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ubet63 online casino register WACO, Texas (AP) — Georgia's Dasha Vidmanova and Columbia's Michael Zheng won NCAA singles tennis titles on Sunday. Vidmanova, a 21-year-old senior from the Czech Republic, beat DJ Bennett of Auburn 6-3, 6-3 for the Bulldogs' first women's singles championship since 2010. Zheng, a 20-year-old junior from Montville, New Jersey, beat Ozan Baris of Michigan State 6-2, 4-6, 6-2 to become the first Ivy League player to collect an NCAA men's singles crown since 1922. The final between Zheng and Baris was the first men's NCAA tennis singles final between two Americans since 2017. More AP tennis: https://apnews.com/hub/tennis

Georgia's Dasha Vidmanova, Columbia's Michael Zheng win NCAA singles titlesLautaro Martinez ends goal drought as Inter keep pressure on Serie A leaders

(All times Eastern) Schedule subject to change and/or blackouts Friday, Dec. 20 COLLEGE BASKETBALL (MEN’S) 4 p.m. ESPNU — Chris Paul HBCU Challenge: Norfolk St. vs. Grambling St., Uncasville, Conn. 6:30 p.m. ESPNU — Chris Paul HBCU Challenge: Delaware St. vs. Alabama St., Uncasville, Conn. 8 p.m. FOX — St. John’s at Providence 8:30 p.m. ESPNU — Cincinnati vs. Dayton, Cincinnati COLLEGE BASKETBALL (WOMEN’S) 8:30 p.m. FS1 — Ohio St. vs. Stanford, San Francisco 11 p.m. FS1 — Creighton vs. UCLA, San Francisco COLLEGE FOOTBALL Noon ESPN — The StaffDNA Cure Bowl: Ohio vs. Jacksonville St., Orlando, Fla. 3:30 p.m. ESPN2 — The Union Home Mortgage Gasparilla Bowl: Tulane vs. Florida, Tampa, Fla. 8:10 p.m. ABC — CFP First Round: Indiana at Notre Dame ESPN — CFP First Round: Indiana at Notre Dame ESPN2 — CFP First Round: Indiana at Notre Dame (Command Center) GOLF 3:30 a.m. GOLF — DP World Tour: The AfrAsia Bank Mauritius Open, Second Round, Mont Choisy Le Golf, Grand-Baie, Mauritius Noon GOLF — PGA Tour: The PNC Championship Pro-Am, Ritz-Carlton Golf Club, Orlando, Fla. 4 a.m. (Saturday) GOLF — DP World Tour: The AfrAsia Bank Mauritius Open, Third Round, Mont Choisy Le Golf, Grand-Baie, Mauritius HORSE RACING 3 p.m. FS2 — NYRA: America’s Day at the Races NBA BASKETBALL 7:30 p.m. NBATV — Milwaukee at Cleveland NBA G-LEAGUE BASKETBALL 11 a.m. ESPNU — Winter Showcase: Texas vs. Motor City, Orlando, Fla. 1 p.m. NBATV — Winter Showcase: San Diego vs. Long Island, Orlando, Fla. 1:30 p.m. ESPNU — Winter Showcase: Mexico City vs. Rip City, Orlando, Fla. 3:30 p.m. NBATV — Winter Showcase: Cleveland vs. Salt Lake, Orlando, Fla. 4 p.m. ESPNEWS — Winter Showcase: Delaware vs. Santa Cruz, Orlando, Fla. TENNIS 6 a.m. TENNIS — Next Gen ATP Finals: Round Robin 11 a.m. TENNIS — Next Gen ATP Finals: Round Robin The Associated Press created this story using technology provided by Data Skrive TV listings provided by LiveSportsOnTV .The Biden administration is preparing to initiate a trade investigation into Chinese semiconductor imports, aiming to safeguard US national security and domestic industries. The move, expected in the coming days, focuses on older-model semiconductors, which are widely used in products such as medical devices, cars, smartphones, and weaponry, according to sources familiar with the matter. Section 301 Investigation into Unfair Trade Practices Officials have debated for months whether to proceed with the probe under Section 301 , which allows the US to impose trade restrictions on countries engaging in unfair trade practices. This week, the administration agreed to move forward, marking a significant step to shield the US semiconductor industry. The inquiry could lead to tariffs or import restrictions but is unlikely to conclude until President-elect Donald Trump’s team assumes office. By initiating the investigation now, the Biden administration ensures the incoming leadership will have the option to impose measures to protect domestic semiconductor production. White House Focus on Semiconductor Industry Bolstering the US semiconductor industry has been a central focus of Biden’s economic and national security policies. The administration has taken steps to limit advanced US technology exports to China while promoting domestic chip production through significant legislative incentives. “The Biden administration’s resolve to protect national interests has paved the way for this probe,” a source indicated, underscoring the critical role semiconductors play in national security and economic competitiveness. Global Competition and Concerns over Market Disruption Over the past two years, the US has imposed export controls on advanced semiconductors produced with American and allied technology. However, China has continued to manufacture older, more accessible chips at lower costs, raising concerns that Beijing could flood global markets with inexpensive semiconductors. Officials worry this strategy could drive US and allied manufacturers out of business, undermining efforts to expand domestic semiconductor production. In May 2024 , the