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Preclinical tests show mRNA-based treatments effective for blinding condition November 27, 2024 Mass Eye and Ear A new study found that a novel mRNA-based therapy that targets a protein called RUNX1 may be able to prevent blindness and scarring from proliferative vitreoretinopathy (PVR), a disease caused by a traumatic eye injury or surgery like a retinal detachment repair that currently lacks effective treatments other than additional surgical procedures. Since RUNX1 is active in other diseases, the researchers also hope in the future to apply their mRNA technique to treat other retinal conditions like wet age-related macular degeneration and diabetic retinopathy. Facebook Twitter Pinterest LinkedIN Email A new preclinical study by Mass Eye and Ear investigators showed that a novel mRNA-based therapy may be able to prevent blindness and scarring from proliferative vitreoretinopathy (PVR) following a retinal detachment repair or traumatic injury to the eye. There is no current treatment for PVR other than surgery, which itself carries a high risk of causing or exacerbating PVR. Their results, published in Science Translational Medicine , show the promise that mRNA-based therapies may one day offer patients with PVR and other retinal conditions. "This therapy is the first to deliver mRNA-based treatments inside the eye," said co-corresponding author of the study Leo A. Kim, MD, PhD, the Monte J. Wallace Ophthalmology Chair in Retina at Massachusetts Eye and Ear. "We were pleasantly surprised that we could even use this approach inside the eye without causing excessive inflammation. We hope that these early findings can usher in new treatment options for PVR and other eye diseases." PVR is scar tissue that forms inside the eye, commonly after eye trauma, that can contract and detach the retina. This pathologic scar tissue response, rather than the eye injury itself, is what can lead to blindness. In the new paper, the researchers detail preclinical studies using mRNA as a therapeutic in the eye. Messenger RNA, or mRNA, is an essential part of every single cell in the body. Cells copy the code of genes into pieces of RNA and these RNAs act as messengers that ferry the genetic codes to the ribosomes, which use it to create proteins. Strands of mRNA can code for any protein -- even ones not in the cell's genome. When introduced into cells, the cellular machinery turns these mRNAs into proteins. Proteins make up the structure of the cell and help it carry out its functions. They can also turn other genes on or off. In the new study, the research team used cell-based, tissue-based, and preclinical models of proliferative vitreoretinopathy and abnormal blood vessel growth to show that mRNA-based therapeutics can be used safely in the eye. The researchers developed and studied the efficacy of various mRNAs encoding for proteins related to the scar tissue formation to see which might be useful as a therapeutic. To develop a treatment for PVR, the researchers targeted a protein called RUNX1 that regulates the expression of a gene that turns eye cells into scar tissue. Earlier in their careers, Kim and study co-corresponding author Joseph Arboleda-Velasquez, MD, PhD, discovered that RUNX1 was involved in two processes seen in several retinal diseases: the formation of abnormal blood vessels, called aberrant angiogenesis, and scar tissue, or fibrosis. In PVR and other diseases, the gene that RUNX1 regulates is overexpressed in the eye, causing scar tissue and abnormal blood vessels to grow. The investigators initially believed that targeting RUNX1 was the best approach, but current technologies were limited. mRNA is primarily used to increase protein expression, whereas the issue in PVR was excessive RUNX1. A key insight for developing this new experimental therapy was the idea of creating a molecule that would trap RUNX1 and inhibit its function -- a strategy known as a dominant-negative inhibitor in biology. These dominant negative molecules are powerful and their effects cannot be easily compensated by cells. They settled on an mRNA called RUNX1-Trap, which keeps RUNX1 in a cell's cytoplasm, preventing it from entering the nucleus and turning on the gene that turns the cells into scar tissue. They saw that in patient-derived cells in a lab culture, in an animal model, and in patient tissues in the lab, treating the cells with this mRNA helped stop the development of scar tissue and abnormal blood vessels. The researchers consider this study a proof of concept that suggests that the mRNA approach may be useful for PVR and other eye diseases. The study's limitations include that the experiments were in cellular and preclinical models. This approach has not been tested in human subjects. The technology itself may have some limitations