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Pat Riley spoke out loud and clear about Jimmy Butler's NBA futureGUJRAT: A month-long faculty training workshop successfully concluded here at Hafiz Hayat Campus of the University of Gujrat on Thursday. Organized by the ORIC, in collaboration with the Higher Education Commission (HEC) of Pakistan’s National Academy for Higher Education (NAHE), the workshop – ‘National Outreach Program for Higher Education Faculty’ – was a part of HEC’s extensive faculty development training series. Vice Chancellor Prof. Dr Muhammad Mushahid Anwar was the chief guest of the closing ceremony. Other distinguished guests included NAHE Director Suleman Ahmed, Deputy Director Muhammad Saleem Qamar, UoG faculty deans, and participating teachers. The event was hosted by ORIC Director Prof. Dr Audil Rashid. The workshop focussed on enhancing the mental, intellectual and technical capabilities of UoG faculty members, enabling them to deliver high-quality education amid rapidly changing technological landscapes. As many as 30 faculty members from various departments participated in diverse teaching exercises and practical activities, improving their skills and abilities. Emphasizing that teaching at a high level is a noble duty, Prof. Dr Muhammad Mushahid Anwar said teachers contribute to society by shaping the intellectual and mental framework of students, fostering positive societal change and nation-building. “An excellent teacher refines students’ leadership qualities,” he said. Suleman Ahmed stressed that the actual role of teachers is to guide students to the pinnacle of academic success, in addition to shaping their character and personality. Practical training of teachers makes the educational process more beneficial for students. Better educational and research outcomes can be guaranteed by aligning faculty skills with modern technical and vocational needs. Dr Audil Rashid underscored the significance of faculty training. “The freshness of knowledge and teaching techniques count a lot and always yield positive results for students,” Dr Audil said. He added that the feedback from teachers at the end of the training was encouraging. Dr Audil lauded the role of workshop resource persons in introducing new teaching techniques and methods to the faculty. Teacher representatives Hamad Ismail, Dr Waqas Manzoor, Saadia Noreen and Dr Shahida Basheer praised the workshop’s high-quality content and modules. Prof. Dr Muhammad Mushahid Anwar presented certificates to all the teachers upon successful completion of the workshop. Save my name, email, and website in this browser for the next time I comment. Δ document.getElementById( "ak_js_1" ).setAttribute( "value", ( new Date() ).getTime() );
Report: Former Nebraska coach Scott Frost returns to UCF as head coachMathias Brunet Makes a Big Statement on Patrik Laine, and There's an Update on His Injury
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Malik Moore goes for 30, Grizzlies fall on the road to St. ThomasNoneBollywood director and producer Karan Johar's mother Hiroo Johar has been admitted to the hospital due to her health deterioration. According to the information received, Hiroo Johar was admitted to Kokilaben Ambani Hospital in Mumbai on December 6. A video is going viral on social media and in this video, Karan Johar is seen leaving the hospital with his friend and popular designer Manish Malhotra. No other information about Hiroo Johar's health is yet available. Karan Johar (adsbygoogle = window.adsbygoogle || []).push({}); shares a close relationship with his mother Hiroo Johar. She has played an important role not only in Karan's personal life but also in shaping his values. Karan often acknowledges her as his anchor and guiding force. Over the years he has repeatedly expressed gratitude for the wisdom and strength she has given him, even publicly celebrating her life lessons on special occasions like his birthday. Moreover the filmmaker lives with her mother and childrean Yashi and Roohi at his Mumbai residence.
Mid-American Conference football goes all in on November weeknights for the TV viewersStock markets waver as traders weigh Trump tariffs, inflation
Louisville scores 52 second-half points to race past No. 14 Indiana 89-61 in the Battle 4 AtlantisTihar Jail Santa: Sukesh Chandrashekhar’s Christmas surprise for Jacqueline could be the most expensive gift everVisionary design coupled with stunning views across the Brisbane River puts Teneriffe Banks in a class of its own. On its launch day, Teneriffe Banks shattered Queensland’s record for the highest single-day sales , with an astonishing $285 million worth of apartments sold. This followed a highly effective Expressions of Interest campaign, with over 4,800 registrations prior to launch. The development has captured the attention of discerning buyers seeking the highest levels of luxury and lifestyle. Located at 17-27 Skyring Terrace, on Brisbane’s last undeveloped riverfront site, Teneriffe Banks offers over 200 luxury apartments, priced from $1 million to an epic $25 million. Drawing inspiration from Teneriffe’s iconic wool stores, this $1.5 billion project features five distinct architecturally designed buildings within thoughtfully planned parkland and laneways. Design-led by award-winning Melbourne developer Kokoda Property Group, Teneriffe Banks is brought to life through a collaboration with Studio McCue, Cottee Parker, Carr, Urbis, and Eckersley Garden Architecture. The precinct will comprise four residential buildings and a five-star international hotel, The Kimpton, all atop a vibrant riverside dining and retail precinct. This record-breaking development has captured the attention of Brisbane buyers. Teneriffe Banks’ residential offering includes: The Interloom, The Skyline, The Ferry Building, The Store Houses and within them, The Store House Lofts – expansive double storey warehouse loft-conversion style residences. Each building features luxury apartments and penthouses, with resort-style living as part of the every-day, complete with private dining rooms, rooftop pools, spas, and social and wellness areas. "The interior design throughout the precinct thoughtfully integrates with its surroundings in Teneriffe, bringing together the water and urban environment," says Kokoda Property Group founder and managing director, Mark Stevens. "The natural stone used throughout, with its rippling movement, mirrors the flow of the nearby river, creating a cohesive look that enhances the buildings’ connection to their picturesque setting." Although each building has its own character, Stevens explains they'll all blend beautifully. "There's a strong connection between the architecture and interior design across the entire masterplan, creating unique spaces where you can appreciate the scale, detail, and your own place within the precinct," he says. Following the unprecedented sales success for the first release; The Interloom and The Skyform buildings, the precinct's most anticipated building, The Ferry Building, has just been released. Here's the breakdown of each building for interested buyers: Offering riverfront luxury living and positioned adjacent to the Kimpton Hotel, the building features one- to four-bedroom apartments, as well as penthouse collections. Its design captures the urban character and geometry of the masterplan, with apartments designed to take advantage of both city and river views. Located adjacent to the iconic Teneriffe Ferry Terminal, this tower offers expansive modernist homes with 3.6-metre ceiling heights and river views. The design blends the historic character of the wool stores with contemporary craftsmanship and apartment living. This smaller, village-scale building features eight storeys. The final release of the development is located along Skyring Terrace and offers city views. The residences include apartments, penthouses, and modern warehouse homes known as The Store House Lofts, which are situated across the lower levels. The design is a contemporary interpretation of the iconic Teneriffe warehouse, influenced by some of the world’s best post-industrial residences. Similar to The Ferry Building, this is a smaller, village-scale building with only eight storeys. Offering city-view, resort-style living, some apartments boast both city and river views. Homes include one- to three-bedroom apartments, penthouse collections, and Store House Lofts on the lower levels. The design embraces the bold, modern aesthetic of the masterplan, with carefully framed views that highlight both