19. Systemic Sclerosis- Market Drivers and Barriers 20. Systemic Sclerosis- Future Perspectives and Conclusion 21. Systemic Sclerosis Analyst Views 22. Systemic Sclerosis Key Companies 23. Appendix For further information on the Systemic Sclerosis pipeline therapeutics, reach out to Systemic Sclerosis Unmet Needs and Analyst Views- https://www.delveinsight.com/sample-request/systemic-sclerosis-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=apr Trending Reports: •Rhino Conjunctivitis Market: https://www.delveinsight.com/report-store/allergic-rhino-conjunctivitis-market •Sialidosis Market: https://www.delveinsight.com/report-store/sialidosis-market •Stable Angina Market: https://www.delveinsight.com/report-store/stable-angina-market •Thymic Carcinoma Market: https://www.delveinsight.com/report-store/thymus-cancer-market •Turner Syndrome Market: https://www.delveinsight.com/report-store/turner-syndrome-market •Ventricular Fibrillation Market: https://www.delveinsight.com/report-store/ventricular-fibrillation-market •Waiha Market: https://www.delveinsight.com/report-store/warm-autoimmune-hemolytic-anemia-waiha-market •Wegener S Granulomatosis/granulomatosis With Polyangiitis Market: https://www.delveinsight.com/report-store/wegeners-granulomatosis-market Contact Us: Ankit Nigam Manager Marketing info@delveinsight.com +14699457679 https://www.delveinsight.com/asco-conference-coverage About DelveInsight DelveInsight is a leading Life Science market research and business consulting company recognized for its off-the-shelf syndicated market research reports and customized solutions to firms in the healthcare sector. This release was published on openPR.The TV presenter and journalist defied doctors’ orders by joining thousands of farmers in London on Tuesday to protest against agricultural inheritance tax changes. The 64-year-old, who fronts Prime Video’s Clarkson’s Farm, which documents the trials of farming on his land in Oxfordshire, wrote in a post on the Top Gear website in 2010: “I have bought a farm. There are many sensible reasons for this: Land is a better investment than any bank can offer. The government doesn’t get any of my money when I die. And the price of the food that I grow can only go up.” Clarkson also told the Times in 2021 that avoiding inheritance tax was “the critical thing” in his decision to buy land. Addressing the claim in a new interview with The Times, the former Top Gear presenter said: “I never did admit why I really bought it.” The fan of game bird shooting added: “I wanted to have a shoot – I was very naive. I just thought it would be a better PR story if I said I bought it to avoid paying tax.” Clarkson was among the thousands who took to the streets this week to protest over the changes in the recent Budget to impose inheritance tax on farms worth more than £1 million and he addressed the crowds at the march in central London. He told the newspaper he is not happy to be the public face of the movement, saying: “It should be led by farmers.” The presenter said he does not consider himself a farmer because there are “so many basic jobs” which he cannot do, but he feels his role is to “report on farming”. Earlier this month, it was confirmed Clarkson’s Farm, which has attracted huge attention to his Diddly Squat farm shop, had been renewed for a fifth series. Asked whether the issue behind the tax protest is that rural poverty is hidden, Clarkson agreed and said his programme was not helping to address the situation. “One of the problems we have on the show is we’re not showing the poverty either, because obviously on Diddly Squat there isn’t any poverty”, he said. “But trust me, there is absolute poverty. I’m surrounded by farmers. I’m not going out for dinner with James Dyson. “It’s people with 200 acres, 400 acres. Way past Rachel Reeves’s threshold. They are f*****.” The newspaper columnist also presents Who Wants To Be A Millionaire? on ITV. The Grand Tour, his motoring show with former Top Gear colleagues Richard Hammond and James May, ended in September. Discussing whether he might move into politics, Clarkson said: “I’d be a terrible political leader, hopeless. “I’m a journalist at heart, I prefer throwing rocks at people than having them thrown at me.” However, he said he would be “100% behind any escalation” after the farmers’ march. Clarkson revealed last month he had undergone a heart procedure to have stents fitted after experiencing a “sudden deterioration” in his health which brought on symptoms of being “clammy”, a “tightness” in his chest and “pins and needles” in his left arm. He said in a Sunday Times column that one of his arteries was “completely blocked and the second of three was heading that way” and doctors said he was perhaps “days away” from becoming very ill. Asked if he is thinking about retiring, the Doncaster-born celebrity said: “Probably not. It depends when you die, I always think. “You’d be surprised, us Northerners are made of strong stuff.”baccarat jewelry

'It will be a long journey and this moment will be really tough'