as mRNA doesn't remain in the cell very long making proteins. Thus, the researchers don't know how long the effects of one treatment may last or whether a patient may require multiple doses over weeks or months for the treatment to effectively prevent PVR. The researchers are now looking at ways to extend the half-life of the mRNA so that it can last longer and to determine the optimal timing of the treatment to ensure the mRNA gets in the eye at the right time. Since RUNX1 is active in other diseases, the researchers also hope to apply their mRNA system and RUNX1-Trap therapy to treat other retinal conditions like wet age-related macular degeneration and diabetic retinopathy. "We believe targeting RUNX1 could lead to new therapies for sight-threatening conditions," said Arboleda- Velasquez, an associate scientist at Mass Eye and Ear. "The same idea of making dominant negative molecules produced using mRNA could result in the generation of potentially effective treatments for other conditions, greatly expanding the potential uses for mRNA," added Arboleda- Velasquez. Study co-first author William P. Miller, PhD, a postdoctoral fellow in the Department of Ophthalmology at Mass Eye and Ear and Harvard Medical School, noted, "This work is the result of substantial effort put forth by our team, encompassing multiple experts across several different fields. It demonstrates novel applications of mRNA technology in ophthalmology and has implications for other aspects of medicine as well." Story Source: Materials provided by Mass Eye and Ear . Note: Content may be edited for style and length. Journal Reference : Cite This Page :Abu Dhabhi [UAE], November 26 (ANI/WAM): Under the patronage of Sheikh Mansour bin Zayed Al Nahyan, Vice President, Deputy Prime Minister and Chairman of the Presidential Court, Global Food Week officially began today at ADNEC Abu Dhabi and will run until 28th November. The event underscores Abu Dhabi's pivotal role in leading global dialogue on food security challenges and opportunities, aiming to strengthen global food security and unify international efforts. Also Read | Blue Origin Forced To Remove Astronaut Emily Calandrelli's Space Video Amid Sexist and Misogynistic Backlash. The week features four main events: the Global Food Security Summit, Abu Dhabi International Food Exhibition, Abu Dhabi Date Palm Exhibition, and Abu Dhabi Coffee Festival. The summit, the highlight of the week, was inaugurated by Amna bint Abdullah Al Dahak, Minister of Climate Change and Environment. Also Read | Bangladesh: Lawyer Killed in Chittagong After Clashes Over Hindu Priest Chinmoy Krishna Das’ Arrest, Muhammad Yunus Orders Probe. Abdullah bin Touq Al Marri, Minister of Economy, stated that the UAE has adopted several impactful food security initiatives as part of its pioneering strategic vision, driven by a resilient framework supported by wise leadership. He announced plans to implement over 30 initiatives in partnership with the private sector, research centres, academic institutions, and government entities, focusing on R&D and value chain integration. Al Marri stressed the importance of collective responsibility to address the global food crisis. The summit brings together 21 ministers and government officials to discuss sustainable solutions, international collaboration, and strengthening efforts to combat hunger and bolster global food security systems. Over 80 global experts will share insights on climate-smart agriculture, agri-tech, and supply chain resilience, with the aim of building sustainable food systems and fostering global partnerships to address common challenges. ADNEC Group, the organiser of the Global Food Security Summit, has committed to reducing food waste during the event. The initiative aligns with the group's sustainability goals, which include innovative measures to eliminate food waste, establish new consumption standards, and host environmentally friendly events, contributing to global food security efforts. The Abu Dhabi International Food Exhibition 2024 showcases over 660 exhibitors from more than 70 countries, featuring leading brands and the latest advancements in food technology and sustainable food industries. The exhibition hosts discussions on global food systems, sustainable production, health-focused systems, and consumer trends towards health, wellness, and value. The Abu Dhabi Coffee Festival, held at ADNEC Abu Dhabi, is a first-of-its-kind event in the region, offering coffee enthusiasts, professionals, and curious visitors an immersive experience. Organised by the UAE Specialty Coffee Association, the festival blends food culture with coffee exploration. It celebrates the UAE's growing coffee culture, offering visitors live competitions, interactive workshops, and a vibrant social atmosphere. The "Coffee Market" features