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90 jili slot login By MICHELLE L. PRICE WEST PALM BEACH, Fla. (AP) — An online spat between factions of Donald Trump’s supporters over immigration and the tech industry has thrown internal divisions in his political movement into public display, previewing the fissures and contradictory views his coalition could bring to the White House. The rift laid bare the tensions between the newest flank of Trump’s movement — wealthy members of the tech world including billionaire Elon Musk and fellow entrepreneur Vivek Ramaswamy and their call for more highly skilled workers in their industry — and people in Trump’s Make America Great Again base who championed his hardline immigration policies. The debate touched off this week when Laura Loomer , a right-wing provocateur with a history of racist and conspiratorial comments, criticized Trump’s selection of Sriram Krishnan as an adviser on artificial intelligence policy in his coming administration. Krishnan favors the ability to bring more skilled immigrants into the U.S. Loomer declared the stance to be “not America First policy” and said the tech executives who have aligned themselves with Trump were doing so to enrich themselves. Much of the debate played out on the social media network X, which Musk owns. Loomer’s comments sparked a back-and-forth with venture capitalist and former PayPal executive David Sacks , whom Trump has tapped to be the “White House A.I. & Crypto Czar.” Musk and Ramaswamy, whom Trump has tasked with finding ways to cut the federal government , weighed in, defending the tech industry’s need to bring in foreign workers. It bloomed into a larger debate with more figures from the hard-right weighing in about the need to hire U.S. workers, whether values in American culture can produce the best engineers, free speech on the internet, the newfound influence tech figures have in Trump’s world and what his political movement stands for. Trump has not yet weighed in on the rift, and his presidential transition team did not respond to a message seeking comment. Musk, the world’s richest man who has grown remarkably close to the president-elect , was a central figure in the debate, not only for his stature in Trump’s movement but his stance on the tech industry’s hiring of foreign workers. Technology companies say H-1B visas for skilled workers, used by software engineers and others in the tech industry, are critical for hard-to-fill positions. But critics have said they undercut U.S. citizens who could take those jobs. Some on the right have called for the program to be eliminated, not expanded. Born in South Africa, Musk was once on an a H-1B visa himself and defended the industry’s need to bring in foreign workers. “There is a permanent shortage of excellent engineering talent,” he said in a post. “It is the fundamental limiting factor in Silicon Valley.” Related Articles National Politics | Should the U.S. increase immigration levels for highly skilled workers? National Politics | Trump threat to immigrant health care tempered by economic hopes National Politics | In states that ban abortion, social safety net programs often fail families National Politics | Court rules Georgia lawmakers can subpoena Fani Willis for information related to her Trump case National Politics | New 2025 laws hit hot topics from AI in movies to rapid-fire guns Trump’s own positions over the years have reflected the divide in his movement. His tough immigration policies, including his pledge for a mass deportation, were central to his winning presidential campaign. He has focused on immigrants who come into the U.S. illegally but he has also sought curbs on legal immigration , including family-based visas. As a presidential candidate in 2016, Trump called the H-1B visa program “very bad” and “unfair” for U.S. workers. After he became president, Trump in 2017 issued a “Buy American and Hire American” executive order , which directed Cabinet members to suggest changes to ensure H-1B visas were awarded to the highest-paid or most-skilled applicants to protect American workers. Trump’s businesses, however, have hired foreign workers, including waiters and cooks at his Mar-a-Lago club , and his social media company behind his Truth Social app has used the the H-1B program for highly skilled workers. During his 2024 campaign for president, as he made immigration his signature issue, Trump said immigrants in the country illegally are “poisoning the blood of our country” and promised to carry out the largest deportation operation in U.S. history. But in a sharp departure from his usual alarmist message around immigration generally, Trump told a podcast this year that he wants to give automatic green cards to foreign students who graduate from U.S. colleges. “I think you should get automatically, as part of your diploma, a green card to be able to stay in this country,” he told the “All-In” podcast with people from the venture capital and technology world. Those comments came on the cusp of Trump’s budding alliance with tech industry figures, but he did not make the idea a regular part of his campaign message or detail any plans to pursue such changes.WASHINGTON (AP) — El presidente Joe Biden dijo el domingo que el repentino colapso del gobierno de Bashar Assad en Siria es un “acto fundamental de justicia” después de décadas de represión, pero también “un momento de riesgo e incertidumbre” para Medio Oriente. Biden habló en la Casa Blanca horas después de que grupos rebeldes completaran la toma del país tras más de una docena de años de guerra civil y décadas de liderazgo por parte de Assad y su familia. Biden dijo que Estados Unidos no estaba seguro del paradero de Assad, pero estaba monitoreando