the city skyline and the riverfront. The array of high-calibre residences mean Brisbane buyers have ample choice. Teneriffe Banks redefines luxury living with its one, two, three, and four-bedroom apartments. Interiors feature oak timber floors, marble benches, and brushed nickel tapware, equipped with deluxe European appliances from Miele or Sub-Zero. "Each home is meticulously designed with the luxurious and elevated details that Kokoda is celebrated for," Mark adds. Residents will enjoy exclusive access to the Canopy Club, a private membership club nestled in the tree canopies overlooking the river. Inside, residents can take advantage of private dining rooms, a private bar, library, cinema, sports simulation room, boardroom, and workspaces. “The Canopy Club offers an expansive indoor and outdoor space with the quality and detail of a high-end hotel and hospitality venue," Stevens says. The five rooftops will host serene subtropical retreats with river and/or city views, including amenities such as infinity-edge pools, cabanas, saunas, hot and cold plunge pools, and yoga pods. Additionally, the riverfront will feature Brisbane's first Kimpton Hotel, complete with signature restaurants and bars, a fitness centre, meeting and event spaces, and a rooftop with stunning city views, further establishing Teneriffe as a global destination. Revolutionising the Brisbane skyline, Teneriffe Banks has broken single-day sales records. The project's design not only enhances the living experience but also integrates beautifully with the local environment, providing direct access to the Brisbane River Walk and stunning views. The development will connect Teneriffe to the river, with an extension of the River Walk along the 210m site frontage. In close proximity to the area’s dining and retail hotspots, Teneriffe Banks is a stone’s throw from the ever-popular James St, Gasworks and local gems around Teneriffe, New Farm and Newstead. This development isn't just a place to live—it’s a lifestyle revolution, blending heritage and modernity on Brisbane’s vibrant riverbank. With limited availability remaining and the highly sought-after Ferry Building already commanding swift interest, we invite you to secure an exclusive appointment to experience Teneriffe Banks within the immersive Kokoda House display. Reserve your visit now for an unparalleled opportunity before it’s too late.
Gypsy-Rose Blanchard Is Ready to Tell Her Story — Then Leave It All BehindJollof rice, a cherished culinary tradition in West Africa , boasts countless variations, each a delicious testament to the region's vibrant cultural tapestry. This savory one-pot rice delicacy, typically seasoned with tomatoes, onions, and chili peppers, holds a special place at celebrations and gatherings. With each country and individual household claiming their distinct jollof rice recipe, this versatile dish promises a unique gastronomic adventure with every serving. Nigerian jollof: A spicy delight Nigerian jollof rice packs a spicy punch with its bold, layered flavors. They use long-grain parboiled rice. It gets its bold flavor from curry powder, thyme, and ginger, with Scotch bonnet peppers serving as the real game-changer. Bay leaves are added for their distinctive fragrance. Paired with sweet fried plantains and smoky grilled chicken, it's not just a dish, but a whole meal. Ghanaian jollof: The perfect balance Ghanaian jollof rice shines with a well-rounded tomato taste and subtle smokiness, offering a less spicy but equally delicious alternative to the Nigerian version. Ghanaians opt for basmati or jasmine rice, resulting in a lighter, fluffier texture. The secret to Ghanaian jollof's depth lies in the addition of smoked fish or shrimp powder, lending a unique umami kick that sets it apart. Senegalese jollof: A cultural heritage Locally referred to as Thieboudienne , Senegalese jollof rice isn't just a dish, it is a cultural heritage of the nation. This variant is unique because it doesn't depend solely on tomato paste for its color, instead, it uses tamarind juice, which imparts a tangy taste. Additionally, it incorporates veggies like carrots, cabbage, and okra, ensuring the dish is not only flavorful but also healthy. Liberian jollof: A creamy twist The secret ingredient in Liberian jollof is coconut milk! It adds a creamy richness and hint of sweetness that sets this version apart. You'll also find a mix of meats (think chicken and beef) in Liberian jollof, but you can easily make it vegetarian by leaving these out. And, get this: Liberians love their jollof with sliced avocados on top! Talk about a refreshing twist. Tips for perfecting your jollof rice To master jollof rice, concentrate on rice choice and heat control. Opt for long-grain parboiled rice for its sturdiness in withstanding the sauce. Start cooking on high to develop flavors, then reduce to a low simmer to avoid burning the bottom. This technique guarantees evenly cooked, tasty rice without any sogginess.
100 percent of evaluable patients for minimal residual disease (MRD) testing achieved MRD negativity in MajesTEC-5 as induction therapy and MajesTEC-4 as maintenance therapy SAN DIEGO , Dec. 8, 2024 /PRNewswire/ -- Johnson & Johnson (NYSE:JNJ) today announced new frontline data featuring TECVAYLI ® (teclistamab-cqyv) from two investigational studies in patients with newly diagnosed multiple myeloma (NDMM) in induction and maintenance settings. The MajesTEC-5 ( Abstract #493 ) and MajesTEC-4 ( Abstract #494 ) studies establish the potential of TECVAYLI ® for use in newly diagnosed patients, with promising efficacy and a tolerable safety profile. These data were highlighted as oral presentations at the 2024 American Society of Hematology (ASH) Annual Meeting. 1,2 Forty-nine patients with transplant-eligible NDMM were treated with TECVAYLI ® in combination with DARZALEX FASPRO ® (daratumumab and hyaluronidase-fihj), lenalidomide and dexamethasone (Tec-DRd) or DARZALEX FASPRO ® , bortezomib, lenalidomide and dexamethasone (Tec-DVRd) as induction therapy in the MajesTEC-5 study. 1 All patients who were evaluated for MRD negativity after cycle 3 of induction therapy achieved MRD negativity (10 -5 ) and maintained through cycle 6. 1 "These data from the MajesTEC-5 study build on the growing body of evidence of TECVAYLI combinations that support the potential combinability of TECVAYLI with other effective therapies, demonstrating high rates of MRD-negative responses for evaluable patients with newly diagnosed multiple myeloma," said Rachel Kobos, M.D., Vice President, Oncology Research & Development, Johnson & Johnson Innovative Medicine. "At Johnson & Johnson, our deep expertise and understanding of multiple myeloma has shaped the regimens we're developing, including our bispecific antibodies in new combinations, and we're committed to exploring the full potential of our therapies to improve outcomes for patients." The safety profiles were manageable and consistent with individual safety profiles. 1 No treatment-emergent adverse events (TEAEs) led to study treatment discontinuation or death; cytokine release syndrome (CRS; Grade 1 or 2) occurred in 65 percent of patients. 1 No patients experienced immune effector cell-associated neurotoxicity syndrome (ICANS). 1 Grade 3/4 TEAEs included lymphopenia (43 percent), neutropenia (57 percent) and infections (35 percent). 1 "There remains opportunity to achieve even deeper and more sustained outcomes for a broader patient population in the frontline setting," said Marc S. Raab , M.D., Heidelberg University Hospital, Germany .* "These data reinforce the potential of TECVAYLI when used in earlier lines and show that TECVAYLI can be leveraged to optimize existing standard regimens in combination." Results from the safety run-in of the Phase 3 MajesTEC-4 study highlighted the potential of TECVAYLI ® to be administered as a maintenance therapy following autologous stem cell transplant (ASCT). 2 MajesTEC-4 is the first study to present data on a B-cell maturation antigen (BCMA) bispecific as monotherapy or combination therapy after ASCT. 2 Low rates of non-hematologic Grade 3/4 TEAEs and discontinuation of treatment due to all TEAEs (5.3 percent) were observed. CRS events were all Grade 1/2, mostly occurring during step-up dosing, and ICANS was not observed. Neutropenia and infections were the most common Grade 3/4 TEAEs. 2 Grade 3/4 neutropenia at 6 months showed a decreased trend in cohorts 2 and 3 with less frequent TECVAYLI ® dosing (cohort 1: 94 percent, cohort 2: 63 percent, cohort 3: 47 percent). 