(BPT) - Tech gifts are consistently some of the most popular presents to give and receive during the holidays. In fact, according to the annual Consumer Technology Holiday Purchase Patterns report , a record 233 million U.S. adults (89%) will buy tech products during the 2024 holiday season. But with so many devices out there, it can be hard to decide on the perfect option for the loved one on your list. A tablet like the new Fire HD 8 from Amazon offers the versatility of an all-in-one device, with access to streaming, gaming, video chatting, reading or writing all at your fingertips. Fire HD 8 also features a vibrant 8-inch HD display and lightweight, portable design, for high-quality entertainment on the go. Plus, Fire HD 8 comes with three new AI features that can help you get the most out of your tablet experience. Check them out below and learn how they can help you with daily tasks this holiday season and beyond. 1. Meet your personal writing assistant Do you struggle with writing a heartfelt message or finessing a tricky email? Fear not! Writing Assist is here to help. Writing Assist works as part of your Fire tablet's device keyboard and compatible apps, including email, Word documents and social media. In just a few taps, you can transform your writing from good to great. Try Writing Assist's pre-set styles to turn a simple email into a professionally written note. Or, you can ask Writing Assist for grammar suggestions to make your writing more concise, or elaborate on your ideas. You can even "emojify" your writing to add more fun and personality. 2. Learn more in less time Say goodbye to scrolling through pages of information. The new Webpage Summaries feature allows you to learn pertinent information as quickly as possible. Available on the Silk browser on Fire tablets, Webpage Summaries provides quick insights on web articles. In a matter of seconds, this feature will distill the key points in an article or on a webpage into a clear, concise summary of what you need to know. 3. Get creative with your device wallpaper With Wallpaper Creator, you can easily add a touch of creative flair and customization to your tablet's home screen. You can choose from one of the curated prompts to get started on creating a unique background. Or, if you're ready to let your imagination run wild, type a description of what you'd like to see. For example, you can ask for an image of a tiger swimming underwater or a watercolor-style image of a desert landscape in space. Wallpaper Creator will then turn your vision into a reality, delivering a high-resolution image that you can use as your tablet's wallpaper. Celebrate an AI-powered holiday season Writing Assist, Webpage Summaries, and Wallpaper Creator are now available on Amazon's new Fire HD 8 and other compatible Fire tablet devices, including the latest Fire HD 10 and Fire Max 11 tablets. To learn more, or to order a new Fire tablet this gift-giving season, visit Amazon.com .It’s been another eventful year for U.S. air travel. Just five days into the year, a door panel blew off of a nearly new Boeing 737 Max, operated by Alaska Airlines , as it climbed out of Portland, Oregon, after sunset, plunging the airplane manufacturer back in crisis mode and delaying deliveries of new jets for months. Two weeks later, a federal judge blocked JetBlue Airways ’ planned purchase of Spirit Airlines, leaving the smaller, battered budget carrier to fend for itself. Struggling Spirit ultimately filed for Chapter 11 bankruptcy protection in November. The drama-filled year also included an activist campaign in one of the country’s most cautious carriers, a tech meltdown that stranded hundreds of thousands of travelers during the height of summer travel, and the first major U.S. airline merger since Barack Obama was president. Federal Aviation Administration chief Mike Whitaker announced he’ll step down on Jan. 20, about a year into a five-year term, and the day President-elect Donald Trump is inaugurated, leaving the critical agency that oversees everything from aircraft certification to the U.S. airspace yet again without a leader. Airline CEOs have been clamoring for more air traffic controllers and investment in air traffic technology. Meanwhile, carriers duked it out for who could be the most “premium” and profitable, with cabins closer to the front of the plane becoming more popular purchases for travelers (sorry to those seeking free upgrades) . The top two contenders — stalwart Delta and challenger United — brought most of the industry’s profits, and their stock prices hit records, while smaller airlines leaned into higher-end seats and announced higher-end credit cards. Airlines played chicken until the industry trimmed its glut of U.S. flights that were pushing down fares. But the international travel boom, well into the off-season , is showing no signs of slowing down. Through it all, demand for air travel overall smashed records, and CEOs are optimistic about next year, too. Here’s how they each fared in 2024: Delta Air Lines The most profitable of U.S. carriers struggled to recover from a July 19 CrowdStrike outage that took hundreds of Microsoft Windows machines offline. It cost Delta Air Lines more than $500 million and left thousands of stranded customers, with a cancellation tally that topped all of 2019. Still, the carrier’s stock price hit a record this month. CEO Ed Bastian told CNBC last week that demand looks strong going into 2025. The airline has been stepping up its premium offerings for high-paying customers, like with three new Delta One lounges, dedicated to travelers flying in that eponymous highest-tier cabin; New York, Los Angeles and Boston opened this year, with more on the way. It’s a sign of Delta’s continued focus on upscale travelers and its “premium” brand, which like Spirit for budget travel , has become a punchline about the upper end of travel to the point that a “Saturday Night Live” sketch last week featured Martin Short playing a Delta employee who blocks actor Paul Rudd from entering a coveted Delta Sky Club, saying his name “sounds poor.” Delta carrier stopped short of rolling out a business-class lite product that some