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Copy link Copied Copy link Copied Subscribe to gift this article Gift 5 articles to anyone you choose each month when you subscribe. Already a subscriber? Login The Australian sharemarket extended its rebound this week, taking a strong lead from Wall Street where the world’s largest technology companies powered all three major benchmarks higher. The benchmark S & P/ASX 200 Index opened the shortened Christmas Eve session 6 points higher at 8207.6, extending its rally from Monday when the benchmark surged 1.7 per cent in its best single session in six months . The sharemarket will close on Tuesday at 2.10pm Sydney time. Copy link Copied Copy link Copied Subscribe to gift this article Gift 5 articles to anyone you choose each month when you subscribe. Already a subscriber? Login Introducing your Newsfeed Follow the topics, people and companies that matter to you. Latest In Equity markets Fetching latest articles Most Viewed In MarketsBad Axe: Wisconsin wary of rival Minnesota with bowl bid in peril
Justin Tucker’s erratic season isn’t getting any better, and it’s hurting Baltimore’s outlookMANCHESTER, England (AP) — Manchester City's players were booed by their own fans Tuesday after blowing a three-goal lead against Feyenoord in the Champions League to extend their winless run to six games. Jeers rang around the Etihad Stadium after the final whistle of a dramatic 3-3 draw. After five-straight losses in all competitions, City looked to be cruising to victory after going three up inside 50 minutes. But Feyenoord mounted an improbable comeback and leveled the game in the 89th minute to leave the home crowd stunned. While the worst losing streak of Guardiola’s managerial career was brought to an end, his wait for a first win since Oct. 26 goes on. Erling Haaland had scored twice, with Ilkay Gundogan also on target to put City in control. But goals from Anis Hadj Moussa in the 75th, Santiago Gimenez in the 82nd and David Hancko in the 89th turned the game on its head. City's players, including Bernardo Silva, Josko Gvardiol and Haaland looked visibly frustrated as they left the field to cheers of the delirious traveling Dutch fans in the away section of the stadium. City plays Premier League leader Liverpool on Sunday — defeat would leave it 11 points adrift of its title rival. James Robson is at AP soccer:
LAHAINA, Hawaii — Keshon Gilbert scored 24 points and Curtis Jones added 19 to lead No. 5 Iowa State to an 89-84 win over Dayton in the Maui Invitational on Tuesday. The Cyclones (4-1) rallied from a nine-point deficit late in the first half and held off the Flyers (5-2) in a game that featured 11 ties and 10 lead changes. Gilbert made a pair of free throws with 44.9 seconds left to give Iowa State the lead for good. He shot 12 of 14 from the line. Dishon Jackson had 12 points and six rebounds, and Milan Momcilovic scored 10 for Iowa State. Malachi Smith scored a career-high 22 points for Dayton. Takeaways Iowa State: Point guard Tamin Lipsey, a preseason All-Big 12 first-team pick, was limited to six points and two assists in 16 minutes. He fouled out with 2:42 to play. Dayton: The Cyclones entered leading the country in scoring defense at 58.8 points per game, but the Flyers shot 58% (29 of 50) from the field and had four players score in double figures. Iowa State guard Keshon Gilbert (10) reacts to scoring against Dayton during the second half of an NCAA college basketball game at the Maui Invitational Tuesday, Nov. 26, 2024, in Lahaina, Hawaii. Iowa State won 89-84. Credit: AP/Lindsey Wasson Key moment Gilbert grabbed an offensive rebound and was fouled by Dayton's Zed Key as he went up for a putback with 44.9 seconds left. After a review, the foul was upgraded to a flagrant-1. Gilbert knocked down both free throws, then made it a four-point possession with a driving layup and high finish off the glass to give the Cyclones an 85-81 lead with 26.8 seconds remaining. Key stat The Cyclones made 25 of 29 free throws for the game and shot 60% (15 of 25) from the field in the second half to overcome a 41-37 halftime deficit. Up next Iowa State will play Colorado for fifth place Wednesday, while Dayton will meet No. 2 UConn for seventh place.Bidu: The Game-Changer of the Future? Discover the Revolutionary Tech Crafting the Next Gaming Era
A gesture as simple as a smile can often convey what words cannot. This is part of why nonverbal communication is so central to human interaction. It is also why facial nerve disorders and injuries can be devastating. These conditions are typically treated with nerve tissue taken from elsewhere in a patient’s body, known as autografts. This technique for repairing injured nerves presents issues for patients, such as damage to the donor site and the odds of functional recovery being nearly a coin toss. Synthetic alternatives have been explored in the past but have yet to live up to the performance of autografts. Bioengineers at the University of Pittsburgh may have developed a new solution with the help of some of nature’s best engineers — stem cells. Leveraging these cells’ ability to create a restorative environment, the team produced implantable conduits to act as bridges, providing directional, mechanical, and biochemical guidance for injured nerves to regenerate across large gaps. Experiments in the facial nerves of rats showed that the technology matched autografts. These