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CARLSBAD, Calif. , Dec. 19, 2024 /PRNewswire/ -- Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) announced today that the U.S. Food and Drug Administration (FDA) has approved TRYNGOLZATM (olezarsen) as an adjunct to diet to reduce triglycerides in adults with familial chylomicronemia syndrome (FCS), a rare, genetic form of severe hypertriglyceridemia (sHTG) that can lead to potentially life-threatening acute pancreatitis (AP). TRYNGOLZA is the first-ever FDA-approved treatment that significantly and substantially reduces triglyceride levels in adults with FCS and provides clinically meaningful reduction in AP events when used with an appropriate diet (≤20 grams of fat per day). TRYNGOLZA is self-administered via an auto-injector once monthly. Experience the full interactive Multichannel News Release here: https://www.multivu.com/ionis-pharmaceuticals/9295551-en-tryngolza-olezarsen-fda-approval "Today's FDA approval of TRYNGOLZA heralds the arrival of the first-ever FCS treatment in the U.S. – a transformational moment for patients and their families. For the first time, adults with FCS can now access a treatment that substantially reduces triglycerides and the risk of debilitating and potentially life-threatening acute pancreatitis," said Brett P. Monia , Ph.D., chief executive officer, Ionis. "We are proud of our long-standing partnership with the FCS community and are grateful to the patients, families and investigators who participated in our clinical studies, enabling Ionis to make this new treatment a reality. The FDA approval of TRYNGOLZA is also a pivotal moment for Ionis, representing our evolution into a fully integrated commercial-stage biotechnology company – a goal we set out to achieve five years ago. With our rich pipeline of potentially life-changing medicines, we expect TRYNGOLZA to be the first in a steady cadence of innovative medicines we will deliver independently to people living with serious diseases." The FDA approval was based on positive data from the global, multicenter, randomized, placebo-controlled, double-blind Phase 3 Balance clinical trial in adult patients with genetically identified FCS and fasting triglyceride levels ≥880 mg/dL. In the Balance study, TRYNGOLZA 80 mg demonstrated a statistically significant placebo-adjusted mean reduction in triglyceride levels of 42.5% from baseline to six months (p=0.0084). Reductions from baseline to 12 months were further improved, with TRYNGOLZA achieving a placebo-adjusted 57% mean reduction in triglycerides. TRYNGOLZA also demonstrated a substantial, clinically meaningful reduction in AP events over 12 months; one patient (5%) experienced one episode of AP in the TRYNGOLZA group compared with seven patients (30%) who experienced 11 total episodes of AP in the placebo group. TRYNGOLZA demonstrated a favorable safety profile. The most common adverse reactions (incidence >5% of TRYNGOLZA-treated patients and at a >3% higher frequency than placebo) were injection site reactions (19% and 9%, respectively), decreased platelet count (12% and 4%, respectively) and arthralgia (9% and 0%, respectively). Results from the Phase 3 Balance study were previously published in The New England Journal of Medicine (NEJM). "With no treatment options previously available, we were limited to relying only on extremely strict diet and lifestyle changes as the sole preventative treatment option," said Alan Brown , M.D., FNLA, FACC, FAHA, clinical professor of medicine, Rosalind Franklin University of Medicine and Science ; Balance trial investigator. "The FDA approval of TRYNGOLZA is an important moment for people living with FCS, their families and physicians who now, for the first time, have a treatment that significantly lowers triglycerides and decreases the risk of potentially life-threatening acute pancreatitis events, as an adjunct to a low-fat diet. I am excited to have a medicine I can prescribe to my patients that has been shown to change the course of their disease." FCS is a rare, genetic, potentially life-threatening form of sHTG that prevents the body from breaking down fats and severely impairs the body's ability to remove triglycerides from the bloodstream due to an impaired function of the enzyme lipoprotein lipase (LPL). While healthy levels for adults are below 150 mg/dL, people with FCS often have triglyceride levels of more than 880 mg/dL and often have a history of pancreatitis. Those living with FCS have a high risk of potentially fatal AP, which is a painful inflammation of the pancreas, and chronic health issues such as fatigue and severe, recurrent abdominal pain. People living with FCS can also experience psychological