White House announced plans to increase tariffs on Chinese legacy semiconductors from 25% to 50% by 2025. Despite this, Biden officials determined additional measures were necessary to prevent long-term disruptions. Looking Ahead: Incoming Trump Administration The upcoming trade probe aligns with a broader effort to curtail China’s influence in global semiconductor markets. As Biden’s term concludes, his administration’s decision ensures President-elect Trump’s team will have actionable findings and the authority to impose new tariffs or restrictions. By leveraging the same trade authority Trump previously used to impose tariffs on $300 billion worth of Chinese goods, Biden’s move underscores the bipartisan concern about China’s role in global technology markets and national security. The impending investigation highlights ongoing US efforts to counter Beijing’s trade practices while promoting domestic semiconductor production. With national security at stake, the Biden administration’s decision sets the stage for the next administration to address challenges in the global semiconductor industry. Read More : Elon Musk’s Net Worth Reaches Historic $500 Billion

NEW DELHI: Power stocks were trading lower on Wednesday at 10:34AM Energy Development Company Ltd.(up 4.97%), Ravindra Energy Ltd.(up 2.41%), Power and Instrumentation(Gujarat)Ltd.(up 2.00%), Karma Energy Ltd.(up 0.85%), KEC International Ltd.(up 0.72%), India Power Corporation Ltd.(up 0.52%) and RattanIndia Power Ltd.(up 0.51%) were among the top gainers. NTPC Green Energy Ltd.(down 3.64%), Voltamp Transformers Ltd.(down 2.37%), Indowind Energy Ltd.(down 2.14%), Suzlon Energy Ltd.(down 1.97%), ACME Solar Holdings Ltd.(down 1.96%), Power Grid Corporation of India Ltd.(down 1.75%), SJVN Ltd.(down 1.73%), Hitachi Energy India Ltd.(down 1.68%), Kalpataru Projects International Ltd.(down 1.67%) and Reliance Power Ltd.(down 1.57%) were among the top losers. The NSE Nifty50 index was trading 40.25 points down at 24295.75, while the 30-share BSE Sensex was down 172.05 points at 80512.4 at around 10:34AM. Dr. Reddy's Laboratories Ltd.(up 2.44%), Cipla Ltd.(up 1.52%), Sun Pharmaceutical Industries Ltd.(up 1.4%), Tata Consumer Products Ltd.(up 1.25%), HCL Technologies Ltd.(up 1.05%), Reliance Industries Ltd.(up 0.96%), Eicher Motors Ltd.(up 0.92%), Wipro Ltd.(up 0.8%), Trent Ltd.(up 0.78%) and Tech Mahindra Ltd.(up 0.78%) were among the top gainers in the Nifty pack. 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41,715 Shares in The Kraft Heinz Company (NASDAQ:KHC) Acquired by Segall Bryant & Hamill LLC

BOCA RATON, Fla. , Dec. 17, 2024 /PRNewswire/ -- Boca Woods Country Club is thrilled to announce the grand opening of its newly redesigned Woods golf course. This momentous occasion took place on Sunday, December 8th at 12:00 PM , with a celebration and ribbon cutting ceremony marking the culmination of a remarkable $9M transformation that has captivated the attention of golf enthusiasts far and wide. More than 450 Members and distinguished guests from industry and government joined the Club for the ribbon cutting ceremony, cocktails and hors d' oeuvres. Attendees included PGA Junior Club Members standing aside past Club Presidents, sharing a commitment to excellence demonstrated by the investment to fully renovate the Woods Course. The ceremony concluded with the presentation of a lifetime Boca Woods Country Club Membership accepted by Rees Jones . The outcome of this extensive renovation: a formidable championship golf course, meticulously designed by the renowned Rees Jones and delivered through the craftsmanship of LaBar Golf. Stretching to a maximum yardage of 7,043 yards, the course boasts key risk/reward decisions for the experienced golfer while offering better playable options for those less experienced. Some key highlights of the renovation include: " The Woods course is now a true championship layout, playing to a maximum yardage of 7,043 yards." Said Jeff Gullett , Director of Golf. He continued, " Rees Jones has incorporated a combination of green complexes and bunkering that will test every golfer's ability. We are confident that our Members will be delighted with the results." The Woods golf course offers an inspired blend of challenging greens and strategically placed bunkers, promising to test the mettle of even the most seasoned golfers. The harmonious fusion of design elements guarantees a truly exceptional and unforgettable round of golf. What truly distinguishes the Woods course is its serene and secluded setting. Nestled away from the luxury homes that dot the community, the course immerses players in the tranquility of South Florida's nature, offering a respite from the hustle and bustle of everyday life. " Bryce Swanson and I are pleased that the Woods Course at Boca Woods is reopening on time and on budget. The redesign of the golf course enhances the course's playability, strategy, and