analysts expected during a November investor day, but the new lounges could relieve crowding at Delta’s popular Sky Clubs. United Airlines Can it beat Delta? It’s not clear whether the Magnolia Bakery banana pudding is enough to get more travelers to buy up to first class, but United Airlines is making other big moves, like expanding its network to include more premium leisure destinations from Mongolia to Greenland to northern Spain in the next year to capture customers seeking to travel off the beaten path of traditional U.S. airline destinations. The carrier has thrilled investors with its results this year and set lofty targets for next year. Its stock has more than doubled in 2024, becoming the top-performing carrier. United is introducing freshly outfitted narrow-body planes with new interiors featuring seat-back screens and Bluetooth connections into its fleet. It announced a WiFi partnership powered by Elon Musk -owned SpaceX’s Starlink, and it won’t charge for the service, following Delta and JetBlue. CEO Scott Kirby early in the year said the carrier isn’t counting on Boeing’s yet-to-be-certified 737 Max 10 and will look at more Airbus planes as an alternative, but he’s thrown his support behind the planemaker’s new chief executive, Kelly Ortberg . Southwest Airlines Say goodbye to open seating. The Dallas-based carrier shocked customers — faithful and frustrated alike — when it said in July that it would start assigning seats and update its uniform cabin to include several rows with extra legroom in a bid to increase its revenue. It was the biggest strategy change for the carrier in its almost half century of flying. While Southwest said it was working on the changes for months, the carrier announced them after activist hedge fund Elliott Investment Management took a roughly $2 billion stake in the airline and pushed for changes, including CEO Bob Jordan’s ouster. He survived the campaign, though ex-CEO and former Chairman Gary Kelly agreed to retire. In a truce, Southwest appointed six new board members in October, including five of Elliott’s nominees. American Airlines American Airlines ousted its commercial chief , Vasu Raja, in May after a sales strategy that cut out travel agencies in favor of selling directly to business travelers backfired and the carrier abruptly slashed its sales guidance. Its outlook has improved, and executives are upbeat about year-end demand and into 2025. It inked a new credit-card deal with its partner Citi , and will end things with its co-brand partner Barclays, a holdover from American’s 2013 merger with US Airways. Spirit Airlines The budget carrier comedians love to hate saw its problems snowball this year, starting with a federal judge blocking Spirit’s acquisition by JetBlue in January. Merger off, Spirit was left to face its other problems: a surge in labor and other costs post-pandemic, high competition in domestic markets, a jump in travel demand to places it doesn’t fly (like Italy and Japan) and Pratt & Whitney’s engine recall that has had an outsize affect on Spirit, grounding dozens of its planes. Hemorrhaging money with a refinancing deadline approaching, Spirit filed for Chapter 11 bankruptcy protection last month, becoming the first major U.S. carrier to do since American Airlines in 2011. It expects to emerge in the first quarter and it’s an open question whether it will again attempt a combination with fellow budget carrier Frontier . The carrier changed its longstanding business model of charging a low fare and adding on fees for everything else, like seat selection, to offering more bundled options in the summer. JetBlue Airways While Spirit saw its stock delisted after filing for bankruptcy, JetBlue forged ahead after the judge blocked the planned acquisition with a singular focus: Slash costs and get back to profitability. New CEO Joanna Geraghty and former commercial chief Marty St. George, who returned to the airline as president in February, set out on JetForward, a strategy that aimed to refocus the airline, which had added too many money-losing routes after the pandemic with its premium-outfitted planes deployed to the wrong places. The carrier earlier this month announced it would update some of its jets with a domestic business class , to complement its aircraft that feature its top-tier Mint business class. Its shares are up more than 40% this year through Tuesday’s close, topping the S&P 500′ s performance. Investors have been happy with its latest update that showed better-than-expected revenue. Alaska Airlines The airline started the year with the door-plug blowout of one of its new Boeing planes, which led to a temporary grounding of Max 9s, and later a payout from Boeing, which makes the Maxes a few miles away in Renton, Washington. Months later, it was back to focusing on its nearly $2 billion acquisition of struggling carrier Hawaiian Airlines, a combination that got through antitrust regulators in the summer, marking the first merger of major U.S. carriers since Alaska bought Virgin America in 2016. Alaska has posted solid profits and enjoyed a surge in its stock price of more than 70% so far this year, a nearly threefold premium over the broader market. Executives painted an ambitious picture for investors earlier this month, announcing a global expansion for the combined airline that includes nonstop service on wide-body planes from Seattle — where its top competitor is Delta — to Europe and Asia. Frontier Airlines First-class Frontier? The carrier is turning a profit again and is trying to go upscale, planning to outfit its planes with first-class domestic