and financial stress, which can significantly impact their quality of life. In the U.S., FCS is estimated to impact up to approximately 3,000 people, the vast majority of whom remain undiagnosed. "As a rare and difficult to diagnose disease, FCS has a profound impact on the lives of patients and families. Many people living with FCS have experienced severe pain their whole lives – sometimes so intense they require lengthy hospitalization stays – and struggle through life with daily fatigue, nausea, brain fog and stomach pain," said Lindsey Sutton Bryan , co-founder and co-president, FCS Foundation. "Until now, our treatment options have been limited, relying on diet alone to try to manage triglyceride levels and keep acute pancreatitis attacks at bay. For the first time, adults with FCS have seen their hope for a treatment become a reality." TRYNGOLZA will be available in the U.S. before year end. Ionis is committed to helping people access the medicines they are prescribed and will offer a suite of services designed to meet the unique needs of the FCS community through Ionis Every StepTM. As part of Ionis Every Step , patients and healthcare providers will have access to services throughout the treatment journey provided by dedicated Patient Education Managers and Ionis Every Step Case Managers, including insurance and affordability support, as well as services and resources, such as disease and nutrition education. Visit TRYNGOLZA.com for more information. TRYNGOLZA was reviewed by the FDA under Priority Review and had previously been granted Fast Track designation for the treatment of FCS, Orphan Drug designation and Breakthrough Therapy designation. Olezarsen is undergoing review in the European Union and regulatory filings in other countries are planned. Olezarsen is currently being evaluated in three Phase 3 clinical trials – CORE, CORE2 and ESSENCE – for the treatment of sHTG. Olezarsen has not been reviewed or approved for the treatment of sHTG by regulatory authorities. Webcast Ionis will hold a webcast today at 6:45pm ET to discuss the FDA approval. Interested parties may access the webcast here . A webcast replay will be available for a limited time. About TRYNGOLZATM (olezarsen) TRYNGOLZATM (olezarsen) was approved by the U.S. Food and Drug Administration as an adjunct to diet to reduce triglycerides in adults with familial chylomicronemia syndrome (FCS). TRYNGOLZA is an RNA-targeted medicine designed to lower the body's production of apoC-III, a protein produced in the liver that is a key regulator of triglyceride metabolism. It is the only treatment currently indicated in the U.S. for FCS, a potentially life-threatening disease. For more information about TRYNGOLZA, visit TRYNGOLZA.com . IMPORTANT SAFETY INFORMATION CONTRAINDICATIONS TRYNGOLZA is contraindicated in patients with a history of serious hypersensitivity to TRYNGOLZA or any of the excipients in TRYNGOLZA. Hypersensitivity reactions requiring medical treatment have occurred. WARNINGS AND PRECAUTIONS Hypersensitivity Reactions Hypersensitivity reactions (including symptoms of bronchospasm, diffuse erythema, facial swelling, urticaria, chills and myalgias) have been reported in patients treated with TRYNGOLZA. Advise patients on the signs and symptoms of hypersensitivity reactions and instruct patients to promptly seek medical attention and discontinue use of TRYNGOLZA if hypersensitivity reactions occur. ADVERSE REACTIONS The most common adverse reactions (incidence >5% of TRYNGOLZA-treated patients and >3% higher frequency than placebo) were injection site reactions, decreased platelet count and arthralgia. Please see full Prescribing Information for TRYNGOLZA. About Familial Chylomicronemia Syndrome (FCS) FCS is a rare, genetic disease characterized by extremely elevated triglyceride levels. It is caused by impaired function of the enzyme lipoprotein lipase (LPL). Because of limited LPL production or function, people with FCS cannot effectively break down chylomicrons, lipoprotein particles that are 90% triglycerides. FCS is estimated to impact up to approximately 3,000 people in the U.S. People living with FCS are at high risk of acute pancreatitis (AP) in addition to other chronic health issues such as fatigue and severe, recurrent abdominal pain. People living with FCS are sometimes unable to work, adding to the burden of disease. About the Balance Study Balance is a global, multicenter, randomized, double-blind, placebo-controlled Phase 3 study evaluating the efficacy and safety of olezarsen in patients with FCS at six and 12 months. The primary endpoint was the percent change from baseline in fasting triglyceride levels at six months compared to placebo. Secondary endpoints