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mnl168 casino register Stock Market News Today Live Updates on November 28, 2024 : BFSI Stock Picks: ICICI Bank, SBI among Mirae Asset's top 10 picks for investors after mixed Q2; Should you buy or hold?The decision to launch the airstrikes came after a series of rocket attacks on U.S. personnel and facilities in Iraq, including a rocket attack in Erbil that killed a non-American contractor and injured several others. These attacks were attributed to Iranian-backed militias operating in the region, raising concerns about the security of U.S. personnel and interests in the area.Old Dominion Freight Line, Inc. ODFL today reported certain less-than-truckload ("LTL") operating metrics for November 2024. Revenue per day decreased 8.2% as compared to November 2023 due to an 8.0% decrease in LTL tons per day and a slight decrease in LTL revenue per hundredweight. The decrease in LTL tons per day was attributable to a 6.8% decrease in LTL shipments per day and a 1.2% decrease in LTL weight per shipment. For the quarter-to-date period, LTL revenue per hundredweight decreased 1.2% as compared to the same period last year and LTL revenue per hundredweight, excluding fuel surcharges, increased 3.7% as compared to the same period last year. Marty Freeman, President and Chief Executive Officer of Old Dominion, commented, "Our revenue results for November reflect the continued softness in the domestic economy as well as the impact of lower fuel surcharge revenue on our yields. While our LTL volumes declined on a year-over-year basis in November, the improvement in our revenue per hundredweight, excluding fuel surcharges, demonstrates our continued commitment to yield management. We have achieved consistent, cost-based increases in our yield metrics, excluding fuel surcharges, by remaining committed to providing our customers with superior service at a fair price. As we continue to deliver on these core elements of our long-term strategic plan, we remain confident in our ability to win market share and increase shareholder value over the long term." Forward-looking statements in this news release are made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. We caution the reader that such forward-looking statements involve risks and uncertainties that could cause actual events and results to be materially different from those expressed or implied herein, including, but not limited to, the following: (1) the challenges associated with executing our growth strategy, and developing, marketing and consistently delivering high-quality services that meet customer expectations; (2) changes in our relationships with significant customers; (3) our exposure to claims related to cargo loss and damage, property damage, personal injury, workers' compensation and healthcare, increased self-insured retention or deductible levels or premiums for excess coverage, and claims in excess of insured coverage levels; (4) reductions in the available supply or increases in the cost of equipment and parts; (5) various economic factors such as inflationary pressures or downturns in the domestic economy, and our inability to sufficiently increase our customer rates to offset the increase in our costs; (6) higher costs for or limited availability of suitable real estate; (7) the availability and cost of third-party transportation used to supplement our workforce and equipment needs; (8) fluctuations in the availability and price of diesel fuel and our ability to collect fuel surcharges, as well as the effectiveness of those fuel surcharges in mitigating the impact of fluctuating prices for diesel fuel and other petroleum-based products; (9) seasonal trends in the less-than-truckload ("LTL") industry, harsh weather conditions and disasters; (10) the availability and cost of capital for our significant ongoing cash requirements; (11) decreases in demand for, and the value of, used equipment; (12) our ability to successfully consummate and integrate acquisitions; (13) various risks arising from our international business relationships; (14) the costs and potential adverse impact of compliance with anti-terrorism measures on our business; (15) the competitive environment with respect to our industry, including pricing pressures; (16) our customers' and suppliers' businesses may be impacted by various economic factors such as recessions, inflation, downturns in the economy, global uncertainty and instability, changes in international trade policies, changes in U.S. social, political, and regulatory conditions or a disruption of financial markets; (17) the negative impact of any unionization, or the passage of legislation or regulations that could facilitate unionization, of our employees; (18) increases in the cost of employee compensation and benefit packages used to address general labor market challenges and to attract or retain qualified employees, including drivers and maintenance technicians; (19) our ability to retain our key employees and continue to effectively execute our succession plan; (20) potential costs and liabilities associated with cyber incidents and other risks with respect to our information technology systems or those of our third-party service providers, including system failure, security breach, disruption by malware or ransomware or other damage; (21) the failure to adapt to new technologies implemented by our competitors in the LTL and transportation industry, which could negatively affect our ability to compete; (22) the failure to keep pace with developments in technology, any disruption to our technology infrastructure, or failures of essential services upon which our technology platforms rely, which could cause us to incur costs or result in a loss of business; (23) disruption in the operational and technical services (including software as a service) provided to us by third parties, which could result in operational delays and/or increased costs; (24) the Compliance, Safety, Accountability initiative of the Federal Motor Carrier Safety Administration ("FMCSA"), which could adversely impact our ability to hire qualified drivers, meet our growth projections and maintain our customer relationships; (25) the costs and potential adverse impact of compliance with, or violations of, current and future rules issued by the Department of Transportation, the FMCSA and other regulatory agencies; (26) the costs and potential liabilities related to compliance with, or violations of, existing or future governmental laws and regulations, including environmental laws; (27) the effects of legal, regulatory or market responses to climate change concerns; (28) emissions-control and fuel efficiency regulations that could substantially increase operating expenses; (29) expectations relating to environmental, social and governance considerations and related reporting obligations; (30) the increase in costs associated with healthcare and other mandated benefits; (31) the costs and potential liabilities related to legal proceedings and claims, governmental inquiries, notices and investigations; (32) the impact of changes in tax laws, rates, guidance and interpretations; (33) the concentration of our stock ownership with the Congdon family; (34) the ability or the failure to declare future cash dividends; (35) fluctuations in the amount and frequency of our stock repurchases; (36) volatility in the market value of our common stock; (37) the impact of certain provisions in our articles of incorporation, bylaws, and Virginia law that could discourage, delay or prevent a change in control of us or a change in our management; and (38) other risks and uncertainties described in our most recent Annual Report on Form 10-K and other filings with the SEC. Our forward-looking statements are based upon our beliefs and assumptions using information available at the time the statements are made. We caution the reader not to place undue reliance on our forward-looking statements as (i) these statements are neither a prediction nor a guarantee of future events or circumstances and (ii) the assumptions, beliefs, expectations and projections about future events may differ materially from actual results. We undertake no obligation to publicly update any forward-looking statement to reflect developments occurring after the statement is made, except as otherwise required by law. Old Dominion Freight Line, Inc. is one of the largest North American LTL motor carriers and provides regional, inter-regional and national LTL services through a single integrated, union-free organization. Our service offerings, which include expedited transportation, are provided through an expansive network of service centers located throughout the continental United States. The Company also maintains strategic alliances with other carriers to provide LTL services throughout North America. In addition to its core LTL services, the Company offers a range of value-added services including container drayage, truckload brokerage and supply chain consulting. View source version on businesswire.com: https://www.businesswire.com/news/home/20241203903746/en/ © 2024 Benzinga.com. Benzinga does not provide investment advice. All rights reserved.

In the ever-evolving landscape of modern football, Neymar's decision serves as a testament to the complexities and challenges that players face when navigating high-profile transfers. As the dust settles on the Neymar-Barcelona saga, one thing remains clear: in the world of elite football, even the most anticipated moves can be derailed by registration uncertainties and financial intricacies, shaping the narratives that define the beautiful game.