a variety of coffee-inspired products, from cosmetics and food to accessories, providing a multifaceted coffee experience. The 10th Abu Dhabi Date Palm Exhibition, held in collaboration with the Khalifa International Award for Date Palm and Agricultural Innovation, offers a global platform for producers, suppliers, and experts in the date palm industry. With participants from over 20 date-producing countries, the exhibition focuses on advancements in sustainable farming practices. The Hosted Buyer Programme connects food and beverage suppliers with key buyers across sectors such as aviation and hospitality, creating unparalleled business opportunities during Abu Dhabi Date Palm Week. University students and academic institutions will lead sessions and discussions during Global Food Week, inspiring and empowering future leaders in food security innovation. On the sidelines of the event, the Abu Dhabi Quality and Conformity Council, in partnership with the Abu Dhabi Public Health Centre, launched the "Nutrition Label" initiative - the first of its kind in the region. This new front-of-pack labelling system aims to help consumers make informed and healthier food choices. Global Food Week 2024 represents a collective effort to secure food for future generations. Abu Dhabi's strategic role as a hub for agricultural innovation and global trade underscores its commitment to addressing food security challenges worldwide. (ANI/WAM) (This is an unedited and auto-generated story from Syndicated News feed, LatestLY Staff may not have modified or edited the content body)
Whales with a lot of money to spend have taken a noticeably bullish stance on Microchip Technology . Looking at options history for Microchip Technology MCHP we detected 10 trades. If we consider the specifics of each trade, it is accurate to state that 70% of the investors opened trades with bullish expectations and 20% with bearish. From the overall spotted trades, 7 are puts, for a total amount of $647,449 and 3, calls, for a total amount of $215,668. What's The Price Target? Analyzing the Volume and Open Interest in these contracts, it seems that the big players have been eyeing a price window from $47.5 to $87.5 for Microchip Technology during the past quarter. Volume & Open Interest Development In today's trading context, the average open interest for options of Microchip Technology stands at 373.38, with a total volume reaching 5,381.00. The accompanying chart delineates the progression of both call and put option volume and open interest for high-value trades in Microchip Technology, situated within the strike price corridor from $47.5 to $87.5, throughout the last 30 days. Microchip Technology Option Activity Analysis: Last 30 Days Biggest Options Spotted: Symbol PUT/CALL Trade Type Sentiment Exp. Date Ask Bid Price Strike Price Total Trade Price Open Interest Volume MCHP PUT SWEEP BEARISH 12/20/24 $3.1 $2.95 $3.0 $70.00 $430.3K 489 1.4K MCHP CALL SWEEP BULLISH 02/21/25 $4.9 $4.7 $4.9 $70.00 $98.0K 584 212 MCHP CALL SWEEP BEARISH 02/21/25 $2.3 $2.2 $2.18 $77.50 $76.7K 140 751 MCHP PUT SWEEP BULLISH 12/20/24 $2.05 $2.0 $2.05 $67.50 $49.6K 1.1K 435 MCHP PUT SWEEP BULLISH 05/16/25 $7.8 $7.6 $7.6 $70.00 $41.0K 298 314 About Microchip Technology Microchip Technology became an independent company in 1989 when it was spun off from General Instrument. More than half of revenue comes from MCUs, which are used in a wide array of electronic devices from remote controls to garage door openers to power windows in autos. The company's strength lies in lower-end 8-bit MCUs that are suitable for a wider range of less technologically advanced devices, but the firm has expanded its presence in higher-end MCUs and analog chips as well. In light of the recent options history for Microchip Technology, it's now appropriate to focus on the company itself. We aim to explore its current performance. Current Position of Microchip Technology Trading volume stands at 3,162,874, with MCHP's price down by -1.88%, positioned at $68.54. RSI indicators show the stock to be may be approaching oversold. Earnings announcement expected in 65 days. Professional Analyst Ratings for Microchip Technology 5 market experts have recently issued ratings for this stock, with a consensus target price of $88.4. Unusual Options Activity Detected: Smart Money on the Move Benzinga Edge's Unusual Options board spots potential market movers before they happen. See what positions big money is taking on your favorite stocks. Click here for access .