2 A similar trend was observed for all-grade infections (cohort 1: 94 percent; cohort 2: 78 percent; cohort 3: 77 percent). 2 All evaluable patients in cohort 1 who underwent MRD assessment after 12 months of therapy were MRD negative, and 100 percent of evaluable patients assessed in cohorts 2 and 3 were also MRD negative at cycle 6. 2 Further analysis of combination therapies will be evaluated in the Phase 3 MajesTEC-7 study, which is currently enrolling. About MajesTEC-5 Study MajesTEC-5 ( NCT05695508 ) is an ongoing, Phase 2 study of teclistamab and talquetamab, evaluating the safety and efficacy of combination regimens in participants with newly diagnosed transplant eligible multiple myeloma. 3 About MajesTEC-4 Study MajesTEC-4 ( NCT05243797 ) is an ongoing, multicenter, randomized, open-label, Phase 3 study of teclistamab in combination with lenalidomide and teclistamab alone versus lenalidomide alone in participants with newly diagnosed multiple myeloma as maintenance therapy following autologous stem cell transplantation. 4 About MajesTEC-7 Study MajesTEC-7 ( NCT05552222 ) is a Phase 3 randomized study comparing teclistamab in combination with daratumumab SC and lenalidomide (Tec-DR) and talquetamab in combination with daratumumab SC and lenalidomide (Tal-DR) versus daratumumab SC, lenalidomide, and dexamethasone (DRd) in participants with newly diagnosed multiple myeloma who are either ineligible or not intended for autologous stem cell transplant as initial therapy. 5 About TECVAYLI ® TECVAYLI ® (teclistamab-cqyv) received approval from the U.S. FDA in October 2022 as an off-the-shelf (or ready-to-use) antibody that is administered as a subcutaneous treatment for adult patients with relapsed or refractory multiple myeloma (RRMM) who have received at least four prior lines of therapy, including a proteasome inhibitor, an immunomodulatory agent and an anti-CD38 antibody. 6 The European Commission (EC) granted TECVAYLI ® conditional marketing authorization (CMA) in August 2022 as monotherapy for the treatment of adult patients with RRMM who have received at least three prior therapies, including a proteasome inhibitor, an immunomodulatory agent and an anti-CD38 antibody, and have demonstrated disease progression since the last therapy. In August 2023 , the EC granted the approval of a Type II variation application for TECVAYLI ® , providing the option for a reduced dosing frequency of 1.5 mg/kg every two weeks in patients who have achieved a complete response (CR) or better for a minimum of six months. TECVAYLI ® is a first-in-class, bispecific T-cell engager antibody therapy that uses innovative science to activate the immune system by binding to the CD3 receptor expressed on the surface of T-cells and to the B-cell maturation antigen (BCMA) expressed on the surface of multiple myeloma cells and some healthy B-lineage cells. In February 2024 , the U.S. FDA approved the supplemental Biologics License Application (sBLA) for TECVAYLI ® for a reduced dosing frequency of 1.5 mg/kg every two weeks (Q2W) in patients with relapsed or refractory multiple myeloma who have achieved and maintained a CR or better for a minimum of six months. For more information, visit www.TECVAYLI.com . About DARZALEX FASPRO ® and DARZALEX ® DARZALEX FASPRO ® (daratumumab and hyaluronidase-fihj) received U.S. FDA approval in May 2020 and is approved for nine indications in multiple myeloma, four of which are for frontline treatment in newly diagnosed patients who are transplant eligible or ineligible. It is the only subcutaneous CD38-directed antibody approved to treat patients with MM. DARZALEX FASPRO ® is co-formulated with recombinant human hyaluronidase PH20, Halozyme's ENHANZE ® drug delivery technology. DARZALEX ® is the first CD38-directed antibody approved to treat multiple myeloma. DARZALEX ® -based regimens have been used in the treatment of more than 585,000 patients worldwide and more than 239,000 patients in the U.S. alone. In August 2012 , Janssen Biotech, Inc. and Genmab A/S entered a worldwide agreement, which granted Janssen an exclusive license to develop, manufacture and commercialize daratumumab. For more information, visit https://www.darzalexhcp.com. About Multiple Myeloma Multiple myeloma is an incurable blood cancer that affects a type of white blood cell called plasma cells, which are found in the bone marrow. 7 In multiple myeloma, these plasma cells proliferate and spread rapidly and replace normal cells in the bone marrow with tumors. 8 Multiple myeloma is the third most common blood cancer worldwide and remains an incurable disease. 9 In 2024, it was estimated that more than 35,000 people will be diagnosed with multiple myeloma in the U.S. and more than 12,000 people would die from the disease. 10 People living with multiple myeloma have a 5-year survival rate of 59.8 percent. 11 While some people diagnosed with multiple myeloma initially have no symptoms, most patients are diagnosed due to symptoms that can include bone fracture or pain, low red blood cell counts, tiredness, high calcium levels and kidney problems or infections. 12,13 TECVAYLI ® IMPORTANT SAFETY INFORMATION WARNING: CYTOKINE RELEASE SYNDROME and NEUROLOGIC TOXICITY including IMMUNE EFFECTOR CELL- ASSOCIATED NEUROTOXICITY SYNDROME Cytokine release syndrome (CRS), including life-threatening or fatal reactions, can occur in patients receiving TECVAYLI ® . Initiate treatment with TECVAYLI ® step-up dosing schedule to reduce risk of CRS. Withhold TECVAYLI ® until CRS resolves or permanently discontinue based on severity. Neurologic toxicity, including Immune Effector Cell-Associated Neurotoxicity Syndrome (ICANS) and serious and life- threatening reactions, can occur in patients receiving TECVAYLI ® . Monitor patients for signs or symptoms of neurologic toxicity, including ICANS, during treatment. Withhold TECVAYLI ® until neurologic toxicity resolves or permanently discontinue based on severity. TECVAYLI ® is available only through a restricted program called the TECVAYLI ® and TALVEY ® Risk Evaluation and Mitigation Strategy (REMS). INDICATION AND USAGE TECVAYLI ® (teclistamab-cqyv) is a bispecific B-cell maturation antigen (BCMA)-directed CD3 T-cell engager indicated for the treatment of adult patients with relapsed or refractory multiple myeloma who have received at least four prior lines of therapy, including a proteasome inhibitor, an immunomodulatory agent and an anti-CD38 monoclonal antibody. This indication is approved under accelerated approval based on response rate. Continued approval for this indication may be contingent upon verification and description of clinical benefit in confirmatory trial(s). WARNINGS AND PRECAUTIONS Cytokine Release Syndrome - TECVAYLI ® can cause cytokine release syndrome (CRS), including life-threatening or fatal reactions. In the clinical trial, CRS occurred in 72% of patients who received TECVAYLI ® at the recommended dose, with Grade 1 CRS occurring in 50% of patients, Grade 2 in 21%, and Grade 3 in 0.6%. Recurrent CRS occurred in 33% of patients. Most patients experienced CRS following step-up dose 1 (42%), step-up dose 2 (35%), or the initial treatment dose (24%). Less than 3% of patients developed first occurrence of CRS following subsequent doses of TECVAYLI ® . The median time to onset of CRS was 2 (range: 1 to 6) days after the most recent dose with a median duration of 2 (range: 1 to 9) days. Clinical signs and symptoms of CRS included, but were not limited to, fever, hypoxia, chills, hypotension, sinus tachycardia, headache, and elevated liver enzymes (aspartate aminotransferase and alanine aminotransferase elevation). Initiate therapy according to TECVAYLI ® step-up dosing schedule to reduce risk of CRS. Administer pretreatment medications to reduce risk of CRS and monitor patients following administration of TECVAYLI ® accordingly. At the first sign of CRS, immediately evaluate patient for hospitalization. Administer supportive care based on severity and consider further management per current practice guidelines. Withhold or permanently discontinue TECVAYLI ® based on severity. TECVAYLI ® is available only through a restricted program under a REMS. Neurologic Toxicity including ICANS - TECVAYLI ® can cause serious or life-threatening neurologic toxicity, including Immune Effector Cell-Associated Neurotoxicity Syndrome (ICANS). In the clinical trial, neurologic toxicity occurred in 57% of patients who received TECVAYLI ® at the recommended dose, with Grade 3 or 4 neurologic toxicity occurring in 2.4% of patients. The most frequent neurologic toxicities