CHANTILLY, Va.--(BUSINESS WIRE)--Dec 16, 2024-- Amentum Holdings, Inc. (“Amentum” or the “Company”) (NYSE: AMTM), a leading advanced engineering and technology company, today announced results for the fiscal year ended September 27, 2024, and affirmed its outlook for fiscal year 2025. “We reported strong results for fiscal year 2024, delivering top-line and bottom-line growth,” commented Amentum Chief Executive Officer John Heller. “2024 was a significant year in our Company’s history, culminating in the merger of Amentum with Jacobs’ Critical Mission Solutions and Cyber & Intelligence businesses to create one of the strongest advanced engineering and technology companies in the industry. Today, over two months since the merger, we continue to be excited about the combined strength of these two historic businesses. We have transformed Amentum into a larger, more diversified company with broader customer reach and capabilities to deliver greater value to the world’s most complex challenges. In fiscal year 2025 we already see positive momentum and are confident in our outlook.” Revenues $8,388 $7,865 7% Operating income $291 $57 Net loss $(82) $(314) Diluted loss per share $(0.90) $(3.49) Pro Forma Revenues $13,858 $13,371 4% Pro Forma Adjusted EBITDA 1 $1,052 $986 7% Pro Forma Adjusted EBITDA Margin 1 7.6% 7.4% +20 bps Pro Forma Adjusted Net Income 1 $489 $453 8% Pro Forma Adjusted Diluted Earnings Per Share (EPS) 1 $2.01 $1.86 8% 1 – Non-GAAP financial measures should be considered in addition to, but not as a substitute for, the information provided in accordance with GAAP. Management believes that these non-GAAP measures provide another measure of Amentum’s results of operations and financial condition, including its ability to comply with financial covenants. See Unaudited Pro Forma Non-GAAP Financial Measures at the end of this press release for more information and a reconciliation of our selected reported results to these non-GAAP measures. GAAP Results GAAP revenues, which exclude Jacobs' Critical Mission Solutions and Cyber & Intelligence (CMS) businesses, increased 7% year-over-year driven by new contract awards and growth on existing programs. GAAP operating income increased primarily as a result of a non-cash impairment charge that was recognized during fiscal year 2023. Operating income also benefited from reduced intangible amortization expense and the higher revenue volume. GAAP net loss and diluted loss per share improved year-over-year due to the higher operating income and a gain on the acquisition of a controlling interest, partially offset by higher interest expense and a loss on extinguishment of debt. Pro Forma and Non-GAAP Results Pro forma revenues, which include the results of CMS prepared in accordance with the requirements of Article 11 of Regulation S-X, increased 4% year-over-year driven by new contract awards and growth on existing programs partially offset by the expected ramp-down of other historical programs. Pro Forma Adjusted EBITDA increased 7% year-over-year primarily due to the higher revenue volume and improved operating performance. Pro Forma Adjusted Net Income and Adjusted Diluted Earnings Per Share increased due to the higher operating income partially offset by increased tax expense. As of September 27, 2024, the Company had a total backlog of $45.0 billion, compared with $26.8 billion a year ago, an increase of $18.2 billion primarily due the addition of backlog from CMS. Funded backlog as of September 27, 2024 was $7.6 billion. Notable Fiscal Year 2024 Awards Amentum affirms its fiscal year 2025 guidance originally presented at Capital Markets Day on August 13, 2024 and provides Adjusted Diluted Earnings Per Share (EPS) guidance. Revenues $13,800 - $14,200 Adjusted EBITDA 1 $1,060 - $1,100 Adjusted Diluted EPS 1 $2.00 - $2.20 Free Cash Flow 1 $475 - $525 1 – Represents a Non-GAAP financial measure - see the related explanations included elsewhere in this release. Amentum does not provide a reconciliation of forward-looking non-GAAP financial measures to the most directly comparable GAAP measures due to the inherent difficulty in forecasting and quantifying certain significant items. These items are uncertain, depend on various factors and could have a material impact on GAAP reported results for the relevant period. Amentum will host a conference call beginning at 8:30 a.m. Eastern time on Tuesday, December 17, 2024 to discuss the results for the fiscal year ended September 27, 2024. The conference call will be webcast simultaneously to the public through a link on the Investor Relations section of the Amentum website at . After the call concludes, a replay of the webcast can be accessed on the Investor Relations website. Amentum is a global leader in advanced engineering and innovative technology solutions, trusted by the United States and its allies to address their most significant and complex challenges in science, security and sustainability. Our people apply undaunted curiosity, relentless ambition and boundless imagination to challenge convention and drive progress. Our commitments are underpinned by the belief that safety, inclusion and well-being are integral to success. Headquartered in Chantilly, Virginia, we have more than 53,000 employees in approximately 80 countries. Visit us at to learn how we advance the future together. This release contains or incorporates by reference statements that relate to future events and expectations and, as such, could be interpreted to be “forward-looking statements” as that term is defined in the Private Securities Litigation Reform Act of 1995 and other federal securities laws. Forward-looking statements may be characterized by terminology such as “believe,” “project,” “expect,” “anticipate,” “estimate,” “forecast,” “outlook,” “target,” “endeavor,” “seek,” “predict,” “intend,” “strategy,” “plan,” “may,” “could,” “should,” “will,” “would,” “will be,” “will continue,” “will likely result,” or the negative thereof or variations thereon or similar terminology generally intended to identify forward-looking statements. All statements other than statements of historical fact are statements that could be deemed forward-looking statements, including projections of financial performance; statements of plans, strategies and objectives of management for future operations; any statement concerning developments, performance or industry rankings relating to products or services; any statements regarding future economic conditions or performance; any statements of assumptions underlying any of the foregoing; and any other statements that address activities, events or developments that the Company intends, expects, projects, believes or anticipates will or may occur in the future. Important factors that could cause actual results to differ materially from such plans, estimates or expectations include, among others: changes in U.S. or global economic, financial, business and political conditions, including changes to governmental budgetary priorities; our ability to comply with the various procurement and other laws and regulations; risks associated with contracts with governmental entities; reviews and audits by the U.S. government and others; changes to our professional reputation and relationship with government agencies; the occurrence of an accident or safety incident; the ability of the Company to control costs, meet performance requirements or contractual schedules, compete effectively or implement its business strategy; the ability of the Company to retain and hire key personnel, and retain and engage key customers and suppliers; the failure to realize the anticipated benefits of the 2024 transaction with Jacobs Solutions Inc.; potential liabilities associated with shareholder litigation or other settlements or investigations; evolving legal, regulatory and tax regimes; and other factors set forth under Item 1A, Risk Factors in the annual report on Form 10-K (the “Annual Report”), and from time to time in documents that we file with the SEC. The above list of factors is not exhaustive or necessarily in order of importance. For additional information on identifying factors that may cause actual results to vary materially from those stated in forward-looking statements, see the discussions under the section entitled “Risk Factors” in the Annual Report. Any forward-looking statement speaks only as of the date on which it is made, and we assume no obligation to update or revise such statement, whether as a result of new information, future events or otherwise, except as required by applicable law. This release includes the presentation and discussion of pro forma financial information that incorporates the results of CMS prepared in accordance with the requirements of Article 11 of Regulation S-X. This release also includes the presentation and discussion of Pro Forma Adjusted EBITDA, Pro Forma Adjusted EBITDA Margin, Pro Forma Adjusted Net Income, Pro Forma Adjusted Diluted Earnings Per Share, and Free Cash Flow, which are not measures of financial performance under Generally Accepted Accounting Principles in the United States (“GAAP”). These pro forma and non-GAAP measures should be considered only as supplements to, and should not be considered in isolation or used as substitutes for, financial information prepared in accordance with GAAP. Management of the Company believes