included percent changes in triglyceride levels at 12 months, percent changes in other lipid parameters and adjudicated acute pancreatitis event rates over the treatment period. Following treatment and the end-of-trial assessments, patients were eligible to enter an open-label extension study to continue receiving olezarsen once every four weeks. About Ionis Pharmaceuticals, Inc. For three decades, Ionis has invented medicines that bring better futures to people with serious diseases. Ionis has discovered and developed six marketed medicines for serious diseases, including breakthrough medicines for neurologic and cardiovascular diseases. Ionis has a leading pipeline in neurology, cardiology and other areas of high patient need. As the pioneer in RNA-targeted medicines, Ionis continues to drive innovation in RNA therapies in addition to advancing new approaches in gene editing. A deep understanding of disease biology and industry-leading technology propels our work, coupled with a passion and urgency to deliver life-changing advances for patients. To learn more about Ionis, visit Ionis.com and follow us on X (Twitter) , LinkedIn and Instagram . Ionis Forward-Looking Statements This press release includes forward-looking statements regarding Ionis' business and the therapeutic and commercial potential of TRYNGOLZA, Ionis' technologies and other products in development. Any statement describing Ionis' goals, expectations, financial or other projections, intentions or beliefs is a forward-looking statement and should be considered an at-risk statement. Such statements are subject to certain risks and uncertainties, including but not limited to those related to our commercial products and the medicines in our pipeline, and particularly those inherent in the process of discovering, developing and commercializing medicines that are safe and effective for use as human therapeutics, and in the endeavor of building a business around such medicines. Ionis' forward-looking statements also involve assumptions that, if they never materialize or prove correct, could cause its results to differ materially from those expressed or implied by such forward-looking statements. Although Ionis' forward-looking statements reflect the good faith judgment of its management, these statements are based only on facts and factors currently known by Ionis. Except as required by law, we undertake no obligation to update any forward-looking statements for any reason. As a result, you are cautioned not to rely on these forward-looking statements. These and other risks concerning Ionis' programs are described in additional detail in Ionis' annual report on Form 10-K for the year ended Dec. 31, 2023 , and most recent Form 10-Q, which are on file with the SEC. Copies of these and other documents are available at www.Ionis.com . Ionis Pharmaceuticals® and TRYNGOLZATM are trademarks of Ionis Pharmaceuticals, Inc. Ionis Investor Contact: D. Wade Walke , Ph.D. info@ionis.com 760-603-2331 Ionis Media Contact: Hayley Soffer media@ionis.com 760-603-4679 View original content: https://www.prnewswire.com/news-releases/tryngolza-olezarsen-approved-in-us-as-first-ever-treatment-for-adults-living-with-familial-chylomicronemia-syndrome-as-an-adjunct-to-diet-302336747.html SOURCE Ionis Pharmaceuticals, Inc.TRYNGOLZATM (olezarsen) approved in U.S. as first-ever treatment for adults living with familial chylomicronemia syndrome as an adjunct to dietPerimeter Provides Update on Canada Postal Strike and Mailing of the Company's 2024 Annual General Meeting Materials

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Wesley Learns Book Drive: Bridging Financial Literacy Gaps 12-03-2024 10:50 PM CET | Business, Economy, Finances, Banking & Insurance Press release from: Getnews / PR Agency: Authority Titans Image: https://www.getnews.info/wp-content/uploads/2024/12/1733251785.jpg Denver, Colorado - December 3, 2024 - The Global Children Financial Literacy Foundation (GCFLF) has announced Denver Councilwoman Flor Alvidrez as the inaugural sponsor of the 2025 Annual Wesley Learns Book Drive. This initiative, led by GCFLF co-founders Chadrick Davis and Prince Dykes, aims to empower underserved communities through financial education and first-time stock ownership opportunities. The Wesley Learns Book Drive is more than a campaign-it's a movement to address critical gaps in financial education. This initiative will impact five major U.S. cities: Denver, Atlanta, New York City, Baltimore, and Washington, D.C. Denver will proudly kick off the campaign in April 2025 during Financial Literacy Month, setting the stage for transformative community involvement. Why Financial Literacy Matters: Councilwoman Flor Alvidrez, a