informes de que buscaba refugio en Moscú. La administración saliente de Biden y el presidente electo Donald Trump estaban trabajando para comprender las nuevas amenazas y oportunidades en todo Medio Oriente. Biden atribuyó lo ocurrido a la acción de Estados Unidos y sus aliados por debilitar a los partidarios de Siria —Rusia, Irán y Hezbollah. Dijo que los partidarios de Siria “por primera vez” ya no podían defender el control de Assad sobre el poder. “Nuestro enfoque ha cambiado el equilibrio de poder en Medio Oriente”, dijo Biden, después de una reunión con su equipo de seguridad nacional en la Casa Blanca. RELATED COVERAGE Análisis: La caída de Assad en Siria, un golpe para el ‘Eje de Resistencia’ de Irán Al menos 14 muertos, incluidos niños, en ataques en Gaza Reacciones globales a la repentina destitución de Assad en Siria varían entre júbilo y alarma Trump dijo el domingo que Assad había huido de su país porque el presidente ruso Vladímir Putin “ya no estaba interesado en protegerlo”. Esos comentarios en la plataforma de redes sociales de Trump llegaron un día después de que usara otra publicación para deplorar la posibilidad de que Estados Unidos interviniera militarmente en Siria para ayudar a los rebeldes, declarando, “ESTA NO ES NUESTRA LUCHA”. La administración de Biden no tiene intención de intervenir, según el actual asesor de seguridad nacional. Estados Unidos tiene alrededor de 900 efectivos en Siria, incluidas fuerzas que trabajan con aliados kurdos en el noreste controlado por la oposición para prevenir cualquier resurgimiento del grupo Estado Islámico. Biden dijo que tiene la intención de que esas tropas permanecieran, agregando que las fuerzas estadounidenses realizaron el domingo “docenas” de lo que él llamó “ataques aéreos de precisión” en campamentos y operaciones del Estado Islámico en Siria. La oposición siria que derrocó a Assad está liderada por Hayat Tahrir al-Sham. La administración Biden ha designado al grupo como una organización terrorista y dice que tiene vínculos con al-Qaeda, aunque Hayat Tahrir al-Sham dice que desde entonces ha roto lazos con al-Qaeda. “Permaneceremos vigilantes”, dijo Biden. “No se equivoquen, algunos de los grupos rebeldes que derrocaron a Assad tienen su propio sombrío historial de terrorismo y abusos de derechos humanos”. Añadió que los grupos están “diciendo las cosas correctas ahora”. “Pero a medida que asumen mayor responsabilidad, evaluaremos no solo sus palabras, sino sus acciones”, dijo Biden. La caída de Assad se suma a una situación ya tensa en gran parte de la región en muchos frentes, incluida la guerra de Israel con Hamás en Gaza y su frágil alto el fuego con Hezbollah en Líbano. Trump, quien asume el cargo el 20 de enero de 2025, hizo una conexión entre lo ocurrido en Siria y la guerra de Rusia en Ucrania, señalando que Rusia e Irán “están en un estado debilitado en este momento”. El vicepresidente electo JD Vance, un veterano de la guerra de Irak, escribió en sus propias redes sociales el domingo para expresar escepticismo sobre los insurgentes. “Muchos de ‘los rebeldes’ son literalmente una ramificación de ISIS. Uno puede esperar que se hayan moderado. El tiempo lo dirá”, dijo, usando otro acrónimo para el grupo. Trump ha sugerido que la destitución de Assad puede avanzar las perspectivas para poner fin a los combates en Ucrania, que fue invadida por Rusia en febrero de 2022. Trump escribió que el gobierno de Putin “perdió todo interés en Siria debido a Ucrania” y el republicano pidió un alto el fuego inmediato, un día después de reunirse en París con los líderes franceses y ucranianos. Daniel B. Shapiro, un subsecretario asistente de defensa para el Medio Oriente, dijo que la presencia militar estadounidense continuará en el este de Siria pero fue “únicamente para asegurar la derrota duradera del EI y no tiene nada que ver con otros aspectos de este conflicto”. “Hacemos un llamado a todas las partes en Siria para que protejan a los civiles, particularmente a aquellos de las comunidades minoritarias de Siria, para que respeten las normas militares internacionales y trabajen para lograr una resolución que incluya el acuerdo político”, dijo Shapiro. “Varios actores en este conflicto tienen un terrible historial que incluye los horribles crímenes de Assad, el bombardeo aéreo indiscriminado de Rusia, la participación de milicias respaldadas por Irán y las atrocidades del EI”, agregó. Shapiro, sin embargo, fue cuidadoso en no decir directamente que Assad había sido depuesto por los insurgentes. “Si se confirma, nadie debería derramar lágrimas por el régimen de Assad”, dijo. A medida que avanzaban hacia la capital siria de Damasco, la oposición liberó a detenidos políticos de las prisiones gubernamentales. La familia del periodista estadounidense desaparecido Austin Tice renovó los llamados para encontrarlo. “A todos en Siria que escuchen esto, por favor recuerden a la gente que estamos esperando a Austin”, dijo la madre de Tice, Debra, en comentarios que los grupos de defensa de rehenes difundieron en redes sociales. “Sabemos que cuando salga, va a estar bastante aturdido y va a necesitar mucho cuidado y dirección. ¡Diríjanlo a su familia, por favor!” Tice desapareció en 2012 fuera de Damasco, en medio de la intensificación de lo que se convirtió en una guerra civil de más de una década. “Hemos permanecido comprometidos en devolverlo a su familia”, dijo Biden en la Casa Blanca. “Creemos que está vivo, pensamos que podemos recuperarlo, pero aún no tenemos pruebas directas de eso. Y Assad debe ser responsabilizado”. El presidente agregó: “Tenemos que identificar dónde está”. ___ Esta historia fue traducida del inglés por un editor de AP con la ayuda de una herramienta de inteligencia artificial generativa.

