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FILE – Author Percival Everett attends the 75th National Book Awards ceremony at Cipriani Wall Street on Wednesday, Nov. 20, 2024, in New York. (Photo by Andy Kropa/Invision/AP, File) FILE – Taylor Swift performs during “The Eras Tour” on Friday, Dec. 6, 2024, in Vancouver, British Columbia. (AP Photo/Lindsey Wasson, File) FILE – Riley Keough, left, and her mother Lisa Marie Presley arrive at the 24th annual ELLE Women in Hollywood Awards on Oct. 16, 2017, in Los Angeles. (Photo by Jordan Strauss/Invision/AP, File) FILE – First lady Melania Trump stands next to the 2020 Official White House Christmas tree as it is presented on the North Portico of the White House, Monday, Nov. 23, 2020, in Washington. (AP Photo/Andrew Harnik, File) FILE – This cover image released by FSG shows “Intermezzo” by Sally Rooney. (FSG via AP, File) FILE – This cover image released by Random House shows “From Here to the Great Unknown” by Lisa Marie Presley and Riley Keough. (Random House via AP, File) FILE – This cover image released by Simon & Schuster shows “War” by Bob Woodward. (Simon & Schuster via AP, File) FILE – This cover image released by Dey Street Books shows “Cher: The Memoir, Part One,” releasing on Nov. 19. (Dey Street Books via AP, File) FILE – This cover image released by Random House shows “Knife: Meditations After an Attempted Murder” by Salman Rushdie. The book, about the attempt on his life that left him blind in his right eye, will be published April 16, 2024. Rushdie’s first book since the 2022 stabbing he thought might end his life is both explicit in the violence Rushdie sustains and heroic in the will to live that Rushdie retains. (Random House via AP, File) FILE – Author Percival Everett attends the 75th National Book Awards ceremony at Cipriani Wall Street on Wednesday, Nov. 20, 2024, in New York. (Photo by Andy Kropa/Invision/AP, File) Even through a year of nonstop news about elections, climate change, protests and the price of eggs, there was still time to read books.Detroit's Renaissance Center would lose two towers, add apartments, riverfront park under new proposal
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Democrats and Republicans offer hypocritical response to ICC's Netanyahu arrest warrantJimmy Carter, 39th US president, Nobel winner, dies at 100CAMBRIDGE, Mass., Dec. 09, 2024 (GLOBE NEWSWIRE) -- Relay Therapeutics, Inc. (Nasdaq: RLAY), a clinical-stage precision medicine company transforming the drug discovery process by combining leading-edge computational and experimental technologies, today announced that updated clinical data for RLY-2608 600mg BID + fulvestrant in patients with PI3Kα-mutated, HR+, HER2- locally advanced or metastatic breast cancer will be presented at the upcoming San Antonio Breast Cancer Symposium, taking place December 10-13, 2024. Details of the RLY-2608 + fulvestrant poster presentation are as follows: Abstract Title: PS7-01: Efficacy of RLY-2608, a mutant-selective PI3Kα inhibitor in patients with PIK3CA-mutant HR+HER2- advanced breast cancer: ReDiscover trial Abstract Number: SESS-2211 Session: Concurrent Poster Spotlight Session 7: Targeting the ER and PI3K pathway: Novel drugs and combinations Date/Time: Wednesday, December 11, 8:00-9:30 a.m. ET (7:00-8:30 a.m. CT) Conference Call Information Relay Therapeutics will host a conference call to discuss these data on Wednesday, December 11, 2024 at 7:00 a.m. ET (6:00 a.m. CT). Registration and dial-in for the conference call and webcast may be accessed through Relay Therapeutics’ website under Events in the News & Events section through the following link: https://ir.relaytx.com/news-events/events-presentations . An archived replay of the webcast will be available following the event. The poster will be available at the start of the session on the company’s website at https://relaytx.com/publications/ . About RLY-2608 RLY-2608 is the lead program in Relay Therapeutics’ efforts to discover and develop mutant selective inhibitors of PI3Kα, the most frequently mutated kinase in all cancers, with oncogenic mutations detected in about 14% of patients with solid tumors. RLY-2608 has the potential, if approved, to address more than 300,000 patients per year in the United States, one of the largest patient populations for a precision oncology medicine. Traditionally, the development of PI3Kα inhibitors has focused on the active, or orthosteric, site. The therapeutic index of orthosteric inhibitors is limited by the lack of clinically meaningful selectivity for mutant versus wild-type (WT) PI3Kα and off-isoform activity. Toxicity related to inhibition of WT PI3Kα and other PI3K isoforms results in sub-optimal inhibition of mutant PI3Kα with reductions in dose intensity and frequent discontinuation. The Dynamo® platform enabled the discovery of RLY-2608, the first known allosteric, pan-mutant, and isoform-selective PI3Kα