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jiliplay bet TikTok Canada’s closure will make privacy probes difficult: watchdogDazostinag sodium is under clinical development by and currently in Phase I for Triple-Negative Breast Cancer (TNBC). According to GlobalData, Phase I drugs for Triple-Negative Breast Cancer (TNBC) have an 81% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. Dazostinag sodium overview Dazostinag sodium (TAK-676) is under development for the treatment of advanced or metastatic solid tumors including non-small cell lung cancer, triple-negative breast cancer (TNBC), oropharyngeal cancer, colorectal cancer and head and neck cancer squamous cell carcinoma. The drug candidate is cyclic purine dinucleotide and acts by targeting stimulator of interferon genes (STING/TMEM173). It is a new molecular entity. It is administered via intravenous route. Takeda Pharmaceutical overview (Takeda) is a global pharmaceutical company primarily engaged in the research, development, production, and commercialization of biopharmaceutical products. It provides treatment for inflammatory bowel disease, acid-related diseases, motility disorders and liver diseases; hemophilia and hereditary bleeding disorders; primary immunodeficiency and multifocal motor neuropathy; major depressive disorder and attention-deficit hyperactivity disorder; and its cancer treatment encompasses multiple myeloma, mantle cell lymphoma, non-small cell lung cancer and chronic myeloid leukemia. While the company markets its pharmaceutical products directly, it also collaborates with marketing alliance partners in worldwide. Takeda operates in various countries worldwide, including Japan, the US, Europe, Latin America, Africa, the Middle East, and the Asia Pacific region. Takeda is headquartered in Tokyo, Japan. For a complete picture of Dazostinag sodium’s drug-specific PTSR and LoA scores, This content was updated on 12 April 2024 From Blending expert knowledge with cutting-edge technology, GlobalData’s unrivalled proprietary data will enable you to decode what’s happening in your market. You can make better informed decisions and gain a future-proof advantage over your competitors. , the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article. GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s .Jefferies Financial Group Inc. (NYSE:JEF) Shares Purchased by Victory Capital Management Inc.

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On paper, Luigi Mangione had it all: wealth, intellect, athleticism, good looks. But the child of a prominent Maryland family may have spurned it all in a spasm of violence, in a killing that has mesmerized Americans. The 26-year-old was arrested Monday and charged with the murder of Brian Thompson, a health insurance chief executive and father of two who was gunned down in Manhattan last week by someone who, evidence suggests, has endured his own debilitating health crises and grew angry with the privatized US medical system. The cold-blooded killing has laid bare the deep frustration many Americans feel toward the country's labyrinthine health care system: while many have condemned the shooting, others have praised Mangione as a hero. It has also prompted considerable interest in how a young engineer with an Ivy League education could have gone off the rails to commit murder. News of his capture at a Pennsylvania McDonald's triggered an explosion of online activity, with Mangione quickly amassing new followers on social media as citizen sleuths and US media tried to understand who he is. As Americans have looked for clues about a political ideology or potential motive, a photo on his X account (formerly Twitter) includes an X-ray of an apparently injured spine. Mangione lived in Hawaii in 2022 and, according to his former roommate R.J. Martin, suffered from back pain, and was hoping to strengthen his back. After a surfing lesson, Mangione was "in bed for about a week" because of the pain, Martin told CNN. Earlier this year, Martin said, Mangione confirmed he'd had back surgery and sent him photos of the X-rays. Police said the suspect carried a hand-written manifesto of grievances in which he slammed America's "most expensive health care system in the world." "He was writing a lot about his disdain for corporate America and in particular the health care industry," New York police chief detective Joseph Kenny told ABC. According to CNN, a document recovered when Mangione was arrested included the phrase "these parasites had it coming." Meanwhile, memes and jokes proliferated, many riffing on his first name and comparing him to the "Mario Bros." video game character Luigi. Many expressed at least partial sympathy, having had their own harrowing experiences with the US health care system. "Godspeed. Please know that we all hear you," wrote one user on Facebook. Mangione hails from the Baltimore area. His wealthy Italian-American family owns local businesses, including the Hayfields Country Club, according to local outlet the Baltimore Banner, and cousin Nino Mangione is a Maryland state delegate. A standout student, Luigi graduated at the top of his high school class in 2016. A former student who knew Mangione at the elite Gilman School told AFP the suspect struck him as "a normal guy, nice kid." "There was nothing about him that was off, at least from my perception," the person said. Mangione attended the prestigious University of Pennsylvania, where he completed both a bachelor's and master's degree in computer science by 2020, according to a university spokesperson. While at Penn, Mangione co-led a group of 60 undergraduates who collaborated on video game projects, as noted in a now-deleted university webpage. On Instagram Mangione shared snapshots of his travels, and shirtless images of himself flaunting a six-pack. X users have scoured Mangione's posts for potential motives. His header photo includes an X-ray of a spine with bolts attached. Finding a political ideology that fits neatly onto the right-left divide has proved elusive, though he had written a review of Ted Kaczynski's manifesto on online site Goodreads, calling it "prescient." Kaczynski, known as the Unabomber, carried out multiple bombings in the United States from 1978 to 1995, in a campaign he said was aimed at halting the advance of modern society and technology. Mangione has also linked approvingly to posts criticizing secularism as a harmful consequence of Christianity's decline, and retweeted posts on the impact mobile phones and social media have on mental health. ia/abo-mlm/nro