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BISMARCK, N.D. (AP) — North Dakota regulators approved permits Thursday for underground storage of carbon dioxide delivered through a sprawling pipeline proposed for the Midwest, marking another victory for the project that has drawn fierce opposition from landowners. The state’s governor-led, three-member Industrial Commission voted unanimously to approve the permits for Summit Carbon Solutions’ three proposed storage sites in central North Dakota. It’s unclear when construction of the storage sites would begin but it’s expected that resistant landowners in that area will file lawsuits seeking to block the storage plans. Summit’s proposed 2,500-mile (4,023-kilometer), $8 billion pipeline would transport planet-warming CO2 emissions from 57 ethanol plants in North Dakota, South Dakota, Iowa, Minnesota and Nebraska for underground storage in central North Dakota. The company has permits for its route in Iowa and North Dakota but can’t yet begin construction. Also on Thursday, Minnesota utility regulators approved a permit for a 28-mile (45-kilometer) leg of the project in western Minnesota. Summit also recently applied in South Dakota, where regulators denied the company’s previous application last year. Summit still faces several lawsuits related to the project, including a state Supreme Court appeal in North Dakota over a property rights law related to the underground storage plan. Approval from the governor-led, three-member Industrial Commission is another victory for Summit Carbon Solutions' controversial project, though further court challenges are likely. Last month, the company gained approval for its North Dakota route , and Iowa regulators also have given conditional approval. North Dakota Republican Gov. Doug Burgum chairs the Industrial Commission, which includes the state attorney general and agriculture commissioner and oversees a variety of energy topics and state-owned enterprises. Burgum is President-elect Donald Trump's choice for Interior Secretary and to lead a new National Energy Council. Burgum supports Summit's project and has frequently touted North Dakota's underground carbon dioxide storage as a “geologic jackpot.” In 2021, he set a goal for the No. 3 oil-producing state to be carbon-neutral by 2030. His term ends Saturday. Summit applied for permits for three storage facilities, which would hold a combined, estimated maximum of 352 million metric tons of CO2 over 20 years. The pipeline would carry up to 18 million metric tons of CO2 per year to be injected about 1 mile (1.6 kilometers) underground, according to an application fact sheet. Summit's documents detail a well site layout encompassing a pump/meter building, gas detection stations, inlet valves and emergency shutoff valve. Carbon dioxide would move through the pipeline in a pressurized form to be injected deep underground into a rock formation. Jessie Stolark, who leads a group that includes Summit and supports the project, said the oil industry has long used similar technology. “We know that this can be done safely in a manner that is protective of human health and underground sources of drinking water,” said Stolark, executive director of the Carbon Capture Coalition. Summit's project has drawn the ire of landowners around the region. They oppose the potential taking of their property for the pipeline and fear a pipe rupture releasing a cloud of heavy, hazardous gas over the land. A North Dakota landowners group is challenging a property rights law related to the underground storage, and attorney Derrick Braaten said they likely would challenge the granting of permits for the storage plans. “The landowners that I'm working with aren't necessarily opposed to carbon sequestration itself,” Braaten said. “They're opposed to the idea that a private company can come in and use their property without having to negotiate with them or pay them just compensation for taking their private property and using it.” Carbon capture projects such as Summit's are eligible for lucrative federal tax credits intended to encourage cleaner-burning ethanol and potentially result in corn-based ethanol being refined into jet fuel. Some opponents argue the amount of greenhouse gases sequestered through the process would make little difference and could lead farmers to grow more corn despite environmental concerns about the crop. In Minnesota, regulators granted a route permit that would connect an ethanol plant in Fergus Falls to Summit’s broader network. They attached several conditions, including requirements that Summit begin construction in North Dakota before it starts in Minnesota. An administrative law judge who conducted hearings concluded in November that the environmental impacts from the Minnesota segment would be minimal and noted that Summit has secured agreements from landowners along most of the recommended route. Environmental groups that oppose the project disputed the judge’s finding that the project would have a net benefit for the environment. In addition to North Dakota, Summit has a permit from Iowa for its route, but regulators for that state required the company to obtain approvals for routes in the Dakotas and underground storage in North Dakota before it can begin construction. The Iowa Utilities Commission's approval sparked lawsuits related to the project. Last year, South Dakota regulators rejected Summit's application. The company submitted another permit application last month. In Nebraska, where there is no state regulatory process for CO2 pipelines, Summit is working with individual counties to advance its project. At least one county has denied a permit. Karnowski reported from Minneapolis.