variety. The remodeled golf course will provide an enjoyable and thought-provoking experience for the Members and their guests on a continuing basis. It has been a pleasure to work with all involved in this project," said Rees Jones . This renovation is particularly significant due to Boca Woods' unique position in the golfing world. With 36 holes of championship golf and a limited Membership of only 590 golfers, Boca Woods provides an unparalleled level of exclusivity and access. The newly renovated Woods course further solidifies the club's reputation as a golfer's paradise, offering a rare combination of world-class amenities and a close-knit community of passionate enthusiasts. " It is amazing to witness the evolution taking place at this Club." Says David Sweet, General Manager/ COO. He continues, "In the last four years, Members have supported the development of modern amenities: a new Clubhouse with state-of-the-art virtual meeting spaces, a sports and wellness complex that offers 10,000 sq ft of fitness, modern racquet sports facilities including lights for night play, and now this championship course developed in partnership with the best names in the business. Rees has left his mark on Boca Woods, and the Club's future is bright!" Central to the course's allure is the masterful touch of Rees Jones , whose design philosophy seamlessly integrates the natural beauty of the surroundings with the strategic demands of the game. The result is a golfing experience that is both visually captivating and intellectually stimulating. "The Rees Jones' update to our Woods Course is inspirational. Coupled with renovations designed by Kipp Schulties on the Lakes Course, we offer a small community of players a wide range of golfing opportunities. As President of Boca Woods, I am proud of what we accomplished and the time frame we worked within. We listened to our players: men and women, scratch players and weekenders... the result is 36 holes of magnificent golf course architecture that challenges the best and offers playable options for every level. Our demographics say it all (reference the generations photo), and there are tee boxes for every player at every age to enjoy. Boca Woods is setting the standard" said Howard Mittleman , Board President for Boca Woods Country Club. The renovation of the Woods golf course represents a substantial investment in elevating the club's amenities, ensuring Members have exceptional golf experiences. The comprehensive project followed a $14.5M building and facilities renovation. For more information on the new Woods golf course or to inquire about membership opportunities, please visit bocawoodscc.com . The Club foresees many future investments, including the installation of TopTracer (technology owned and used by Top Golf Entertainment Group) on the driving range, sharing information about every shot for Members through fully integrated technology inclusive of ballistics scopes delivering multiple data points for every shot. About Boca Woods Country Club Boca Woods Country Club is an established residential country club community located in Boca Raton, Florida . Membership at Boca Woods offers extraordinary value in a golf community that features two championship golf courses and all the amenities that private country club living has to offer. Boca Woods Country Club is dedicated to providing a residential country club lifestyle featuring a community and club culture characterized by friendliness, civility and respect for its members and staff in an overall setting of refinement and casual elegance. Media Contact: membership@bocawoodscc.com View original content to download multimedia: https://www.prnewswire.com/news-releases/grand-opening-of-the-rees-jones-woods-golf-course-announced-at-boca-woods-country-club-302334242.html SOURCE Boca Woods Country ClubWASHINGTON — Former House Speaker Nancy Pelosi was hospitalized after she “sustained an injury” during an official engagement in Luxembourg, according to a spokesman. Pelosi, 84, was in Europe with a bipartisan congressional delegation to mark the 80th anniversary of the Battle of the Bulge in World War II. Her spokesman, Ian Krager, said in a statement that she was “receiving excellent treatment from doctors and medical professionals” and is unable to attend the remainder of events on her trip. He did not describe the nature of her injury or give any additional details, but a person familiar with the incident said Pelosi tripped and fell at an event with the other members of Congress. The person requested anonymity to discuss the fall. Krager said Pelosi “looks forward to returning home to the U.S. soon.” Among the members on the trip was Rep. Michael McCaul, R-Texas, who posted on social media that he was “praying for a speedy recovery” for Pelosi. The two lawmakers were captured holding hands in a group photo Friday at the U.S. Embassy in Luxembourg. Get local news delivered to your inbox!

