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Corcept Therapeutics' chief accounting officer sells $80,031 in stock
Leila Cruz (center) smartly drills in a kill between two Nxled blockers. —PVL IMAGES Capital1 snapped a three-game skid by staging a stunning comeback to steal the second set before dominating the next two for a 21-25, 25-21, 25-15, 25-18 triumph over dumbfounded Nxled in the PVL All-Filipino Conference at the Philsports Arena on Saturday. Leila Cruz and Heather Guino-o formed the Solar Spikers’ 1-2 punch, finishing with a combined 38 points with Patty Orendain coming off the bench to chip in with 10 points. The victory was a welcome relief for Capital1, which had previously faltered against top contenders Chery Tiggo, Choco Mucho and PLDT. “I am so happy, because all of our hard work finally showed on the floor,” said Guino-o, who delivered 21 points, including 19 attacks and two blocks, in Filipino. Trailing 20-12 in the second set, Capital1 got the boost from Guino-o, who led a 13-2 run that eventually tied the game at a set each. In helping the Solar Spikers to a 1-3 record, Guino-o emphasized that staying optimistic will be key to staying in the running for a slot in the playoffs. “We will work even harder from hereon so we can have this feeling [of winning] more often,” said the former Far Eastern standout in the UAAP. Chiara Permentilla led Nxled with an impressive 23-point effort, but struggled with fatigue in the latter stages. The Chameleons also suffered from a lack of consistent support, with Jaila Atienza and Lycha Ebon adding just nine and six points, respectively. The Solar Spikers’ remarkable turnaround in the second set not only derailed Nxled’s momentum but also crushed their confidence, setting the stage for Capital1’s dominant performance in the final two sets. Subscribe to our daily newsletter By providing an email address. I agree to the Terms of Use and acknowledge that I have read the Privacy Policy .Aleph To Sponsor Juan Martín Del Potro In Farewell Match Against Novak DjokovicDazostinag sodium is under clinical development by and currently in Phase I for Non-Small Cell Lung Cancer. According to GlobalData, Phase I drugs for Non-Small Cell Lung Cancer have an 80% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. Dazostinag sodium overview Dazostinag sodium (TAK-676) is under development for the treatment of advanced or metastatic solid tumors including non-small cell lung cancer, triple-negative breast cancer (TNBC), oropharyngeal cancer, colorectal cancer and head and neck cancer squamous cell carcinoma. The drug candidate is cyclic purine dinucleotide and acts by targeting stimulator of interferon genes (STING/TMEM173). It is a new molecular entity. It is administered via intravenous route. Takeda Pharmaceutical overview (Takeda) is a global pharmaceutical company primarily engaged in the research, development, production, and commercialization of biopharmaceutical products. It provides treatment for inflammatory bowel disease, acid-related diseases, motility disorders and liver diseases; hemophilia and hereditary bleeding disorders; primary immunodeficiency and multifocal motor neuropathy; major depressive disorder and attention-deficit hyperactivity disorder; and its cancer treatment encompasses multiple myeloma, mantle cell lymphoma, non-small cell lung cancer and chronic myeloid leukemia. While the company markets its pharmaceutical products directly, it also collaborates with marketing alliance partners in worldwide. Takeda operates in various countries worldwide, including Japan, the US, Europe, Latin America, Africa, the Middle East, and the Asia Pacific region. Takeda is headquartered in Tokyo, Japan. For a complete picture of Dazostinag sodium’s drug-specific PTSR and LoA scores, This content was updated on 12 April 2024 From Blending expert knowledge with cutting-edge technology, GlobalData’s unrivalled proprietary data will enable you to decode what’s happening in your market. You can make better informed decisions and gain a future-proof advantage over your competitors. , the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article. GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s .
