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Swinging golf clubs at Top Golf before the big football game is a must for Vanderbilt and Georgia Tech players on Christmas Eve. This is a time for them to bond with one another before the Birmingham Bowl. Both coaches say this downtime in the Magic City also allows them to reflect on a successful season off the field. "I couldn't be more proud to sit up here and say that these guys at Georgia Tech just finished with a 3.0 GPA as a team for the entire semester, but it's the highest in-season GPA in the history of our football program,” Brent Key, Georgia Tech head coach, said. “I'm proud of this team, the genuine connection that they have, and I'm talking about the players. The coaches are a part of it, too. It's fun for us coaches to be a part of a team that cares about one another,” Clark Lea, Vanderbilt head coach, said. For Vanderbilt safety Marlen Sewell, playing against Georgia Tech in Protective Stadium is exciting. The former Shades Valley High School athlete will have loved ones cheering him on. “My old high school teammates, family, friends from other states, so I'm going to have a big crowd out there,” Marlen Sewell, safety for Vanderbilt, said. Georgia Tech players say they have a large senior class this year. Time spent like this off the field makes spending the holidays away from home alright. “Outside of football, obviously, you know, kind of trying to hang out as a team, you know, chop it up, see where guys heads are and things like that. you know, golfing will be a great opportunity for us to compete,” LaMiles Brooks, defensive back for Georgia Tech, said.– ENERGIZE-T Study Achieved Primary and All Key Secondary Endpoints in Adult Patients with Transfusion-Dependent Alpha- or Beta-Thalassemia – – ENERGIZE-T is First Phase 3 Study to Demonstrate Efficacy of an Oral, Disease-Modifying Treatment for Transfusion-Dependent Alpha- and Beta-Thalassemia – – Company Filed for Regulatory Approval of Mitapivat (PYRUKYND ® ) for the Treatment of Adult Patients with Non-Transfusion-Dependent and Transfusion-Dependent Alpha- or Beta-Thalassemia in U.S., European Union, Kingdom of Saudi Arabia and United Arab Emirates – – Live and Webcast Investor Event with Agios Leadership and Medical Experts will be Hosted in San Diego on Monday, December 9 at 7:00 a.m. PT – CAMBRIDGE, Mass., Dec. 08, 2024 (GLOBE NEWSWIRE) -- Agios Pharmaceuticals, Inc. (Nasdaq: AGIO), a leader in cellular metabolism and pyruvate kinase (PK) activation pioneering therapies for rare diseases, today presented positive results from the Phase 3 ENERGIZE-T study investigating mitapivat, an oral, small molecule PK activator, in adults with transfusion-dependent alpha- or beta-thalassemia. These findings were shared in an oral presentation (abstract #409) at the 66 th American Society of Hematology (ASH) Annual Meeting and Exposition in San Diego, California. Thalassemia is a rare inherited blood disorder caused by genetic mutations that lead to a reduced production of healthy hemoglobin, compromising red blood cell development, health and survival, and resulting in chronic anemia. Patients with thalassemia often experience a range of debilitating complications, both from the disease itself and as secondary effects of common management strategies such as blood transfusions and iron chelation therapy, including organ damage, stroke, and other serious health issues. In the ENERGIZE-T trial, mitapivat demonstrated a statistically significant reduction in transfusion burden compared to placebo in patients with transfusion-dependent alpha- or beta-thalassemia, achieving its primary endpoint. Additionally, the ENERGIZE-T study met all the key secondary endpoints, with mitapivat demonstrating a statistically significant reduction in additional measures of transfusion reduction response compared to placebo. In June 2024, Agios also presented positive results from the Phase 3 ENERGIZE study, which evaluated mitapivat in adults with non-transfusion-dependent alpha- or beta-thalassemia. “Treatment options for patients with transfusion-dependent thalassemia are extremely limited, and transfusions carry serious risks, such