Clover Health to Participate in Upcoming 43rd Annual J.P. Morgan Healthcare Conference

WOBURN, Mass., Dec. 17, 2024 (GLOBE NEWSWIRE) -- NeuroMetrix, Inc. ("NeuroMetrix" or the "Company") NURO today announced it has entered into a definitive merger agreement whereby electroCore, Inc. ("electroCore") ECOR , a commercial stage bioelectronic medicine and wellness company, will acquire NeuroMetrix. The transaction has been unanimously approved by the Boards of Directors of both companies and is expected to close late in the first quarter of 2025. Under the terms of the merger agreement, a subsidiary of electroCore will merge with NeuroMetrix and NeuroMetrix will become a wholly owned subsidiary of electroCore. The shareholders of NeuroMetrix will be entitled to receive the equivalent of the balance of NeuroMetrix's net cash at the closing of the transaction, subject to certain adjustments and deductions. Assuming the transaction closes on March 31, 2025, NeuroMetrix estimates that the balance of net cash to be paid to its shareholders, after deduction of, among other things, transaction expenses, severance costs, and accrued liabilities, will be approximately $9M in the aggregate. The final balance of net cash will be determined at the time of closing and will be based on a formula set out in the merger agreement. NeuroMetrix shareholders will also receive one non-tradeable contingent value right (a "CVR") per share of NeuroMetrix common stock. Each CVR will represent the right to receive (i) certain future net proceeds from any divestiture of the Company's DPNCheck ® platform that is consummated prior to the closing of the transaction with electroCore and (ii) certain royalties, up to an aggregate maximum of $500,000, on net sales of prescription Quell ® products over the first two years following the closing of the transaction. "This announcement represents the culmination of our strategic review process announced in February 2024, and marks a positive outcome for the Company's shareholders. Through this transaction, we will efficiently return balance sheet cash to our shareholders while providing potential upside through the CVR," said Shai N. Gozani, M.D., Ph.D., Chairman and CEO of NeuroMetrix. "A further advantage of this transaction is that we expect patients with chronic pain to have expanded access to our novel and proprietary Quell wearable neuromodulation technology through the commercial channel that electroCore has built. Although the DPNCheck platform is not included in the acquisition, we expect to divest this business such that patients and physicians continue to benefit from its unique and important diagnostic capabilities." Consummation of the transaction is subject to approval by the shareholders of NeuroMetrix, NeuroMetrix having at least $8 million of net cash at closing, and the filing of NeuroMetrix's Form 10-K with respect to the fiscal year ended December 31, 2024, in addition to certain customary closing conditions. About NeuroMetrix NeuroMetrix is a commercial stage healthcare company that develops and commercializes neurotechnology devices to address unmet needs in the chronic pain and diabetes markets. The Company's products are wearable or hand-held medical devices enabled by proprietary consumables and software solutions that include mobile apps, enterprise software and cloud-based systems. The Company has two commercial brands. Quell ® is a wearable neuromodulation platform. DPNCheck ® is a point-of-care screening test for peripheral neuropathy. For more information, visit www.neurometrix.com . About electroCore electroCore is a commercial stage bioelectronic medicine and wellness company dedicated to improving health through its non-invasive vagus nerve stimulation ("nVNS") technology platform. Its focus is the commercialization of medical devices for the management and treatment of certain medical conditions and consumer product offerings utilizing nVNS to promote general wellbeing and human performance in the United States and select overseas markets. Safe Harbor Statement The statements contained in this press release include forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. Such forward-looking statements include information concerning possible or assumed future results of operations of the Company, the expected completion and timing of the transaction and other information relating to the transaction. Without limiting the foregoing, the words "believes," "anticipates," "plans," "expects," "intends," "forecasts," "should," "estimates," "contemplate," "future," "goal," "potential," "predict," "project," "projection," "may," "will," "could," "should," "would," "assuming" and similar expressions are intended to identify forward-looking statements. You should read statements that contain these words carefully. They discuss the Company's future expectations or state other forward-looking information and may involve known and unknown risks over which the Company has no control. While the company believes the forward-looking statements contained in this press release are accurate, there are a number of factors that could cause actual events or results to differ materially from those indicated by such forward-looking statements, including, without limitation, (i) the risk that the transaction may not be