seats . It’s also planning to offer more bundles that include seat assignments, baggage and no change fees. CEO Barry Biffle said the airline expects to get back to double-digit margins in mid-2025 and credits recent improvement in results with a series of network changes, such as cutting flying during lower-demand days like Tuesdays, Wednesdays and Saturdays and in crowded markets like in Florida and Las Vegas. Allegiant Air Allegiant Travel ’s foray into the hotel business hit a rough patch and said this summer said it would undergo a strategic review for its Sunseeker Resort in Florida. It added this fall that it was closing in on a capital partner for the property that located north of Fort Myers. The main business, low-cost Allegiant Airlines , has turned a corner, seeing high demand in peak periods, new CEO Greg Anderson told investors this fall. The carrier updated its fourth-quarter guidance that came in ahead of analyst estimates in early December. Sun Country With enviable margins, especially for a low-fare airline, the carrier has benefitted from its cargo-flying contract with Amazon and competitors cutting capacity from its home hub of Minneapolis, Deutsche Bank airline analyst Mike Linenberg said this month. “ Sun Country ’s revenue diversity provides the company with an economic moat that has allowed the carrier to maintain profitability during even the most volatile and intensely competitive quarters since the pandemic,” he wrote in a Dec. 11 note. The airline has been successful at switching its schedule with the seasons, ramping up service to warmer destinations in the winter. Disclosure: NBCUniversal is the parent company of CNBC and NBC, which broadcasts “Saturday Night Live.”Long-term investment is the key to life-changing returns in the stock market, and few companies highlight this concept better than Nvidia ( NVDA -2.25% ) . If you bought $1,000 worth of the chipmaker's stock 10 years ago, you would have roughly $267,000 today -- a return of 26,600%. That said, past returns don't guarantee future results -- especially in an incredibly speculative new industry. Let's examine the pros and cons of Nvidia stock to determine whether the legendary technology giant still has multibagger potential over the long term. A history of boom and bust cycles Nvidia's core business has always been designing and selling graphics processing units (GPUs), a type of computer chip capable of parallel processing (running multiple calculations simultaneously). This tech proved crucial in rendering video game graphics, helping Nvidia dominate the custom PC and gaming laptop markets in the 2000s. When Bitcoin launched in 2009, GPUs found another use case in cryptocurrency mining, leading to Nvidia's second boom cycle. At the time, many blockchains used GPU computing power to validate their networks and mint more coins in a process called proof-of-work (PoW). This market declined substantially in 2022, erasing billions from Nvidia's market cap. Video gaming and crypto mining hardware are both represented in Nvidia's gaming segment, which posted third-quarter sales of just $3.3 billion or just around 9% of total sales . Generative artificial intelligence (AI) has become the company's latest boom cycle, causing its data center business to soar to represent 88% of total sales. The company is very nondiversified and vulnerable to another rapid change in its fortunes. How will the generative AI story end? Over the next 10 years, Nvidia's AI hardware business could face threats to its growth and profitability. And it isn't hard to see why. With a gross margin of 75%, Nvidia is selling hardware at software-level margins. For context, software-as-a-service (SaaS) giant Microsoft has a gross margin of just 69%, selling mainly digital products and services. Nvidia's market dominance will naturally encourage customers to replace its products wherever possible. While Nvidia seems to be able to keep direct competition (from other AI chipmakers like Advanced Micro Devices ) at bay, it can't stop "hyperscaler" clients like Alphabet and Amazon from designing their own custom chips or simply holding on to their old Nvidia hardware instead of upgrading to the latest models every year. Nvidia's sky-high margins may also come under increasing pressure from suppliers like Taiwan Semiconductor , which helps manufacture its highest-end AI chips. In June, analysts at Morgan Stanley reported that the fab is considering raising production fees for Nvidia. And if this is true, it could eventually eat into the company's margins. To be fair, however, Nvidia's third-quarter operating income soared 174% to $18.6 billion. And its forward price-to-earnings (P/E) of just 33 seems quite low compared to this growth rate, suggesting a possible slowdown in earnings growth may already be partially priced in. Is Nvidia stock a buy? Generally, time in the market is better than timing the market. And even if you bought Nvidia stock at the peak of its previous boom cycles, you would still have come out ahead if you held shares long enough. That said, with a market cap of $3.5 trillion, Nvidia has become the second-largest company in the world. So, things may be different now. Newton's second law of motion states that the larger an object is, the more force is needed to move it. And while the 18th-century physicist probably didn't have financial markets in mind, the concept can hold true for stocks. Investors who buy Nvidia now are making some very optimistic assumptions about the future of the AI industry. And it may make more sense to wait until the hype dies down before buying shares.