as iron overload, infections and immune reactions. There is a significant need for alternative treatments to manage this debilitating disease,” said Maria Domenica Cappellini, M.D., professor, Internal Medicine, University of Milan, Italy. “The strong Phase 3 ENERGIZE-T results build on the positive findings from the Phase 3 ENERGIZE study in patients with non-transfusion-dependent alpha- or beta-thalassemia presented earlier this year, pointing to mitapivat as a potential transformative advancement in thalassemia care.” Phase 3 ENERGIZE-T Study Results ENERGIZE-T is a Phase 3, double-blind, randomized, placebo-controlled and multicenter 48-week study. A total of 258 patients were enrolled in the study worldwide, with 171 patients randomized to mitapivat 100 mg twice-daily (BID) and 87 patients randomized to matched placebo. The study’s primary endpoint of transfusion reduction response (TRR) was defined as a ≥50% reduction in transfused red blood cell (RBC) units with a reduction of ≥2 units of transfused RBCs in any consecutive 12-week period through Week 48 compared with baseline. A TRR was achieved by 30.4% (n=52/171) of patients in the mitapivat arm compared to 12.6% (n=11/87) of patients in the placebo arm (2-sided p=0.0003). Additionally, mitapivat demonstrated statistically significant reductions in transfusion burden compared with placebo as measured by the three key secondary endpoints of transfusion reduction response reflective of durability of response up to 36 weeks during the 48-week double-blind period. The key secondary endpoint TRR2, defined as a ≥50% reduction in transfused RBC units in any consecutive 24-week period through Week 48 compared with baseline, was achieved in 13.5% (n=23/171) versus 2.3% (n=2/87) of patients in the mitapivat and placebo arms, respectively (2-sided p=0.0003). The key secondary endpoints TRR3 and TRR4 were defined as a ≥33% and ≥50% reduction in transfused RBC units, respectively, from Week 13 through Week 48 compared with baseline. TRR3 was achieved in 14.6% (n=25/171) versus 1.1% (n=1/87) of patients in the mitapivat and placebo arms, respectively (2-sided pis philucky legit 。

Gemini – (21st May to 20th June) Daily Horoscope Prediction says, Connect the Dots Today, Gemini may find inspiration in unexpected places. Keep an open mind and be ready to adapt to changing circumstances for a fruitful day. Today encourages Geminis to stay open to new possibilities and embrace flexibility. Surprising inspirations might cross your path, so be attentive to them. Balancing personal desires with external responsibilities will bring satisfaction. Allow yourself the space to be adaptable, and you'll find opportunities for growth and success throughout the day. Gemini Love Horoscope Today: In the realm of love, today presents a chance to enhance communication with your partner. Geminis may find that listening actively can lead to a deeper understanding of their partner's needs and emotions. Single Geminis might encounter intriguing individuals through shared interests or social activities. Stay open to new experiences and interactions, as they could enrich your romantic life. Remember, showing appreciation and being attentive are keys to nurturing a loving relationship. Gemini Career Horoscope Today: At work, Geminis should focus on collaboration and effective communication. Engaging with colleagues could lead to innovative ideas and solutions. Embrace opportunities for teamwork, as they might open doors to new projects or advancements. Staying organized and adaptable will be crucial to navigating any unexpected challenges. Maintaining a positive attitude and being receptive to feedback can enhance your professional growth and help you achieve your career goals. Gemini Money Horoscope Today: Financially, Geminis should be cautious about impulsive spending today. It's a good time to review your budget and consider long-term savings goals. Being prudent and making informed decisions can lead to financial stability. Seek advice if you're unsure about investments or expenditures. By maintaining a clear focus on financial priorities, you can ensure that your resources are being used