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j rich The Amazon Global Selling Seller Summit, a premier event for online sellers, has made its first appearance in Nanjing, China, showcasing the city's growing importance as a hub for cross-border e-commerce. Hosted in the historical district of Jianye, the event has not only brought together international business leaders and entrepreneurs but also highlighted the city's potential for further elevation on the global stage.

SAN DIEGO and TORONTO, Nov. 25, 2024 (GLOBE NEWSWIRE) -- Aptose Biosciences Inc. ("Aptose” or the "Company”) (NASDAQ: APTO, TSX: APS), a clinical-stage precision oncology company developing highly differentiated oral targeted agents to treat hematologic malignancies, today announced the closing of its previously announced "reasonable best efforts" public offering with participation from the CEO and existing and new healthcare focused investors for the purchase and sale of 40,000,000 common shares at a price of $0.20 per share and warrants to purchase up to 20,000,000 common shares (the "Offering”). The warrants have an exercise price of $0.25 per share, are exercisable immediately and will expire five years from the issuance date. The Company received aggregate gross proceeds of $8 million, before deducting placement agent fees and other offering expenses, and intends to use the net proceeds from this Offering for working capital and general corporate purposes. A.G.P./Alliance Global Partners is acting as the sole placement agent for the Offering. The securities described above were offered pursuant to a registration statement on Form S-1 (File No. 333-281201) previously filed with the Securities and Exchange Commission ("SEC") on August 2, 2024, as amended, which was declared effective on November 21, 2024. This Offering was made only by means of a prospectus forming part of the effective registration statement. A preliminary prospectus relating to the Offering has been filed with the SEC. An electronic copy of the final prospectus relating to the Offering may be obtained on the SEC's website located at http://www.sec.gov and may also be obtained from A.G.P./Alliance Global Partners, 590 Madison Avenue, 28th Floor, New York, NY 10022, or by telephone at (212) 624-2060, or by email at [email protected] . This press release shall not constitute an offer to sell or the solicitation of an offer to buy nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction. About Aptose Aptose Biosciences is a clinical-stage biotechnology company committed to developing precision medicines addressing unmet medical needs in oncology, with an initial focus on hematology. The Company's small molecule cancer therapeutics pipeline includes products designed to provide single agent efficacy and to enhance the efficacy of other anti-cancer therapies and regimens without overlapping toxicities. The Company's lead clinical-stage, oral kinase inhibitor tuspetinib (TUS) has demonstrated activity as a monotherapy and in combination therapy in patients with relapsed or refractory acute myeloid leukemia (AML), and is being developed as a frontline triplet therapy in newly diagnosed AML. For more information, please visit www.aptose.com . Forward Looking Statements This press release contains forward-looking statements within the meaning of Canadian and U.S. securities laws, including, but not limited to, statements relating to the intended use of proceeds and statements relating to the Company's plans, objectives, expectations and intentions and other statements including words such as "continue”, "expect”, "intend”, "will”, "hope” "should”, "would”, "may”, "potential” and other similar expressions. Such statements reflect our current views with respect to future events and are subject to risks and uncertainties and are necessarily based upon a number of estimates and assumptions that, while considered reasonable by us, are inherently subject to significant market and other conditions, business, economic, competitive, political and social uncertainties and contingencies. Many factors could cause our actual results, performance or achievements to be materially different from any future results, performance or achievements described in this press release. Such factors could include, among others: our ability to obtain the capital required for research and operations; the inherent risks in early stage drug development including demonstrating efficacy; development time/cost and the regulatory approval process; the progress of our clinical trials; our ability to find and enter into agreements with potential partners; our ability to attract and retain key personnel; changing market and economic conditions; unexpected manufacturing defects and other risks detailed from time-to-time in our ongoing current reports, quarterly filings, annual information forms, annual reports and annual filings with Canadian securities regulators and the United States Securities and Exchange Commission. Should one or more of these risks or uncertainties materialize, or should the assumptions set out in the section entitled "Risk Factors" in our filings with Canadian securities regulators and the United States Securities and Exchange Commission underlying those forward-looking statements prove incorrect, actual results may vary materially from those described herein. These forward-looking statements are made as of the date of this press release and we do not intend, and do not assume any obligation, to update these forward-looking statements, except as required by law. We cannot assure you that such statements will prove to be accurate as actual results and future events could differ materially from those anticipated in such statements. Investors are cautioned that forward-looking statements are not guarantees of future performance and accordingly investors are cautioned not to put undue reliance on forward-looking statements due to the inherent uncertainty therein. For further information, please contact:

Furthermore, the introduction of Answers also aligns with Reddit's broader efforts to increase monetization opportunities and drive revenue growth. By improving the search experience for users, Reddit can potentially increase user engagement, drive more targeted advertising opportunities, and boost its overall ad revenue.No. 9 SMU aims to improve playoff odds vs. Cal

According to the official report, a number of patrons of the bathhouse experienced symptoms of dizziness, nausea, and vomiting shortly after using the facilities. The affected individuals were quickly attended to by staff members and emergency services were contacted to provide immediate medical assistance. Several individuals were subsequently transported to nearby hospitals for further evaluation and treatment.Manchester United officially announced the signing of a 14-year-old grassroots midfield talent, who goes by the name of Little Wizard. The young prodigy revealed that his dream is to become the next "Boy Wonder" at Old Trafford, rejecting offers from both Arsenal and Chelsea in the process. The news sent shockwaves through the football world, with many praising the Red Devils for securing such a promising talent at such a young age.