these pro forma and non-GAAP measures, when read in conjunction with the Company’s financial statements prepared in accordance with GAAP and, where applicable, the reconciliations herein to the most directly comparable GAAP measures, provide useful information to management, investors and other users of the Company’s financial information in evaluating operating results and understanding operating trends by adjusting for the effects of items we do not consider to be indicative of the Company’s ongoing performance, the inclusion of which can obscure underlying trends. Additionally, management of the Company uses such measures in its evaluation of business performance, particularly when comparing performance to past periods, and believes these measures are useful for investors because they facilitate a comparison of financial results from period to period. The computation of pro forma and non-GAAP measures may not be comparable to similarly titled measures reported by other companies, thus limiting their use for comparability. Definitions of applicable non-GAAP measures and reconciliations to the most directly comparable GAAP measures are provided elsewhere in this release. Cost of revenues (2,013 ) (1,894 ) (7,590 ) (7,083 ) Selling, general, and administrative expenses (137 ) (99 ) (353 ) (297 ) Amortization of intangibles (57 ) (74 ) (228 ) (298 ) Equity earnings of non-consolidated subsidiaries 22 10 74 56 Goodwill impairment charges — — — (186 ) Interest expense and other, net (108 ) (112 ) (438 ) (397 ) Loss on extinguishment of debt (42 ) — (45 ) — Gain on acquisition of controlling interest 69 — 69 — Benefit for income taxes 76 9 40 19 Less: net loss attributable to non-controlling interests 4 17 1 7 Current assets: Cash and cash equivalents $ 452 $ 305 Accounts receivable, net 2,401 1,440 Prepaid expenses and other current assets 231 186 Total current assets 3,084 1,931 Property and equipment, net 144 85 Equity method investments 123 104 Goodwill 5,556 2,891 Intangible assets, net 2,623 988 Other long-term assets 444 414 Total assets $ 11,974 $ 6,413 Current liabilities: Current portion of long-term debt $ 36 $ 45 Accounts payable 764 560 Accrued compensation and benefits 696 369 Contract liabilities 113 120 Other current liabilities 356 282 Total current liabilities 1,965 1,376 Long-term debt, net of current portion 4,643 4,067 Deferred tax liabilities 370 141 Other long-term liabilities 444 413 Total liabilities 7,422 5,997 Common stock, $0.01 par value – 1,000,000,000 shares authorized and 243,302,173 shares issued and outstanding at September 27, 2024; no shares authorized, issued or outstanding at September 29, 2023. 2 — Additional paid-in capital 4,962 772 Retained deficit (527 ) (445 ) Accumulated other comprehensive income 23 48 Total Amentum shareholders' equity 4,460 375 Non-controlling interests 92 41 Total shareholders' equity 4,552 416 Total liabilities and shareholders' equity $ 11,974 $ 6,413 Net income (loss) $ 22 $ (23 ) $ (83 ) $ (321 ) Adjustments to reconcile net income (loss) to net cash (used in) provided by operating activities: Depreciation 6 7 23 27 Amortization of intangibles 57 74 228 298 Amortization of deferred loan costs and original issue discount 6 5 22 21 Goodwill impairment charges — — — 186 Derivative instruments 3 16 37 21 Equity earnings of non-consolidated subsidiaries (22 ) (10 ) (74 ) (56 ) Distributions from equity method investments 15 7 61 49 Deferred income taxes (98 ) (43 ) (115 ) (62 ) Equity-based compensation 15 — 18 3 Gain on acquisition of controlling interest (69 ) — (69 ) — Other 8 (1 ) 14 2 Changes in assets and liabilities, net of effects of business acquisition: Accounts receivable, net 52 (36 ) 81 (68 ) Prepaid expenses and other assets 8 49 78 56 Accounts payable, contract liabilities, and other current liabilities (100 ) 109 (211 ) (24 ) Accrued employee compensation and benefits (14 ) (40 ) 43 (82 ) Other long-term liabilities (2 ) 18 (6 ) 17 Net cash (used in) provided by operating activities (113 ) 132 47 67 Acquisitions, net of cash acquired 488 — 488 — Purchase of property and equipment (4 ) (4 ) (11 ) (12 ) Contributions to equity method investments (1 ) (1 ) (1 ) (17 ) Return of capital from equity method investments — — — 14 Other — — (1 ) (2 ) Net cash provided by (used in) investing activities 483 (5 ) 475 (17 ) Borrowings on revolving credit facilities — 234 562 1,201 Payments on revolving credit facilities — (234 ) (562 ) (1,201 ) Proceeds from borrowing under the term loans 2,620 — 2,620 — Repayments of borrowings under the credit agreement (4,002 ) (9 ) (4,177 ) (34 ) Proceeds from issuance of Senior Notes 1,000 — 1,000 — Payments of debt issuance fees (38 ) — (38 ) — Proceeds from borrowings under other agreements — — 1 5 Repayments of borrowings under other agreements (3 ) (3 ) (13 ) (67 ) Capital contribution 235 — 235 — Capital contribution from non-controlling interest — — — 13 Distributions to non-controlling interests (4 ) (1 ) (6 ) (24 ) Other (1 ) (2 ) (4 ) (5 ) Net cash used in financing activities (193 ) (15 ) (382 ) (112 ) Effect of exchange rate changes on cash 4 (2 ) 7 1 Net change in cash and cash equivalents 181 110 147 (61 ) Cash and cash equivalents, beginning of period 271 195 305 366 Cash and cash equivalents, end of period $ 452 $ 305 $ 452 $ 305 The presentation and discussion of Pro Forma Adjusted EBITDA, Pro Forma Adjusted EBITDA Margin, Pro Forma Adjusted Net Income, Pro Forma Adjusted Diluted EPS, and Free Cash Flow are not measures of financial performance under Generally Accepted Accounting Principles in the United States (“GAAP”). These non-GAAP measures should be considered only as supplements to, and should not be considered in isolation or used as a substitute for, financial information prepared in accordance with GAAP. Management believes these non-GAAP measures, when read in conjunction with our consolidated financial statements prepared in accordance with GAAP and the reconciliations herein to the most directly comparable GAAP measures, provide useful information in assessing trends in our ongoing operating performance and may provide greater visibility in understanding the long-term financial performance of the Company. The computation of non-GAAP measures may not be comparable to similarly titled measures reported by other companies, thus limiting their use for comparability. is defined as pro forma net (loss) income attributable to common shareholders, which incorporates the results of CMS prepared in accordance with the requirements of Article 11 of Regulation S-X, adjusted for pro forma interest expense and other, net, pro forma (benefit) provision for income taxes, pro forma depreciation and amortization, and excludes the following discrete pro forma items: is defined as Pro Forma Adjusted EBITDA divided by Pro Forma Revenues. is defined as pro forma net (loss) income attributable to common shareholders, which incorporates the results of CMS prepared in accordance with the requirements of Article 11 of Regulation S-X, excluding the discrete pro forma items listed under Pro Forma Adjusted EBITDA and the related pro forma tax impacts. is defined as Pro Forma Adjusted Net Income divided by pro forma diluted weighted average number of common shares outstanding. is defined as GAAP cash flow provided by operating activities less purchases of property and equipment. The following table presents the unaudited pro forma combined reconciliation of Pro Forma Adjusted EBITDA, Pro Forma Adjusted EBITDA Margin, Pro Forma Adjusted Net Income and Pro Forma Adjusted Diluted EPS to the most directly comparable pro forma measures for the Company, including CMS, for the fiscal year ended September 27, 2024: Non-operating expense, net (390 ) — — 45 — — (345 ) Provision for income taxes 1 (37 ) (13 ) (120 ) (11 ) — — (181 ) Less: net income attributable to non-controlling interests (3 ) — — — (16 ) — (19 ) Net income margin 2 0.2 % 3.5 % Depreciation expense 37 — — — — — 37 Amortization of intangibles 499 — (499 ) — — — — Interest expense and other, net 345 — — — — — 345 Provision for income taxes 37 13 120 11 — — 181 EBITDA margin 6.9 % 7.6 % 1 - Calculation uses a full year estimated statutory rate on each non-GAAP tax deductible adjustment, unless the nature of the item requires application of specific tax treatment for related impacts. 2 - Calculated as net loss attributable to common shareholders divided by revenues. The following table presents the unaudited pro forma combined reconciliation of Pro Forma Adjusted EBITDA, Pro Forma Adjusted EBITDA Margin, Pro Forma Adjusted Net Income and Pro Forma Adjusted Diluted EPS to the most directly comparable pro forma measures for the Company, including CMS, for the fiscal year ended September 29, 2023: Non-operating expense, net (279 ) — — (69 ) — — (348 ) (Provision) benefit for income taxes 1 (4 ) (9 ) (142 ) 17 (2 ) — (140 ) Less: net (loss) income attributable to non-controlling interests 9 — — — (41 ) — (32 ) Net (loss) income margin 2 (1.1 )% 3.4 % Depreciation expense 45 — — — — — 45 Amortization of intangibles 592 — (592 ) — — — — Interest expense and other, net 348 — — — — — 348 Provision (benefit) for income taxes 4 9 142 (17 ) 2 — 140 EBITDA margin 6.3 % 7.4 % 1 - Calculation uses a full year estimated statutory rate on each non-GAAP tax deductible adjustment, unless the nature of the item requires application of specific tax treatment for related impacts. 