Former Indian cricketers like Harbhajan Singh, Yuvraj Singh, Virender Sehwag and VVS Laxman mourned the death of ex-PM Manmohan Singh. Dr Singh passed away in New Delhi at the age of 92. New Delhi: Former Indian cricketers offered their condolences on the passing away of ex-Prime Minister Dr Manmohan Singh in Delhi on Thursday. Dr Singh was admitted to AIIMS after his health deteriorated at around 8 PM and finally around 10 PM, the statesman breathed his last. AIIMS Delhi in a press statement late on Thursday night informed about the demise of the veteran politician. A tall politician who contributed immensely towards transforming India into an economic power as the Finance Minister of the country back in the 90s, passed away at the age of 92. Dr Singh had multiple health problems from quite some time and at the hospital, he was being treated for a lung infection and breathing difficulties. “With profound grief, we inform the demise of Former Prime Minister of India, Dr. Manmohan Singh, aged 92. He was being treated for age-related medical conditions and had sudden loss of consciousness at home on 26th December 2024,” AIIMS said in a statement. Indian cricket fraternity mourns death While the who’s who of the political sphere offered their condolences on the sad demise of the former PM, ex-Indian cricketers also came forward to mourn the death of the veteran leader. Harbhajan Singh, Yuvraj Singh and VVS Laxman were among the first one’s who took to social media to offer their condolences. Former Indian spinner Harbhajan Singh wrote that he was saddened by the sudden demise of the ex-PM, calling Dr Singh a visionary leader and a thorough gentleman. Ex-Indian cricketers Virender Sehwag and VVS Laxman also took to social media late Thursday night to mourn the loss of the former Prime Minister. The Union government declared a seven-day mourning in honour of former PM Dr Manmohan Singh, officials said. They added that the Cabinet will meet at 11 am on Friday to pay tributes to him. Click for more latest Cricket news . Also get top headlines and latest news from India and around the world at News9. A professional career of over 12 years in the digital media sector, I have been an ardent follower of news, with sports atop my priority table. Have been fortunate enough to have my professional stints with some of the most reputed media organizations in the country like ESPN, Sony Six, Zee Media Corporation and NDTV. Enjoy working on meaningful stories that bring you to the edge of your seat. Believe in the concept of 'power of a good header' in a story and try to strongly abide by it. When I am not working, sports, good music, a long car drive and good food keep me engaged.

