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OSAKA, Japan and MONTREAL , Dec. 5, 2024 /PRNewswire/ -- Ono Pharmaceutical Co., Ltd. (Headquarters: Osaka, Japan ; President: Toichi Takino; "Ono") announced that it has entered into a drug discovery collaboration agreement with Congruence Therapeutics (Headquarters: Montreal, Quebec, Canada ; CEO: Clarissa Desjardins; "Congruence") to generate novel small molecule correctors against multiple protein targets in the oncology area by leveraging Congruence's proprietary drug discovery platform, RevenirTM. Under the terms of the agreement, Congruence will generate small molecule correctors by leveraging Congruence's proprietary drug discovery engine called, RevenirTM. Ono will obtain an exclusive option right to develop, manufacture and commercialize the identified small molecule correctors worldwide. Congruence will be eligible to receive an upfront payment, research expenses, milestone payments based on research and development progress and sales, as well as tiered royalties based on net sales. "We believe that this collaboration with Congruence may help generating novel small molecule correctors for validated targets in the oncology area by leveraging their own technologies in protein dynamics and computational biology, leading to our development pipeline," said Seishi Katsumata , Corporate Officer / Executive Director, Discovery & Research of Ono. "We will be committed to delivering innovative new drugs to cancer patients as soon as possible." "Congruence is thrilled to partner with Ono, which has established itself as a global leader in drug development, particularly in the oncology space. We believe that our RevenirTM platform and capabilities in protein dynamics will accelerate the discovery of novel therapies for compelling targets of interest to both companies," said Sharath Hegde PhD, Chief Scientific Officer of Congruence. About RevenirTM Drug Discovery Platform RevenirTM, Congruence's proprietary computational drug discovery platform, captures the dynamic biophysical changes caused by mutations in proteins, offering unique insights into protein defects and their correction. By examining surface features and a spectrum of biophysical descriptors across an ensemble of protein conformers, RevenirTM predicts small molecule induced correction of the underlying defect. About Congruence Therapeutics Congruence is a computationally-driven biotechnology company building a unique pipeline of transformative small molecule correctors rationally designed to rescue aberrant protein function. Congruence's proprietary scalable platform, RevenirTM, captures the biophysical features of proteins across their conformational ensembles, in order to identify novel allosteric and cryptic pockets which are virtually screened to generate novel chemical matter. For more information, please visit www.congruencetx.com . View original content to download multimedia: https://www.prnewswire.com/news-releases/ono-enters-into-drug-discovery-collaboration-agreement-with-congruence-therapeutics-to-generate-novel-small-molecule-correctors-in-the-oncology-area-302324452.html SOURCE Ono Pharmaceutical co., ltd.Ono Enters into Drug Discovery Collaboration Agreement with Congruence Therapeutics to Generate Novel Small Molecule Correctors in the Oncology AreaSwinney: I'd consider Australia-style ban on social media use for teenagers under the age of 16 Click here to visit the Scotland home page for the latest news and sport By TOM GORDON DEPUTY SCOTTISH POLITICAL EDITOR Published: 17:25 EST, 11 December 2024 | Updated: 18:20 EST, 11 December 2024 e-mail View comments John Swinney has said he would consider following Australia in banning social media for under-16s. The First Minister said young people had to be protected from a ‘social media storm’ and said there was a ‘strong argument’ for a similar move in the UK. Australia last month became the first country in the world to pass a law intended to stop children using platforms such as TikTok , Instagram , Snapchat , Facebook and X. Prime Minister Anthony Albanese said there was a ‘clear, causal link’ between the rise of addictive social media and harm to ‘the mental health of young Australians’. Firms flouting the law, which will take at least a year to kick in, could be fined A$50million (£25 million). But there are doubts about how age restrictions can be imposed in practice, especially as privacy tools can be used to get round checks. Mr Swinney, who has a 14-year-old son, said social media could have a ‘significant effect’ on children’s wellbeing. He said: ‘I’ve called for much stronger steps to be taken to regulate the activities of social media giants. Teens face harm due to algorithms that allow them to be bombarded with toxic content ‘I think young people are being caught up in a social media storm, which can have a significant effect on their wellbeing. He said he was already in ‘dialogue’ with the UK Government about taking steps to improve protection for children and young people. When asked if that would include a ban on social media for under-16s, the First Minister said: ‘I would certainly consider that. ‘I think there’s a strong argument for it. Australia is obviously going down that direction, and it’s one of the issues that I think we should look at.’ Labour Secretary of State for Science and Technology Peter Kyle last month said a social media ban for under-16s was ‘not on the cards at the moment’ in the UK. But he revealed he was in contact with the Australian government, and wanted to do more to prevent the deaths of children linked to social media. Scottish Liberal Democrat education spokesman Willie Rennie said: ‘There are many tragic stories about the effect of social media on children and young people, it’s clear both our governments and social media companies must do more to protect children from harmful content online.' A Scottish Conservative spokesman said: ‘We will carefully scrutinise the details of what this would ultimately mean if any proposals were put forward.’ Labour MSP Martin Whitfield added: ‘All options must be considered when it comes to making the internet a safer place for children and young people.’ Instagram Facebook TikTok Anthony Albanese Share or comment on this article: Swinney: I'd consider Australia-style ban on social media use for teenagers under the age of 16 e-mail Add comment