2 - Calculated as net loss attributable to common shareholders divided by revenues. The following table presents the unaudited pro forma combined reconciliation of Pro Forma Adjusted EBITDA, Pro Forma Adjusted EBITDA Margin, Pro Forma Adjusted Net Income and Pro Forma Adjusted Diluted EPS to the most directly comparable pro forma measures for the Company, including CMS, for the quarter ended September 27, 2024: Non-operating expense, net (140 ) — — 42 — — (98 ) Provision for income taxes 1 (11 ) (4 ) (30 ) (10 ) — — (55 ) Less: net (loss) income attributable to non-controlling interests 2 — — — (3 ) — (1 ) Net (loss) income margin 2 (1.4 )% 3.2 % Depreciation expense 9 — — — — — 9 Amortization of intangibles 125 — (125 ) — — — — Interest expense and other, net 98 — — — — — 98 Provision for income taxes 11 4 30 10 — — 55 EBITDA margin 5.4 % 7.8 % 1 - Calculation uses a full year estimated statutory rate on each non-GAAP tax deductible adjustment, unless the nature of the item requires application of specific tax treatment for related impacts. 2 - Calculated as net loss attributable to common shareholders divided by revenues. The following table presents the unaudited pro forma combined reconciliation of Pro Forma Adjusted EBITDA, Pro Forma Adjusted EBITDA Margin, Pro Forma Adjusted Net Income and Pro Forma Adjusted Diluted EPS to the most directly comparable pro forma measures for the Company, including CMS, for the quarter ended September 29, 2023: Non-operating expense, net (91 ) — — — — (91 ) Provision for income taxes 1 (2 ) (4 ) (36 ) (1 ) — (43 ) Less: net income attributable to non-controlling interests 19 — — (28 ) — (9 ) Net (loss) income margin 2 1.1 % 4.0 % Depreciation expense 11 — — — — 11 Amortization of intangibles 148 — (148 ) — — — Interest expense and other, net 91 — — — — 91 Provision for income taxes 2 4 36 1 — 43 EBITDA margin 8.1 % 8.0 % 1 - Calculation uses a full year estimated statutory rate on each non-GAAP tax deductible adjustment, unless the nature of the item requires application of specific tax treatment for related impacts. 2 - Calculated as net loss attributable to common shareholders divided by revenues. View source version on : CONTACT: Investor Relations Contact Nathan Rutledge Contact Roela Santos KEYWORD: VIRGINIA UNITED STATES NORTH AMERICA INDUSTRY KEYWORD: ENVIRONMENT OTHER DEFENSE HOMELAND SECURITY CONSULTING OTHER ENERGY PROFESSIONAL SERVICES PUBLIC POLICY/GOVERNMENT ENERGY STATE/LOCAL DEFENSE SOURCE: Amentum Holdings, Inc. Copyright Business Wire 2024. PUB: 12/16/2024 04:30 PM/DISC: 12/16/2024 04:28 PMLegal Context and AnalysisAs Salah continues to dazzle on the pitch and lead Liverpool to success, fans and pundits alike will be eagerly watching to see what he can achieve in the coming months. With his electrifying pace, clinical finishing, and knack for creating goals out of nothing, Salah has cemented his place as one of the most exciting players in the English Premier League.

The much-anticipated film "Botticelli, Florence, and the Medici Family" is set to hit the screens on December 13th, and pre-sale tickets are now available for eager fans of art, history, and Italian culture. This captivating documentary promises to take viewers on a mesmerizing journey through the life and works of the renowned Italian painter Sandro Botticelli, the vibrant city of Florence, and the influential Medici family.

Monitoring Tools Market Future Scope, Opportunities, Business Growth, Size, Share, Segmentation, Dynamics and Forecast to 2028 12-16-2024 10:22 PM CET | Business, Economy, Finances, Banking & Insurance Press release from: ABNewswire Microsoft (US), Google (US), AWS (US), IBM (US), Cisco (US), Dynatrace (US), Splunk (US), Solarwinds (US), Netscout (US), New Relic (US), Logic Monitor (US), Paessler AG (Germany), Netreo (US), ManageEngine (US), Idera (US), Sematext (US), Datadog (US), I Monitoring Tools Market by Offering (Software (by Deployment) & Services), Type (Infrastructure Monitoring, Application Performance Monitoring, Security Monitoring and End User Experience Monitoring), Vertical and Region - Global Forecast to 2028. The Monitoring Tools market [ https://www.marketsandmarkets.com/Market-Reports/monitoring-tools-market-156908970.html?utm_campaign=monitoringtoolsmarket&utm_source=abnewswire.com&utm_medium=paidpr ] is projected to expand from USD 24.5 billion in 2023 to USD 63.7 billion by 2028, registering a CAGR of 21.1% during the forecast period. Monitoring tools, also referred to as network or performance monitoring solutions, are software systems designed to track the performance, health, and availability of various components across networks, systems, and applications. These tools gather data from multiple sources, including servers, network devices, applications, and databases, offering real-time insights and analysis to ensure seamless and efficient operations. Download PDF Brochure@ https://www.marketsandmarkets.com/pdfdownloadNew.asp?id=156908970 [ https://www.marketsandmarkets.com/pdfdownloadNew.asp?id=156908970&utm_campaign=monitoringtoolsmarket&utm_source=abnewswire.com&utm_medium=paidpr ] Healthcare & Lifesciences to account for higher CAGR during the forecast period The monitoring tools market in the Healthcare & Life Sciences vertical has witnessed significant growth and innovation in recent years. With the increasing complexity and demands of the healthcare industry, monitoring tools have become invaluable in ensuring the efficient delivery of patient care, optimizing processes, and enhancing overall operational effectiveness. Monitoring tools in this sector encompass a wide range of technologies and solutions designed to monitor various aspects of healthcare and life sciences, including patient health, medical devices, drug development, and clinical trials. In the healthcare industry, monitoring tools are used to track vital signs, such as heart rate, blood pressure, and oxygen saturation, providing healthcare professionals with real-time data for accurate diagnosis and treatment decisions. These tools enable remote monitoring, allowing patients to be monitored from their homes, reducing the need for frequent hospital visits, and improving patient convenience. These tools play a vital role in improving healthcare outcomes, enhancing patient care, and ensuring the safety and effectiveness of medical devices and treatments. As the industry continues to evolve, collaboration between healthcare providers, technology companies, and regulatory authorities will be crucial to address challenges and drive further innovation in monitoring tools for the healthcare and life sciences sector. Services Segment to account for higher CAGR during the forecast period The market for Monitoring tools is bifurcated based on offering into software and services. The CAGR of services is estimated to be highest during the forecast period. Professional and managed services have a significant impact on the monitoring tools market by offering a range of valuable services to businesses. Professional services providers assist with the implementation, configuration, and customization of monitoring tools, ensuring optimal functionality and alignment with specific business requirements. They provide consulting and advisory services, guiding organizations in selecting the right monitoring tools and developing effective monitoring strategies. These providers also offer training and educational programs, equipping businesses with the necessary knowledge and skills to utilize monitoring tools effectively. Managed services providers, on the other hand, offer ongoing monitoring and management of infrastructure and applications, relieving businesses of the burden of maintaining and optimizing their monitoring environment. They provide proactive monitoring, incident management, and performance optimization, ensuring efficient operations and minimizing downtime. These services enhance the effectiveness of monitoring solutions, allowing businesses to focus on their core activities while ensuring their monitoring needs are met by skilled providers. Asia Pacific to exhibit the highest CAGR during the forecast period The CAGR of Asia Pacific is estimated to be highest during the forecast period. Monitoring tools is rapidly growing in Asia Pacific, which includes China, India, Japan, South Korea, ASEAN, and ANZ (Australia and New Zealand). Asia Pacific is expected to be the fastest-growing market for monitoring tools. In this region, monitoring tools technologies are utilized for rural and agricultural development. The region encompasses a diverse range of countries, including but not limited to China, India, Japan, South Korea, Australia, and Southeast Asian nations. The increasing adoption of digitalization and the growing importance of data-driven decision-making across various industries, such as IT, telecommunications, healthcare, finance, and manufacturing, have been key drivers of the monitoring tools market in the region. Several factors have contributed to the rise in demand for monitoring tools in Asia Pacific. The surging number of internet users, mobile phone subscribers, and connected devices has created a vast pool of data that requires efficient monitoring and analysis. The escalating cybersecurity threats have prompted organizations to invest in advanced monitoring solutions