Argentina's Racing wins its first Copa Sudamericana championship by beating Brazil's Cruzeiro 3-1Fifteen minutes before the doors opened Friday morning, a dozen people waited outside the Rapid City Public Library. Young children holding their parent's hand. Elderly patrons with a cane in one hand and a book in the other. Some carried bags of books, backpacks and laptops. The two-story building on Quincy Street in downtown Rapid City offers more than just books — it's a community hub, a shelter for knowledge regardless of class, status or ability to pay — and a free one at that. The entrance to the Rapid City Public Library at 610 Quincy St. The Rapid City Public Library saw nearly a million items checked out in 2023, according to its most recent annual report. Darsha Dodge, Journal staff "I talk to people in the community and they'll say, 'Well, I haven't been to the library since I had young kids taking them to story time,' and I'm like, 'You really need to come and check it out,' because we are always evolving to meet our community's needs," said Laurinda Tapper, public relations coordinator for the library. That evolution has expanded the library far beyond books. Patrons in Rapid City can check out books, of course, but also puzzles, board games and video games. There are kits — everything from tools to fishing rods to disc golf sets — available for use. A makerspace houses specialized equipment like 3D printers, laser engravers and lamination machines. The makerspace at Rapid City Public Library, which includes laser engravers and a 3D printer. Darsha Dodge, Journal staff Computers and free wifi are available throughout the facility, and librarians can help users create emails, cover letters and utilize a number of research databases. Visitors can obtain free state park passes and Journey Museum passes, free notary services and test proctoring, as well as attend numerous free events year-round. South Dakota has 130 public library outlets, including 106 central libraries, 18 branches and six bookmobiles. According to data from the 2023 South Dakota Library Services Survey , South Dakotans checked out 5.5 million items and accessed the internet from library computers and wifi 1.7 million times. The same data showed state libraries hosted more than 290,000 people at 15,000 programs — and 66% of those attending in-person events were children. The Rapid City Public Library alone saw nearly a million items checked out in 2023, according to its annual report , along with issuing 4,100 new library cards and almost doubling attendance at community events. In her proposed Fiscal Year 2026 budget , Gov. Kristi Noem asked the state legislature to cut funding to the State Library, which falls under the state Department of Education, by $1,030,267. She also asked to cut full-time employees by 12.5; the State Library only employs 19 people. An excerpt from Gov. Kristi Noem's proposed FY2026 budget showing her plan to cut 12 full-time employees from the State Library. South Dakota Bureau of Finance and Management According to the State Library's Five Year Plan , 57% of the state's libraries serve communities of less than 2,500. Eighty-three percent are automated, but only 73% have online catalogs connected to the internet. "By cutting library funding, we are not considering the educational needs of kids kindergarten all the way through college," Tapper said. "In these smaller schools, in these smaller libraries, the research databases that the State Library funds, that is all they have access to. Google is not enough to meet these needs, and without these, there is going to be a cut in education." Data from the State Library shows local governments contributed $32.8 million to library funding in 2023. Rapid City Mayor Jason Salamun proposed $4,480,084 for the local library in his 2025 budget presentation , a 1.86% increase over 2024. Should the state slash library funding, Rapid City will see a significant impact in the state's courier service — the coordination of materials between larger and smaller library collections statewide. "Consider these smaller libraries. They're losing their databases; they're losing access to materials," Tapper said. "So it is actually going to really isolate those smaller communities and deprive them access to education and resources, and this is going to have a huge impact to our community." "We shouldn't teach great books, we should teach a love of reading" reads a quote from B.F. Skinner displayed at the Rapid City Public Library. Darsha Dodge, Journal staff Noem's budget proposal is just a recommendation. State legislators will convene in Pierre for the 100th legislative session beginning Tuesday, Jan. 14. A vehicle downtown spreads Thanksgiving cheer on Thursday morning. Darsha Dodge, Journal staff Darsha Dodge, Journal staff Snow greeted Rapid City residents on Thanksgiving morning. Darsha Dodge, Journal staff Darsha Dodge, Journal staff Darsha Dodge, Journal staff Expect temperatures in the mid-30s to lower 40s this weekend. More snow is possible on Thursday, according to AccuWeather. Darsha Dodge, Journal staff Darsha Dodge, Journal staff Lyndon B. Johnson braves the snow while wearing a stocking cap on Thursday, Nov. 29 in downtown Rapid City. Darsha Dodge, Journal staff Darsha Dodge, Journal staff Darsha Dodge, Journal staff Darsha Dodge, Journal staff Darsha Dodge, Journal staff Darsha Dodge, Journal staff Darsha Dodge, Journal staff Darsha Dodge, Journal staff Darsha Dodge, Journal staff Darsha Dodge, Journal staff(The Center Square) – Paula Scanlan is hopeful the narrative around gender ideology is shifting, especially as Republicans prepare for majorities in both chambers of the 119th Congress and a seat in the White House. “I am hopeful that with the majorities now that we will be able to get across the finish line,” Scanlan told The Center Square on Thursday, speaking of more legislation on the way to protect women's spaces. “Obviously, this goes beyond sports ... So ideally, I think that the biggest thing would be to federally pass something that says this is what a woman is.” Javascript is required for you to be able to read premium content. Please enable it in your browser settings.