were headache (25%), motor dysfunction (16%), sensory neuropathy (15%), and encephalopathy (13%). With longer follow-up, Grade 4 seizure and fatal Guillain-Barré syndrome (one patient each) occurred in patients who received TECVAYLI ® . In the clinical trial, ICANS was reported in 6% of patients who received TECVAYLI ® at the recommended dose. Recurrent ICANS occurred in 1.8% of patients. Most patients experienced ICANS following step-up dose 1 (1.2%), step-up dose 2 (0.6%), or the initial treatment dose (1.8%). Less than 3% of patients developed first occurrence of ICANS following subsequent doses of TECVAYLI ® . The median time to onset of ICANS was 4 (range: 2 to 8) days after the most recent dose with a median duration of 3 (range: 1 to 20) days. The most frequent clinical manifestations of ICANS reported were confusional state and dysgraphia. The onset of ICANS can be concurrent with CRS, following resolution of CRS, or in the absence of CRS. Monitor patients for signs and symptoms of neurologic toxicity during treatment. At the first sign of neurologic toxicity, including ICANS, immediately evaluate patient and provide supportive therapy based on severity. Withhold or permanently discontinue TECVAYLI ® based on severity per recommendations and consider further management per current practice guidelines. Due to the potential for neurologic toxicity, patients are at risk of depressed level of consciousness. Advise patients to refrain from driving or operating heavy or potentially dangerous machinery during and for 48 hours after completion of TECVAYLI ® step-up dosing schedule and in the event of new onset of any neurologic toxicity symptoms until neurologic toxicity resolves. TECVAYLI ® is available only through a restricted program under a REMS. TECVAYLI ® and TALVEY ® REMS - TECVAYLI ® is available only through a restricted program under a REMS called the TECVAYLI ® and TALVEY ® REMS because of the risks of CRS and neurologic toxicity, including ICANS. Hepatotoxicity - TECVAYLI ® can cause hepatotoxicity, including fatalities. In patients who received TECVAYLI ® at the recommended dose in the clinical trial, there was one fatal case of hepatic failure. Elevated aspartate aminotransferase (AST) occurred in 34% of patients, with Grade 3 or 4 elevations in 1.2%. Elevated alanine aminotransferase (ALT) occurred in 28% of patients, with Grade 3 or 4 elevations in 1.8%. Elevated total bilirubin occurred in 6% of patients with Grade 3 or 4 elevations in 0.6%. Liver enzyme elevation can occur with or without concurrent CRS. Monitor liver enzymes and bilirubin at baseline and during treatment as clinically indicated. Withhold TECVAYLI ® or consider permanent discontinuation of TECVAYLI ® based on severity. Infections - TECVAYLI ® can cause severe, life-threatening, or fatal infections. In patients who received TECVAYLI ® at the recommended dose in the clinical trial, serious infections, including opportunistic infections, occurred in 30% of patients, with Grade 3 or 4 infections in 35%, and fatal infections in 4.2%. Monitor patients for signs and symptoms of infection prior to and during treatment with TECVAYLI ® and treat appropriately. Administer prophylactic antimicrobials according to guidelines. Withhold TECVAYLI ® or consider permanent discontinuation of TECVAYLI ® based on severity. Monitor immunoglobulin levels during treatment with TECVAYLI ® and treat according to guidelines, including infection precautions and antibiotic or antiviral prophylaxis. Neutropenia - TECVAYLI ® can cause neutropenia and febrile neutropenia. In patients who received TECVAYLI ® at the recommended dose in the clinical trial, decreased neutrophils occurred in 84% of patients, with Grade 3 or 4 decreased neutrophils in 56%. Febrile neutropenia occurred in 3% of patients. Monitor complete blood cell counts at baseline and periodically during treatment and provide supportive care per local institutional guidelines. Monitor patients with neutropenia for signs of infection. Withhold TECVAYLI ® based on severity. Hypersensitivity and Other Administration Reactions - TECVAYLI ® can cause both systemic administration-related and local injection-site reactions. Systemic Reactions - In patients who received TECVAYLI ® at the recommended dose in the clinical trial, 1.2% of patients experienced systemic-administration reactions, which included Grade 1 recurrent pyrexia and Grade 1 swollen tongue. Local Reactions - In patients who received TECVAYLI ® at the recommended dose in the clinical trial, injection-site reactions occurred in 35% of patients, with Grade 1 injection-site reactions in 30% and Grade 2 in 4.8%. Withhold TECVAYLI ® or consider permanent discontinuation of TECVAYLI ® based on severity. Embryo-Fetal Toxicity - Based on its mechanism of action, TECVAYLI ® may cause fetal harm when administered to a pregnant woman. Advise pregnant women of the potential risk to the fetus. Advise females of reproductive potential to use effective contraception during treatment with TECVAYLI ® and for 5 months after the last dose. ADVERSE REACTIONS The most common adverse reactions (≥20%) were pyrexia, CRS, musculoskeletal pain, injection site reaction, fatigue, upper respiratory tract infection, nausea, headache, pneumonia, and diarrhea. The most common Grade 3 to 4 laboratory abnormalities (≥20%) were decreased lymphocytes, decreased neutrophils, decreased white blood cells, decreased hemoglobin, and decreased platelets. Please read full Prescribing Information , including Boxed WARNING, for TECVAYLI ® . DARZALEX FASPRO ® INDICATIONS AND IMPORTANT SAFETY INFORMATION INDICATIONS DARZALEX FASPRO ® (daratumumab and hyaluronidase-fihj) is indicated for the treatment of adult patients with multiple myeloma: IMPORTANT SAFETY INFORMATION CONTRAINDICATIONS DARZALEX FASPRO ® is contraindicated in patients with a history of severe hypersensitivity to daratumumab, hyaluronidase, or any of the components of the formulation. WARNINGS AND PRECAUTIONS Hypersensitivity and Other Administration Reactions Both systemic administration-related reactions, including severe or life-threatening reactions, and local injection-site reactions can occur with DARZALEX FASPRO ® . Fatal reactions have been reported with daratumumab-containing products, including DARZALEX FASPRO ® . Systemic Reactions In a pooled safety population of 1249 patients with multiple myeloma (N=1056) or light chain (AL) amyloidosis (N=193) who received DARZALEX FASPRO ® as monotherapy or in combination, 7% of patients experienced a systemic administration-related reaction (Grade 2: 3.2%, Grade 3: 0.7%, Grade 4: 0.1%). Systemic administration-related reactions occurred in 7% of patients with the first injection, 0.2% with the second injection, and cumulatively 1% with subsequent injections. The median time to onset was 2.9 hours (range: 5 minutes to 3.5 days). Of the 165 systemic administration-related reactions that occurred in 93 patients, 144 (87%) occurred on the day of DARZALEX FASPRO ® administration. Delayed systemic administration-related reactions have occurred in 1% of the patients. Severe reactions included hypoxia, dyspnea, hypertension, tachycardia, and ocular adverse reactions, including choroidal effusion, acute myopia, and acute angle closure glaucoma. Other signs and symptoms of systemic administration-related reactions may include respiratory symptoms, such as bronchospasm, nasal congestion, cough, throat irritation, allergic rhinitis, and wheezing, as well as anaphylactic reaction, pyrexia, chest pain, pruritus, chills, vomiting, nausea, hypotension, and blurred vision. Pre-medicate patients with histamine-1 receptor antagonist, acetaminophen, and corticosteroids. Monitor patients for systemic administration-related reactions, especially following the first and second injections. For anaphylactic reaction or life-threatening (Grade 4) administration-related reactions, immediately and permanently discontinue DARZALEX FASPRO ® . Consider administering corticosteroids and other medications after the administration of DARZALEX FASPRO ® depending on dosing regimen and medical history to minimize the risk of delayed (defined as occurring the day after administration) systemic administration-related reactions. Ocular adverse reactions, including acute myopia and narrowing of the anterior chamber angle due to ciliochoroidal effusions with potential for increased intraocular pressure or glaucoma, have occurred with daratumumab-containing products. If ocular symptoms occur, interrupt DARZALEX FASPRO ® and seek immediate ophthalmologic