* An analyst from Susquehanna persists with their Positive rating on Microchip Technology, maintaining a target price of $90. * Maintaining their stance, an analyst from Citigroup continues to hold a Buy rating for Microchip Technology, targeting a price of $82. * Consistent in their evaluation, an analyst from Rosenblatt keeps a Buy rating on Microchip Technology with a target price of $90. * Consistent in their evaluation, an analyst from Piper Sandler keeps a Overweight rating on Microchip Technology with a target price of $85. * An analyst from Evercore ISI Group downgraded its action to Outperform with a price target of $95. Options are a riskier asset compared to just trading the stock, but they have higher profit potential. Serious options traders manage this risk by educating themselves daily, scaling in and out of trades, following more than one indicator, and following the markets closely. If you want to stay updated on the latest options trades for Microchip Technology, Benzinga Pro gives you real-time options trades alerts. © 2024 Benzinga.com. Benzinga does not provide investment advice. All rights reserved.SANTA CLARA, Calif. (AP) — De'Vondre Campbell's decision to quit on his team in the middle of a game overshadowed the bigger issues for the San Francisco 49ers. An offense that was one of the most dynamic in the NFL during a run to the Super Bowl last season has been just ordinary for most of 2024 and was downright bad in a 12-6 loss to the Los Angeles Rams on Thursday night that just about ended San Francisco's playoff hopes. San Francisco (6-8) was held to its fewest yards (191) in a regular-season game in eight seasons under coach Kyle Shanahan and its fewest points since Shanahan's debut in 2017 on a rainy night that will be remembered mostly for Campbell walking off the field in the middle of the game with a towel draped over his head. The game also featured San Francisco going three-and-out on four drives as Brock Purdy struggled to connect with his receivers. Deebo Samuel dropped a potential touchdown pass after complaining earlier in the week about a lack of touches. Purdy then missed Ricky Pearsall on an underthrown deep shot in the fourth quarter before throwing an interception into the end zone that ended the Niners' comeback attempt. “I just feel like I had a lot of plays left out there that I could have made for our team,” Purdy said. “I thought the defense and special teams played so good. That’s what’s hurting me is I just feel like I failed the team. I could have been better for our offense and we could have put up more points.” Scoring has been an issue this season for the 49ers, who have been missing key playmakers like Christian McCaffrey and Brandon Aiyuk for much of the season. San Francisco is scoring 8.5 fewer points per game on offense than the Niners did through 14 games last season. What’s working Red-zone defense. After allowing touchdowns on 13 consecutive red-zone drives over the previous four games, the 49ers kept the Rams out of the end zone on all three drives that went inside the 20. What needs help Receivers. The 49ers failed to get much production from their wide receivers with Purdy going 6 for 20 for 63 yards with an INT and a 19.4 rating when targeting wideouts. Samuel had 16 yards on seven targets with the key drop. Jauan Jennings had two drops and was the target on the interception. Pearsall had one catch for 16 yards on four targets. Stock up LB Dre Greenlaw returned for the first time since tearing his left Achilles tendon in last season's Super Bowl. Greenlaw had eight tackles in the first half as he brought needed intensity and physical play that had been missing for much of the season. Stock down Campbell. The 49ers are deciding whether to waive or suspend Campbell, who lost his starting job when Greenlaw returned and then refused to play when he was needed. “His actions from the game just is not something you can do to your team or your teammates and still expect to be a part of our team,” Shanahan said. “We’re working through exactly the semantics of it right now, but we’ll handle the situation appropriately.” Injuries Greenlaw came out of the game feeling OK after leaving with soreness in his knee and Achilles tendon. He is day to day. ... S Ji’Ayir Brown (groin) and LB Dee Winters (neck) are also day to day. ... LT Trent Williams (ankle) is still trying to get back to play after missing the last four games. Shanahan said Williams' recovery has been "a lot slower than anticipated.” Key number 0 — The Niners didn't reach the red zone once all game, with their deepest penetration into Rams territory being when they reached the 27 on a third-quarter field goal drive. This marked the first time since Week 11 in 2010 that the 49ers didn't run a single play inside the opponent's 25. What’s next The 49ers visit Miami on Dec. 22. ___ AP NFL: https://apnews.com/hub/NFL Josh Dubow, The Associated PressTHE 10 KG 99.99% PURE GOLD THE DANCE SCREEN (THE SCREAM TOO), A ONE-OF-A-KIND COIN FROM THE ROYAL CANADIAN MINT, SURPASSES $1.5 MILLION AT HEFFEL AUCTIONWhat do Reviews of Real Mitolyn Users Say About Purple Peel Exploit for Weight Loss?
