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MCLA-129 is a monoclonal antibody commercialized by , with a leading Phase II program in Solid Tumor. According to Globaldata, it is involved in 3 clinical trials, which are ongoing. Smarter leaders trust GlobalData The gold standard of business intelligence. The revenue for MCLA-129 is expected to reach an annual total of $35 mn by 2040 globally based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress. MCLA-129 Overview MCLA-129 is under development for the treatment of solid tumor including non-small cell lung cancer, gastric cancer, esophageal squamous cell cancer (ESCC), gastroesophageal junction (GC/GEJ) adenocarcinoma, Paranasal Sinus And Nasal Cavity Cancer; Oropharyngeal Cancer; Laryngeal Cancer, head and neck cancer and colorectal cancer. It is administered through intravenous drip. The therapeutic candidate is a bi-specific monoclonal antibody that acts by targeting epidermal growth factor receptor (EGFR) and hepatocyte growth factor receptor (MET). The drug candidate is being developed based on Multiclonics (biclonics) technology platform. Merus Overview is a clinical-stage oncology company that develops innovative antibody therapeutics. The company utilizes the Multiclonics, Biclonics and Triclonics platforms to develop human bispecific and tri-specific antibodies. Its pipeline products include petosemtamab (MCLA-158), a low-fucose human full-length IgG1 antibody that targets head and neck squamous cell carcinoma (HNSCC); MCLA-129 and MCLA-145 targeting advanced non-small cell lung cancer (NSCLC) and solid tumors; Zenocutuzumab (MCLA-128), antibody-dependent cell-mediated cytotoxicity (ADCC) drug for non-small cell lung cancer and pancreatic cancer; ONO-4685 for refractory T cell lymphoma and psoriasis; and INCA32459 and INCA33890 for advanced malignancies and select advanced solid tumors. The company operates through its subsidiaries in the Netherlands and the US. is headquartered in Utrecht, the Netherlands. The company reported revenues of (US Dollars) US$44 million for the fiscal year ended December 2023 (FY2023), an increase of 5.7% over FY2022. The operating loss of the company was US$156.6 million in FY2023, compared to an operating loss of US$160 million in FY2022. The net loss of the company was US$154.9 million in FY2023, compared to a net loss of US$131.2 million in FY2022. The company reported revenues of US$7.3 million for the second quarter ended June 2024, a decrease of 7.1% over the previous quarter. For a complete picture of MCLA-129’s valuation, This content was updated on 11 March 2024 From Blending expert knowledge with cutting-edge technology, GlobalData’s unrivalled proprietary data will enable you to decode what’s happening in your market. You can make better informed decisions and gain a future-proof advantage over your competitors. , the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article. To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, drug margins and company expenses. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company. The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate valuation, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA) and phase transition success rate (PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s .As of the week before Thanksgiving, just 1 in 10 Californians have received an updated COVID vaccineJon Coupal: New laws coming in the new year Californians need to know about
An orphaned well sits in a field near Red Deer, Alta., on May 24, 2023. GEOFF ROBINS/Getty Images The oil and gas sector in Alberta spent close to $770-million to clean up inactive wells in 2023, but the industry is not doing anywhere near enough to address the full scale of environmental liabilities around the province, according to one expert. Combined with the cash from the government’s site-rehabilitation program and the industry-funded Orphan Well Association, spending on cleaning up inactive wells surpassed $1-billion in 2023. But that massive outlay barely made a dent, reducing the number of inactive wells in the province by only about 5 per cent, according to the Alberta Energy Regulator ’s annual liability monitoring report released Thursday. The oil and gas sector in Alberta is required to spend a certain amount each year on cleaning up inactive wells and pipelines. Last year, the AER set that number at $700-million. But the scale of environmental liabilities in the province dwarfs the spending quota set by the AER, says Martin Olszynski, an associate professor and Chair in Energy, Resources and Sustainability at the University of Calgary Faculty of Law. The AER has attached a $33.3-billion price tag to the cost of cleaning up the province’s hundreds of thousands of oil and gas wells, but Prof. Olszynski believes that number is off by a huge margin. Indeed, internal AER documents suggest the province’s environmental liability could be nearly triple the estimate the agency announced earlier this year. Those documents pegged the total cost of well cleanup to be about $88-billion. Prof. Olszynski said the industry isn’t spending enough to tackle the problem, and would like the AER to force the sector’s hand. “The point is the AER has no plan to get that money for those liabilities from profitable companies,” Prof. Olszynski said. He pointed to Canadian Natural Resources Ltd., which has about 20,000 of Alberta’s 80,000 inactive wells. The company is making “making money hand over fist” right now, he said, “but when are you ever going