evaluation prior to restarting DARZALEX FASPRO ® . Local Reactions In this pooled safety population, injection-site reactions occurred in 7% of patients, including Grade 2 reactions in 0.8%. The most frequent (>1%) injection-site reaction was injection-site erythema. These local reactions occurred a median of 5 minutes (range: 0 minutes to 6.5 days) after starting administration of DARZALEX FASPRO ® . Monitor for local reactions and consider symptomatic management. Neutropenia Daratumumab may increase neutropenia induced by background therapy. Monitor complete blood cell counts periodically during treatment according to manufacturer's prescribing information for background therapies. Monitor patients with neutropenia for signs of infection. Consider withholding DARZALEX FASPRO ® until recovery of neutrophils. In lower body weight patients receiving DARZALEX FASPRO ® , higher rates of Grade 3-4 neutropenia were observed. Thrombocytopenia Daratumumab may increase thrombocytopenia induced by background therapy. Monitor complete blood cell counts periodically during treatment according to manufacturer's prescribing information for background therapies. Consider withholding DARZALEX FASPRO ® until recovery of platelets. Embryo-Fetal Toxicity Based on the mechanism of action, DARZALEX FASPRO ® can cause fetal harm when administered to a pregnant woman. DARZALEX FASPRO ® may cause depletion of fetal immune cells and decreased bone density. Advise pregnant women of the potential risk to a fetus. Advise females with reproductive potential to use effective contraception during treatment with DARZALEX FASPRO ® and for 3 months after the last dose. The combination of DARZALEX FASPRO ® with lenalidomide, thalidomide, or pomalidomide is contraindicated in pregnant women because lenalidomide, thalidomide, and pomalidomide may cause birth defects and death of the unborn child. Refer to the lenalidomide, thalidomide, or pomalidomide prescribing information on use during pregnancy. Interference With Serological Testing Daratumumab binds to CD38 on red blood cells (RBCs) and results in a positive indirect antiglobulin test (indirect Coombs test). Daratumumab-mediated positive indirect antiglobulin test may persist for up to 6 months after the last daratumumab administration. Daratumumab bound to RBCs masks detection of antibodies to minor antigens in the patient's serum. The determination of a patient's ABO and Rh blood type are not impacted. Notify blood transfusion centers of this interference with serological testing and inform blood banks that a patient has received DARZALEX FASPRO ® . Type and screen patients prior to starting DARZALEX FASPRO ® . Interference With Determination of Complete Response Daratumumab is a human immunoglobulin G (IgG) kappa monoclonal antibody that can be detected on both the serum protein electrophoresis (SPE) and immunofixation (IFE) assays used for the clinical monitoring of endogenous M-protein. This interference can impact the determination of complete response and of disease progression in some DARZALEX FASPRO ® -treated patients with IgG kappa myeloma protein. ADVERSE REACTIONS In multiple myeloma, the most common adverse reaction (≥20%) with DARZALEX FASPRO ® monotherapy is upper respiratory tract infection. The most common adverse reactions with combination therapy (≥20% for any combination) include fatigue, nausea, diarrhea, dyspnea, insomnia, headache, pyrexia, cough, muscle spasms, back pain, vomiting, hypertension, upper respiratory tract infection, peripheral sensory neuropathy, constipation, pneumonia, and peripheral edema. The most common hematology laboratory abnormalities (≥40%) with DARZALEX FASPRO ® are decreased leukocytes, decreased lymphocytes, decreased neutrophils, decreased platelets, and decreased hemoglobin. Please click here to see the full Prescribing Information for DARZALEX FASPRO ® . About Johnson & Johnson At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com/ or at www.innovativemedicine.jnj.com . Follow us at @JanssenUS and @JNJInnovMed . Janssen Research & Development, LLC and Janssen Biotech, Inc. are both Johnson & Johnson companies. Cautions Concerning Forward-Looking Statements This press release contains "forward-looking statements" as defined in the Private Securities Litigation Reform Act of 1995 regarding product development and the potential benefits and treatment impact of TECVAYLI ® (teclistamab-cqyv ) and DARZALEX FASPRO ® (daratumumab and hyaluronidase-fihj). The reader is cautioned not to rely on these forward-looking statements. These statements are based on current expectations of future events. If underlying assumptions prove inaccurate or known or unknown risks or uncertainties materialize, actual results could vary materially from the expectations and projections of Janssen Research & Development, LLC, Janssen Biotech, Inc., and/or Johnson & Johnson. Risks and uncertainties include, but are not limited to: challenges and uncertainties inherent in product research and development, including the uncertainty of clinical success and of obtaining regulatory approvals; uncertainty of commercial success; manufacturing difficulties and delays; competition, including technological advances, new products and patents attained by competitors; challenges to patents; product efficacy or safety concerns resulting in product recalls or regulatory action; changes in behavior and spending patterns of purchasers of health care products and services; changes to applicable laws and regulations, including global health care reforms; and trends toward health care cost containment. A further list and descriptions of these risks, uncertainties and other factors can be found in Johnson & Johnson's Annual Report on Form 10-K for the fiscal year ended December 31, 2023 , including in the sections captioned "Cautionary Note Regarding Forward-Looking Statements" and "Item 1A. Risk Factors," and in Johnson & Johnson's subsequent Quarterly Reports on Form 10-Q and other filings with the Securities and Exchange Commission. Copies of these filings are available online at www.sec.gov , www.jnj.com or on request from Johnson & Johnson. None of Janssen Research & Development, LLC, Janssen Biotech, Inc. nor Johnson & Johnson undertake to update any forward-looking statement as a result of new information or future events or developments. * Marc S. Raab , M.D., has provided consulting, advisory, and speaking services to Johnson & Johnson; he has not been paid for any media work. 1 Raab, Marc, S., et al, 493 Phase 2 Study of Teclistamab-Based Induction Regimens in Patients with Transplant-Eligible (TE) Newly Diagnosed Multiple Myeloma (NDMM): Results from the GMMG-HD10/DSMM-XX (MajesTEC-5) Trial. 2024 American Society of Hematology Annual Meeting. December 2024 . 2 Zamagni, Elena, et al., 494 Phase 3 Study of Teclistamab (Tec) in Combination with Lenalidomide (Len) and Tec Alone Versus Len Alone in Newly Diagnosed Multiple Myeloma (NDMM) As Maintenance Therapy Following Autologous Stem Cell Transplantation (ASCT): Safety Run-in (SRI) Results from the MajesTEC-4/EMN30 Trial. 2024 American Society of Hematology Annual Meeting. December 2024 . 3 GMMG-HD10 / DSMM-XX / 64007957MMY2003, MajesTEC-5 (HD10/DSMMXX). https://clinicaltrials.gov/study/NCT05695508 . Accessed November 2024 . 4 Phase 3 Study of Teclistamab in Combination With Lenalidomide and Teclistamab Alone Versus Lenalidomide Alone in Participants With Newly Diagnosed Multiple Myeloma as Maintenance Therapy Following Autologous Stem Cell Transplantation (MajesTEC-4). https://clinicaltrials.gov/study/NCT05243797 . Accessed November 2024 . 5 A Study of Teclistamab in Combination With Daratumumab and Lenalidomide (Tec-DR) and Talquetamab in Combination With Daratumumab and Lenalidomide (Tal-DR) in Participants With Newly Diagnosed Multiple Myeloma (MajesTEC-7). https://classic.clinicaltrials.gov/ct2/show/NCT05552222 . Accessed November 2024 . 6 U.S. FDA Approves TECVAYLI ® (teclistamab-cqyv), the First Bispecific T-cell Engager Antibody for the Treatment of Patients with Relapsed or Refractory Multiple Myeloma. https://www.jnj.com/u-s-fda-approves-tecvayli-teclistamab-cqyv-the-first-bispecific-t-cell-engager-antibody-for-the-treatment-of-patients-with-relapsed-or-refractory-multiple-myeloma . Accessed November 2024 . 7 Rajkumar SV. Multiple myeloma: 2020 update on diagnosis, risk-stratification and management. Am J Hematol. 2020;95(5):548-5672020;95(5):548-567. http://www.ncbi.nlm.nih.gov/pubmed/32212178 8 National Cancer Institute. Plasma Cell Neoplasms. https://www.cancer.gov/types/myeloma/patient/myeloma-treatment-pdq . Accessed November 2024 . 