BRKH, ARCH, B URGENT: The M&A Class Action Firm Encourages $hareholders to Act Before the Vote

Empowered Funds LLC lifted its holdings in TG Therapeutics, Inc. ( NASDAQ:TGTX – Free Report ) by 3.1% during the third quarter, according to its most recent 13F filing with the Securities and Exchange Commission (SEC). The firm owned 46,431 shares of the biopharmaceutical company’s stock after buying an additional 1,386 shares during the quarter. Empowered Funds LLC’s holdings in TG Therapeutics were worth $1,086,000 as of its most recent SEC filing. Several other institutional investors also recently modified their holdings of TGTX. Sei Investments Co. bought a new position in shares of TG Therapeutics during the first quarter valued at approximately $591,000. Russell Investments Group Ltd. grew its stake in shares of TG Therapeutics by 133.5% in the 1st quarter. Russell Investments Group Ltd. now owns 52,339 shares of the biopharmaceutical company’s stock worth $796,000 after buying an additional 29,923 shares during the last quarter. ProShare Advisors LLC increased its position in TG Therapeutics by 8.5% during the 1st quarter. ProShare Advisors LLC now owns 24,914 shares of the biopharmaceutical company’s stock valued at $379,000 after buying an additional 1,961 shares in the last quarter. State Board of Administration of Florida Retirement System raised its stake in TG Therapeutics by 10.5% during the first quarter. State Board of Administration of Florida Retirement System now owns 43,283 shares of the biopharmaceutical company’s stock valued at $651,000 after buying an additional 4,120 shares during the last quarter. Finally, Lazard Asset Management LLC bought a new stake in TG Therapeutics in the first quarter worth $91,000. 58.58% of the stock is currently owned by institutional investors. TG Therapeutics Stock Performance Shares of TGTX opened at $35.07 on Friday. The firm has a market capitalization of $5.46 billion, a P/E ratio of -350.70 and a beta of 2.19. The company has a debt-to-equity ratio of 1.27, a current ratio of 4.59 and a quick ratio of 3.91. TG Therapeutics, Inc. has a one year low of $12.30 and a one year high of $36.50. The business has a fifty day moving average of $25.62 and a 200 day moving average of $21.64. Analysts Set New Price Targets TGTX has been the subject of several recent analyst reports. TD Cowen initiated coverage on TG Therapeutics in a research report on Tuesday, October 29th. They issued a “buy” rating and a $50.00 price target for the company. The Goldman Sachs Group lifted their target price on shares of TG Therapeutics from $20.00 to $22.00 and gave the stock a “neutral” rating in a report on Tuesday, November 5th. B. Riley increased their price target on shares of TG Therapeutics from $29.00 to $34.00 and gave the company a “buy” rating in a report on Wednesday, August 7th. Finally, HC Wainwright boosted their price objective on shares of TG Therapeutics from $49.00 to $55.00 and gave the stock a “buy” rating in a report on Tuesday, November 5th. Two investment analysts have rated the stock with a hold rating and five have given a buy rating to the company’s stock. According to data from MarketBeat, the stock has a consensus rating of “Moderate Buy” and a consensus target price of $37.67. Read Our Latest Analysis on TGTX Insider Activity at TG Therapeutics In other news, Director Sagar Lonial sold 5,000 shares of TG Therapeutics stock in a transaction on Monday, November 11th. The shares were sold at an average price of $30.44, for a total transaction of $152,200.00. Following the transaction, the director now owns 100,195 shares in the company, valued at $3,049,935.80. This trade represents a 4.75 % decrease in their position. The sale was disclosed in a legal filing with the SEC, which is available through this hyperlink . 10.50% of the stock is currently owned by company insiders. About TG Therapeutics ( Free Report ) TG Therapeutics, Inc, a commercial stage biopharmaceutical company, focuses on the acquisition, development, and commercialization of novel treatments for B-cell mediated diseases in the United States and internationally. It provides BRIUMVI, an anti-CD20 monoclonal antibody for the treatment of adult patients with relapsing forms of multiple sclerosis (RMS), including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease in adults. Read More Want to see what other hedge funds are holding TGTX? Visit HoldingsChannel.com to get the latest 13F filings and insider trades for TG Therapeutics, Inc. ( NASDAQ:TGTX – Free Report ). Receive News & Ratings for TG Therapeutics Daily - Enter your email address below to receive a concise daily summary of the latest news and analysts' ratings for TG Therapeutics and related companies with MarketBeat.com's FREE daily email newsletter .

MONTREAL - Police say they’ve arrested several people following an anti-NATO protest that included two car fires and left some businesses with smashed windows. Montreal police say they made at least three arrests following a demonstration that began late afternoon Friday. Police say that during the march, smoke bombs were deployed, metal barriers were thrown into the street and windows of businesses and at the convention centre were smashed. Delegates from NATO member states and partner countries are in Montreal this weekend to discuss issues including support for Ukraine, climate change and the future of the alliance. The protest was planned by the groups Divest for Palestine and the Convergence of Anti-Capitalist Struggles, who did not immediately respond to requests for comment Saturday. Foreign Affairs Minister Mélanie Joly condemned the protests in a Saturday morning post on social media platform X, saying that “rioting is not peaceful protest and has no place in Montreal or anywhere in Canada.” “Those who spread hate and antisemitism, use violence, loot and destroy property must be condemned and held accountable,” she added. Police spokesperson Manuel Couture says the demonstrators were completely dispersed at around 7 p.m.