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Share Tweet Share Share Email Deutsche Bank stated in a letter following a meeting with the company’s head of investor relations that Tesla intends to launch its robotaxi service with a company-owned fleet supported by human teleoperators for safety. TakeAway Points: Tesla aims to start its robotaxi service with a company-owned fleet backed up by human teleoperators for safety, Deutsche Bank said in a note after a meeting with the company’s head of investor relations. Cyril Han, president of Ant Group and head of finance, will succeed Eric Jing as CEO starting next year. During the company’s twentieth anniversary celebrations, which also included a speech by Alibaba and Ant Group founder Jack Ma, the management changes were revealed. Ma predicted that the 20-year artificial intelligence era would “exceed everyone’s imagination.” Robotxi with teleoperator backup The electric vehicle maker is still shooting for a launch of its cheaper vehicle in the first half of next year and other models later in the year, the bank said after the meeting with investor relations chief Travis Axelrod. It published the note on Friday. Tesla plans to launch robotaxi service in California and Texas next year, Deutsche Bank said. Tesla had set that goal earlier this year. “Tesla believes it would be reasonable to assume some type of teleoperator would be needed at least initially for safety/redundancy purposes,” the bank said in the note. “Management intends to start off entirely with the company-owned fleet” and to use an internally developed ride-hail app, it said. Deutsche Bank also raised its price target for Tesla shares to $370 from $295. Tesla shares were trading down nearly 1% at $386.04 on Monday. Ant Group gets new CEO Ant Group president and finance chief Cyril Han will take over as chief executive officer from next year, the financial technology giant announced Sunday as it looks to reignite growth after Beijing’s crackdown on the tech sector. Han will take over the role from Eric Jing, who will remain as chairman, according to an email announcing the changes. Han will report to Jing and the changes will take effect on Mar. 1, 2025. Ant Group, which runs the massive payments app Alipay, is one of China’s biggest technology firms. The management changes were announced as part of the company’s twentieth anniversary celebrations, which also featured a speech from Alibaba and Ant Group founder Jack Ma. Ma said that his generation was lucky to seize the opportunities that the internet brought. However, the artificial-intelligence era over the next 20 years would “exceed everyone’s imagination,” Ma said, according to a transcript published by Chinese media. It’s a rare public appearance from Ma, who was impacted by the Chinese government’s regulatory tightening of the domestic tech sector. Ant Group’s public listing, which would have been record-breaking, was cancelled abruptly by Chinese authorities at the end of 2020. Since then, Ant Group has been overhauling its business to be compliant with regulators. Alibaba, the Chinese e-commerce company Ma co-founded, was also the subject of Beijing’s scrutiny. The crackdown hurt the growth of many of China’s biggest technology companies but regulators have recently softened their stance as the Chinese economy remains under pressure. Related Items: Robotaxi , Teleoperator Backup , Tesla Share Tweet Share Share Email Recommended for you Waymo Plans Expansion To Miami Elon Musk Loses Bid To Get $56 Billion Pay Package Reinstated Super Micro Shares Pop 30% After Company Names New Auditor CommentsThis study evaluated factors affecting the duration of the infusion appointment times for 392 clinical trial patients. We found no significant correlations, although further research is needed. This study identified variables significantly affecting the duration of appointment times for oncology clinical trial patients. Additionally, researchers sought to differentiate between intrinsic and extrinsic delays to determine areas needing optimization. Conducted as a single-center, retrospective quality improvement initiative, the study looked at data from adult patients enrolled in oncology clinical trials at UC Davis Comprehensive Cancer Center in Sacramento, California, from July 1, 2019, to July 1, 2022. The analysis involved descriptive statistics and multiple linear regression to evaluate factors affecting infusion appointment duration and arrival-to-chair time. Variables included patient age, number of investigational products administered, appointment time (morning vs afternoon), type and phase of the study, pharmacokinetics at chair time, and the use of interactive response technology kit assignment. The study examined 392 individuals and found no significant correlations between the analyzed variables and infusion appointment duration ( = .085-.53) or arrival-to-chair time ( = .085-.93). Although this analysis did not yield definitive results, it highlights the complexity of delays in oncology infusion chair times. The lack of significant correlations suggests intricate interactions among various factors, emphasizing the need for further research to uncover these complexities and optimize appointment efficiency for patients in clinical trials. Image credit: Seventyfour | stock.adobe.com The UC Davis Comprehensive Cancer Center (UCDCCC) in Sacramento, California, is a National Cancer Institute–designated comprehensive cancer center that conducts early-phase clinical trial research, operating hundreds of oncology clinical trials annually. UCDCCC is the main hub for cancer treatment in the Central Valley region. High patient volume has affected the infusion center schedule, leading to a long wait list. Patients who travel long distances, such as from Southern California or out of state, need to complete multiple care-related activities in a single day, including obtaining laboratory tests and seeing their provider, all on top of receiving their cancer treatment. This is especially the case for clinical trial patients seeking care at UCDCCC because their local institution may not conduct clinical trials or be permitted to conduct study-related activities for the trial on which they are enrolled. Typical reasons for extended infusion appointments, from a patient scheduling perspective, include satisfying trial requirements. Examples include accommodating predose and up to 10 hours postdose pharmacokinetic (PK) blood samples, infusions with durations of several hours, extensive postdose observation and monitoring periods, and numerous infusions. Examples of extenuating circumstances faced by many sites, which are not specific to clinical trials themselves, include patients arriving late, clinic providers experiencing delays in starting at the scheduled time, and other infusion patients utilizing a chair longer than expected. Although some of these reasons are consistent with challenges faced by standard of care, several are unique to clinical trials. Irrespective of the reason for prolonged treatment days, it is important to reduce patient chair time and improve care experiences at UCDCCC. Many US and international institutions have experienced similar challenges with infusion center efficiency and attempted to create tools to shorten infusion chair wait times and improve patient satisfaction. Examples include developing simulation models, process mapping, and Plan-Do-Study-Act cycles. In 2023, a quality improvement (QI) study was performed at UC Davis Health to identify areas of intervention for increased workflow efficiency and decreased infusion chair time for clinical trial patients. This QI project was completed through EPIC (electronic health record software)-generated reports and examined the current workflow by calculating the time intervals for the following: comprehensive metabolic panel and complete blood count laboratory processing, clinical trial medication orders signed by physician to medication verification by pharmacist, patient arrival to study medication dispense, patient arrival to administration of study medication, and the time of appointment (morning [am] or afternoon [pm]). No significant findings were identified, aside from the fact that patients with am appointments waited, on average, 10 minutes longer than patients with pm appointments. It is unclear whether am appointments happened to be generally longer, or because of the complexity of treatment (eg, the patient had multiple study medications administered at the same visit, multiple PK blood draws), these patients were scheduled in the am to ensure treatment could be completed during operating infusion hours. These follow-up study results extend the insights gained from the aforementioned 2023 UC Davis Health study that noted a significant difference between am and pm appointment delays, confirming trends identified in a 2019 study by the Infusion Efficiency Workgroup under the National Comprehensive Cancer Network. The study further investigated the variances in infusion chair time optimization for oncology clinical trial patients by comparing the duration of the appointment vs examined variables and arrival-to-chair time vs examined variables to ascertain their impact on the chair time duration. This study was a single-center, retrospective, continuous quality improvement study. An EPIC report was generated for all adult patients with a scheduled infusion clinic appointment between July 1, 2019, and July 1, 2022, who were enrolled in a clinical trial that involved infusion treatment. From the report, the following variables were collected and examined per patient and infusion appointment encounter, with up to the first 3 encounters included for each patient: age, am or pm appointment, type of study, phase of the study, requiring PK blood draw at chair time, requiring investigational product (IP) supply allocated by interactive response technology (IRT) kit assignment, and number of IPs administered. The primary objective was to determine any variable(s) that significantly affects the duration of the appointment time for oncology clinical trial patients. The secondary objective was to determine whether the intrinsic delay from the variable(s) differs from the extrinsic delay that needs optimization. Examples of intrinsic variables include type of study (industry, national, investigator-initiated), phase of study (eg, phase 1, 2, 3, 4), requiring PK blood draw at chair time, requiring IP IRT kit assignment, and number of IPs administered; these are inherent to the clinical trial process and not directly controllable by the clinical team and are not changeable (as is age). Extrinsic variables are am/pm appointment times and arrival-to-chair time, which reflect elements that may require external optimization. To compare the 2 types of delays, we examined arrival-to-chair time (extrinsic variable) to all mentioned intrinsic variables. Descriptive statistics were used to summarize the data. This included calculating continuous variables’ mean, median, SD, and range. Frequency and percentage were used for categorical variables. These descriptive analyses helped to understand the general characteristics of the data set and the distribution of appointment durations. A multiple linear regression analysis was used to examine the relationship between the dependent variable (duration of appointment time) and the independent variables (am/pm appointment, type of study, phase of study, requiring PK blood draw at chair time, requiring IP IRT kit assignment, number of IP administered, and age). This model helped to determine which variables were statistically significant predictors of appointment duration and the extent of their impact. A separate regression analysis focused on intrinsic vs extrinsic variables to help identify factors needing optimization through policy changes or additional resources. For this study, data from the 392 participants included in the final 2023 study analysis were examined. Most patients (59.4%) received 1 IP during their encounter, did not get PK blood draw done at chair time (62.7%), did not get IRT assignment for IP (82.7%), had equal occurrence of industry study (41.4%) vs federal study (41.3%), and participated in a phase 1 or phase 1/2 study (41.2%). Additionally, 77.9% of appointments were in am vs pm (22.1%) ( ). IP, investigational product; IIT, investigator-initiated trial; IRT, interactive response technology, PK, pharmacokinetics. For the primary objective, For the primary objective, the appointment time (am/pm) was not significantly associated with the appointment duration ( = .2776). The model showed that pm appointments were, on average, 41 minutes shorter, although this difference is not statistically significant. The type of study (ie, industry, investigator-initiated trials [IITs], national) was also not significantly associated with appointment duration (overall model = .4475). Each type of study showed no significant impact on the duration compared with the intercept. The phase of the study showed some indication trending toward association with the duration of the appointment (overall model = .0555), with phase 3 studies being associated with a significant increase in appointment duration by 98.4 minutes ( = .0433) ( ). Whether requiring PK at chair time was performed (Yes [Y]/No [N]) was not significantly associated with the duration of the appointment ( = .5344), and whether requiring IP IRT kit was assigned (Y/N) also did not significantly affect the duration of the appointment ( = .254). Age was significantly associated with the duration of the appointment ( = .0443), with each year increase in age reducing the appointment duration by 2.79 minutes. The number of IPs administered showed some indication of association with appointment duration (overall model = .085), particularly for category 3, which significantly increased the duration by 151.21 minutes ( = .0127) ( ). For the secondary objective, the time of the scheduled appointment (am/pm) showed no significant association with arrival-to-chair time ( = .2961). The pm appointments were associated with increased arrival-to-chair time by 5.41 minutes, which was not statistically significant. The type of study (ie, industry, IIT, national) did not significantly affect arrival-to-chair time (overall model = .2747), with no significant differences observed across the types of study mentioned. The phase of the study had a suggestive, yet not universally significant, association with arrival-to-chair time (overall model = .0851). Specifically, phase 2 and phase 3 studies showed a significant increase in arrival-to-chair time by 20.15 minutes ( = .0322), indicating some variability based on the study phase. Whether requiring PK at chair time did not significantly influence arrival-to-chair time ( = .267), indicating no significant impact of this variable. Requiring IP IRT kit assignment also showed no significant effect on arrival-to-chair time ( = .6808). Age was not significantly associated with arrival-to-chair time ( = .8127), with a coefficient indicating a negligible change in arrival-to-chair time per year of age. The number of IPs administered did not show a significant association with arrival-to-chair time (overall model = .9305), indicating no significant impact on arrival-to-chair time delay ( ). IP, investigational product; IRT, interactive response