9 City of Hope. Multiple Myeloma: Causes, Symptoms & Treatments. https://www.cancercenter.com/cancer-types/multiple-myeloma . Accessed November 2024 . 10 American Cancer Society. Key Statistics About Multiple Myeloma. https://www.cancer.org/cancer/multiple-myeloma/about/key-statistics.html#:~:text=Multiple%20myeloma%20is%20a%20relatively,men%20and%2015%2C370%20in%20women . Accessed November 2024 . 11 SEER Explorer: An interactive website for SEER cancer statistics [Internet]. Surveillance Research Program, National Cancer Institute. https://seer.cancer.gov/explorer/ . Accessed November 2024 . 12 American Cancer Society. What is Multiple Myeloma? https://www.cancer.org/cancer/multiple-myeloma/about/what-is-multiple-myeloma.html . Accessed November 2024 . 13 American Cancer Society. Multiple Myeloma Early Detection, Diagnosis, and Staging. https://www.cancer.org/cancer/types/multiple-myeloma/detection-diagnosis-staging/detection.html . Accessed November 2024 . Media contacts: Sarah Freeman sfreem21@its.jnj.com Christie Corbett ccorbet6@its.jnj.com Investor contact: Lauren Johnson investor-relations@its.jnj.com U.S. Medical Inquiries +1 800 526-7736 View original content to download multimedia: https://www.prnewswire.com/news-releases/tecvayli-teclistamab-cqyv-demonstrates-potential-as-frontline-combination-therapy-for-patients-with-newly-diagnosed-multiple-myeloma-302325575.html SOURCE Johnson & Johnson1. The super sleek Oura ring , which connects to their smartphone to help monitor their sleep, heart rate, and various fitness goals. It's much more subtle than a bulky smartwatch, so they won't mind keeping this on 24/7. Heads up: The brand recommends buying the Oura sizing kit for $10 first to figure out which size works best — so you might want to gift the kit now to figure out the sizing! Either way, you'll get a $10 credit back for the purchase of an Oura ring! Promising review: "First of all, I love it and never leave reviews. But this needs justice. It looks like a regular ring; nobody would be able to tell the difference. The sleep tracking is super accurate, showing REM, light, and deep sleep, plus heart rate and temperature. The subscription is $6 a month, which is completely worth it, in my opinion. You get detailed info on stress, recovery, and even tips for staying in sync with your body’s natural rhythm. It’s lightweight, water-resistant, and comfy enough to wear 24/7. I never take it off. It charges extremely fast, and the battery life is amazing—I only charge mine once a week." — Ethan A. Get it from Amazon for $349 (available in sizes 9–15 and six colors). 2. A magical pen so they can bring their artwork to life in 3D! It's like Harold's purple crayon, except this hopefully won't get a terrible live-action version starring Zachary Levi. Aspiring artists can load the pen with one of the included colored sticks (they're made of plastic filaments), then press the button to release the moldable plastic and create a 3D masterpiece. Their parents might just want to get in on the fun, too! The kit includes the pen, two refill packs, an activity guide, USB cable, and a doodle pad. Promising review: "I will be the first to admit that I thought this was going to be a novelty toy that my kids used once (then it would fall by the wayside). I mean, it’s basically a glorified glue gun! To my amazement, my kids can’t get enough of it. They fight over it. They use it every single day. To be fair, there is no way a kid can make anything like the examples on the box. I realize their projects aren’t going to make it into a fine art gallery, but it keeps them busy and creative. They fix toys with the doodler and are convinced it is a magical tool that can solve any problem. I never imagined I’d be giving this 5 stars, but whoever thought of this device is a genius (and clearly knows kids better than me!) " — Casey C. Get it from Amazon for $32.99 . 3. A pair of AR sunglasses , which is basically a personal wearable TV screen only they can see. It connects to their smartphone, tablet, or laptop so they can see a projected version of the display through the glasses without having to look down. Their neck will be so grateful. It includes buttons to control brightness and focus levels. This works with most USB-C devices right out of the box, though an adapter will be needed for iPhones with lightning ports. Promising review: "I loved my first pair of VITURE glasses, but the latest iteration has blown me away! The image on the screen is even better than the original and I feel like you can really tell a difference at the edges of the screen. I’ve used them for hours at a time and have found them to be exceptionally comfortable. They have definitely helped with neck and back pain from looking down while working with a laptop in my lap. I also find them to be a great option when I need to work on a plane. I avoid the painful and awkward neck gymnastics when I try to work without them because I no longer have to lean down to try to see the screen that’s canted at a weird angle because of the seat in front of me. Another bonus is the privacy they afford while working in crowded public spaces." — James Get it from Amazon for $499 . 4. A digital notebook they can use again and again. The LCD display acts just like normal paper when they use the included stylus, so they can write to-do lists or doodle whatever creation pops into their head. Once they're done, they can hit the "erase" button to clear the "page." It's basically like an adult version of a Magna Doodle, except they won't be embarrassed to use this in a meeting. Promising review: "The boogie board is a great tool for anyone looking to save on paper while jotting down quick notes. It’s wonderful for quickly writing and erasing math problems, shopping lists, or anything in between. It’s also super affordable, making it a cute and cost-effective gift for any age." — Bradley Get it from Amazon for $16.99 (available in three colors). 5. Or a Rocketbook reusable notebook that lets them take notes they can save digitally, erase, and then use all over again. They can use the Rocketbook app to save all of their "pages" and then erase them with the included wipe. You're essentially gifting them an endless notebook. Promising review: "I am very happy with my purchase of the Rocketbook. I have it set to the side on my desk for quick scribbles when I need to make notes. It has eliminated a bunch of messy scrap pieces of paper all over the place. The pen that came with it works great (I am fussy about that); it feels like normal pen to paper. When I'm done, I just spray a bit of water and wipe clean. Great organizational tool and keeps my office neat and free of extra clutter ." — KMS Get it from Amazon for $36.13+ (available in three styles and 17 colors). 6. A high-tech planter pot for the green thumb on your list who has trouble keeping track of their plant children. The adorable display on the front lets them know how happy their plant is (i.e., if the soil is moist enough and if it's getting enough light), and it even has a self-watering feature they can control through the smartphone app. This is basically a grown-up Tamagotchi. Promising review: "I got this as a gift, and they love their Ivy planter! The digital expressions are cute and adorable, but aside from that, the size and quality of the planter itself make this an excellent planter. The app it comes with is easy to use and makes it easy to take care of your plant. I look forward to getting this for myself in the future!" — Mario Get it from Amazon for $75.04+ (available in five colors). 7. A gorgeous water bottle that keeps track of their daily water intake and glows when they're running behind on their hydration goals — because we could all use some help being a little less thirsty. It even connects with a smartphone app so they can have a snapshot of their weekly hydration habits. Promising review: This is the most amazing water bottle ever! I don’t drink water, I don’t like water. I have a health condition that requires me to drink 60+ ounces of water a day. This is coming from a person who drinks one glass of water every two weeks. When my doctor told me I had to drink 60+ ounces of water a day, I was literally freaking out. I didn’t know how to do it! So I started searching water bottles that will track what you drink because otherwise I wouldn’t know how to track my water intake. When I found this bottle, I thought, okay, I’ll give it a shot and see how it goes. It literally has changed the way I drink water. Getting on the app and connecting to the bottle was super easy. The bottle tracks your water intake, and if you’re not drinking enough, it will light up to remind you that you need to drink water. I’m really busy during the day, and most of the time, I don’t drink water, and I sure as heck don’t pay attention to my water intake. The light up reminder, which is really neat, and you get to select the color, makes you very conscious of needing to drink." — Amazon Customer Get it from Amazon for $49 (available in four colors). 