inhibitor, designed to overcome these limitations. Relay Therapeutics solved the full-length cryo-EM structure of PI3Kα, performed computational long time-scale molecular dynamic simulations to elucidate conformational differences between WT and mutant PI3Kα, and leveraged these insights to support the design of RLY-2608. RLY-2608 is currently being evaluated in a first-in-human trial designed to treat patients with advanced solid tumors with a PIK3CA (PI3Kα) mutation. For more information on RLY-2608, please visit here . About Relay Therapeutics Relay Therapeutics is a clinical-stage precision medicine company transforming the drug discovery process by combining leading-edge computational and experimental technologies with the goal of bringing life-changing therapies to patients. As the first of a new breed of biotech created at the intersection of complementary techniques and technologies, Relay Therapeutics aims to push the boundaries of what’s possible in drug discovery. Its Dynamo® platform integrates an array of leading-edge computational and experimental approaches designed to drug protein targets that have previously been intractable or inadequately addressed. Relay Therapeutics’ initial focus is on enhancing small molecule therapeutic discovery in targeted oncology and genetic disease indications. For more information, please visit www.relaytx.com or follow us on Twitter . Cautionary Note Regarding Forward-Looking Statements This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, as amended, including, without limitation, implied and express statements regarding Relay Therapeutics’ strategy, business plans and focus; the progress and timing of the clinical development of the programs across Relay Therapeutics’ portfolio; the expected therapeutic benefits and potential efficacy and tolerability of RLY-2608, both as a monotherapy and in combination with other agents, and its other programs, including lirafugratinib as well as the clinical data for RLY-2608; the interactions with regulatory authorities and any related approvals; the potential market opportunity for RLY-2608; the cash runway projection and the expectations regarding Relay Therapeutics’ use of capital, expenses and potential cost savings. The words “may,” “might,” “will,” “could,” “would,” “should,” “plan,” “anticipate,” “intend,” “believe,” “expect,” “estimate,” “seek,” “predict,” “future,” “project,” “potential,” “continue,” “target” and similar words or expressions, or the negative thereof, are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Any forward-looking statements in this press release are based on management's current expectations and beliefs and are subject to a number of risks, uncertainties and important factors that may cause actual events or results to differ materially from those expressed or implied by any forward-looking statements contained in this press release, including, without limitation, risks associated with: the impact of global economic uncertainty, geopolitical instability and conflicts, or public health epidemics or outbreaks of an infectious disease on countries or regions in which Relay Therapeutics has operations or does business, as well as on the timing and anticipated results of its clinical trials, strategy, future operations and profitability; the delay or pause of any current or planned clinical trials or the development of Relay Therapeutics’ drug candidates; the risk that the preliminary or interim results of its preclinical or clinical trials may not be predictive of future or final results in connection with future clinical trials of its product candidates and that interim and early clinical data may change as more patient data become available and are subject to audit and verification procedures; Relay Therapeutics’ ability to successfully demonstrate the safety and efficacy of its drug candidates; the timing and outcome of its planned interactions with regulatory authorities; and obtaining, maintaining and protecting its intellectual property. These and other risks and uncertainties are described in greater detail in the section entitled “Risk Factors” in Relay Therapeutics’ most recent Annual Report on Form 10-K and Quarterly Report on Form 10-Q, as well as any subsequent filings with the Securities and Exchange Commission. In addition, any forward-looking statements represent Relay Therapeutics' views only as of today and should not be relied upon as representing its views as of any subsequent date. Relay Therapeutics explicitly disclaims any obligation to update any forward-looking statements. No representations or warranties (expressed or implied) are made about the accuracy of any such forward-looking statements. Contact: Megan Goulart 617-322-0814 mgoulart@relaytx.com Media: Dan Budwick 1AB 973-271-6085 dan@1abmedia.com