technology; PK, pharmacokinetics. IP, investigational product; IRT, interactive response technology; PK, pharmacokinetic. The findings from our comprehensive analysis underscore the complexity of optimizing infusion chair time for patients with cancer enrolled in clinical trials. Despite initial assumptions about the potential impact of various intrinsic and extrinsic variables, our results suggest that few factors significantly influence the duration of patient appointments and arrival to chair time. One noteworthy result involved the phase of the clinical trial. Phase 3 studies were associated with significantly longer appointment durations, with an increase of approximately 98.4 minutes. This finding was unexpected because phase 1 studies usually have many more checks and more extensive data collection with PKs, etc. Furthermore, phase 2 and phase 3 studies showed a significant increase in arrival-to-chair time, particularly reflecting the complexity and resource allocation necessary at these stages. These results highlight the need for targeted strategies to manage the higher demands of advanced trial phases effectively. Age also emerged as a significant factor, albeit in a somewhat unexpected direction. With each incremental year in age, appointment durations decreased slightly by approximately 2.79 minutes. This counterintuitive finding might be explained by more streamlined or less intensive treatment regimens often prescribed for older patients or perhaps more experienced patient handling by clinical staff. Moreover, this reduction could be reflective of an adjustment in clinical trial protocols or the health care team’s more efficiently adapting to older adults. Interestingly, most other intrinsic variables—including the type of study, requiring PK blood draw at chair time, and requiring IP IRT kit assignment—showed no significant association with either the duration of the appointments or the arrival-to-chair time; this was a surprise. Time is added to the appointment for IRT kit assignment because it requires the pharmacy to wait on the assignment. These findings suggest that such intrinsic factors might be well managed within current clinical workflows or that their impact is minimal compared with other elements. As for extrinsic variables, the timing of appointments (am/pm) was anticipated to influence efficiency potentially, but the data did not support this hypothesis. Although pm appointments were, on average, shorter by 41 minutes, this difference was not statistically significant. It is unclear whether am appointments happened to be generally longer, or because of the complexity of treatment (eg, the patient had multiple study medications administered at the same visit, multiple PK blood draws, etc), these patients were scheduled in the am to ensure treatment could be completed during operating infusion hours. Therefore, scheduling adjustments alone might not yield substantial improvements in chair-time efficiency. The discovery that the number of IPs administered during a visit also significantly extended appointment times by approximately 151.21 minutes when a patient receives 3 IPs underscores the logistical and procedural burdens associated with multi-drug protocols. This insight points to the need for specialized processes or additional support for handling multi-IP sessions to reduce inefficiencies. Although the current study results provide valuable insights into the factors influencing infusion chair time for oncology clinical trial patients, several limitations must be acknowledged. First, the study duration of approximately 3 years might not be sufficient to capture longer-term trends and variations in clinical trial workflows and infusion times. Seasonal variations, periodic protocol changes, and other temporal factors could play a role in influencing appointment durations, which might not be fully encapsulated within this relatively short time frame. Second, as a single-center study conducted within the UC Davis Health System, the findings may have limited generalizability to other institutions. The workflows, resources, and patient demographics at our center may differ from those at other comprehensive cancer centers or community treatment facilities. Consequently, the results might not be entirely applicable to different clinical settings with varying operational protocols or patient populations. Last, the study involved nurses manually inputting time from the patient’s arrival to the end of the appointment, which introduced a potential for human error and variability in data accuracy. Relying on manual recording can lead to inconsistencies in time documentation, which may have affected the precision of our findings. Automated data collection systems could yield more reliable and consistent data, minimizing the risk of inaccuracies in manual entry. Considering these limitations, future research should aim for longer study durations to better capture temporal variability, multicenter collaborations to enhance generalizability, and the implementation of automated time-tracking systems to improve data accuracy. Addressing these areas will help refine our understanding of infusion chair time optimization and lead to more robust and widely applicable conclusions. into the factors influencing infusion chair time among patients with cancer participating in clinical trials. Although the patient’s age and the phase of the study were significantly associated with changes in appointment duration, most other intrinsic variables examined, including the type of study, PK at chair time, and IRT kit assignment, did not have a statistically significant impact. Moreover, extrinsic variables such as the time of the appointment (am/pm) also showed no significant effect on either the overall appointment duration or arrival-to-chair time. The significant increases in duration for phase 3 studies and appointments involving multiple IPs suggest specific areas where targeted interventions could be effective. For example, additional staffing or dedicated resources during phase 3 trials might help to manage the increased complexity and requirements associated with treatments for these types of trials. Likewise, optimizing processes for multi-drug administrations could reduce procedural delays. is a clinical oncology pharmacist in the Department of Pharmacy and Investigational Drugs Services at Samuel Oschin Cancer Center at Cedars-Sinai in Los Angeles, California, and a former PGY-2 investigational drugs and research pharmacy resident at UC Davis Health in Sacramento, California. is a senior pharmacist in the Oncology & Investigational Drug Service at UC Davis Health in Sacramento, California. The findings emphasize that although certain intrinsic factors are inherent to treatments associated with clinical trial protocols and may require tailored management strategies, many current workflow components are already optimized to a degree that limits further improvements through changes in those areas alone. Future efforts might focus on refining a standardization for clinical trials to ensure consistent care and remove the risk of error caused by different workflows specific to more complex trial phases, and administration of multi-agent regimens to achieve more noticeable enhancements in efficiency and reduction in appointment duration. This study serves as a foundation for further research and quality improvement initiatives aimed at enhancing the experience and care of oncology trial patients. Continuous assessment and incremental adjustments, particularly focused on the identified significant factors, will be essential in moving toward more efficient and patient-friendly clinical trial processes.