8. Or a self-cleaning water bottle — it uses a UV-C LED light in the cap to help purify water and keep the inside clean. Tap the button on the top to activate, and then it'll run a cleaning cycle every two hours to keep things clean and fresh. The insulated design keeps drinks cold for 24 hours and hot for 12 hours. Promising review: "Yes, this bottle is pricey, but having purchased it for travel, I found it very comforting knowing whatever water source I was filling up from, my water would be clean due to the interior UV sanitizer. And I actually saved money instead of buying tons of plastic water bottles for a month-long trip. Highly suggest the insulated bottle, as I purchased the slightly cheaper non-insulated bottle as well, and although lighter, preferred the contents staying nice and cool while traveling through the summer." — Mike L. Get it from Amazon for $99+ (available in two sizes and seven sizes). 9. A smart bird feeder with a camera inside so they can see all the delightful visitors who stop by for a snack. It connects to the accompanying smartphone app and can send them an alert when a bird has appeared so they can see a live feed of their new flying friends. They can also save videos and photos, so be prepared to see so many bird pics on their Instagram story. Promising review: "The bird feeder is easy to assemble and very easy to set up. The motion detection is just the right amount and reliable. I enjoy getting notifications of birds at my feeder. The product is durable and not cheap feeling. This feeder brings a lot of joy to my day. It's easy to share your videos with friends, so many of my friends get to enjoy it as well." — Robert F. Get it from Amazon for $149 (available in two colors). 10. A pet camera that adds a distinctly 2024 upgrade: they can play with their pet via a smartphone app! The app lets them control a laser pointer so their ball of fluff can tire themselves out and get some mental stimulation even when their hoomans aren't at home. This is the future Nintendogs promised!!! Promising review: "I didn’t know what to expect when I got this as far as quality of video or laser toy or connectivity away from the house. All I can say it has far surpassed my expectations in every way. Let me give you an example. I was on my way down to the ground on a plane. I thought, let me check on my cat. Using the Wi-Fi on the plane, I was able to access the video feed in my home living room and see my cat was there bored and needing to play. I enabled the laser toy and proceeded to play with her for five minutes while we finished landing. She had a great time and I was reassured she was ok. The quality of the video was great, almost no lag, and the laser toy worked like a charm! There is a little lag for the laser toy but it still is great. A+ for this. I would gladly recommend to anyone." — B. Mann Get it from Amazon for $79.99 . 11. A pair of smart goggles I bet even Michael Phelps would be impressed with. The display on the inside displays their heart rate, time, distance, stroke count, and pace — and they can connect them to the accompanying app to keep track of their workouts. Note: This requires a $99/year subscription service to access guided workouts and a digital compass. Promising review: "I’ve been using the goggles for the past few weeks, mostly in the pool. The goggles capture everything I need (i.e., heart rate, stroke rate, and pace) without having to wear a sports watch. Accuracy and reliability for heart rate are impressive. I train with HR while running, so it’s nice to bring this approach to the pool." — Elliott Get it from Amazon for $249. 12. A spinning ball decked out with LED lights that flies around on its own. They can channel their inner Doctor Strange and make it hover over their hand, or they can throw it and watch as it boomerangs back to them. I don't know how they managed to make a ball futuristic, but I tip my hat to the designers. Promising review: "You control where this flies by the tilt you put into when releasing. Really fun to play catch with someone by tilting it toward them and gently releasing. You can also boomerang it back to yourself by tilting it backwards and tossing it up diagonally away from you. The cage around it is effective in protecting both you and it." — Dem Get it from Amazon for $28.80+ (available in seven colors). 13. A five-panel clock that looks straight out of Blade Runner . It features five small screens that can be customized to display everything from the time (duh) to the weather and stock market performance. The accompanying app even lets them create pixel art to display on the screen if they're feeling creative. Promising review: "I was skeptical before buying this thing but it actually works really well. There is tons of pixel art you can download and display and it can do really cool, useful stuff like show you the weather or stock prices, too. I'm a huge fan!" — Trevor Get it from Amazon for $113.99+ (available in two colors). 14. A USB fan with an LED clock face that looks like it's levitating in the air, which will make everyone in the office stop in their tracks when they walk by their desk. It also displays the temperature, so they can basically go ahead and delete the Weather Channel app from their phone. Promising review : "Fun at work. I got one of these for my husband at his office. Now EVERYONE has one at his office, including me at home!" — Laurette Triick Get it from Amazon for $15.99 . 15. A UFO-shaped Bluetooth speaker that hovers and spins around while playing all their favorite alien-themed podcasts. Functional and a conversation starter? This is guaranteed to win you some major points with that one family member who is just a little too obsessed with extra-terrestrial beings. ~Cute the X-Files theme song~ Promising review: "I wanted this mostly cuz I thought it looked really cool! It was pretty easy to set up and was going in no time! Everyone that sees it wants one and I am already on my second order! For a small speaker it has decent sound as I am using it for background noise and don't want it loud. It does, however, go up to a nice volume! It is very cool, and I'm so glad I bought one...well two now LOL!" — Karen Get it from Amazon for $99.99 . 16. A mirror with features every mirror should have in the future: built-in lighting, a Bluetooth speaker, and an anti-fog button. If they seem a bit more chipper in the morning than usual, it's because you just massively upgraded their routine. Promising review: "This thing is absolutely neat as all can be, hands down. I've seen the other ones, but this one has JUST enough functionality to make it cool and modern, but not so much that it is fully IOT/Wifi connected, and you have to worry about it potentially spying on you. I love the Bluetooth speaker functionality and the defogging/backlight. I love that this doesn't need to connect to Wi-Fi, doesn't require an app, and just WORKS out of the box, with no fiddling around . For the price, I think I'm going to get a few more of these for my other bathrooms. Wonderful job on this." — Mike Get it from Amazon for $109.99+ (available in nine sizes and three shapes). 17. An electronic upgrade to the classic Rubik's cube , which I strongly feel Elroy Jetson would play with all day long. It features four different games to choose from, or they can choose the "light show" setting to enjoy the glow from the colorful lights once their brains are too tired to play anymore. Promising review: "This little dude is a lot of fun for sure. It keeps my brain occupied and my fingers moving when I can't sit still. Not to mention, the music that plays in the menu is a certified BOP. My only tiny criticism is that the buttons are a tad too stiff when pushing on them, though; I suppose that's a good thing when you're twisting it around in your hands, and you don't accidentally push a button and ruin your score. I love the mute feature during gameplay." — Jennifer Get it from Amazon for $24.99 . 