to safeguard their networks, infrastructure, and sensitive information. The Asia Pacific region is witnessing a dynamic vendor landscape, with both local and international monitoring tool providers vying for market share. To gain a competitive edge, vendors are investing in product innovation, scalability, and ease of integration with existing systems. Request Sample Pages@ https://www.marketsandmarkets.com/requestsampleNew.asp?id=156908970 [ https://www.marketsandmarkets.com/requestsampleNew.asp?id=156908970&utm_campaign=monitoringtoolsmarket&utm_source=abnewswire.com&utm_medium=paidpr ] Unique Features in the Monitoring Tools Market Monitoring tools offer end-to-end tracking across diverse IT environments, including networks, servers, applications, and databases. This holistic approach ensures visibility into every critical component, enabling organizations to identify and address performance bottlenecks effectively. A standout feature of modern monitoring tools is their ability to provide real-time performance analytics. These tools collect and process data continuously, delivering instant insights into system health and alerting users to anomalies or potential issues before they escalate. Many monitoring tools now incorporate artificial intelligence and machine learning algorithms to predict potential failures and optimize system performance. These capabilities help organizations take proactive measures to prevent downtime and enhance operational efficiency. With businesses increasingly adopting hybrid and multi-cloud infrastructures, monitoring tools are designed to integrate seamlessly across various environments. This feature ensures unified visibility and control, regardless of where the systems or applications are hosted. Modern monitoring solutions offer highly customizable dashboards and reporting capabilities, allowing users to tailor visualizations and metrics to their specific needs. This flexibility enables IT teams to focus on the most relevant data for decision-making. Monitoring tools are built to scale alongside an organization's growth. Whether managing a small network or a global enterprise infrastructure, these solutions can adapt to increasing data volumes and complexity without compromising performance. Major Highlights of the Monitoring Tools Market As organizations shift to multi-cloud and hybrid environments, monitoring tools are becoming essential to ensure seamless integration, unified visibility, and efficient management across diverse platforms. This trend is a key driver of market growth. Businesses are prioritizing proactive system management to minimize downtime and optimize performance. Monitoring tools equipped with real-time analytics and predictive capabilities are gaining traction for their ability to identify and mitigate issues before they impact operations. The incorporation of AI and ML technologies in monitoring tools is revolutionizing the market. These features enhance anomaly detection, predict potential failures, and enable automated incident management, making systems more resilient and efficient. The growing frequency of cyber threats has expanded the scope of monitoring tools to include security features. Organizations are increasingly leveraging these tools to detect vulnerabilities, monitor suspicious activities, and ensure compliance with regulations. Monitoring tools are witnessing widespread adoption in industries such as IT, healthcare, BFSI, and manufacturing. These sectors rely on these solutions to ensure the reliability and performance of critical systems, applications, and networks. The market's tools are designed to scale with organizational needs, accommodating everything from small networks to large, global infrastructures. This scalability is a significant factor driving their adoption in enterprises of all sizes. Inquire Before Buying@ https://www.marketsandmarkets.com/Enquiry_Before_BuyingNew.asp?id=156908970 [ https://www.marketsandmarkets.com/Enquiry_Before_BuyingNew.asp?id=156908970&utm_campaign=monitoringtoolsmarket&utm_source=abnewswire.com&utm_medium=paidpr ] Top Companies in the Monitoring Tools Market Major vendors in the global Monitoring tools market are Microsoft (US), Google (US), AWS (US), IBM (US), Cisco (US), Dynatrace (US), Splunk (US), Solarwinds (US), Netscout (US), New Relic (US), Logic Monitor (US), Paessler AG (Germany), Netreo (US), ManageEngine (US), Idera (US), Sematext (US), Datadog (US), Icinga (Germany), Nagios (US), Zabbix (Latvia), Sentry (US), UptimeRobot (Malta), Atera (Israel), Better Stack (Czech Republic), Sumo Logic (US), Checkmk (Germany), Exporise (US), ITRS (UK), Riverbed Technology (US), Nlyte Software (US). Microsoft (US) Microsoft Corporation is a multinational technology firm that provides consumers and organizations all over the world with a vast array of software, hardware, and services. Productivity and Business Processes, Intelligent Cloud, and More Personal Computing are the three primary business segments through which the corporation conducts its operations. Microsoft operates in over 190 countries worldwide, with its headquarters located in Redmond, Washington. Microsoft is a leading player in the Monitoring Tools market, offering a diverse range of solutions to cater to the evolving needs of businesses. One of Microsoft's flagship offerings in this space is Azure Monitor. Azure Monitor is a cloud-native monitoring and observability solution specifically designed for Azure resources and applications. Additionally, Microsoft offers System Center Operations Manager (SCOM), another prominent monitoring tool. SCOM provides businesses with a holistic view of their on-premises and hybrid cloud infrastructure. Microsoft's presence in the Monitoring Tools market extends beyond these specific offerings, as the company continues to invest in research and development to deliver innovative solutions. With a strong focus on cloud-native technologies and a commitment to meeting customer needs, Microsoft remains a trusted partner for businesses seeking robust monitoring tools to enhance their operational efficiency, reduce downtime, and deliver exceptional user experiences. Cisco (US) Cisco was founded in 1984 in San Francisco, US, by a small group of computer scientists from Stanford University. Cisco provides a wide range of service offerings, including technical support and advanced services. The company provides its technical products in routing and switching, home networking, IP telephony, optical networking, security, storage area networking, and wireless technology. The company caters to industries, such as cities and communities, education, financial services, government, healthcare, manufacturing, mining, oil and gas, retail, sports and entertainment, transportation, and utilities. The company operates in 115+ countries and has global reach in the Americas, Europe, Middle East & Africa, and Asia Pacific. Cisco's flagship monitoring tool, Cisco DNA Center, offers businesses a centralized platform for managing and monitoring their network infrastructure. With its intuitive interface and advanced analytics capabilities, Cisco DNA Center enables organizations to monitor network performance, track devices, detect anomalies, and troubleshoot issues efficiently. In addition to network monitoring, Cisco provides robust security monitoring solutions to protect against evolving threats. Cisco SecureX integrates with Cisco's security products, enabling businesses to consolidate security alerts, monitor security events, and respond to incidents effectively. Furthermore, Cisco offers network monitoring solutions for specific industries and use cases. Such as Cisco Meraki provides cloud-managed monitoring tools for networking and security in retail, healthcare, education, and other sectors. Media Contact Company Name: MarketsandMarkets Trademark Research Private Ltd. Contact Person: Mr. Rohan Salgarkar Email:Send Email [ https://www.abnewswire.com/email_contact_us.php?pr=monitoring-tools-market-future-scope-opportunities-business-growth-size-share-segmentation-dynamics-and-forecast-to-2028 ] Phone: 18886006441 Address:1615 South Congress Ave. Suite 103, Delray Beach, FL 33445 City: Florida State: Florida Country: United States Website: https://www.marketsandmarkets.com/Market-Reports/monitoring-tools-market-156908970.html This release was published on openPR.Former Police Commissioner Andrew Coster is the new Social Investment Secretary. He’ll oversee a multimillion-dollar fund advising the Government on commissioning services for vulnerable people. Coster sees his role as building a fence at the top of the cliff, describing a lot of policing as the “ambulance at the bottom of the cliff of social failure”. As a new era in policing unfolds under the watchful eye of a new commissioner , the country’s former top cop is relishing a chance to try to stop people ever embarking on a life of crime . Former Police Commissioner Andrew Coster has officially hung up his uniform, stepping into his new role as Social Investment Agency chief executive. He sees the role as much more than a so-called ambulance at the top of the cliff. “I don’t think it’s the ambulance, I think it’s the fence. Police spends a lot of its time at the bottom of the cliff of social failure. Social investment is about trying to get the settings right in order to avoid the need for that,” Coster said.