PITTSBURGH , Dec. 13, 2024 /PRNewswire/ -- "I'm a distributer for a company that sells wide format yard signs, which are very popular during election time. These signs are often bent or destroyed by wind. I thought there could be a way to protect them and change the face of outdoor advertising, so we invented the SUPER FRAMES," said one of two inventors, from South Bend, Ind. "Our design ensures signs and advertisements look good for a longer period of time." The patent-pending invention provides an improved way to display large outdoor yard signs. In doing so, it would help keep signs from being destroyed by wind. As a result, it provides added protection, and it could enhance the appearance of the sign. The invention features a durable design that is easy to install so it is ideal for homeowners and companies that display large political or advertising yard signs. Additionally, a prototype model and technical drawings are available upon request. The original design was submitted to the Indianapolis sales office of InventHelp. It is currently available for licensing or sale to manufacturers or marketers. For more information, write Dept. 23-SGM-398, InventHelp, 100 Beecham Drive, Suite 110, Pittsburgh, PA 15205-9801, or call (412) 288-1300 ext. 1368. Learn more about InventHelp's Invention Submission Services at http://www.InventHelp.com . SOURCE InventHelpBasketball Roundup: Mustangs start new era 2-0; Lady Jags, Falcons, 'Dogs pick up wins
Mets to retire former captain David Wright’s number in 2025
By HILLEL ITALIE NEW YORK (AP) — Even through a year of nonstop news about elections, climate change, protests and the price of eggs, there was still time to read books. U.S. sales held steady according to Circana, which tracks around 85% of the print market, with many choosing the relief of romance, fantasy and romantasy. Some picked up Taylor Swift’s tie-in book to her blockbuster tour, while others sought out literary fiction, celebrity memoirs, political exposes and a close and painful look at a generation hooked on smartphones. Here are 10 notable books published in 2024, in no particular order. “House of Flame and Shadow,” by Sarah J. Maas Asking about the year’s hottest reads would basically yield a list of the biggest hits in romantasy, the blend of fantasy and romance that has proved so irresistible fans were snapping up expensive “special editions” with decorative covers and sprayed edges. Of the 25 top sellers of 2024, as compiled by Circana, six were by romantasy favorite Sarah J. Maas, including “House of Flame and Shadow,” the third of her “Crescent City” series. Millions read her latest installment about Bryce Quinlan and Hunter Athalar and traced the ever-growing ties of “Maasverse,” the overlapping worlds of “Crescent City” and her other series, “Throne of Glass” and “A Court of Thorns and Roses.” “The Anxious Generation,” by Jonathan Haidt If romantasy is for escape, other books demand we confront. In the bestselling “The Anxious Generation,” social psychologist Jonathan Haidt looks into studies finding that the mental health of young people began to deteriorate in the 2010s, after decades of progress. According to Haidt, the main culprit is right before us: digital screens that have drawn kids away from “play-based” to “phone-based” childhoods. Although some critics challenged his findings, “The Anxious Generation” became a talking point and a catchphrase. Admirers ranged from Oprah Winfrey to Arkansas Gov. Sarah Huckabee, who in a letter to state legislators advocated such “commonsense recommendations” from the book as banning phones in schools and keeping kids off social media until age 16. “War,” by Bob Woodward Bob Woodward books have been an election tradition for decades. “War,” the latest of his highly sourced Washington insider accounts, made news with its allegations that Donald Trump had been in frequent contact with Russian leader Vladimir Putin even while out of office and, while president, had sent Putin sophisticated COVID-19 test machines. Among Woodward’s other scoops: Putin seriously considered using nuclear weapons against Ukraine, and President Joe Biden blamed former President Barack Obama, under whom he served as vice president, for some of the problems with Russia. “Barack never took Putin seriously,” Woodward quoted Biden as saying. “Melania,” by Melania Trump Former (and future) first lady Melania Trump, who gives few interviews and rarely discusses her private life, unexpectedly announced she was publishing a memoir: “Melania.” The publisher was unlikely for a former first lady — not one of the major New York houses, but Skyhorse, where authors include such controversial public figures as Woody Allen and Trump cabinet nominee Robert F. Kennedy Jr. And its success was at least a minor surprise. Melania Trump did little publicity