effectively, contributing to a secure financial future. Gemini Health Horoscope Today: Today is a good day for Geminis to focus on mental and physical well-being. Consider incorporating relaxation techniques, such as meditation or yoga, into your routine to reduce stress. Balancing work with leisure activities can enhance overall health. Paying attention to your body's signals is important, and ensuring adequate rest and nutrition will support your energy levels. Small, consistent efforts can lead to positive changes in your health and wellness journey. Gemini Sign Attributes Strength: Insightful, Wise, Smart, Pleasant, Quick-witted, Charming Weakness: Inconsistent, Gossipy, Lazy Symbol: Twins Element: Air Body Part: Arms & Lungs Sign Ruler: Mercury Lucky Day: Wednesday Lucky Color: Silver Lucky Number: 7 Lucky Stone: Emerald Gemini Sign Compatibility Chart Natural affinity: Aries, Leo, Libra, Aquarius Good compatibility: Gemini, Sagittarius Fair compatibility: Taurus, Cancer, Scorpio, Capricorn Less compatibility: Virgo, Pisces By: Dr. J. N. Pandey Vedic Astrology & Vastu Expert Website: www.astrologerjnpandey.com E-mail: djnpandey@gmail.com Phone: 91-9811107060 (WhatsApp Only)CATL Launches the Bedrock Chassis That Withstands 120 km/h Impact Without Catching Fire or Exploding

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Senate Republicans on Tuesday blocked an effort by Democrats to pass a bipartisan bill that would give journalists greater protections under federal law – a move that comes in the wake of President-elect Donald Trump opposing the measure. Trump called on Republicans to “kill this bill” in a Truth Social post last month. Known as the PRESS Act, the Protect Reporters from Exploitative State Spying Act would prevent the government from forcing journalists to reveal their sources and limit the seizure of their data without their knowledge. The bill passed the GOP-controlled House earlier this year. After Trump’s reelection, press advocacy groups redoubled their efforts to get the legislation signed into law before the end of President Joe Biden’s term. But the bill’s failure to pass on Tuesday comes as time is fast-running out before the Democratic president leaves office. The bill is unlikely to win 60 votes, and Senate Majority Leader Chuck Schumer has prioritized confirming judges during the lame-duck session. Government funding and a must-pass defense policy bill will also take up valuable floor time before lawmakers leave town for the winter holiday break. On Tuesday evening, Democratic Sen. Ron Wyden of Oregon went to the Senate floor and asked for unanimous consent to pass the bill. But GOP Sen. Tom Cotton of Arkansas objected, blocking the attempt. Any single senator has the power to halt a bill put forward by a unanimous consent request. The Freedom of the Press Foundation said on X that Democrats knew the move would fail and called on the chamber to cut the holiday break short if necessary to try to pass the bill. “Speeches aren’t enough. The senate has had all year to pass this bipartisan bill,” the group said. Schumer spoke in support of the bill on the floor and urged passage, calling the provisions “common sense” and “more important now than ever before when we’ve heard so many in the incoming administration talk about going after the press one way or another.” Cotton argued in remarks on the floor that the bill is a threat to US national security and said its passage would turn the Senate “into the active accomplice of deep-state leakers, traitors and criminals, along with the America-hating and fame-hungry journalists who help them out.” Earlier on Tuesday, the Reporters Committee for Freedom of the Press used the release of a Justice Department’s inspector general report into leak investigations during Trump’s first term to argue for passage of the act. “This investigation highlights the need for a reasonable, common-sense law to protect reporters and their sources,” the group’s executive director, Bruce D. Brown, said. “It’s time for Congress to pass the PRESS Act, which has overwhelming bipartisan support, to prevent government interference with the free flow of information to the public.”