completed in a timely manner or at all, which may adversely affect the Company's business and the price of the common stock of the combined company following the merger, (ii) the failure to satisfy the conditions to the consummation of the transaction, including the adoption of the merger agreement by the stockholders of the Company and the receipt of any required regulatory approvals from various governmental entities (including any conditions, limitations or restrictions placed on these approvals) and the risk that one or more governmental entities may deny approval, (iii) the occurrence of any event, change or other circumstance that could give rise to the termination of the merger agreement, (iv) the risk that the merger agreement may be terminated in circumstances that require the Company to pay a termination fee; (v) risks regarding the failure to obtain the necessary financing to complete the merger, (vi) the effect of the announcement or pendency of the transaction on the Company's business relationships, operating results and business generally, (vii) risks that the proposed transaction disrupts current plans and operations, (viii) risks related to diverting management's attention from the Company's ongoing business operations, and (ix) the outcome of any legal proceedings that may be instituted against the Company related to the merger agreement or the transaction. . There can be no assurance that future developments will be those that the company has anticipated. Further risks that could cause actual results to differ materially from those matters expressed in or implied by such forward-looking statements are described in the company's most recent Annual Report on Form 10-K, Quarterly Reports on Form 10-Q, as well as other documents that may be filed from time to time with the Securities and Exchange Commission (the "SEC") or otherwise made public. The company is providing the information in this press release only as of the date hereof, and expressly disclaims any intent or obligation to update the information included in this press release or revise any forward-looking statements. Additional Information and Where to Find It In connection with the transaction, the Company intends to file relevant materials with the SEC, including a proxy statement on Schedule 14A. Promptly after filing its definitive proxy statement with the SEC, the Company will mail the definitive proxy statement and a proxy card to each stockholder entitled to vote at the special meeting relating to the transaction. INVESTORS AND SECURITY HOLDERS OF THE COMPANY ARE URGED TO READ THESE MATERIALS (INCLUDING ANY AMENDMENTS OR SUPPLEMENTS THERETO) AND ANY OTHER RELEVANT DOCUMENTS IN CONNECTION WITH THE TRANSACTION THAT THE COMPANY OR ELECTROCORE WILL FILE WITH THE SEC WHEN THEY BECOME AVAILABLE BECAUSE THEY WILL CONTAIN IMPORTANT INFORMATION ABOUT THE PARTIES AND THE TRANSACTION. The definitive proxy statement, the preliminary proxy statement and other relevant materials in connection with the transaction (when they become available), and any other documents filed by the Company or electroCore with the SEC, may be obtained free of charge at the SEC's website ( http://www.sec.gov ). In addition, materials filed by the Company may be obtained on the Company's website neurometrix.com, and materials filed by electroCore may be obtained on electroCore's website at www.electroCore.com . Participants in the Solicitation The Company and each of its directors and executive officers may be deemed to be participants in the solicitation of proxies from the Company's stockholders with respect to the merger. Information about the Company's directors and executive officers and their ownership of the Company's common stock is set forth in the proxy statement on Schedule 14A filed with the SEC on March 27, 2024 and the Company's Annual Report on Form 10-K for the fiscal year ended December 31, 2023 filed with the SEC on March 1, 2024. To the extent that such individual's holdings of the Company's common stock have changed since the amounts included in the Company's Annual Report on Form 10-K for the fiscal year ended December 31, 2023 filed with the SEC on March 1, 2024, such changes have been or will be reflected on Statements of Change in Ownership on Form 4 filed with the SEC. Information regarding the identity of the potential participants, and their direct or indirect interests in the merger, by security holdings or otherwise, will be set forth in the proxy statement and other materials to be filed with SEC in connection with the merger. Source: NeuroMetrix, Inc. Thomas T. Higgins SVP and Chief Financial Officer neurometrix.ir@neurometrix.com © 2024 Benzinga.com. Benzinga does not provide investment advice. All rights reserved.UConn quarterback Joe Fagnano threw for two touchdowns and the Huskies' defense overwhelmed North Carolina for a 27-14 victory in the Fenway Bowl on Saturday in Boston. Mel Brown ran for 96 yards and the Huskies (9-4) reached the nine-win level for the third time in program history. It was a miserable day for the Tar Heels (6-7), who are in transition as they await Bill Belichick, who now takes over as head coach. Freddie Kitchens served as interim coach on Saturday following Mack Brown's departure at the end of the regular season and had praise for his team