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Somerset House has been a key part of London's landscape for hundreds of years, with its grand architecture and prominent position close to the River Thames and the Covent Garden area. But its leaders say its current role as a center for arts and culture is not fully understood, with one even describing it as "London and the U.K.'s best-kept secret." While its courtyard is well known as a striking venue for a winter ice rink and summer movie screenings, people are less aware that hundreds of artists and creatives work within its walls. And as it approaches 25 years in its most recent guise, the organization wants to raise its profile — in 2025, there will be a raft of exhibitions and events aiming to show off its artistic endeavors. "There wasn't a ... moment when Somerset House was revealed in its full glory. And, in a way, next year is a kind of belated moment to do that," said Jonathan Reekie, director of the Somerset House Trust, the organization that preserves the building and its activities for the public. Somerset House has had many transformations. Queen Elizabeth I lived there in the 16th century, and since then it has been a Navy headquarters, a home for the Royal Academy of Arts and a newspaper tax office, before being completely rebuilt in 1801. "In the ... 1770s, 1780s, [King] George III needed to build an 'office block' for his newly formed civil service. So, this is what he built," Reekie said as he took CNBC on a tour. With four large wings surrounding the large, cobbled courtyard (plus a "new" wing added in the 19 th century), the striking Renaissance property housed the multiple offices of the U.K. government's tax and excise authority for more than 150 years — and in more recent times, the courtyard was even covered with asphalt and used as a parking lot. In 1997, the house gained charitable status after a long campaign led by author and newspaper editor Simon Jenkins and philanthropist Lord Rothschild. "When Somerset House ... opened to the public in May 2000, this building was still mostly full of civil servants," Reekie said. "My predecessors basically had to negotiate with each government department to get rid of them," he said. The tax authority — now known as His Majesty's Revenue and Customs — finally closed its Somerset House office in 2011. Its current role is that of a "self-sustaining home to cultural innovators," according to Somerset House Trust chair Gail Rebuck, speaking at an event in September. But its varied facets are not always well understood, she said. When a fire broke out in August, there was an "outpouring of concern," Rebuck said, but "people struggled to describe Somerset House," she said of news reports at the time. "That's our fault, in a way, and something we want to correct ... We're a very special creative cluster," Rebuck said. "It's also London and the U.K.'s best-kept secret ... it's really important that the 3 million visitors who come through our doors actually know what goes on underneath," she said — Somerset House was the U.K.'s 10th most-visited attraction in 2023, with 2.7 million visits according to the Association of Leading Visitor Attractions . Rebuck referred to the network of rooms and areas that are home to multiple artists and creatives who work from the building, in offices, co-working places and studios. When Reekie joined the organization in 2014, he was asked what Somerset House should "be." "Part of the question in terms of how would it work as a cultural space is: what can you do with lots of rooms?" he said. One of Reekie's first jobs was to transform what was essentially a long corridor of government offices into rooms that would be desirable to artists — which now make up Somerset House Studios — raising money to do so from scratch. The artists' rent is subsidized by Somerset House's activities: It makes most of its income — £21.2 million ($27.5 million) for the financial year ending March 31, 2023 — from its own events like the ice rink and arts exhibitions curated in-house, as well as from hiring spaces to other organizations such as the 1-54 Contemporary African Art Fair. There are now around 60-70 artists, teams or collectives working in Somerset House Studios, overseen by director Marie McPartlin. The studios' first resident in 2016 was British fashion designer Gareth Pugh, and composer Anna Meredith was its second, with many others working in the visual arts. "Most of them are doing socially-engaged work ... or engaging with emergent, evolving and advanced technologies," McPartlin said. Artists are encouraged to collaborate — one high-profile name was turned down a studio place because of concerns that they would not have been on site enough of the time. "The community is the most important thing," McPartlin said. "The majority of artists don't have gallery representation — it's such a precarious existence ... really quickly, we realized that long-term support is something Somerset House was able to offer." Artists are resident for between one and seven years, with some on site for up to 10 years. In 2025, McPartlin will curate sculpture "The Spell or The Dream" by Turner Prize-winning artist Tai Shani, a resident of the studios, which will sit at the courtyard's center in August and September. Inspired by a sleeping beauty-type figure, it will reflect "on the urgent contemporary issues of our time," according to a release. McPartlin will also curate an artwork by resident artists Lydia Ourahmane and Sophia Al Maria, which