Pep Guardiola hits out at Gary Neville and Gary Lineker with Man City boss 'desperate'NEW YORK (AP) — U.S. stocks tiptoed to more records amid a mixed Tuesday of trading, tacking a touch more onto what’s already been a stellar year so far. The S&P 500 edged up by 2 points, or less than 0.1%, to set an all-time high for the 55th time this year. It’s climbed in 10 of the last 11 days and is on track for one of its best years since the turn of the millennium. The Dow Jones Industrial Average slipped 76 points, or 0.2%, while the Nasdaq composite added 0.4% to its own record set a day earlier. AT&T rose 4.6% after it boosted its profit forecast for the year. It also announced a $10 billion plan to send cash to its investors by buying back its own stock, while saying it expects to authorize another $10 billion of repurchases in 2027. On the losing end of Wall Street was U.S. Steel, which fell 8%. President-elect Donald Trump reiterated on social media that he would not let Japan’s Nippon Steel take over the iconic Pennsylvania steelmaker. Nippon Steel announced plans last December to buy the Pittsburgh-based steel producer for $14.1 billion in cash, raising concerns about what the transaction could mean for unionized workers, supply chains and U.S. national security. Earlier this year, President Joe Biden also came out against the acquisition. Tesla sank 1.6% after a judge in Delaware reaffirmed a previous ruling that the electric car maker must revoke Elon Musk’s multibillion-dollar pay package. The judge denied a request by attorneys for Musk and Tesla’s corporate directors to vacate her ruling earlier this year requiring the company to rescind the unprecedented pay package. All told, the S&P 500 rose 2.73 points to 6,049.88. The Dow fell 76.47 to 44,705.53, and the Nasdaq composite gained 76.96 to 19,480.91. In the bond market, Treasury yields held relatively steady after a report showed U.S. employers were advertising slightly more job openings at the end of October than a month earlier. Continued strength there would raise optimism that the economy could remain out of a recession that many investors had earlier worried was inevitable. The yield on the 10-year Treasury rose to 4.23% from 4.20% from late Monday. Yields have seesawed since Election Day amid worries that Trump’s preferences for lower tax rates and bigger tariffs could spur higher inflation along with economic growth. But traders are still confident the Federal Reserve will cut its main interest rate again at its next meeting in two weeks. They’re betting on a nearly three-in-four chance of that, according to data from CME Group. Lower rates can give the economy more juice, but they can also give inflation more fuel. The key report this week that could guide the Fed’s next move will arrive on Friday. It’s the monthly jobs report , which will show how many workers U.S. employers hired and fired during November. It could be difficult to parse given how much storms and strikes distorted figures in October. Based on trading in the options market, Friday’s jobs report appears to be the biggest potential market mover until the Fed announces its next decision on interest rates Dec. 18, according to strategists at Barclays Capital. In financial markets abroad, the value of South Korea’s currency fell 1.1% against the U.S. dollar following a frenetic night where President Yoon Suk Yeol declared martial law and then later said he’d lift it after lawmakers voted to reject military rule. Stocks of Korean companies that trade in the United States also fell, including a 1.6% drop for SK Telecom. Japan’s Nikkei 225 jumped 1.9% to help lead global markets. Some analysts think Japanese stocks could end up benefiting from Trump’s threats to raise tariffs , including for goods coming from China . Trade relations between the U.S. and China took another step backward after China said it is banning exports to the U.S. of gallium, germanium, antimony and other key high-tech materials with potential military applications. The counterpunch came swiftly after the U.S. Commerce Department expanded the list of Chinese technology companies subject to export controls to include many that make equipment used to make computer chips, chipmaking tools and software. The 140 companies newly included in the so-called “entity list” are nearly all based in China. In China, stock indexes rose 1% in Hong Kong and 0.4% in Shanghai amid unconfirmed reports that Chinese leaders would meet next week to discuss planning for the coming year. Investors are hoping it may bring fresh stimulus to help spur growth in the world’s second-largest economy. In France, the CAC 40 rose 0.3% amid continued worries about politics in Paris , where the government is battling over the budget. AP Business Writers Yuri Kageyama and Matt Ott contributed.Mateychuk turning heads in leadup to WHL Prospects Draft

On Football analyzes the biggest topics in the NFL from week to week. For more On Football analysis, head here . Getting benched may have been the best thing that happened to Bryce Young and Anthony Richardson. Both second-year quarterbacks are playing well since returning to the starting lineup. Young has steadily improved after coming back in Week 8. He’s displayed the skills that earned him a Heisman Trophy at Alabama and convinced the Carolina Panthers to draft him ahead of C.J. Stroud with the No. 1 overall pick in 2023. Young had his best game on Sunday, nearly leading Carolina to an overtime win over Tampa Bay if it weren’t for Chuba Hubbard’s fumble in field-goal range. He threw for 298 yards and a go-ahead touchdown pass in the final minute of a 26-23 loss . Young almost led the Panthers to a win over the two-time defending Super Bowl champion Chiefs a week earlier only to see Patrick Mahomes drive Kansas City into position for a winning field goal as time expired. Rookie coach Dave Canales benched Young for veteran Andy Dalton after just two games in which he had a 44.1 passer rating. The 23-year-old has completed 60.4% of his passes for 1,062 yards, six TDs and three interceptions — none in the past three games — while going 2-3 in the five starts since Young got another opportunity to lead the Panthers (3-9). Richardson has led Indianapolis to a pair of comeback wins late in the fourth quarter in three starts after he regained his starting job. The Colts (6-7) selected Richardson No. 4 last year and he started just 10 games before coach Shane Steichen benched him for Joe Flacco in Week 9. Richardson completed only 44.4% of his passes with four TDs and seven picks in his first six starts. He’s improved to 52.4% with three TDs and two picks since coming back. The 22-year-old tossed a 3-yard TD pass to Alec Pierce on fourth-and-goal with 12 seconds remaining and then ran in for a 2-point conversion to lift the Colts to a 25-24 win over New England on Sunday. Young and Richardson both have a long way to go to prove they can be franchise quarterbacks. But there’s far more optimism now that they’re not busts. Young is on his third head coach and second offensive coordinator in two seasons. Canales is known for