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Echoes of Trump’s victory in Ireland’s general election?MAURA Higgins received a punishing gift from I'm A Celebrity bosses for her 34th birthday. The Love Island star celebrated getting another year older as she woke up in the jungle. Maura said: “Birthday in the jungle! This is definitely going to be one I will never, ever forget.” However, it got off to a cr***y start when new leaders Barry and Danny got the campmates to complete their chores for the day. Birthday girl Maura was left with the chore of cleaning the dunny with Coleen. However, things improved after Tulisa and Melvin won a plate of ready salted Pringles in the Kiosk Kev's Deals On Wheels. The campmates allowed Maura to take a Pringle first, with GK Barry telling her: "What a birthday treat!" However, later, after the campmates had enjoyed their dinner of ostrich egg, there was an unexpected twist in store as a laminate was delivered into camp, as well as a bag of bus tickets. Just before it arrived, the group were discussing why the lights were still on in the jungle camp. GK Barry said: "Predictions... I think we're going to have songs, a little boogy and a bit of birthday cake." Tulisa added: "They're not going to do something negative for Maura's birthday. It's only going to be a treat." Read out by Danny, the laminate explained: “Tonight, you will all have the chance to win treats. However, to be in with a chance of winning, you will all need to take a trip on The Fright Bus!” Maura put her head in her hands as Danny began handing out tickets to the bus. "A lot of the campmates are telling me it's not going to be that bad, but I'm s****ing it," Maura said in the Bush Telegraph. She also grilled her fellow campmates on whether they thought the bus could be full of spiders - her worst fear. Each celebrity could win a piece of luggage each from the luggage rack, described to contain holiday essentials, and even a tasty treat during the task. The challenge was simple: the campmates had to endure the bus and work within their rows of three to escape it, passing four stops on its journey. To do this, each row would wait until their stop to manoeuvre three tokens across the bar to the stop button as fast as they could. Every token won, would equate to one piece of luggage. i'm A Celebrity is back for its 24th series, with a batch of famous faces living in the Aussie jungle. The Sun's Jake Penkethman takes a look at the stars on the show this year.. Coleen Rooney - Arguably the most famous name in the camp, the leading WAG, known for her marriage to Wayne Rooney , has made a grand return to TV as she looks to put the Wagatha Christie scandal behind her. The Sun revealed the mum-of-four had bagged an eye-watering deal worth over £1.5million to be on the show this year making her the highest-paid contestant ever. Tulisa - The popstar and former X Factor judge has made her triumphant TV comeback by signing up to this year's I'm A Celeb after shunning TV shows for many years. Known for being a member of the trio, N-Dubz, Tulisa became a household name back in 2011 when she signed on to replace Cheryl on ITV show The X Factor in a multi-million pound deal. Alan Halsall - The actor, known for playing the long-running role of Tyrone Dobbs on ITV soap opera Coronation Street, was originally signed up to head Down Under last year but an operation threw his scheduled appearance off-course. Now he has become the latest Corrie star to win over both the viewers and his fellow celebrities. Melvin Odoom - The Radio DJ has become a regular face on TV screens after rising to fame with presenting roles on Kiss FM, BBC Radio 1 and 4Music. Melvin has already been for a spin on the Strictly dancefloor and co-hosted The Xtra Factor with Rochelle Humes in 2015 but now he is facing up to his biggest challenge yet - the Aussie jungle . GK Barry - The UK's biggest social media personality, GK, whose real name is Grace Keeling, has transformed her TikTok stardom into a lucrative career. Aside from her popular social media channels, she hosts the weekly podcast, Saving Grace, and regularly appears on ITV talk show, Loose Women. She has even gone on to endorse popular brands such as PrettyLittleThing, KFC and Ann Summers. Dean McCullough - A rising star amongst this year's bunch of celebs , Dean first achieved notability through his radio appearances on Gaydio and BBC Radio 1. He was chosen to join the BBC station permanently in 2021 and has featured prominently ever since. He has enjoyed a crossover to ITV over the past year thanks to his guest slots on Big Brother spin-off show, Late & Live. Oti Mabuse - The pro dancer has signed up to her latest TV show after making her way through the biggest programmes on the box. She originally found fame on Strictly Come Dancing but has since branched out into the world of TV judging with appearances on former BBC show The Greatest Dancer as well as her current role on ITV's Dancing On Ice . Danny Jones - The McFly star was drafted into the programme last minute as a