FORT LAUDERDALE, Fla. (AP) — President-elect Donald Trump promised on Tuesday to “vigorously pursue” capital punishment after President Joe Biden commuted the sentences of most people on federal death row partly to stop Trump from pushing forward their executions. Trump criticized Biden’s decision on Monday to change the sentences of 37 of the 40 condemned people to life in prison without parole, arguing that it was senseless and insulted the families of their victims. Biden said converting their punishments to life imprisonment was consistent with the moratorium imposed on federal executions in cases other than terrorism and hate-motivated mass murder. “Joe Biden just commuted the Death Sentence on 37 of the worst killers in our Country,” he wrote on his social media site. “When you hear the acts of each, you won’t believe that he did this. Makes no sense. Relatives and friends are further devastated. They can’t believe this is happening!” Presidents historically have no involvement in dictating or recommending the punishments that federal prosecutors seek for defendants in criminal cases, though Trump has long sought more direct control over the Justice Department's operations. The president-elect wrote that he would direct the department to pursue the death penalty “as soon as I am inaugurated,” but was vague on what specific actions he may take and said they would be in cases of “violent rapists, murderers, and monsters.” He highlighted the cases of two men who were on federal death row for slaying a woman and a girl, had admitted to killing more and had their sentences commuted by Biden. On the campaign trail, Trump often called for expanding the federal death penalty — including for those who kill police officers, those convicted of drug and human trafficking, and migrants who kill U.S. citizens. “Trump has been fairly consistent in wanting to sort of say that he thinks the death penalty is an important tool and he wants to use it,” said Douglas Berman, an expert on sentencing at Ohio State University’s law school. “But whether practically any of that can happen, either under existing law or other laws, is a heavy lift.” Berman said Trump’s statement at this point seems to be just a response to Biden’s commutation. “I’m inclined to think it’s still in sort of more the rhetoric phase. Just, ‘don’t worry. The new sheriff is coming. I like the death penalty,’” he said. Most Americans have historically supported the death penalty for people convicted of murder, according to decades of annual polling by Gallup, but support has declined over the past few decades. About half of Americans were in favor in an October poll, while roughly 7 in 10 Americans backed capital punishment for murderers in 2007. Before Biden's commutation, there were 40 federal death row inmates compared with more than 2,000 who have been sentenced to death by states. “The reality is all of these crimes are typically handled by the states,” Berman said. A question is whether the Trump administration would try to take over some state murder cases, such as those related to drug trafficking or smuggling. He could also attempt to take cases from states that have abolished the death penalty. Berman said Trump's statement, along with some recent actions by states, may present an effort to get the Supreme Court to reconsider a precedent that considers the death penalty disproportionate punishment for rape. “That would literally take decades to unfold. It’s not something that is going to happen overnight,” Berman said. Before one of Trump's rallies on Aug. 20, his prepared remarks released to the media said he would announce he would ask for the death penalty for child rapists and child traffickers. But Trump never delivered the line. One of the men Trump highlighted on Tuesday was ex-Marine Jorge Avila Torrez, who was sentenced to death for killing a sailor in Virginia and later pleaded guilty to the fatal stabbing of an 8-year-old and a 9-year-old girl in a suburban Chicago park several years before. The other man, Thomas Steven Sanders, was sentenced to death for the kidnapping and slaying of a 12-year-old girl in Louisiana, days after shooting the girl's mother in a wildlife park in Arizona. Court records show he admitted to both killings. Some families of victims expressed anger with Biden's decision, but the president had faced pressure from advocacy groups urging him to make it more difficult for Trump to increase the use of capital punishment for federal inmates. The ACLU and the U.S. Conference of Catholic Bishops were some of the groups that applauded the decision. Biden left three federal inmates to face execution. They are Dylann Roof, who carried out the 2015 racist slayings of nine Black members of Mother Emanuel AME Church in Charleston, South Carolina; 2013 Boston Marathon bomber Dzhokhar Tsarnaev ; and Robert Bowers, who fatally shot 11 congregants at Pittsburgh’s Tree of Life Synagogue in 2018 , the deadliest antisemitic attack in U.S history. _______ Associated Press writers Jill Colvin, Michelle L. Price and Eric Tucker contributed to this report.Ukraine unveiled a new domestically-produced missile drone in early December which should significantly enhance the country’s ability to conduct airstrikes against targets deep inside