getting the best out of quarterbacks, helping Geno Smith and Baker Mayfield revive their careers. He made a bold decision to bench Young after just two games but that allowed him to watch, grow and learn without the pressure of having to perform. Now it appears Young might have a future in Carolina when that seemed unlikely in September. Richardson just needs more experience. He threw only 393 passes in college and started four games as a rookie before he was injured. Steichen’s decision to bench him for Flacco didn’t work out. Flacco, who was the AP NFL Comeback Player of the Year last year after leading Cleveland to the playoffs by going 4-1 in five starts, struggled in two games. Still, that gave Richardson a chance to reset after tapping out for a play in the game before he was benched. Quarterbacks need time to develop. They can’t be judged fairly after one or two seasons, especially when they were high draft picks who joined bad teams that lacked talent. Matt Eberflus lost his job as Chicago’s head coach a day after he watched the offense run out of time with a timeout in hand, missing an opportunity to push Detroit to overtime on Thanksgiving. But Antonio Pierce made an even worse decision on Black Friday that cost the Raiders a chance to beat the Chiefs. Aidan O’Donnell drove Las Vegas to the Chiefs 32 with 15 seconds left. Instead of trying for a game-winning field goal down 19-17, Pierce wanted O’Donnell to take the snap, allow more time to tick and throw the ball away. But O’Donnell wasn’t ready for the snap, the Chiefs recovered the fumble and escaped with the win. aManaging the clock shouldn’t be this difficult for NFL head coaches. Ravens kicker Justin Tucker is having the worst season of his 13-year career. If he wasn’t one of the best kickers in NFL history, Baltimore would’ve made a switch already. But coach John Harbaugh has too much respect for Tucker, who began the season as the most accurate kicker in league history. Tucker has missed a career-high eight field-goal attempts, including two in a 24-19 loss to Philadelphia. Harbaugh, a former special teams coach, isn’t planning to replace Tucker. But the Ravens (8-5) have Super Bowl aspirations and Tucker needs to straighten things out. One solution would be to place him on injured reserve to work on his technique. In this case, Tucker has earned the right not to be released. Plus, he’s signed through 2027. AP NFL: https://apnews.com/hub/nflUS News Live: Get the latest updates and breaking news from the US on elections, politics, crime, trends, weather along with national affairs. Stay up to date with news developments on Joe Biden, Kamala Harris, and Donald Trump. all right here This is an AI-generated live blog and has not been edited by Hindustan Times staff. ...Read More US News Live: Hunger, nausea, exhaustion: Man replicates Donald Trump's diet for a week, wonders how president-elect ‘is still alive’

With his background in economic development and policy formulation, Gan is well-equipped to address the challenges facing Shanxi Province. As an official in the central government, Gan has gained valuable insights into national policies and strategies, which will undoubtedly benefit Shanxi Province in its efforts to promote economic growth and social stability.

Title: Time to Open the Windows and Make a Change!

With such a stellar lineup of talent, the competition for Best Actress at this year's Golden Globe Awards is sure to be intense. Each nominee brings something unique and special to their roles, making it impossible to predict who will come out on top.MINNEAPOLIS--(BUSINESS WIRE)--Dez 16, 2024-- HistoSonics , Entwickler und Hersteller des Edison® Histotripsy Systems, gab heute bekannt, dass die ersten Patienten mit Pankreastumoren erfolgreich in der von dem Unternehmen gesponserten GANNON-Studie behandelt wurden. Die Machbarkeitsstudie soll die Sicherheit der Histotripsie, einer neuartigen nicht-invasiven Technologie, die gezielt Tumorgewebe mit fokussiertem Ultraschall zerstört, bei bis zu 30 Patienten mit inoperablen Pankreas-Adenokarzinom-Tumoren untersuchen, bei denen eine inoperable lokal fortgeschrittene Erkrankung (Stadium 3) diagnostiziert wurde oder bei denen sich eine geringe Anzahl von Tumoren auf andere Körperteile ausgebreitet hat (Stadium 4). Diese Pressemitteilung enthält multimediale Inhalte. Die vollständige Mitteilung hier ansehen: https://www.businesswire.com/news/home/20241216108664/de/ Die GANNON-Studie wird am Sant Pau Hospital in Barcelona, Spanien, unter der Leitung von Dr. Santiago Sánchez Cabús, klinischer Leiter der Hepatopankreatobiliären Chirurgie am Hospital de Sant Pau und Professor für Chirurgie an der Autonomen Universität Barcelona, durchgeführt. Bauchspeicheldrüsentumore gehören zu den am schwierigsten zu behandelnden Tumoren. Jedes Jahr sind weltweit über 510.000 Menschen davon betroffen, und allein in den USA werden im Jahr 2024 schätzungsweise 66.440 Patienten diagnostiziert1,2. Mit der höchsten Sterblichkeitsrate aller wichtigen Tumorarten sind Tumore der Bauchspeicheldrüse derzeit die dritthäufigste Ursache für tumorbedingte Todesfälle in den Vereinigten Staaten, nach Lungen- und Darmkrebs, und es wird erwartet, dass sie bis 2030 zur zweithäufigsten Ursache werden2. Angesichts einer relativen Fünf-Jahres-Überlebensrate von 13 % über alle Stadien des Krankheitsverlaufs hinweg und begrenzter chirurgischer Möglichkeiten für die meisten Patienten sind neue Behandlungsmethoden wie die Histotripsie dringend erforderlich. Weniger als 20 % der Patienten, die an einem Pankreastumor leiden, kommen aufgrund des Fortschreitens der Krankheit zum Zeitpunkt der Diagnose für eine Operation in Frage. Pankreastumore sind oft von dichtem, undurchdringlichem fibrotischem Gewebe umgeben, das die Wirksamkeit systemischer oder pharmakologischer Therapien einschränkt, da es nicht in der Lage ist, die Tumorzellen effektiv zu erreichen und anzugreifen.2,3 „Die Histotripsie hat das Potenzial, die Behandlung von Patienten mit Bauchspeicheldrüsentumoren zu revolutionieren, die bisher mit herkömmlichen Ansätzen als unbehandelbar galten. Ihr neuartiger Wirkmechanismus zielt sowohl auf den Tumor als auch auf das umgebende fibrotische Gewebe ab und bietet neue Hoffnung für Patienten mit fortgeschrittener Erkrankung, die die Mehrheit der Fälle ausmachen“, so Dr. Joan Vidal-Jove, medizinische Direktorin von HistoSonics. „Die meisten Patienten mit Bauchspeicheldrüsentumoren haben nur begrenzte Behandlungsmöglichkeiten und kommen aufgrund des fortgeschrittenen Krankheitsstadiums nicht für eine Operation in Frage“, so Mike Blue, CEO und Präsident von HistoSonics. „Wir glauben, dass die Histotripsie eine nicht-invasive Option zur Behandlung von Tumoren bietet, die bisher als unheilbar galten", so Mike Blue, CEO und Präsident von HistoSonics. „Unser Ziel ist es, das Potenzial der Histotripsie bei verschiedenen Tumorarten zu erweitern und die Ergebnisse für Patienten und Familien erheblich zu verbessern. Unsere ersten Forschungsergebnisse aus der GANNON-Studie werden uns und unsere Partnerärzte dabei helfen, die Histotripsie zu optimieren, um das Leben der Patienten erheblich zu verbessern.