despite the loss. "I commend them for everything they've done the last three weeks. We didn't really catch any breaks today," Kitchens told reporter after the game. "You've got to make your own breaks sometimes. These guys just kept fighting." North Carolina's Chris Culliver returned a kickoff 95 yards for a touchdown and backup quarterback Michael Merdinger threw for 86 yards. Six of the team's 10 first downs came in the final 11 minutes. Fagnano finished 16-for-23 for 151 yards for the Huskies, who were limited to a field goal in the second half after rolling up a 24-7 haltime lead. North Carolina lost starting quarterback Jacolby Criswell to an apparent shoulder injury on the team's second offensive series. The Tar Heels, who were without running back Omarion Hampton (going into NFL draft), didn't pick up a first down until less than 30 seconds remained in the first half, and that was followed by an interception. UConn's first points came on Chris Freeman's 32-yard field goal. Then, with 3:45 left in the quarter, Fagnano connected with Skyler Bell on a 38-yard touchdown. The Huskies led 10-0 before Culliver's ensuing kickoff return, the only glitch for UConn in the first quarter. Fifty seconds into the second quarter, Fagnano hit Alex Honig with a pass for a 4-yard touchdown. The final first-half touchdown came on running back Cam Edwards' leap into the end zone to complete a fourth-and-2 snap. That capped a 14-play drive that consumed almost six minutes. "I feel like a proud father towards this team," UConn head coach Jim Mora Jr. "We ran for 210 yards. That's how you win a football game." North Carolina, which lost its fifth consecutive bowl outing, was credited with 1 rushing yard in the first half. The Tar Heels drove 98 yards on eight plays to score on running back Caleb Hood's 17-yard pass to John Copenhaver with 6:46 left in the game. Hood rushed for a team-high 78 yards. UConn had gone 0-3 against teams from the Atlantic Coast Conference this season, but it had no trouble in snapping that streak against the Tar Heels. --Field Level MediaSeibert misses an extra point late as the Commanders lose their 3rd in a row, 34-26 to the Cowboys

Priority Technology (NASDAQ:PRTH) Shares Gap Up – What’s Next?Raw milk might be more dangerous than assumed. Researchers just found evidence that influenza viruses that end up in raw milk can infect people for almost up to a week. Scientists at Stanford University conducted the study, which aimed to quantify the threat of being exposed to influenza through contaminated milk. They found that one particular strain of influenza A virus was still infectious after five days in refrigerated raw milk. The findings suggest that raw milk is a viable transmission route for similar influenza strains—particularly bird flu viruses that are now actively spreading among dairy cows. Pasteurization is the simple and brief heating of foods and liquids to kill off microbes that can cause spoilage or food poisoning. Unsurprisingly, extensive research has shown that unpasteurized, or raw, dairy products can spread harmful germs. A 2018 study, for instance, found that raw milk and cheese products accounted for 96% of all reported foodborne illnesses traced back to dairy over a five-year span. The emergence of H5N1, a strain of highly pathogenic avian influenza A (HPAI), in dairy cows this year has made raw milk even more of a gamble. People have already found H5N1 in commercially sold raw milk products. And some animals, particularly cats living on farms, are suspected of having contracted H5N1 by drinking raw milk. But the Stanford University researchers say theirs is the first research to examine the persistence of influenza in raw milk under more real-world conditions for people. The researchers seeded raw milk samples with an H1N1 strain of influenza A. They used a starting dose of the virus similar to the doses seen in contaminated store-brand milk products (thanks to pasteurization, though, no infectious virus was found in these products). Then they kept the samples refrigerated at a typical temperature and tracked how long it took for levels of viable virus to drop off before it wouldn’t be able to infect someone any longer. They also tested how pasteurization would affect the viability of the virus. As with other research , they found that pasteurization fully removed the presence of any infectious influenza virus. But it took up to five days for the raw milk samples to no longer be infectious. “Overall, our study demonstrates that influenza viruses remain infectious in raw milk, where it could pose a significant human health risk,” the researchers wrote in their paper, published this month in the journal Environmental Science & Technology Letters . The study did look at a different strain of influenza A than H5N1. But other studies have shown that the infectiousness of both strains seems to decay at about the same rate in milk, and that influenza A viruses in general don’t differ much from each other in that respect. So H1N1 is likely a good surrogate for H5N1. As of early December , outbreaks of H5N1 among dairy cows have occurred in 16 states this year, though only California and Nevada reported cases in the past month. In the U.S., 60 human cases of H5N1 have been documented, most linked to contact with infected