President-elect Donald Trump’s second term could bring big changes to Main Street, but small business advocacy groups have mixed views about his agenda. It comes as the National Federation of Independent Business’ measure of uncertainty is at its highest level on record, according to a newly released survey taken before the election. In addition to the shifting political environment, many business owners are grappling with inflation and workforce shortages. “With the election over, small business owners will begin to feel less uncertain about future business conditions,” said NFIB chief economist Bill Dunkelberg. “Although optimism is on the rise on Main Street, small business owners are still facing unprecedented economic adversity.” It comes as some small business owners are bracing for the impact of increased tariffs. On Monday, Trump posted on Truth Social that one of his first executive orders will impose a 25% tax on all products coming into the United States from Mexico and Canada. “This Tariff will remain in effect until such time as Drugs, in particular Fentanyl, and all Illegal Aliens stop this Invasion of our Country! Both Mexico and Canada have the absolute right and power to easily solve this long simmering problem,” Trump furthered. Ris Lacoste, a restaurant owner in Washington, D.C., is concerned prices for some ingredients could go up. “We do get some produce from the warmer climates, and that includes Mexico, so I think that's going to affect us, especially over the winter,” Lacoste said. “I think it's going to be difficult. I’m hoping not. I'm hoping that a lot of these things don't happen.” She's not the only one with concerns. "Small business owners are already hunkering down to weather the painful impact of a potential trade war. They're stocking up on inventory. They're even thinking of moving operations offshore to manufacture for the export market, if they're able to do that," said John Arensmeyer, the founder and CEO of Small Business Majority. NFIB’s vice president of federal government relations, Jeff Brabant, said they're not taking a formal stance on Trump’s tariffs proposal at this point, but, generally, their members are optimistic about his re-election. "They're hopeful there will be less burdensome regulations, and they're hopeful that they're not going to see a massive tax increase at the end of next year,” Brabant said. The Tax Cuts and Jobs Act, which passed during Trump’s first term, allowed eligible small business owners to deduct up to 20 percent of their business income. Supporters say the provision, also called the pass-through deduction, leveled the playing field with big corporations. “It was a resounding success, but unfortunately, a lot of those provisions are about to expire,” Brabant said. Brabant believes Congress, which will soon be controlled by Republicans, is well-positioned to extend the policy or make it permanent. However, critics of the pass-through deduction argue it disproportionately benefits the wealthiest Americans and excludes some small businesses. They are calling for a different approach to help Main Street. “We've proposed a $25,000 standard deduction to small business income that would be from the bottom up so that those smaller businesses would be actually getting a bigger percentage benefit than those larger businesses,” Arensmeyer said. As lawmakers prepare to revisit that tax debate next year, it’s still unclear who will lead the Small Business Administration during Trump’s second term. As of Saturday morning, Trump had not announced his pick to lead the agency, but it’s likely to be a new face. Trump has already tapped his former SBA administrator, Linda McMahon, to lead the Department of Education. Molly Day, vice president of public affairs for the National Small Business Association, said the choice will be a chance for Trump to signal his priorities for the agency. “The pick for SBA administrator should support a fully staffed SBA Office of Advocacy which has been absent a chief counsel for years. This small office plays a major role in protecting small businesses when it comes to regulations, and they need someone with robust legal and small business experience. The next SBA administrator should also be committed to maintaining SBA’s strong lending programs as well as increasing the federal government’s federal contracting goal from 23 percent to 30 percent,” Day wrote in a statement.