for the book, and offered few revelations beyond posting a video expressing support for abortion rights — a break from one of the cornerstones of GOP policy. But “Melania” still sold hundreds of thousands of copies, many in the days following her husband’s election. “The Eras Tour Book,” by Taylor Swift Taylor Swift was more than a music story in 2024. Like “Melania,” the news about Taylor Swift’s self-published tie-in to her global tour isn’t so much the book itself, but that it exists. And how well it sold. As she did with the “Eras” concert film, Swift bypassed the established industry and worked directly with a distributor: Target offered “The Eras Tour Book” exclusively. According to Circana, the “Eras” book sold more than 800,000 copies just in its opening week, an astonishing number for a publication unavailable through Amazon.com and other traditional retailers. No new book in 2024 had a better debut. “Intermezzo,” by Sally Rooney Midnight book parties are supposed to be for “Harry Potter” and other fantasy series, but this fall, more than 100 stores stayed open late to welcome one of the year’s literary events: Sally Rooney’s “Intermezzo.” The Irish author’s fourth novel centers on two brothers, their grief over the death of their father, their very different career paths and their very unsettled love lives. “Intermezzo” was also a book about chess: “You have to read a lot of opening theory — that’s the beginning of a game, the first moves,” one of the brothers explains. “And you’re learning all this for what? Just to get an okay position in the middle game and try to play some decent chess. Which most of the time I can’t do anyway.” “From Here to the Great Unknown,” by Lisa Marie Presley and Riley Keough Lisa Marie Presley had been working on a memoir at the time of her death , in 2023, and daughter Riley Keough had agreed to help her complete it. “From Here to the Great Unknown” is Lisa Marie’s account of her father, Elvis Presley, and the sagas of of her adult life, notably her marriage to Michael Jackson and the death of son Benjamin Keough. To the end, she was haunted by the loss of Elvis, just 42 when he collapsed and died at his Graceland home while young Lisa Marie was asleep. “She would listen to his music alone, if she was drunk, and cry,” Keough, during an interview with Winfrey, said of her mother. “Cher: The Memoir, Part One,” by Cher Meanwhile, Cher released the first of two planned memoirs titled “Cher” — no further introduction required. Covering her life from birth to the end of the 1970s, she focuses on her ill-fated marriage to Sonny Bono, remembering him as a gifted entertainer and businessman who helped her believe in herself while turning out to be unfaithful, erratic, controlling and so greedy that he kept all the couple’s earnings for himself. Unsure of whether to leave or stay, she consulted a very famous divorcee, Lucille Ball, who reportedly encouraged her: “F— him, you’re the one with the talent.” “James,” by Percival Everett A trend in recent years is to take famous novels from the past, and remove words or passages that might offend modern readers; an edition of “The Adventures of Huckleberry Finn” cuts the racist language from Mark Twain’s original text. In the most celebrated literary work of 2024, Percival Everett found a different way to take on Twain’s classic — write it from the perspective of the enslaved Jim. “James,” winner of the National Book Award, is a recasting in many ways. Everett suggests to us that the real Jim was nothing like the deferential figure known to millions of readers, but a savvy and learned man who concealed his intelligence from the whites around him, and even from Twain himself. “Knife,” by Salman Rushdie Salman Rushdie’s first National Book Award nomination was for a memoir he wished he had no reason to write. In “Knife,” he recounts in full detail the horrifying attempt on his life in 2022, when an attendee rushed the stage during a literary event in western New York and stabbed him repeatedly, leaving with him a blinded eye and lasting nerve damage, but with a spirit surprisingly intact. “If you had told me that this was going to happen and how would I deal with it, I would not have been very optimistic about my chances,” he told The Associated Press last spring. “I’m still myself, you know, and I don’t feel other than myself. But there’s a little iron in the soul, I think.”
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SARATOGA SPRINGS, N.Y. — The Section 2 boys soccer banquet was held Sunday, Dec. 8, at the Saratoga Holiday Inn. There was a large school banquet and a small school banquet with more than 550 people attending. Below are the awards from the banquet.The Golden Thread Award is presented to someone who has gone above [...]
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