replacement for Tommy Fury. Danny is the second member of McFly to enter the jungle , after Dougie Poynter won the show in 2011. He is also considered a rising star on ITV as he's now one of the mentors on their Saturday night talent show, The Voice , along with bandmate Tom Fletcher. Jane Moore - The Loose Women star and The Sun columnist is braving the creepy crawlies this year. The star is ready for a new challenge - having recently split from her husband . It will be Jane's first foray into reality TV with the telly favourite having always said no to reality shows in the past. Barry McGuigan - Former pro boxer Barry is the latest fighting champ to head Down Under following in the footsteps of Tony Bellew and Amir Khan. It comes after a tough few years for Irish star Barry, who lost his daughter Danika to bowel cancer . He told The Late Late Show in 2021: "She was such an intrinsic part of the family that every day we ache." Maura Higgins - The Irish TV beauty first found fame on Love Island where she found a brief connection with dancer Curtis Pritchard . Since then, she has competed on Dancing On Ice as well as hosting the Irish version of the beauty contest, Glow Up. Since last year, she has been working on building up her career in the US by being the social media correspondent and host of Aftersun to accompany Love Island USA. She even guest hosted an episode of the spin-off, Love Island Games, in place of Maya Jama last year. Rev. Richard Coles - Former BBC radio host the Rev Richard Coles is a late arrival on I’m A Celebrity , and he's ready to spill the beans on his former employer. The former Communards and Strictly star , said the BBC did not know its a**e from its elbow last year. An insider said: "Rev Coles will have a variety of tales to tell from his wild days as a pop star in the Eighties, through to performing on Strictly and his later life as a man of the cloth." As each celebrity took their seats, birthday girl Maura got a shock when she realised she was at the back of the bus and would therefore have to endure the longest trip. As the Fright Bus started its journey, creepy crawlies began to fall and there were screams that could be heard all over the jungle. Monday night's episode then ended on a cliffhanger, with I'm A Celebrity hosts Ant and Dec telling fans they would see the conclusion in the next episode. Taking to X, one fan wrote: "Tomorrow nights show???? Why we being left on a cliffhanger please? What is this like?!"
Jimmy Carter: The Peanut Farmer who Became a Global HumanitarianAdvocates are urging the Liberal government not to play politics with the remaining provisions under a firearms bill passed in December 2023, warning any further delay could put more women’s lives at risk. Brian Sweeney, a self-described “broken-hearted man,” whose daughter Angie was fatally shot by her ex-boyfriend last year in Sault Ste. Marie, was among those who told Ottawa reporters Monday that the government needs to act quickly. Angie was killed by a man who had a history of intimate partner violence, who, after killing her, headed home and shot his own three children and turned the gun on himself. Sweeney helped found Angie’s Angels, an organization he promised will be “active” in the next election to rally Canadians in support of candidates who back Bill C-21, the Liberals’ hallmark gun control bill. That legislation promised to bring in red and yellow flag laws by banning anybody under a protection order, such as a restraining order, from owning or possessing guns. Those convicted of domestic violence offences would also be subject to the prohibition, with officers ordered to revoke a licence within 24 hours if they have “reasonable grounds” to suspect that someone may have stalked or committed domestic violence against a partner. Regulations to bring those rules into force remain in the works, a reality that Sweeney said is unacceptable and dangerous. “Clearly, every month that goes by without these new laws being enforced in our cities, towns and across rural and remote communities puts the lives of women and children at greater risk,” he said. “I can’t bring my daughter back, but what I can do is use my grief and great sadness to help prevent other femicides." Nathalie Provost, a representative with gun control advocacy organization PolySeSouvient, expressed anger and frustration that the feds are not moving on the “potentially life-saving measures” with the urgency needed. She noted that no timeline has been given for the remaining regulations. Suzanne Zaccour, a spokesperson for the National Association of Women and the Law, took it a step further and called on the feds to bring in the provisions before the next election. She argued that if they fail to do so, all four opposition parties must commit to upholding and enforcing the measures on their forthcoming platforms. While the feds want red and yellow flag laws to come into force “as soon as