Russia. Dubbed the “Peklo” (“Hell” in Ukrainian), this new addition to the Ukrainian arsenal has a reported range of 700 kilometers and can reach speeds of up to 700 kilometers per hour. In a social media post showcasing the weapon, Ukrainian President Volodymyr Zelenskyy said the first batch of Peklo missile drones had already been delivered to the Ukrainian military and had proved its combat effectiveness. “The mission now is to scale up production and deployment,” he commented. The Peklo is one of a number of long-range weapons currently being developed by Ukraine as the country seeks to boost its ability to strike targets inside Russia. Speaking in Kyiv on December 10, Zelenskyy announced that serial production of the long-range Palyanytsia missile drone was now underway, with trials of the new Ruta missile ongoing. Meanwhile, a long-range version of Ukraine’s domestically produced Neptune cruise missile is expected to become operational in the near future. The Neptune is currently best known as the weapon used to sink the flagship of Russia’s Black Sea Fleet, the Moskva, during the initial months of the Russian invasion in spring 2022. In addition to these developments, the Ukrainian Defense Ministry recently announced plans to deliver more than 30,000 long-range attack drones in 2025, with production partially financed by international partners. Since the beginning of 2024, Ukraine has conducted an extensive air offensive against Russia’s energy industry and military infrastructure using long-range drones. With domestic output now reaching record levels, the coming year is likely to witness a sharp escalation in Ukrainian attacks. As the world watches the Russian invasion of Ukraine unfold, UkraineAlert delivers the best Atlantic Council expert insight and analysis on Ukraine twice a week directly to your inbox. Ukraine’s efforts to expand the domestic production of long-range weapons reflect widespread frustration in Kyiv over restrictions imposed by the country’s Western partners on attacks inside Russia. For almost the entire war, Western leaders have prevented Ukraine from striking back against Russian targets due to concerns over possible retaliatory measures from the Kremlin. This has allowed Russia to launch attacks against Ukrainian cities and civilian infrastructure with impunity, while forcing Ukraine to effectively defend itself with one arm tied behind its back. The United States and other partners recently relaxed these restrictions and authorized some categories of Ukrainian strikes inside Russia using Western weapons. However, a number of constraints are believed to remain in place. The missiles provided to Ukraine by the country’s Western allies also have a relatively modest maximum range of up to 300 kilometers, making them of limited use against a country as vast as Russia. Many in Kyiv believe an expanded long-range arsenal is essential in order to secure a viable peace with Russia. Advocates of increased long-range strikes argue that unless Ukraine is able to bring Putin’s invasion home to Russia, the Kremlin dictator will have little reason to seek a settlement. They believe that missile attacks can weaken Russia’s military potential while also starving Putin’s war machine of funding by targeting oil refineries and other elements of the country’s economically crucial but highly vulnerable energy industry. Zelenskyy has repeatedly stressed the importance of being able to strike targets deep inside Russia, and has frequently pressed Ukraine’s allies to supply more long-range weapons. His recently presented victory plan reportedly contained one confidential segment proposing the delivery of US-made Tomahawk missiles with a range of almost 2,500 kilometers as part of a “non-nuclear deterrence package.” While this request was widely dismissed as unrealistic, it underlined the importance attached to long-range strike capabilities among officials in Kyiv as Ukrainian policymakers search for the tools to secure a lasting peace. Recent increases in the production of long-range drones and missiles come as Ukraine seeks to revive the country’s long-neglected defense industry and reduce reliance on military aid. Since the onset of Russia’s full-scale invasion almost three years ago, Ukraine has managed to dramatically increase domestic output in areas ranging from armored vehicles and artillery shells to electronic warfare equipment and naval drones. Much of this is being financed by Ukraine’s partners, who are being encouraged to place orders with Ukrainian producers. As talk turns to the possibility of a peace deal once Donald Trump returns to the White House in January 2025, Ukrainians are taking nothing for granted and are preparing for a fourth year of Europe’s largest war since World War II. They hope that by enhancing their ability to strike back inside Russia, they will be able to increase the pressure on Vladimir Putin and strengthen their own position ahead of any negotiations. Peter Dickinson is editor of the Atlantic Council’s UkraineAlert service. Further reading The views expressed in UkraineAlert are solely those of the authors and do not necessarily reflect the views of the Atlantic Council, its staff, or its supporters.

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