passionate advocate for financial literacy and member of Denver's Budget & Policy Committee, expressed her enthusiasm for the program:"As a proud sponsor of the Global Children's Financial Literacy Foundation, I am thrilled to support a program helping shape the future of Denver's youth. Financial literacy is the key to success, and I hear directly from young people in our city-they want to understand money and how to save, invest, and plan for their dreams. This program not only makes learning about finances fun and accessible but also encourages Denver families to come together and have important conversations about a topic that can sometimes feel uncomfortable. We're building a stronger, more empowered Denver for future generations by fostering informed decision-making and strengthening family bonds." Image: https://lh7-rt.googleusercontent.com/docsz/AD_4nXe9n00lRfzKfy2zON-lyZJ-KhM3z3D0rForhRqDM8tcTJdEr88ETYModKaImvEXfX7maOWfU2XcJuMuQoGkIjAn85cicUHGS13cnitSobvnP0Ftk3o8iHi0Jccm_cACrkEwZIqB?key=Nd4HPBmNVJ1n2fHaexOk_lwo Photo Courtesy: Chadrick Davis & Prince Dyke / Flor Alvidrez This partnership aims to: * Donate financial literacy books to underserved children. * Create first-time shareholders, empowering young people to take their first steps into financial independence. Councilwoman Alvidrez's leadership amplifies the importance of bridging financial education gaps and ensuring all children, regardless of their background, have the tools to succeed. Wesley Learns Book Drive: Transforming Education Into Action The Wesley Learns Book Drive combines education and real-world application, providing children with engaging financial literacy resources like the Wesley Learns book series, authored by GCFLF Co-Founder Prince Dykes. Featuring iconic figures like NFL Hall of Famer Terrell Davis, the series simplifies complex financial concepts, making them accessible and inspiring for young readers. The campaign's timeline spans from October 15, 2024, to March 31, 2025, culminating with a kickoff event in Denver in April 2025. This event will spotlight community involvement and showcase the collective effort to empower the next generation through financial literacy. A National Movement with Local Impact The Wesley Learns Book Drive will reach five U.S. cities through partnerships with local city councils and community leaders. Each city will tailor the program to address its unique challenges, creating a nationwide ripple effect of empowerment and inclusion. Chadrick Davis, GCFLF Co-Founder, emphasized the campaign's importance:"This initiative is about more than books. It's about sparking conversations, building confidence, and fostering inclusion. Financial literacy is the foundation for success, and by investing in our children today, we're creating a better tomorrow for everyone." Support the 2025 Wesley Learns Book Drive The success of the 2025 Wesley Learns Book Drive relies on community support. GCFLF invites individuals, families, educators, and organizations to participate by: * Visiting the website: Visit their website to contribute to this life-changing initiative. * Volunteering: Partner with local events or sponsor a drive in your community. * Raising Awareness: Share the message through social media and community networks. About Global Children Financial Literacy Foundation (GCFLF): The Global Children Financial Literacy Foundation (GCFLF) is committed to empowering underserved communities through innovative financial education programs and first-time stock ownership opportunities. Co-founded by Chadrick Davis and Prince Dykes, the foundation bridges the gap in financial literacy by offering engaging resources and real-world applications for young people. Through initiatives like the Wesley Learns Book Drive, GCFLF fosters inclusion, confidence, and informed decision-making to build a better tomorrow for all. Stay informed about the initiative by following their updates on Facebook [ https://www.facebook.com/gcflf/ ], Instagram [ https://www.instagram.com/childrenfinancialliteracy/?hl=en ], and LinkedIn [ https://www.linkedin.com/company/global-children-financial-literacy-foundation/?viewAsMember=true ]. Media Contact Company Name: Global Children Financial Literacy Foundation (GCFLF) Contact Person: Chadrick & Prince Dykes Email: Send Email [ http://www.universalpressrelease.com/?pr=wesley-learns-book-drive-bridging-financial-literacy-gaps ] Phone: 240608-2647 Country: United States Website: http://www.gcflf.org This release was published on openPR.In the ever-evolving landscape of virtual entertainment, Palia PS is poised to revolutionize the gaming world. Envisioned by a group of avant-garde developers, this game pairs quaint village life with