18. A super sleek lamp with a small globe that ~magically floats~ in the air — and it will even spin for up to 20 minutes if they give it a quick tap with their finger. I suspect all lamps in the future will feature some sort of gravity-defying feature. Promising review: "Globe is lightweight. This is a great thing to gift someone. It's fun to watch spin, and the light in the back is beautiful. It doesn’t spin on its own; you have to gently spin it, but once you start it, it lasts for quite a while." — Emilly Get it from Amazon for $32.39+ (available in three colors). 19. An app-controlled moon-shaped dock that functions as a lamp, wireless charger, and a bluetooth speaker because the future is truly all about multiuse products and saving outlet space. I suspect this is what Zenon uses to charge her SpacePhone and listen to "SuperNova Girl." Promising review: "The vibrant colors of the lamp look really beautiful!!! The speakers and the lights that dance to the beats are perfect for a mini disco atmosphere . It works great as a bedtime lamp for my bedroom, and the app is really convenient to control the light and music (white noise included!). This is a fun gadget for my teens. I give 5 out of 5 stars, satisfied." — Vanshika Sharma Get it from Amazon for $46.99 . 20. A smart meat thermometer — it will basically be their very own personal electronic sous chef. It connects to the Meater app to help configure cooking times and tell them the temperature right on their phone. The days of continuously opening the oven door to check on their roasted meats will be far behind them. It works for meats cooked in the smoker, grill, rotisserie, oven, pan, and air fryer! Promising review: "The Meater works so well, you hardly have to do anything while you cook any sort of meat. Once it alerts you the meat is ready, you remove it from any heat, and when the app says you’re ready to dig in, there’s no second guessing whether or not your meat is fully cooked. No under/overcooking with this; it’s perfect EVERY time. Couldn’t be more happy with this product and app." — Pam Walter Get it from Amazon for $79.95 . 21. A "Worky" station , the on-the-go desk they never knew they needed. Once they unfold the suitcase-style design, they'll have plenty of space for their laptop and office supplies, and there are even USB ports to charge their devices. Perhaps best of all, the top portion (which also functions as a whiteboard!) has LED lights, so they'll be in perfect lighting for all of their Zoom meetings. This is truly the ultimate gift for the remote workers on your list. Check out a TikTok of the Worky station in action. Promising review : "I've had my Worky for three months now and have loved it. I love that everything is in one place, and then I can close it up and work disappears. The compartments are great for tucking away piles of paperwork, the multiple charging outlets are convenient, and the LED lights are helpful on Zoom calls when lighting in the room is not ideal. Everything in one place, simple and convenient. Just the way I like it." — Amy Worky is a small business that specializes in products to improve remote working experiences. Get it from Amazon for $119.99 . 22. A Bitzee — it puts a 3D spin on the traditional virtual pet from our childhood. Simply open the capsule to reveal one of 15 pets that respond to touch, tilts, and swipes. There's even a Disney version with characters like Stitch, Wall-E, and Lightning McQueen! When their pets evolve into Super Bitzees, they can find cool outfits and mini-games. In a rare turn of events, batteries are included! Promising review: "My 8-year-old loves this thing so much that she hasn't put it down since she got it. It was the star of the show for Christmas, and I got so many hugs for getting it for her. This is basically the modern take on the old-school Tamagotchis, but it has a fluttering LED bar that zips up and down at an extremely high rate of speed to mimic the appearance of an actual digital pet floating in midair. Seems weird at first, but that fluttering light bar also allows you to feel like you are really touching the animal — very cool in action. If you are a parent looking for the perfect gift for a 5-10-year-old child, then do yourself a favor and grab one of these; you will not regret it! Really awesome toy for a very reasonable price." — M. Myers Get it from Amazon for $24.49+ (available in four styles). 23. A hybrid digital food scale and measuring cup which is some next-level baking tech even Paul Hollywood would be impressed with. Now, they can accurately measure all their ingredients directly in the cup, and they can also use the handle attachment as a stand-alone food scale. Promising review : "I absolutely love this measuring cup!!! What a great invention. I love that I can put flour in, reset it and add sugar, reset it and add milk, etc. One cup for measuring several things at the same time. Love, love, love it!!!!" — wolfpause Get it from Amazon for $18.99+ (available in three colors). 24. A touchscreen toaster to replace the crusty one they've had in the kitchen for longer than they'd like to admit. It heats much faster than a traditional unit and has a touchscreen that lets them choose their preferred level of crispiness. This is the future carb connoisseurs want. So why does a toaster need a touch screen? Because this one has some impressively specific toasting options for their carb of choice. It features fresh, frozen, and reheat options, and they can swipe between bagels, toaster cakes, English muffins, waffles, and bread. They'll probably text you "thank you!" every morning for gifting them with perfectly toasted bagels every time. Promising review: "I have to say, this toaster was well worth the investment. This one beat my old toaster by a mile in terms of how fast it toasts, and it adjusts easily and well to waffles and bagels. The toaster has a fantastic digital display, too. I love the 10-second countdown feature so I can get my butter in place and slather it on while the toast is hot. The design is sleek and elegant, and my favorite surprise is the analog clock display. This makes my old toaster obsolete (it's now collecting dust in the bottom cupboard)." — Rob Get it from Amazon for $299.95+ (available in two colors and with various accessories). 25. A fancy smart mug that will keep their coffee, tea, or other hot beverage of choice at the perfect temperature. It lasts for 90 minutes on a single charge, and if they have enough self-control to make a cup of coffee last longer than that, I simply cannot relate. Promising review: "Best thing since sliced bread! I hate it when my coffee gets cold. I was originally looking for one of those warming coasters, but then I saw the Ember mugs...there was no turning back. I can take my coffee with me into my boss's office, and it still stays hot?? Yes, please. I used that app and have adjusted my temp down to 127 degrees. It stays at that temperature the entire time. I’ve not had an issue with battery life either; it doesn’t take me more than an hour to polish off a cup of coffee. I HIGHLY recommend." — Mathews Get it from Amazon for $92.62+ (available in 11 colors). 26. Oral-B's Genius X Limited electric toothbrush equipped with AI that adapts to their unique brushing style so they can ensure they're getting a deeper clean. It even connects to their smartphone to help keep track of their daily brushing habits. Promising review: "Amazing clean. I was at first hesitant to spend that much on a toothbrush, but it’s worth every penny. It works at least 10x better than my $20 Oral-B electronic toothbrush. The motion sensing is very cool and helpful. After just one brush, my teeth feel almost like they do after a professional cleaning as opposed to how they felt after brushing with my cheap electronic toothbrush. " — Anne E La Perla Get it from Amazon for $190.31+ (available in three colors) 27. A fingerprint padlock so they'll never have to rummage around in their pocket looking for their key before realizing they left it at home. This also connects to a smartphone app if they prefer to control it remotely. Promising review: "This is a superb lock! I got it to use in the gym. I didn't want to use the honor system and hope my locker would be safe without a lock... and I know I am not the best with traditional combo locks. This lock does everything you need. It's easy to set up as many fingerprints for verification as you want ... and you can even just use your phone to unlock it alternatively." — J Z D Get it from Amazon for $36.99 (available in two colors). Reviews have been edited for length and/or clarity.