possible,” the government did not elaborate. “We understand the urgency to act and are giving ourselves the means to do so, including through the National Action Plan to End Gender-Based Violence,” a spokesperson for Public Safety Minister Dominic LeBlanc said in a statement, acknowledging that when a firearm is found in a home, the government knows “dangerous situations are more likely to become deadly.” “Working with provinces, territories and groups advocating in favour of the fight against gender-based violence, we will bring everything to bear to put an end to this scourge.” Alberta woman Tara Graham also shared her personal connection to the issue. Graham’s mother, Brenda Tatlock-Burke, was shot and killed last month by her husband before he killed himself, an incident that sparked calls for greater transparency from the RCMP and how it addresses cases of domestic violence. Graham alleged her stepfather, retired RCMP officer Mike Burke, was toxic and controlling during a three-decade-long relationship with her mother, who was planning to leave him just days before she was killed. She added there are some “critical gaps” in gun control measures that could have prevented her mother’s death, including banning firearm storage within a person's home if their past suspicious behaviour is known and addressing the “myth” that physical harm is the only indicator of intimate partner violence. “Educating both the police and public to recognize coercive control as an equally damaging form of abuse is key,” she added. “It would give victims of psychological and emotional abuse like my mother faith that reaching out to the police for help would be taken as seriously as a broken bone or black eye.” Graham also urged parliamentarians to adopt the NDP's Bill C-332, a push to outlaw coercive control in cases involving intimate partners. That legislation, which the NDP has argued will help address “overlooked and downplayed” forms of abuse while addressing behaviours that instil a fear of violence in victims, remains at second reading in the Senate. “The bottom line is our elected officials have a responsibility to act now” and before it becomes “too late,” Graham said. “I speak today, so no other Canadian will have to travel to Ottawa to plead with you, your politicians, for these common sense solutions.”
Upbound Group strikes $460 million deal for financial inclusion app BrigitSean “Diddy” Combs is using the “But Donald Trump ” defense in his latest bid for a bail release in time for Thanksgiving. Combs’ lawyers have already tried several times to get the incarcerated ex-mogul out on bail . But when prosecutors argued against his latest attempt, making the case that Combs had been trying to influence jurors from behind prison walls, his team cited Trump’s defense that he reserves the right to “criticize and speak out against the prosecution and the criminal trial process that seek to take away his liberty,” in a few filing . “The court should apply Trump’s heightened standard when considering Mr. Combs’ speech,” Combs’ attorney team claims. ADVERTISEMENT Combs was arrested on September 16 in the lobby of a Manhattan hotel, and has remained in prison while awaiting a May 5, 2025 trial for his three-count indictment on racketeering conspiracy, sex trafficking, and transportation to engage in prostitution charges. Between the raids on his home and the many lawsuits accusing him of sexual and physical abuse and forcible drugging, Combs’ legal troubles have been at the center of the news cycle for nearly a year. Citing Trump’s legal defense at length in the new filing, Combs’ lawyers drew a comparison to the “PR campaign” the prosecution accuses him of running from jail to woo jurors to Trump’s defense of his own comments regarding Trump v. United States , the case that would have evaluated his alleged attempts to overturn the 2020 election, before those charges were dropped on Monday . Trump constantly shared public thoughts on the trial via social media, raising the question of whether those comments constituted obstruction of justice. Trump’s team argued , however, that “Only a significant and imminent threat to the administration of criminal justice will support restricting Mr. Trump’s speech.” Combs said that defense should apply to him as well, as his comments about “being a ‘revolutionary’ or about a ‘racist’ prosecution involves thoughts ‘that this prosecution is politically motivated or that he is innocent of the charges against him’—core protected speech,” his lawyers wrote in the filing. On that point, Combs’ defense concludes, “The government is essentially arguing for a standard in which the entire Press community—and civil plaintiffs and the government itself—can wage war against Mr. Combs’ reputation but Mr. Combs can’t even try to influence public opinion himself in response,” which, they write, “is simply not the law.”
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