will explore the idea of the "right to remain," according to a release, while BAFTA-nominated filmmaker and resident Akinola Davies Jr will screen a new movie in the courtyard that will look at the "everyday rituals" of black life in the U.K. Other highlights for 2025 will include "Salt Cosmologies," an installation that will map out India's Inland Customs Line, the extraordinary story of a 2,500 mile-long hedge put in place by the British East India Company to enforce its Salt Tax in the late 19th century. And an immersive exhibition by choreographer Wayne McGregor, named "Infinite Bodies," will be the culmination of Somerset House's 25-year celebration. Near the studios is Makerversity, a community of about 300 designers and makers, who share a wood workshop, photography studio and other "maker" spaces tucked close to the underside of Waterloo Bridge, at the far west border of Somerset House. And there is also The Exchange, a co-working space for creatives, and the Black Business Residency, a program for black entrepreneurs. "Having great artists in the center of London seems quite essential ... the thinking was to make it completely interdisciplinary," Reekie said.

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As the semiconductor industry races toward an anticipated $ 1 trillion in revenue by the end of the decade, the demand for skilled semiconductor engineers has become a global priority. Addressing this pressing need, Synopsys, the industry leader providing silicon to systems design solutions that maximise the capabilities of technology R&D teams, is paving the way for a robust semiconductor workforce through its Synopsys Academic & Research Alliance (SARA) program. The SARA program empowers universities globally by providing access to Synopsys’ advanced tools and technologies, driving education and research in EDA and Integrated Circuit (IC) design. Leveraging cutting-edge platforms like the Fusion Design PlatformTM, Custom Design Platform, and Verification Continuum®, the initiative fuels innovation at the forefront of semiconductor advancements. By bridging the gap between academia and industry, the program enables universities to cultivate talent and equip students and researchers with practical skills and hands-on experience, fostering a diverse and capable workforce to meet the dynamic needs of the semiconductor industry. As a part of this initiative, Synopsys is collaborating with the University of Moratuwa, focused on building the country’s semiconductor ecosystem. By providing advanced electronic design automation (EDA) tools, IT equipment, and educational materials, Synopsys supports both the Department of Electronic and Telecommunication Engineering and the Department of Electrical Engineering in developing skilled professionals. This collaboration is expected to graduate over 150 students annually with IC design and EDA knowledge, significantly boosting Sri Lanka’s semiconductor talent pool. Academic leaders from the University of Moratuwa expressed their enthusiasm for the collaboration with Synopsys, emphasising its transformative impact on education and research. University Vice Chancellor Prof. N.D. Gunawardena remarked that utilising Synopsys’ state-of-the-art EDA tools enables the institution to produce world-class semiconductor talent and establish itself as a regional leader in semiconductor research. Senior lecturer Dr. Ranga Rodrigo highlighted the essential role of these tools, noting that Synopsys’ support in providing equipment, and training empowers graduates to excel in the cutting-edge semiconductor industry. Head of the Department of Electrical Engineering Prof. W.D.A.S. Wijayapala commended on Synopsys’ commitment to enhancing practical learning experiences, expressing excitement about advancing education and fostering innovation through this collaboration. A testimony from Pahan Mendis, a final-year undergraduate from the Department of Electronic and Telecommunication Engineering at the University of Moratuwa, highlighted the impact of Synopsys IC design tools on student learning. “I’ve gained invaluable insights through the use of Synopsys IC design tools,” he shared. “Studying IC design with these tools has profoundly enhanced my understanding of circuit behaviour and design optimisation.” Synopsys’ efforts extend beyond tools and training. Through initiatives such as the University Software Program (USP), collaborative workshops, short courses, and design contests, Synopsys fosters an ecosystem that bridges academia and industry. By collaborating with additional universities in Sri Lanka, Synopsys is committed to expanding IC design and EDA research capabilities across the nation. These efforts underline the company’s dedication to innovation, collaboration, and preparing the next generation of semiconductor engineers. Together, Synopsys and its academic partners are shaping a brighter future for Sri Lanka’s microelectronics industry, empowering students to become leaders in technology and driving progress for the global semiconductor workforce.Baltimore Ravens quarterback Lamar Jackson kept the overall lead in fan voting numbers revealed Monday for the NFL Pro Bowl Games with Philadelphia running back Saquon Barkley a close second. Jackson topped vote-getters with 82,402 and Barkley was next, only 320 votes behind. Barkley was 4,079 votes back of Jackson in last week's first voting results. Javascript is required for you to be able to read premium content. Please enable it in your browser settings.None