high-energy play in an entirely new dimension. The standout feature of Palia PS is its seamless integration of social interaction with immersive storytelling . Unlike conventional multiplayer games which often prioritize competition, Palia PS seeks to recalibrate gaming to foster genuine camaraderie among players. The game’s unique engine allows real-time, dynamic storytelling where players’ decisions reshape both personal story arcs and the broader game world. Incorporating next-generation, artificial intelligence-driven NPCs (Non-Player Characters), Palia PS ensures no two players have the same experience. These AI characters are designed not only to support gamers on their journeys but to create evolving narratives that require strategic thinking and collaboration, inviting players to reassess what they can achieve together. Moreover, Palia PS integrates innovative augmented reality (AR) elements, merging real-world settings with digital quests. Players find themselves engaging in activities that encourage them to explore their own environment, bridging the gap between virtual and real-world exploration. As speculation grows about Palia PS’s impact, players express anticipation for this harmonious blend of peaceful village life and riveting adventure. Whether this game will herald a future of more inclusive and interactive digital playgrounds remains to be seen. Nevertheless, Palia PS invites all to reconsider the potential of gaming as a truly communal experience. Discover the Future of Gaming with Palia PS: A Game-Changer in the Virtual Entertainment Landscape In the rapidly growing world of virtual entertainment, Palia PS stands out as a pioneering force set to redefine gaming experiences. Going beyond traditional gameplay, Palia PS offers a groundbreaking integration of social interaction and immersive storytelling, promising a shift towards more community-focused player engagement. Here’s a look at what makes Palia PS a revolutionary addition to the gaming sphere. Features and Innovations 1. Dynamic Storytelling Engine: One of the most notable aspects of Palia PS is its unique storytelling engine. This feature allows players’ decisions to have real-time consequences, altering personal story arcs and influencing the game’s universe. This approach creates a personalized experience, ensuring that each player’s journey is distinct. 2. Next-Generation AI-Driven NPCs: Palia PS leverages state-of-the-art artificial intelligence to create NPCs that adapt and respond to players’ actions. These advanced characters enhance the gaming experience by offering strategic narratives that encourage collaboration and thoughtful decision-making, setting new standards for interactive storytelling. 3. Augmented Reality Integration: Innovatively combining augmented reality elements, Palia PS invites players to blur the lines between their virtual adventures and real-world environments. By merging digital quests with real-life exploration, players are encouraged to engage interactively with their surroundings, offering an enriched and multifaceted gaming journey. Market Trends and Predictions The integration of social elements and immersive storytelling in Palia PS is reflective of broader trends in the gaming industry. As games increasingly prioritize player interaction and community building, Palia PS is at the forefront of this movement. It is anticipated that such innovations will lead to more collaborative and inclusive virtual platforms in the future, transforming the way we perceive and interact with digital worlds. Potential Limitations While Palia PS offers an intriguing blend of features, there are potential limitations to consider. The reliance on cutting-edge AI and AR technology requires high-performing hardware, which might limit accessibility for some players. Additionally, ensuring the robustness and bug-free performance of dynamic story engines and AR elements can pose significant development challenges. Sustainability Considerations As the gaming industry increasingly focuses on sustainability, Palia PS presents opportunities for eco-friendly gaming. By promoting real-world exploration through AR and minimizing reliance on resource-intensive graphics, such initiatives can play a role in reducing the environmental impact associated with gaming. Conclusion Palia PS is positioned to usher in a new era of gaming, one that emphasizes community, collaboration, and interaction. Its innovative features not only redefine gameplay but also encourage a reimagining of virtual spaces as communal hubs. While challenges remain, the potential impact of Palia PS on the gaming landscape is substantial, poised to influence future developments in virtual entertainment.