Jae Crowder is officially back in the league. The veteran forward officially struck a deal to join the Sacramento Kings on Wednesday, the team announced. Terms of that contract are not yet known, though the Kings put him to work right away. Crowder was in the starting lineup for Sacramento in their game against the Minnesota Timberwolves at the Target Center on Monday night. welcome to the 916, 🤝 — Sacramento Kings (@SacramentoKings) Crowder, 34, spent the last two seasons with the Milwaukee Bucks. The 13-year veteran, who was first selected in the second round of the 2012 draft by the Cleveland Cavaliers, will join his ninth team in the league once his deal with the Kings is official. He averaged 6.2 points and 3.2 rebounds per game last season in Milwaukee. Crowder helped lead both the Miami Heat and the Phoenix Suns to the NBA Finals in back-to-back years, though he’s yet to win a championship. Crowder became a free agent this past offseason, and he worked out with the Kings over the summer, though he was unable to strike a deal to land with any team. The Kings are dealing with significant injuries, and have lost seven of their last 10 games entering Wednesday’s contest in Minnesota. Forward Trey Lyles is out for at least three weeks with a right calf strain, which he sustained in Monday’s loss to the Oklahoma City Thunder. DeMar DeRozan will also miss Wednesday’s game with lower back muscle inflammation, though it’s unknown how long he’ll be sidelined. Third-year coach on Tuesday after he chased down an official in their loss to the Brooklyn Nets on Sunday, too. Though it’s unclear what his role will be with the franchise just yet, Crowder should be able to provide some much-needed depth in the frontcourt behind Keegan Murray and Domantas Sabonis at least in the near future. We’ll see if he’s the missing piece to lift the Kings out of their slump.Rumble Announces Bitcoin Treasury Strategy
Newsom wants CA consumers to pay to replace $7,500 federal EV credit, Tesla excluded
Central 1 reports 2024 third quarter financial resultsMr Carter, a former peanut farmer, served one term in the White House between 1977 and 1981, taking over in the wake of the Watergate scandal and the end of the Vietnam War. After his defeat by Ronald Reagan, he spent his post-presidency years as a global humanitarian, winning the Nobel Peace Prize in 2002. His death on Sunday was announced by his family and came more than a year after he decided to enter hospice care. He was the longest-lived US president. His son, Chip Carter, said: “My father was a hero, not only to me but to everyone who believes in peace, human rights and unselfish love. “My brothers, sister and I shared him with the rest of the world through these common beliefs. “The world is our family because of the way he brought people together, and we thank you for honouring his memory by continuing to live these shared beliefs.” World leaders have paid tribute to Mr Carter, including US President Joe Biden, who was one of the first politicians to endorse Mr Carter for president in 1976 and said the world had “lost an extraordinary leader, statesman and humanitarian”. He said: “Over six decades, we had the honour of calling Jimmy Carter a dear friend. But, what’s extraordinary about Jimmy Carter, though, is that millions of people throughout America and the world who never met him thought of him as a dear friend as well. “With his compassion and moral clarity, he worked to eradicate disease, forge peace, advance civil rights and human rights, promote free and fair elections, house the homeless, and always advocate for the least among us. “He saved, lifted, and changed the lives of people all across the globe.” Irish President Michael D Higgins said Mr Carter was “a principled man who dedicated his life to seeking to advance the cause of peace across the world”. He added: “On behalf of the people of Ireland, may I express my sympathies to President Carter’s children and extended family, to President Joe Biden, to the people of the United States, and to his wide circle of colleagues and friends across the globe.” Mr Carter is expected to receive a state funeral featuring public observances in Atlanta and Washington DC before being buried in his home town of Plains, Georgia. A moderate democrat born in Plains in October 1924, Mr Carter’s political career took him from the Georgia state senate to the state governorship and finally, the White House, where he took office as the 39th president. His presidency saw economic disruption amid volatile oil prices, along with social tensions at home and challenges abroad including the Iranian revolution that sparked a 444-day hostage crisis at the US embassy in Tehran. But he also brokered the Camp David Accords between Egypt and Israel, which led to a peace treaty between the two countries in 1979. After his defeat in the 1980 presidential election, he worked for more than four decades leading the Carter Centre, which he and his late wife Rosalynn co-founded in 1982 to “wage peace, fight disease, and build hope”. Under his leadership, the Carter Center managed to virtually eliminate Guinea Worm disease, which has gone from affecting 3.5 million people in Africa and Asia in 1986 to just 14 in 2023. Mrs Carter, who died last year aged 96, had played a more active role in her husband’s presidency than previous first ladies, with Mr Carter saying she had been “my equal partner in everything I ever accomplished”. Earlier this year, on his 100th birthday, Mr Carter received a private congratulatory message from the King, expressing admiration for his life of public service.
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Linebacker Matt Milano is finally back on the active roster in Buffalo. The Bills announced that they have activated Milano from injured reserve. Milano suffered a season-ending leg injury in Week Five last year and then suffered a biceps injury this summer, so it has been a long time since he’s seen game action. Milano is still listed as questionable to play against the 49ers. The Bills also announced that they are elevating quarterback Mike White and tight end Zach Davidson from the practice squad. Neither Josh Allen nor Mitch Trubisky are on the team’s injury report, so the reason for adding White to the mix is not immediately clear. While White and Davidson will be available, defensive tackle DeWayne Carter will not. He will remain on injured reserve for the time being.Jimmy Carter, the 39th US president, has died at 100