to be able to start chipping away at that massive liability they have?” Prof. Olszynski would instead like to see the AER require that a company put enough money aside to cover reclamation costs when it is issued a well licence. And he would like the regulator to institute a time limit on how long companies have to clean up a well once it is no longer active. “It can’t just be applied against when your company is distressed, because that’s just backwards. That’s counterproductive. You’re just going to spiral out those companies into more distress, and then they’re not paying their taxes or not paying their vendors, and it becomes essentially a zero-sum game between unpaid vendors, service providers, municipalities and landowners,” he said. “This isn’t rocket science.” While the vast majority of oil and gas companies met spending requirements in 2023 set by the AER, 54 of them didn’t. Mostly smaller companies, they represented a mere $5-million in missed quotas. Anita Lewis, the regulator’s senior adviser of liability management, said companies that don’t meet their cleanup obligations and other regulatory requirements are monitored through a licensee management program. It will take compliance action that can include anything from a warning letter to having the Orphan Well Association step in and take over management of their sites. However, she said the AER doesn’t share data on how many of the small companies that are failing to meet their cleanup quotas are also deemed at high risk of struggling to meet their financial obligations. Such companies have a total of about $2-billion of environmental liabilities on their books. The remainder is held by companies deemed to have low or medium financial risks. Editor’s note: This article previously included a headline that incorrectly referred to orphan wells. This version has been updated to refer to inactive wells.
Morgan Rogers looked to have given Emery’s side another famous win when he slammed a loose ball home in stoppage time, but referee Jesus Gil Manzano ruled Diego Carlos to have fouled Juve goalkeeper Michele Di Gregorio and the goal was chalked off. Contact seemed minimal but VAR did not intervene and Villa had to settle for a point in a 0-0 draw. “With the last action, it is the interpretation of the referee,” the Spaniard said. “In England, 80 per cent of those is given a goal and it’s not a foul. It’s very soft. “But in Europe, it could be a foul. We have to accept. “Everybody will know, in England the interpretation is different. The England referees, when actions like that the interpretation is a clear no foul but in Europe that interpretation is different. “They have to be working to get the same decision when some action like that is coming. I don’t know exactly why but we knew before in the Premier League that it is different. “In Europe for example we are not doing a block like in England and we are not doing in front of the goalkeeper in offensive corners the same situations like in England. “When the action happened, I was thinking here in Europe it’s a foul. In England not, but in Europe I have to accept it. “At first, I thought the referee gave us a goal. In cases like that, it’s confusing because he has to wait for VAR. I don’t know what happened but I think so (the referee changed his mind with VAR).” It was a disappointment for Villa, who remain unbeaten at home in their debut Champions League campaign and are still in contention to qualify automatically for the last 16. “We were playing a favourite to be in the top eight and usually a contender to win this competition,” Emery added. “We are a team who for a long time didn’t play in Europe and the Champions League and this year is very important. “We wanted to play competitive and we are in the right way. Today to get one point is very good, we wanted to win but wanted to avoid some mistakes we made in previous games. “We have 10 points and we’re happy.” Before the game Emery called Juventus one of the “best teams in the world, historically and now”, but this was an Italian side down to the bare bones. Only 14 outfield players made the trip from Turin, with striker Dusan Vlahovic among those who stayed behind. Juve boss Thiago Motta, whose side are 19th but still in contention to reach the top eight, said: “There’s just three games left to qualify. The next home against Man City, then Brugge, then Benfica. “One at a time, as we always did with the goal to qualify for the next round. “In the end we will try and reach our goal which is to go to the next round.”WASHINGTON (AP) — One year after the Jan. 6, 2021 , U.S. Capitol attack, Attorney General Merrick Garland said the Justice Department was committed to holding accountable all perpetrators “at any level” for “the assault on our democracy.” That bold declaration won't apply to at least one person: Donald Trump. Special counsel Jack Smith's move on Monday to abandon the federal election interference case against Trump means jurors will likely never decide whether the president-elect is criminally responsible for his attempts to cling to power after losing the 2020 campaign. The decision to walk away from the election charges and the separate classified documents case against Trump marks an abrupt end of the Justice Department’s unprecedented legal effort that once threatened his liberty but appears only to have galvanized his supporters. The abandonment of the cases accusing Trump of endangering American democracy and national security does away with the most serious legal threats he