AP Sports SummaryBrief at 1:37 p.m. EST

NEW YORK , Dec. 3, 2024 /PRNewswire/ -- Report on how AI is driving market transformation - The global PLC software market size is estimated to grow by USD 853.2 million from 2024-2028, according to Technavio. The market is estimated to grow at a CAGR of 5.48% during the forecast period. Increasing industrial automation and digitization is driving market growth, with a trend towards adoption of edge computing and edge plc software for faster processing. However, cybersecurity concerns and the need for plc software security poses a challenge. Key market players include ABB Ltd., Beckhoff Automation, Delta Electronics Inc., Eaton Corp. Plc, Emerson Electric Co., FANUC Corp., General Electric Co., Hitachi Ltd., Honeywell International Inc., IDEC Corp., Keyence Corp., LS ELECTRIC Co. Ltd., Mitsubishi Electric Corp., OMRON Corp., Panasonic Holdings Corp., Rockwell Automation Inc., Schneider Electric SE, Siemens AG, Toshiba Corp., and Yokogawa Electric Corp.. Key insights into market evolution with AI-powered analysis. Explore trends, segmentation, and growth drivers- View Free Sample PDF Market Driver The global PLC (Programmable Logic Controllers) software market is experiencing significant growth due to the increasing adoption of edge computing technology. Edge computing allows data processing closer to the source or at the edge of the network, reducing latency and enabling faster reaction times. In industrial contexts, edge PLC software facilitates real-time data processing and control, enhancing productivity and responsiveness. Manufacturers benefit from increased processing rates, reduced cloud dependency, and decentralized decision-making. The trend is particularly relevant for time-sensitive applications, such as critical control systems and predictive maintenance, where quick action is crucial. Edge computing streamlines operations, leading to improved efficiency and reliability, fueling market growth during the forecast period. The Plc Software Market is experiencing significant trends in various industries. Cloud-based controllers are becoming popular due to their flexibility and cost-effectiveness, allowing for remote access and real-time monitoring. With the increase in global automobile sales and electric vehicle production, there is a growing demand for control systems that ensure operational efficiency, error-proofing, traceability, and safety monitoring. Manufacturing plants in sectors like automotive, steel, energy, chemical, petrochemical, oil and gas, semiconductor and electronics, and building systems require design for harsh industrial environments. Investment in industrial automation, material handling, packaging and labeling, and industrial equipment control is essential for carbon neutrality and supply chain automation. The robotics industry plays a crucial role in process control and energy management. However, cyber threats, data breaches, and system manipulations pose significant challenges, necessitating cybersecurity measures for critical infrastructure. Input and output devices, such as sensors and actuators, are vital components of automation systems. Plc Software Market offers services to address these trends and ensure operational efficiency, process control, and safety monitoring. Request Sample of our comprehensive report now to stay ahead in the AI-driven market evolution! Market Challenges The global PLC software market is experiencing significant challenges due to growing concerns over cybersecurity. With the increasing reliance on PLC systems for industrial automation and digitization, these software solutions have become attractive targets for cyberattacks. The consequences of PLC software vulnerabilities can be severe, leading to production losses, operational disruptions, and potential safety risks. To address these challenges, PLC software providers and industrial businesses must invest in security measures. This includes implementing safe coding practices, encryption, authentication systems, and regular software updates. Additionally, it's essential to establish appropriate access restrictions and secure PLC networks. In a constantly evolving threat landscape, continuous improvement and modification of security measures are necessary to stay ahead. Failure to effectively address cybersecurity issues could negatively impact confidence in PLC systems and hinder the expansion of the global PLC software market. The Plc Software Market faces various challenges in diverse industries such as automobile, steel, energy, chemical, electronic devices, building systems, and production processes. Input and output devices must be against harsh industrial environments with vibration, humidity, temperature, electrical noise, and other factors. Automation in sectors like pharmaceuticals and Industry 4.0 requires software that can handle complex processes and minimize machine downtime. Energy and power, oil and gas, pharmaceutical, food and beverages, pulp and paper industries seek Plc Software for power management, error detection, and multi-functionality. Geopolitical issues and the rise of electric vehicles (EVs) add to the market's complexity. Medium-Sized PLCs require both hardware and software solutions, while consulting and training are