results were published in the Journal of Neural Engineering . “We leaned into the idea that the cells know what they're doing, and they know how to make tissue,” said oral and craniofacial sciences and bioengineering professor Fatima Syed-Picard, Ph.D., the senior author of the study. “These engineered tissues ended up being more biomimetic than many other synthetically derived scaffolds used in tissue engineering.” Getting neurons in line For nerves to be repaired, the long projections that extend from neurons, called axons, need to both regrow and reconnect to the appropriate tissue. With autografts, the former is slow, and the latter is no guarantee, as many patients experience unwanted muscle activity due to regrown nerves connecting to the wrong tissue. Researchers have wielded specific cell populations to accelerate growth, such as neural support cells and stem cells, which produce biomolecules that aid neural tissue regeneration. To orient growing tissue so that axons reach the proper targets, researchers have designed synthetic tissue scaffolds with features, such as grooves, that act as guiderails to regenerating neurons. “It’s difficult to embed and distribute cells evenly in synthetic scaffolds without harming them. Another concern is trying to get these scaffolds to match the structural complexity of innate tissue,” said first author Michelle Drewry, Ph.D., who conducted this research while a graduate student* at the University of Pittsburgh. Many cell types in the body frequently make or remodel the biomolecular scaffolding surrounding them, known as extracellular matrix (ECM). So, instead of making tissue scaffolds from scratch themselves, the researchers thought it might be better to let cells make their own. The authors of the study tested this hypothesis with dental pulp stem cells (DPSCs), a hardy and readily available cell population that produce proteins known to encourage nerve growth. After extracting these cells from adult wisdom teeth provided by the University of Pittsburgh School of Dental Medicine, the researchers put them to work. They wanted to give DPSCs the freedom to create ECM but, at the same time, nudge them into making an environment conducive to supporting aligned axons. To accomplish this, the researchers fabricated rubber molds with rows of 10 micrometer-wide grooves and then covered them with DPSCs. After several days, the DPSCs secreted aligned ECM around themselves, forming thin biological sheets. The authors then peeled the sheets from the rubber templates and rolled them up into cylindrical conduits. The researchers used this approach to make a type of bandage in a previous study , which successfully regenerated the axons of a crushed nerve. With their new work, they sought to clear a higher hurdle of using the conduit to bridge a 5-millimeter gap in the facial nerve of rats — a defect so large that the nerve would not be able to heal on its own. Specifically, they implanted their aligned conduits into gaps made in the buccal branch of the facial nerve. For comparison, the team also implanted autografts into another group of rats. “The buccal branch is the part of the facial nerve that helps with smiling. It's a big part of your quality of life because it’s a large piece of how you communicate with other people and how you're seen in the world. Injury to that nerve can have a life-changing effect,” Drewry said. Crossing the bridge Twelve weeks after implantation, the authors evaluated how well axons had regenerated, primarily through histology. They found that their cell-made conduits contained regenerated axons across their full length. And, in general, the density and number of axons were similar to what they found in autografts. Indicators of developing axons were prevalent in the conduits, suggesting that regeneration may have been more robust with additional time, Drewry noted. But did all this regenerated tissue translate to improved function? To find out, the authors electrically stimulated the nerves on one end and measured the animals’ whisker movement on the other side. The tests showed that the motions of rats implanted with conduits were on par with those treated with autografts. Syed-Picard’s lab aims to better understand the roles the ECM and cells play in healing and then use that information to improve their technology. For example, in addition to encouraging regrowth directly, the conduits may also be helping by dampening inflammation, Syed-Picard explained. Drewry’s work on this study was funded by the Cellular Approaches to Tissue Engineering and Regeneration (CATER) Training Program at the University of Pittsburgh, which is supported by NIBIB grant T32EB001026. “This research exemplifies how our training programs lay a strong foundation for doctoral students. Trainees from this particular program have gone on to receive 58 subsequent NIH grants including fellowships, career awards, and research grants,” said Zeynep Erim, Ph.D., director of the Division of Interdisciplinary Training at the National Institute of Biomedical Imaging and Bioengineering (NIBIB). The research was also supported by the National Institute of Dental and Craniofacial Research (NIDCR; R56DE030881). This science highlight describes a basic research finding. Basic research increases our understanding of human behavior and biology, which is foundational to advancing new and better ways to prevent, diagnose, and treat