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'September 5' review: A look inside a newsroom's live coverage of Munich Olympics hostage crisisThis May 2023 image provided by Jessica Damiano shows a neglected, overgrown property on Long Island, New York. A step-by-step approach is the best strategy for reigning in such gardens. (Jessica Damiano via AP) This May 2023 image provided by Jessica Damiano shows a neglected, overgrown property on Long Island, New York. A step-by-step approach is the best strategy for reigning in such gardens. (Jessica Damiano via AP) This May 2023 image provided by Jessica Damiano shows a neglected, overgrown property on Long Island, New York. A step-by-step approach is the best strategy for reigning in such gardens. (Jessica Damiano via AP) This May 2023 image provided by Jessica Damiano shows a neglected, overgrown property on Long Island, New York. A step-by-step approach is the best strategy for reigning in such gardens. (Jessica Damiano via AP) Devising a game plan now can set you up for a much better view by next winter.

Taylor Swift reacts to Jason and Kylie Kelce's adorable baby announcementImprisoned conman Sukesh Chandrashekhar, who is currently incarcerated at Delhi's Tihar Jail, has once again made headlines with his Christmas letter to Bollywood actress Jacqueline Fernandez . This letter, which has quickly gone viral on social media, comes as part of a series of personal messages Sukesh has written to Jacqueline during his time in custody. ET Year-end Special Reads Corporate Kalesh: Top family disputes of India Inc in 2024 The world of business lost these eminent people in 2024 Fast, faster, fastest: How 2024 put more speed into your shopping An Extravagant Christmas Gift For Jacqueline Fernandez In his Christmas letter, Sukesh expresses deep affection for Jacqueline and reveals an extravagant gift he plans to give her. He writes, “Baby girl, Merry Christmas. Another beautiful year and most favourite festival is passing without our love and togetherness. Our souls are connected. When I wish you a Merry Christmas, I am able to hold both our hands and look into your eyes.” This heartfelt message is just the beginning of his bold gesture, which has captivated social media users and fueled curiosity about their relationship. Sukesh goes on to promise an unexpected gift: “Today, I am gifting you not a bottle of wine but an entire vineyard in the country of love 'France', which you never even dreamed of.” The vineyard he refers to is a 107-year-old estate, complete with a stunning Tuscan-style house. The conman adds that he envisions walking through the vineyard hand-in-hand with Jacqueline, further deepening the intrigue surrounding their connection. “I am desperate to take a walk in this garden holding your hand. The world may think that I am crazy, but I am really crazy in love with you. Wait till I come out, then the whole world will see us together,” he writes, emphasizing the strength of his feelings. Previous Letters and Declarations of Love This isn't the first time Sukesh has penned a letter to Jacqueline. Earlier this year, he wrote to her on his birthday, expressing how much he missed her and how priceless her love was to him. He wrote, “You and your love is the bestest gift which is priceless in my life, you know I am here for you standing by you come what may. Love you my baby, thank you for giving me your heart. I also thank all my supporters and friends, for all your wishes on my birthday. I have received hundreds of letters, greetings. I feel blessed, thank you." In addition to this, Sukesh also wished Jacqueline a Happy Holi in another letter, in which he assured her that he would restore all the colors that had faded or disappeared. These letters, filled with declarations of love and extravagant promises, have continued to fuel speculation about the nature of their relationship. While Sukesh claims they are romantically involved, Jacqueline has denied these allegations. Sukesh’s Criminal Background and Media Attention Sukesh's criminal activities, particularly his involvement in a Rs 200 crore money laundering case, have kept him in the public eye. He was arrested for duping Malvinder Singh's wife and posing as high-ranking government officials to extort money. The Enforcement Directorate (ED) has summoned Jacqueline and other individuals like Nora Fatehi for questioning in connection with the extortion case. Despite the serious nature of his crimes, Sukesh has managed to stay relevant through his constant public communications from prison, which only intensifies the media’s curiosity about his relationship with Jacqueline. Aside from the extortion case, Sukesh is also accused of bribing Election Commission officials to secure a political symbol for the VK Sasikala faction of the AIADMK. Facing charges under the Prevention of Money Laundering Act (PMLA), Sukesh remains a polarizing figure in the media.