essential for successful implementation. Renewable energy, wind power, and smart factories are growing sectors with increasing demands for Plc Software. Discover how AI is revolutionizing market trends- Get your access now! Segment Overview This plc software market report extensively covers market segmentation by 1.1 Cloud-based 1.2 On-premises 2.1 Ladder logic 2.2 FBD 2.3 Others 3.1 North America 3.2 Europe 3.3 APAC 3.4 Middle East and Africa 3.5 South America 1.1 Cloud-based- In the global PLC (Programmable Logic Controller) software market, cloud-based deployment is gaining popularity due to its benefits such as scalability, adaptability, cost-effectiveness, and ease of use. Leading PLC software providers like Siemens, Rockwell Automation, Schneider Electric, and ABB have responded to this trend by introducing cloud-enabled solutions. For instance, Siemens offers the Simatic Automation System, which utilizes its MindSphere IoT operating system, enabling users to access cloud capabilities for data analysis and optimization. Cloud-based PLC software systems facilitate remote monitoring, real-time data analysis, and predictive maintenance, enhancing operational efficiency and minimizing downtime. These systems are particularly advantageous for managing distributed industrial installations by enabling collaboration and data sharing across multiple sites. Furthermore, cloud-based PLC software can be integrated with other cloud services, such as analytics platforms and machine learning algorithms, adding to their value proposition. The increasing demand for enhanced connectivity, scalability, and sophisticated analytics capabilities in industrial automation is driving the shift towards cloud-based deployment, fueling the growth of the global PLC software market. Download a Sample of our comprehensive report today to discover how AI-driven innovations are reshaping competitive dynamics Research Analysis The Plc (Programmable Logic Controller) software market caters to various industries, including Input/Output device manufacturing, Automobile, Steel, Energy, Chemical, Electronic devices, Building systems, and more. Plc software enables automation of industrial processes, improving operational efficiency and reducing machine downtime. It plays a crucial role in power management and error detection in harsh industrial environments. With multi-functionality, Plc software supports industry automation, smart factories, robotics, mass customization, and geopolitical issues. It integrates with hardware, software, and services for material handling, packaging, and labeling, ensuring seamless production processes. Plc software is essential for process control in industries, enhancing the overall productivity and competitiveness of businesses. Market Research Overview The Plc Software Market encompasses a wide range of applications in various industries, including Input and Output devices, Automation in automobiles, steel, energy, chemical, and electronic devices, Building systems, Production processes, Power management, and Industrial Equipment Control. Plc Software plays a crucial role in Harsh industrial environments, ensuring design against Vibration, Humidity, Temperature, Electrical noise, and other challenging conditions. Medium-Sized PLCs, Hardware, and Software solutions cater to diverse industries like Industry 4.0, Pharmaceuticals, Renewable Energy, Wind Power, and Manufacturing plants. Plc Software offers Diagnostic laboratories, Error detection, Multi-functionality, and Industrial processes, minimizing Machine downtime and increasing Operational efficiency. Services such as Training, Maintenance, Consulting, and Energy and power management are essential components of the Plc Software Market. Geopolitical issues, Electric vehicles (EVs), Cloud-based controllers, and Flexible systems are emerging trends shaping the market's future. The Plc Software Market also addresses critical concerns like Cyber threats, Data breaches, and System manipulations, ensuring Safety Monitoring and Traceability in Supply chain automation, Robotics, and the Robotics industry. Industries like Oil and Gas, Pharmaceutical, Food and beverages, Pulp and paper, Semiconductor and Electronics, and Cybersecurity are major consumers of Plc Software solutions. The market's growth is driven by the need for automation in various sectors, operational efficiency, and the transition towards Carbon neutrality and Smart factories. Table of Contents: 1 Executive Summary 2 Market Landscape 3 Market Sizing 4 Historic Market Size 5 Five Forces Analysis 6 Market Segmentation Deployment Cloud-based On-premises Type Ladder Logic FBD Others Geography North America Europe APAC Middle East And Africa South America 7 Customer Landscape 8 Geographic Landscape 9 Drivers, Challenges, and Trends 10 Company Landscape 11 Company Analysis 12 Appendix About Technavio Technavio is a leading global technology research and advisory company. Their research and analysis focuses on emerging market trends and provides actionable insights to help businesses identify market opportunities and develop effective strategies to optimize their market positions. With over 500 specialized analysts, Technavio's report library consists of more than 17,000 reports and counting, covering 800 technologies, spanning across 50 countries. Their client base consists of enterprises of all sizes, including more than 100 Fortune 500 companies. This growing client base relies on Technavio's comprehensive coverage, extensive research, and actionable market insights to identify opportunities in existing and potential markets and assess their competitive positions within changing market scenarios. Contacts Technavio Research Jesse Maida Media & Marketing Executive US: +1 844 364 1100 UK: +44 203 893 3200 Email: [email protected] Website: www.technavio.com/ SOURCE Technavio