disease. Science is an unpredictable and incremental process—each research advance builds on past discoveries, often in unexpected ways. Most clinical advances would not be possible without the knowledge of fundamental basic research. *Drewry is now an associate program officer at the National Academies of Sciences, Engineering, and Medicine (NASEM). Her comments in this article reflect her personal views and not that of NASEM. About the graphics: These two images originally appeared in the Journal of Neural Engineering paper and are available under the Creative Commons license. Images have been adapted for the NIBIB website. Study reference: Michelle Drewry et al. Enhancing facial nerve regeneration with scaffold-free conduits engineered using dental pulp stem cells and their endogenous, aligned extracellular matrix. Journal of Neural Engineering (2024) https://doi.org/10.1088/1741-2552/ad749d
Apiaries abuzz over ruling against widening cross-border trade in live honeybeesTop war-crimes court issues arrest warrants for Netanyahu and others in Israel-Hamas fighting
Foundation renovates Ogun general hospital’s children ward
Israel has agreed to a ceasefire with Hezbollah in Lebanon that will take effect at 4 a.m. Wednesday. Moments after U.S. President Joe Biden announced the ceasefire deal , which Israel's Cabinet approved late Tuesday, an Israeli airstrike slammed into the Lebanese capital. Residents of Beirut and its southern suburbs have endured the most intense day of Israeli strikes since the war began nearly 14 months ago, as Israel's nationwide onslaught of bombings signaled it aims to keep pummeling Hezbollah before the ceasefire is set to take hold. Javascript is required for you to be able to read premium content. Please enable it in your browser settings. Get any of our free email newsletters — news headlines, obituaries, sports, and more.The latest development came hours after thousands of his supporters, defying government warnings, broke through a barrier of shipping containers blocking off Islamabad and entered a high-security zone, where they clashed with security forces, facing tear gas shelling, mass detentions and gunfire. Tension has been high in Islamabad since Sunday when supporters of the former PM began a “long march” from the restive north-west to demand his release. Khan has been in a prison for more than a year and faces more than 150 criminal cases that his party says are politically motivated. Khan’s wife, Bushra Bibi, led the protest, but she fled as police pushed back against demonstrators. Hundreds of Khan’s supporters are being arrested in the ongoing night-time operation. Interior minister Mohsin Naqvi told reporters that the Red Zone, which houses government buildings and embassies, and the surrounding areas have been cleared. Leaders from Khan’s Pakistan Tehreek-e-Insaf party, or PTI, have also fled the protest site. Earlier on Tuesday, Pakistan’s army took control of D-Chowk, a large square in the Red Zone, where visiting Belarusian President Alexander Lukashenko is staying. Since Monday, Mr Naqvi had threatened that security forces would use live fire if protesters fired weapons at them. “We have now authorised the police to respond as necessary,” Mr Naqvi said Tuesday while visiting the square. Before the operation began, protester Shahzor Ali said people had taken to the streets because Khan had called for them. “We will stay here until Khan joins us. He will decide what to do next,” Mr Ali said. Protester Fareeda Bibi, who is not related to Khan’s wife, said people have suffered greatly for the last two years. “We have really suffered for the last two years, whether it is economically, politically or socially. We have been ruined. I have not seen such a Pakistan in my life,” she said. Authorities have struggled to contain the protest-related violence. Six people, including four members of the security services, were killed when a vehicle rammed them on a street overnight into Tuesday. A police officer died in a separate incident. Dozens of Khan supporters beat a videographer covering the protest for the Associated Press and took his camera. He sustained head injuries and was treated in hospital. By Tuesday afternoon, fresh waves of protesters made their way unopposed to their final destination in the Red Zone. Mr Naqvi said Khan’s party had rejected a government offer to rally on the outskirts of the city. Information minister Atta Tarar warned there would be a severe government reaction to the violence. The government says only the courts can order Khan’s release. He was ousted in 2022 through a no-confidence vote in Parliament. In a bid to foil the unrest, police have arrested more than 4,000 Khan supporters since Friday and suspended mobile and internet services in some parts of the country. Messaging platforms were also experiencing severe disruption in the capital. Khan’s party relies heavily on social media and uses messaging platforms such as WhatsApp to share information, including details of events. The X platform, which is banned in Pakistan, is no longer accessible, even with a VPN. Last Thursday, a court prohibited rallies in the capital and Mr Naqvi said anyone violating the ban would be arrested. Travel between Islamabad and other cities has become nearly impossible because of shipping containers blocking the roads. All education institutions remain closed.
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