“ Die Verwendung des Edison-Systems bei Bauchspeicheldrüsenanwendungen ist auf Forschungszwecke beschränkt. Über das Edison® System Das Edison System ist für die nicht-invasive mechanische Zerstörung von Lebertumoren vorgesehen, einschließlich der teilweisen oder vollständigen Zerstörung von inoperablen Lebertumoren durch Histotripsie. Die FDA hat das Edison-System nicht für die Behandlung von Krankheiten, einschließlich, aber nicht beschränkt auf Krebs, oder für spezifische Krebsergebnisse (wie lokale Tumorprogression, 5-Jahres-Überlebensrate oder Gesamtüberlebensrate) bewertet. Das System sollte nur von Ärzten verwendet werden, die eine von HistoSonics durchgeführte Schulung absolviert haben, und seine Verwendung sollte sich nach dem klinischen Urteil eines entsprechend ausgebildeten Arztes richten. Eine vollständige Liste der Warnhinweise und Vorsichtsmaßnahmen sowie eine Zusammenfassung der Ergebnisse klinischer Studien, einschließlich der gemeldeten unerwünschten Ereignisse, finden Sie in der Gebrauchsanweisung des Geräts. Über HistoSonics HistoSonics ist ein in Privatbesitz befindliches Medizintechnikunternehmen, das eine nicht-invasive Plattform und eine proprietäre Schallstrahltherapie auf Basis der wissenschaftlichen Erkenntnisse der Histotripsie entwickelt. Es handelt sich dabei um einen neuartigen Wirkmechanismus, bei dem fokussierter Ultraschall eingesetzt wird, um unerwünschtes Gewebe und Tumore mechanisch zu zerstören und zu verflüssigen. Derzeit konzentriert sich das Unternehmen auf die Kommerzialisierung seines Edison-Systems in den USA und ausgewählten globalen Märkten für die Behandlung der Leber, während gleichzeitig die Anwendung der Histotripsie auf andere Organe wie Niere, Bauchspeicheldrüse und weitere Organe erweitert wird. HistoSonics unterhält Niederlassungen in Ann Arbor, Michigan und Minneapolis, Minnesota. Weitere Informationen zur GANNON-Studie finden Sie unter NCT06282809 unter GANNON Trial Information auf ClinicalTrials.gov . Informationen zum Edison Histotripsy System finden Sie unter: www.histosonics.com/ . Patientenbezogene Informationen finden Sie unter: www.myhistotripsy.com/ . 1Globocan 2022: https://gco.iarc.fr/today/en/fact-sheets-cancers 2Quelle für Statistiken: American Cancer Society: Cancer Facts & Figures 2024 and Pancreatic Treatment Options 3Norton J, Foster D, Chinta M, Titan A, Longaker M. Pancreatic Cancer Associated Fibroblasts (CAF): Under-Explored Target for Pancreatic Cancer Treatment. Cancers. 2020; 12(5):1347. Die Ausgangssprache, in der der Originaltext veröffentlicht wird, ist die offizielle und autorisierte Version. Übersetzungen werden zur besseren Verständigung mitgeliefert. Nur die Sprachversion, die im Original veröffentlicht wurde, ist rechtsgültig. Gleichen Sie deshalb Übersetzungen mit der originalen Sprachversion der Veröffentlichung ab. Originalversion auf businesswire.com ansehen: https://www.businesswire.com/news/home/20241216108664/de/ CONTACT: Josh King Vice President of Global Market Access Joshua.king@histosonics.com 608-332-8124Kimberly Ha KKH Advisors kimberly.ha@kkhadvisors.com 917-291-5744 KEYWORD: MINNESOTA SPAIN NORTH AMERICA UNITED STATES ASIA PACIFIC EUROPE INDUSTRY KEYWORD: MEDICAL DEVICES HOSPITALS CLINICAL TRIALS HEALTH TECHNOLOGY BIOTECHNOLOGY OTHER HEALTH RADIOLOGY HEALTH ONCOLOGY SOURCE: HistoSonics Copyright Business Wire 2024. PUB: 12/16/2024 06:34 PM/DISC: 12/16/2024 06:35 PM http://www.businesswire.com/news/home/20241216108664/deAccording to the school's official statement, the filling material in the winter uniforms is a blend of cotton and synthetic fibers, designed to provide insulation and comfort during the cold winter months. The school has emphasized that all materials used in the uniforms undergo thorough quality checks and are sourced from reliable suppliers.

One of the key highlights of the trailer is the introduction of new characters and storylines that will expand upon the lore of Middle-earth and add depth to the familiar narrative of "The Lord of the Rings." Audiences can look forward to exploring the history of Rohan, the significance of the legendary fortress of Helm's Deep, and the bravery and sacrifice of the Rohirrim in the face of overwhelming odds.

In conclusion, Sun Yingsha's continued dominance in women's table tennis is a testament to her exceptional talent, determination, and hard work. Her consistent performances and unwavering commitment to excellence have earned her the top spot in the rankings for the 50th consecutive week, setting her apart as a true champion of the sport. As she continues to inspire fans and competitors alike, Sun Yingsha's legacy in table tennis will undoubtedly endure for years to come.This Turks and Caicos Villa Has Hosted Rock ‘n’ Roll Royalty. Now It Can Be Yours for $39 Million.

LOS ANGELES (AP) — Receiver Demarcus Robinson will not be suspended by the Los Angeles Rams this week after his arrest on suspicion of driving under the influence. Robinson will be available to play when the Rams (5-6) visit the New Orleans Saints on Sunday, Rams coach Sean McVay said Wednesday. “I think he does understand the severity of this, and how lucky we were that nobody was injured,” McVay said. “I do believe that he's remorseful. We are going to let the legal process take place. The league has a process as well.” Robinson was arrested early Monday morning after California Highway Patrol officers observed a white Dodge sedan driving over 100 mph on the 101 freeway in the western San Fernando Valley, a few miles from the Rams’ training complex in Woodland Hills. The driver, who identified himself as Robinson, had “objective signs and symptoms of alcohol impairment,” the CHP said in a statement released to The Associated Press. Robinson spoke to the team and expressed remorse about his arrest, McVay and quarterback Matthew Stafford said. “I think it was a bad decision he made,” McVay said. “I don't think that makes him a bad person, and I do believe this is something that, with the words that he said, our guys will learn from it, and hopefully nobody is ever going to repeat something like this. Let it be a learning opportunity, and a fortunate outcome that nobody was injured.” Robinson has 26 receptions for 384 yards and a team-leading six touchdown catches while starting all 11 games in his second season with the Rams . He caught a TD pass in the Rams' 37-20 loss to Philadelphia several hours before his arrest. The nine-year NFL veteran has served as a capable No. 3 option for Stafford behind star receivers Cooper Kupp and Puka Nacua. Robinson spent his first six NFL seasons with the Kansas City Chiefs, winning a Super Bowl ring in February 2020, and spent one year with Baltimore before joining the Rams last year. “Let this be a lesson to all of us,” Stafford said. “We're lucky with the result that came of it, to be honest with you, that nobody was hurt or injured. I know that D-Rob is a great person. I love being around him. Love him as a teammate. ... I'm just trying to support him, help him out any way I can.” AP NFL: https://apnews.com/NFL