CARSON, Calif. — The LA Galaxy and the New York Red Bulls have been Major League Soccer mainstays since the league's inaugural season in 1996, signing glamorous players and regularly competing for championships through years of success and setbacks in a league that's perpetually improving and expanding. Yet just a year ago, both of these clubs appeared to be a very long way from the stage they'll share Saturday in the MLS Cup Final. The Galaxy were one of MLS' worst teams after a season of internal turmoil and public fan dissent, while the Red Bulls were merely a steady mediocrity seeking yet another coach to chart a new direction. A year later, these MLS founders are meeting in the league's first Cup final between teams from North America's two biggest markets. "Two original clubs being able to put themselves in this situation, I think it's great," Galaxy coach Greg Vanney said. "To see two clubs that have been at it as long as this league has been around be here, I think it's a special moment. Couldn't be two more different and contrasting styles as well, which could make for an interesting game, and I would imagine a high-intensity game." Everything changed in 2024 after a dismal decade for the Galaxy, who are favored to cap their transformation by winning their team's record sixth MLS championship with a roster that's dramatically different from its past few groups — albeit with one massive injury absence in the final. The transformation of the Red Bulls happened only in the postseason, when a team that hadn't won a playoff game since 2017 suddenly turned into world-beaters under rookie coach Sandro Schwarz. New York struggled through the final three months of league play with only two wins before posting road playoff victories over defending champ Columbus, archrival New York City FC and conference finalist Orlando to storm into the Cup final. "We know about the history (of our club), and we know tomorrow will define what that could mean," Schwarz said Friday. "To feel the pressure for tomorrow, it's necessary, because it's a final, and without pressure it's not possible to bring the best quality on the field." The Red Bulls have never won an MLS Cup, only reaching the championship match once before. What's more, they've somehow never won a Cup in any tournament, although they've collected three Supporters' Shields for MLS' best regular-season record. The Galaxy's trophy case is large and loaded, and those five MLS Cups are on the top shelf. But not much of that team success happened in the past decade for the club that famously brought David Beckham, Zlatan Ibrahimovic, Robbie Keane, Steven Gerrard and many other international stars to Hollywood. In fact, this season has ended a grim era for the Galaxy, who haven't lost all year at their frequently renamed home stadium — which was the site of protests and boycotts just a year ago. The club's fans were tired of LA's steady underachievement and ineptitude in the front office run by team president Chris Klein, who was fired in May 2023. One year ago Thursday, the Galaxy hired Will Kuntz, a longtime Los Angeles FC executive who engineered his new club's roster transformation, most dramatically by landing new designated players Gabriel Pec and Joseph Paintsil — two international talents that LAFC also had in its sights. "I give Will and the group up there a ton of credit," Vanney said. "It's one thing to have players you like, and it's a whole other thing to get them here and get them to connect with your group." Pec and Paintsil combined for 32 goals and 27 assists while boosting the incumbent talents of striker Dejan Joveljic and Riqui Puig, the gifted Barcelona product who runs the offense from the midfield. The Galaxy clicked in the postseason, scoring a jaw-dropping 16 goals in four matches. Puig has been the Galaxy's most important player all season, but he won't be in the MLS Cup Final after tearing a knee ligament late in last week's conference final victory over Seattle. The loss of Puig — who somehow kept playing on his injured knee, and even delivered the game-winning pass to Joveljic — makes the Galaxy even more difficult to anticipate. "He played a lot in the regular season, so it was not so easy to analyze all these games now without him," Schwarz said. "But the main focus is to analyze what we need to do, because it's not clear now how they're playing without him." The Galaxy could give some of Puig's responsibilities to Marco Reus, the longtime Dortmund standout who joined LA in August. Reus is nursing a hamstring injury, but Vanney expects him to play. Get local news delivered to your inbox!Exciting Book Reading Event With Popular Author At Neighborhood Hive in Salt Lake City