The New Climate Math on HurricanesDespite its seemingly noble intentions, the authorities in Tianjin have clarified that there is no such program in existence. The Municipal Education Bureau released a statement urging the public not to believe in or propagate unfounded information that could lead to misunderstandings and false expectations. They emphasized the importance of verifying the authenticity of news before sharing it, highlighting the potential harm that can arise from the spread of misinformation.

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In addition to innovation, the meeting also emphasized the importance of sustainable development and environmental protection in economic planning. With growing concerns about climate change and environmental degradation, policymakers emphasized the need to adopt green technologies, promote renewable energy sources, and implement sustainable practices across industries. Efforts to reduce carbon emissions, improve energy efficiency, and protect natural ecosystems were identified as crucial steps towards achieving a more sustainable and resilient economy.Trump Advisor Criticizes Zelensky's Attire, Sparks ControversyIn conclusion, the FIFPRO Best 11 of the Year showcases the incredible talent and skill of the top footballers in the world, with Mbappe and Haaland leading the pack. While the absence of Messi and Ronaldo may have come as a surprise to many, it is a testament to the evolving nature of the sport and the emergence of new stars who are ready to take their place among the greats. Football fans can only look forward to what the future holds for these exceptional players and the beautiful game they continue to grace with their presence.

It is important to note, however, that investing in Chinese assets carries its own set of risks and challenges. Political uncertainties, regulatory changes, and geopolitical tensions can all impact investor sentiment and market performance. As such, foreign investors should conduct thorough due diligence and seek professional advice before making any investment decisions in Chinese assets.Barcelona, on the other hand, are in the midst of a squad overhaul as they look to rebuild under new manager Xavi Hernandez. The Catalan club see the 26-year-old defender as a key addition to strengthen their defensive unit and provide competition for places in the starting lineup. With Barcelona aiming to return to the summit of European football, the Dutch international could play a crucial role in their resurgence.

Michigan football secures bowl eligibility in 44-point blowout over Northwestern on Senior DayThe incident took place on a busy city street during rush hour, where the streets were filled with vehicles and pedestrians. The driver, whose identity has not yet been disclosed, reportedly took his eyes off the road for a mere second to check a text message on his phone. In that split second, his car veered into the adjacent lane, where it collided with another vehicle before careening onto the sidewalk, where three pedestrians were struck.

After Trump's win, Black women are rethinking their role as America's reliable political organizersRashford, who came through the ranks at Manchester United's academy, has been a key player for the club for several seasons. His pace, skill, and eye for goal have made him a fan favorite at Old Trafford, but recent performances have left some questioning his place in the team.

Employees who have been affected by this buyback scheme have expressed disappointment and frustration, with many feeling that their hard work and contributions to the company have been undervalued. The situation highlights the importance of transparency and fairness in corporate governance, as well as the need for strong protections for employees' rights and interests.Savion Williams rushed for two touchdowns and Josh Hoover threw for 252 yards as TCU pulled away from Arizona in the second half, winning 49-28 on Saturday in Fort Worth, Texas. The Horned Frogs (7-4, 5-3 Big 12) scored touchdowns on five consecutive possessions, starting late in the first half after the Wildcats (4-7, 2-6) pulled within 14-13. Williams carried nine times for 80 yards, scoring on runs of 1 and 20 yards in the first half. Hoover completed 19 of 26 passes, with one touchdown and one interception, before being pulled midway through the fourth quarter when the Frogs were up by 21. TCU took control after leading 21-13 at halftime, going up 35-13 on a 38-yard reception to JP Richardson midway through the third. Arizona kept its hopes alive, ending a 15-play, 75-yard drive with a 3-yard touchdown pass to Chris Hunter on fourth down on the first play of the fourth quarter. The two-point conversion made it 35-21. But the Horned Frogs responded with another TD drive, capped by a 6-yard run by Cam Cook for a 42-21 advantage. Arizona added a 70-yard fumble return touchdown with one minute to go for the game's final score. Tetairoa McMillan caught nine passes for 115 yards to become the Arizona career leader in receiving yardage with 3,355. He surpassed his receivers coach, Bobby Wade (3,351), at the top spot. The Wildcats' Noah Fifita completed 29 of 44 passes for 284 yards with two touchdowns and an interception, which happened on the game's first snap. TCU promptly scored on a 4-yard run by Trent Battle, and Williams added a 1-yard TD run late in the first quarter for a 14-0 lead. But the Wildcats fought back, getting a 17-yard touchdown reception by Hunter and field goals of 53 and 43 yards from Tyler Loop to climb within 14-13 with 1:55 go before halftime. That's almost how the half ended, but the Horned Frogs converted third-and-18 on the ensuing drive and then gained 24 yards on third-and-25 to the Arizona 20. That set up a 20-yard run by Williams on fourth-and-1 with 13 seconds left for a 21-13 lead. --Field Level Media

Louisville scores 52 second-half points to race past No. 14 Indiana 89-61 in the Battle 4 AtlantisFor many years, Tang Shangjun's mother has been living in a rundown and dilapidated old house, which has been a constant source of worry and concern for her devoted son. Despite facing numerous challenges and financial constraints, Tang Shangjun has never wavered in his determination to provide his mother with a comfortable and secure living environment.

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