cows or poultry. So far, human cases have generally been mild, and the virus isn’t believed to have adapted to spread easily between people yet. But there have been more serious cases of H5N1 reported as well. And the longer these strains are allowed to spread among cows and other mammals like us, the greater the risk that a nightmare version of H5N1 will emerge and set off a widespread epidemic—a risk that’s only being amplified by the continued popularity of raw milk. About 4% of Americans are thought to consume raw dairy products at least once a year, with 1% consuming them regularly. “This work highlights the potential risk of avian influenza transmission through consumption of raw milk and the importance of milk pasteurization,” said senior researcher Alexandria Boehm in a statement from the university. Unfortunately, the very same people who love raw milk products are also likely to ignore any warning about them. Sales of raw milk have only skyrocketed since the emergence of H5N1 this year, even in the face of recalls tied to bird flu . And many adherents of raw milk continue to spread misinformation about its supposed benefits over pasteurized milk, such as it boosting people’s immunity.Need a research hypothesis? Ask AI December 19, 2024 Massachusetts Institute of Technology Engineers have developed AI frameworks to identify evidence-driven hypotheses that could advance biologically inspired materials. Facebook Twitter Pinterest LinkedIN Email Crafting a unique and promising research hypothesis is a fundamental skill for any scientist. It can also be time consuming: New PhD candidates might spend the first year of their program trying to decide exactly what to explore in their experiments. What if artificial intelligence could help? MIT researchers have created a way to autonomously generate and evaluate promising research hypotheses across fields, through human-AI collaboration. In a new paper, they describe how they used this framework to create evidence-driven hypotheses that align with unmet research needs in the field of biologically inspired materials. Published today in Advanced Materials , the study was co-authored by Alireza Ghafarollahi, a postdoc in the Laboratory for Atomistic and Molecular Mechanics (LAMM), and Markus Buehler, the Jerry McAfee Professor in Engineering in MIT's departments of Civil and Environmental Engineering and of Mechanical Engineering and director of LAMM. The framework, which the researchers call SciAgents, consists of multiple AI agents, each with specific capabilities and access to data, that leverage "graph reasoning" methods, where AI models utilize a knowledge graph that organizes and defines relationships between diverse scientific concepts. The multi-agent approach mimics the way biological systems organize themselves as groups of elementary building blocks. Buehler notes that this "divide and conquer" principle is a prominent paradigm in biology at many levels, from materials to swarms of insects to civilizations -- all examples where the total intelligence is much greater than the sum of individuals' abilities. "By using multiple AI agents, we're trying to simulate the process by which communities of scientists make discoveries," says Buehler. "At MIT, we do that by having a bunch of people with different backgrounds working together and bumping into each other at coffee shops or in MIT's Infinite Corridor. But that's very coincidental and slow. Our quest is to simulate the process of discovery by exploring whether AI systems can be creative and make discoveries." Automating good ideas As recent developments have demonstrated, large language models (LLMs) have shown an impressive ability to answer questions, summarize information, and execute simple tasks. But they are quite limited when it comes to generating new ideas from scratch. The MIT researchers wanted to design a system that enabled AI models to perform a more sophisticated, multistep process that goes beyond recalling information learned during training, to extrapolate and create new knowledge. The foundation of their approach is an ontological knowledge graph, which organizes and makes connections between diverse scientific concepts. To make the graphs, the researchers feed a set of scientific papers into a generative AI model. In previous work, Buehler used a field of math known as category theory to help the AI model develop abstractions of scientific concepts as graphs, rooted in defining relationships between components, in a way that could be analyzed by other models through a process called graph reasoning. This focuses AI models on developing a more principled way to understand concepts; it also allows them to generalize better across domains. "This is really important for us to create science-focused AI models, as scientific theories are typically rooted in generalizable principles rather than just knowledge recall," Buehler says. "By focusing AI models on 'thinking' in such a manner, we can leapfrog beyond conventional methods and explore more creative uses of AI." For the most recent paper, the researchers used about 1,000 scientific studies on biological materials, but Buehler says the knowledge graphs could be generated using far more or fewer research papers from any field. With the graph established, the