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The UN General Assembly on Wednesday overwhelmingly adopted a resolution calling for an immediate and unconditional ceasefire in Gaza, a symbolic gesture rejected by the United States and Israel. The resolution -- adopted by a vote of 158-9, with 13 abstentions -- urges "an immediate, unconditional and permanent ceasefire," and "the immediate and unconditional release of all hostages" -- wording similar to a text vetoed by Washington in the Security Council last month. At that time, Washington used its veto power on the Council -- as it has before -- to protect its ally Israel, which has been at war with Hamas in the Gaza Strip since the Palestinian militant group's October 7, 2023 attack. It has insisted on the idea of making a ceasefire conditional on the release of all hostages in Gaza, saying otherwise that Hamas has no incentive to free those in captivity. Deputy US Ambassador Robert Wood repeated that position Wednesday, saying it would be "shameful and wrong" to adopt the text. Ahead of the vote, Israel's UN envoy Danny Danon said: "The resolutions before the assembly today are beyond logic. (...) The vote today is not a vote for compassion. It is a vote for complicity." The General Assembly often finds itself taking up measures that cannot get through the Security Council, which has been largely paralyzed on hot-button issues such as Gaza and Ukraine due to internal politics, and this time is no different. The resolution, which is non-binding, demands "immediate access" to widespread humanitarian aid for the citizens of Gaza, especially in the besieged north of the territory. Dozens of representatives of UN member states addressed the Assembly before the vote to offer their support to the Palestinians. "Gaza doesn't exist anymore. It is destroyed," said Slovenia's UN envoy Samuel Zbogar. "History is the harshest critic of inaction." That criticism was echoed by Algeria's deputy UN ambassador Nacim Gaouaoui, who said: "The price of silence and failure in the face of the Palestinian tragedy is a very heavy price, and it will be heavier tomorrow." Hamas's October 2023 attack on southern Israel resulted in the deaths of 1,208 people, mostly civilians, according to an AFP tally based on official figures. That count includes hostages who died or were killed while being held in Gaza. Militants abducted 251 hostages, 96 of whom remain in Gaza, including 34 the Israeli military says are dead. Israel's retaliatory offensive in Gaza has killed at least 44,805 people, a majority of them civilians, according to data from the Hamas-run health ministry that is considered reliable by the United Nations. "Gaza today is the bleeding heart of Palestine," Palestinian UN Ambassador Riyad Mansour said last week during the first day of debate in the Assembly's special session on the issue. "The images of our children burning in tents, with no food in their bellies and no hopes and no horizon for the future, and after having endured pain and loss for more than a year, should haunt the conscience of the world and prompt action to end this nightmare," he said, calling for an end to the "impunity." After Wednesday's vote, he said "we will keep knocking on the doors of the Security Council and the General Assembly until we see an immediate and unconditional ceasefire put in place." The Gaza resolution calls on UN Secretary-General Antonio Guterres to present "proposals on how the United Nations could help to advance accountability" by using existing mechanisms or creating new ones based on past experience. The Assembly, for example, created an international mechanism to gather evidence of crimes committed in Syria starting from the outbreak of civil war in 2011. A second resolution calling on Israel to respect the mandate of the UN agency supporting Palestinian refugees (UNRWA) and allow it to continue its operations was passed Wednesday by a vote of 159-9 with 11 abstentions. Israel has voted to ban the organization starting January 28, after accusing some UNRWA employees of taking part in Hamas's devastating attack. abd/sst/jgc/nro/des

Drones, planes or UFOs? Americans abuzz over mysterious New Jersey sightingsOscar Fairs from Benfleet, Essex, was diagnosed with a rare 7cm ependymoma brain tumour in August 2023 and underwent seven surgeries, one round of chemotherapy and one round of radiotherapy to be told palliative care was the only option. A GoFundMe page was set up to help the family raise £100,000 towards a treatment trial in France. It is with deep and profound sadness that West Ham United confirm the tragic passing of our U15s Academy goalkeeper Oscar Fairs, following his brave battle with cancer. Rest in peace, brave Oscar. — West Ham United (@WestHam) December 13, 2024 West Ham footballers donated £27,000, chairman David Sullivan donated £10,000 and Arsenal footballer and former West Ham star Declan Rice gave £5,000, according to Ms Fairs. On Friday, West Ham announced that the 15-year-old had died. Sporting director Mark Noble said: “Oscar was adored by everyone at the Academy – not only was he a great goalkeeper, he was a true Hammer and a fantastic young person, who will be deeply missed by everyone who had the pleasure to know him. “I have wonderful memories of Oscar playing in my garden – (my son) Lenny and his teammates all loved him. “He was a friendly, happy, well-mannered and polite young man, who had such a bright future ahead of him, and it is just so unimaginably devastating that he has been taken from his family and friends at this age. “The thoughts and sincere condolences of everyone at the Club are with Oscar’s parents, Natalie and Russell, and his brother Harry, and we kindly ask that the family’s privacy is respected at this extremely difficult time.” All scheduled Academy fixtures over the weekend have been postponed as a mark of respect.

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