was facing as he returns to the White House. It was the culmination of a monthslong defense effort to delay the proceedings at every step and use the criminal allegations to Trump's political advantage, putting the final word in the hands of voters instead of jurors. “We always knew that the rich and powerful had an advantage, but I don’t think we would have ever believed that somebody could walk away from everything,” said Stephen Saltzburg, a George Washington University law professor and former Justice Department official. “If there ever was a Teflon defendant, that’s Donald Trump.” While prosecutors left the door open to the possibility that federal charges could be re-filed against Trump after he leaves office, that seems unlikely. Meanwhile, Trump's presidential victory has thrown into question the future of the two state criminal cases against him in New York and Georgia. Trump was supposed to be sentenced on Tuesday after his conviction on 34 felony counts in his New York hush money case , but it's possible the sentencing could be delayed until after Trump leaves office, and the defense is pushing to dismiss the case altogether. Smith's team stressed that their decision to abandon the federal cases was not a reflection of the merit of the charges, but an acknowledgement that they could not move forward under longstanding Justice Department policy that says sitting presidents cannot face criminal prosecution. Trump's presidential victory set “at odds two fundamental and compelling national interests: On the one hand, the Constitution’s requirement that the President must not be unduly encumbered in fulfilling his weighty responsibilities . . . and on the other hand, the Nation’s commitment to the rule of law,” prosecutors wrote in court papers. The move just weeks after Trump's victory over Vice President Kamala Harris underscores the immense personal stake Trump had in the campaign in which he turned his legal woes into a political rallying cry. Trump accused prosecutors of bringing the charges in a bid to keep him out of the White House, and he promised revenge on his perceived enemies if he won a second term. “If Donald J. Trump had lost an election, he may very well have spent the rest of his life in prison,” Vice President-elect JD Vance, wrote in a social media post on Monday. “These prosecutions were always political. Now it’s time to ensure what happened to President Trump never happens in this country again.” After the Jan. 6 attack by Trump supporters that left more than 100 police officers injured, Republican leader Mitch McConnell and several other Republicans who voted to acquit Trump during his Senate impeachment trial said it was up to the justice system to hold Trump accountable. The Jan. 6 case brought last year in Washington alleged an increasingly desperate criminal conspiracy to subvert the will of voters after Trump's 2020 loss, accusing Trump of using the angry mob of supporters that attacked the Capitol as “a tool” in his campaign to pressure then-Vice President Mike Pence and obstruct the certification of Democrat Joe Biden's victory. Hundreds of Jan. 6 rioters — many of whom have said they felt called to Washington by Trump — have pleaded guilty or been convicted by juries of federal charges at the same courthouse where Trump was supposed to stand trial last year. As the trial date neared, officials at the courthouse that sits within view of the Capitol were busy making plans for the crush of reporters expected to cover the historic case. But Trump's argument that he enjoyed absolute immunity from prosecution quickly tied up the case in appeals all the way up to the Supreme Court. The high court ruled in July that former presidents have broad immunity from prosecution , and sent the case back to the trial court to decide which allegations could move forward. But the case was dismissed before the trial court could get a chance to do so. The other indictment brought in Florida accused Trump of improperly storing at his Mar-a-Lago estate sensitive documents on nuclear capabilities, enlisting aides and lawyers to help him hide records demanded by investigators and cavalierly showing off a Pentagon “plan of attack” and classified map. But U.S. District Judge Aileen Cannon dismissed the case in July on grounds that Smith was illegally appointed . Smith appealed to the Atlanta-based 11th U.S. Circuit Court of Appeals, but abandoned that appeal on Monday. Smith's team said it would continue its fight in the appeals court to revive charges against Trump's two co-defendants because “no principle of temporary immunity applies to them.” In New York, jurors spent weeks last spring hearing evidence in a state case alleging a Trump scheme to illegally influence the 2016 election through a hush money payment to a porn actor who said the two had sex. New York prosecutors recently expressed openness to delaying sentencing until after Trump's second term, while Trump's lawyers are fighting to have the conviction dismissed altogether. In Georgia, a trial while Trump is in office seems unlikely in a state case charging him and more than a dozen others with conspiring to overturn his 2020 election loss in the state. The case has been on hold since an appeals court agreed to review whether to remove Fulton County District Attorney Fani Willis over her romantic relationship with the special prosecutor she had hired to lead the case. ____ Associated Press reporter Lisa Mascaro in Washington contributed.
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