researchers developed an AI system for scientific discovery, with multiple models specialized to play specific roles in the system. Most of the components were built off of OpenAI's ChatGPT-4 series models and made use of a technique known as in-context learning, in which prompts provide contextual information about the model's role in the system while allowing it to learn from data provided. The individual agents in the framework interact with each other to collectively solve a complex problem that none of them would be able to do alone. The first task they are given is to generate the research hypothesis. The LLM interactions start after a subgraph has been defined from the knowledge graph, which can happen randomly or by manually entering a pair of keywords discussed in the papers. In the framework, a language model the researchers named the "Ontologist" is tasked with defining scientific terms in the papers and examining the connections between them, fleshing out the knowledge graph. A model named "Scientist 1" then crafts a research proposal based on factors like its ability to uncover unexpected properties and novelty. The proposal includes a discussion of potential findings, the impact of the research, and a guess at the underlying mechanisms of action. A "Scientist 2" model expands on the idea, suggesting specific experimental and simulation approaches and making other improvements. Finally, a "Critic" model highlights its strengths and weaknesses and suggests further improvements. "It's about building a team of experts that are not all thinking the same way," Buehler says. "They have to think differently and have different capabilities. The Critic agent is deliberately programmed to critique the others, so you don't have everybody agreeing and saying it's a great idea. You have an agent saying, 'There's a weakness here, can you explain it better?' That makes the output much different from single models." Other agents in the system are able to search existing literature, which provides the system with a way to not only assess feasibility but also create and assess the novelty of each idea. Making the system stronger To validate their approach, Buehler and Ghafarollahi built a knowledge graph based on the words "silk" and "energy intensive." Using the framework, the "Scientist 1" model proposed integrating silk with dandelion-based pigments to create biomaterials with enhanced optical and mechanical properties. The model predicted the material would be significantly stronger than traditional silk materials and require less energy to process. Scientist 2 then made suggestions, such as using specific molecular dynamic simulation tools to explore how the proposed materials would interact, adding that a good application for the material would be a bioinspired adhesive. The Critic model then highlighted several strengths of the proposed material and areas for improvement, such as its scalability, long-term stability, and the environmental impacts of solvent use. To address those concerns, the Critic suggested conducting pilot studies for process validation and performing rigorous analyses of material durability. The researchers also conducted other experiments with randomly chosen keywords, which produced various original hypotheses about more efficient biomimetic microfluidic chips, enhancing the mechanical properties of collagen-based scaffolds, and the interaction between graphene and amyloid fibrils to create bioelectronic devices. The system was able to come up with these new, rigorous ideas based on the path from the knowledge graph," Ghafarollahi says. "In terms of novelty and applicability, the materials seemed robust and novel. In future work, we're going to generate thousands, or tens of thousands, of new research ideas, and then we can categorize them, try to understand better how these materials are generated and how they could be improved further." Going forward, the researchers hope to incorporate new tools for retrieving information and running simulations into their frameworks. They can also easily swap out the foundation models in their frameworks for more advanced models, allowing the system to adapt with the latest innovations in AI. "Because of the way these agents interact, an improvement in one model, even if it's slight, has a huge impact on the overall behaviors and output of the system," Buehler says. Since releasing a preprint with open-source details of their approach, the researchers have been contacted by hundreds of people interesting in using the frameworks in diverse scientific fields and even areas like finance and cybersecurity. "There's a lot of stuff you can do without having to go to the lab," Buehler says. "You want to basically go to the lab at the very end of the process. The lab is expensive and takes a long time, so you want a system that can drill very deep into the best ideas, formulating the best hypotheses and accurately predicting emergent behaviors. Our vision is to make this easy to use, so you can use an app to bring in other ideas or drag in datasets to really challenge the model to make new discoveries." Story Source: Materials provided by Massachusetts Institute of Technology . Original written by Zach Winn. Note: Content may be edited for style and length. Journal Reference : Cite This Page :