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Pridopidine hydrochloride by Prilenia Therapeutics Development for Huntington Disease: Likelihood of ApprovalThe recent federal conviction and sentence of a man who tried to run over an FBI agent while driving a stolen truck into Mexico highlights a growing trend plaguing South Texas. Multiple cities are seeing a rise in the thefts of four-door SUVs and pickups that are taken into Mexico at the request of the Gulf Cartel. The criminal organization uses the trucks in their ongoing turf wars. This week, 23-year-old Damian Evans Lopez went before U.S. District Judge Rolando Olvera, who sentenced him to almost ten years in prison on the charge of assaulting a federal officer. According to the U.S. Attorney’s Office, Evans pleaded guilty to the charge in September. According to authorities, on June 28, an FBI agent was at one of the international ports of entry in Brownsville, Texas, checking for stolen vehicles when he spotted Evans in a stolen Chevrolet truck. They agent attempted to get the driver to come out of the truck. Evens drove straight at the FBI agent, who had to jump out of the way to avoid being hit. Evans tried to drive away and led authorities on a high-speed chase that ended in the city of San Benito, Texas. In recent months, cities like Brownsville, Harlingen, and Pharr, Texas, have been plagued with a wave of vehicle thefts focused on four-door SUVs and pickups. As Breitbart Texas reported, these vehicles are crossed into Mexico and turned over to the Gulf Cartel. The criminal organization favors these vehicles due to their high clearance and powerful engines. The trucks allow the cartels to move at least four gunmen. In some cases, the stolen trucks are outfitted with makeshift armor plating. The vehicle theft wave has, at times, turned violent. In late November, a gunman held two women at gunpoint outside of a restaurant in Brownsville and took their late model SUV. According to Brownsville police, one of the suspects is believed to be hiding in Mexico. Mexican authorities have largely been ineffective in stopping the car thieves as they cross into Mexico. In the few times that they have tried, the suspects can drive past the security checkpoints on the Mexican side of the border. This week, one of the factions of the Gulf Cartel shared a video on social media where they questioned a young man who claimed to have been sent to Reynosa to steal vehicles for a rival faction of the Gulf Cartel. The fate of the young man remains unknown. In the past, people in similar videos have been tortured and killed. Ildefonso Ortiz is an award-winning journalist with Breitbart Texas. He co-founded Breitbart Texas’ Cartel Chronicles project with Brandon Darby and senior Breitbart management. You can follow him on Twitter and on Facebook . He can be contacted at Iortiz@breitbart.com . Brandon Darby is the managing director and editor-in-chief of Breitbart Texas. He co-founded Breitbart Texas’ Cartel Chronicles project with Ildefonso Ortiz and senior Breitbart management. Follow him on Twitter and Facebook . He can be contacted at bdarby@breitbart.com .mega v

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Trump won about 2.5M more votes this year than he did in 2020. This is where he did itAlthough Brian Daboll declared Tommy DeVito would remain the Giants’ starter for their Week 13 Thanksgiving matchup in Dallas , the popular New York passer has run into injury trouble. The Giants announced that DeVito is not traveling with the team to Dallas on Wednesday. A forearm injury has required more testing, with NFL.com’s Mike Garafolo noting the team’s current QB1 is on track to depart for Dallas later Wednesday. But DeVito may ultimately end up taking a seat. It looks like a long shot DeVito will be ready to play on a short week, ESPN.com’s Jordan Raanan reports . That will move Drew Lock into the lineup. Lock had been Daniel Jones ‘ backup all season, only to see Daboll look past him for DeVito in Week 12. Lock, who is tied to a one-year contract, is now on track to make his first start with the Giants. Tim Boyle , signed shortly after the Giants benched Jones, would be Lock’s backup if DeVito is inactive. DeVito did not appear on the Giants’ injury report going into Tuesday but has since been listed as questionable for the team’s Cowboys rematch. The injury is to DeVito’s right arm, Daboll said ( via SNY’s Connor Hughes ), raising the hurdle for the 2023 UDFA to clear in time for Thursday. Multiple Giants reporters, Hughes among them , have speculated DeVito sustained the injury on a play with 11 seconds remaining in the Giants’ 30-7 loss to the Buccaneers. Lock signed a one-year, $5M deal with the Giants in March. While Seahawks GM John Schneider suggested the move was based largely on Lock receiving a chance to compete with Jones, that never ended up happening . The team did not hold a competition, and Lock settled into a backup role for the fourth straight season. A Broncos starter to close the 2019 season and throughout 2020, Lock ended up demoted — for Teddy Bridgewater — after an erratic 2020 slate in which he led the NFL in INTs. He did not beat out Geno Smith in 2022, upon being included in the Russell Wilson trade, through he did re-sign with the Seahawks last year. DeVito leads Lock in starts over the past two seasons, making seven to Lock’s two, but the latter has 23 over the course of his career. The former second-round pick also led the Seahawks to a Monday-night win over the Eagles last season, with that victory coming as Philadelphia’s defense was mid-freefall. Lock can boost his 2025 free agency stock by playing well Thursday, in what is regularly the NFL’s most-watched regular-season game, and could certainly influence Daboll to give him more starts to close this season. As Jones has since signed with the Vikings , DeVito and Lock may well need to offer competence in order for Daboll to keep his job . The Giants are rumored to be prepared to keep both GM Joe Schoen and Daboll, but an ugly Bucs loss coming out of a bye week did not present good optics. With the Jones re-signing backfiring, neither New York power broker should be too comfortable over this season’s homestretch. This article first appeared on Pro Football Rumors and was syndicated with permission.

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Alabama athletic director hints at major change after CFP snubTrump won about 2.5M more votes this year than he did in 2020. This is where he did it

In the ever-evolving world of gaming technology, FC 25 Хранилище Дубликатов is making waves as the next big breakthrough in data management and storage solutions. As games grow increasingly complex and expansive, developers face the challenge of managing vast amounts of data efficiently. This is where FC 25 steps in, offering a revolutionary approach to duplicate storage. FC 25 Хранилище Дубликатов (Duplicate Storage) is a cutting-edge system designed to optimize the way game data is stored, accessed, and retrieved. What sets FC 25 apart from traditional methods is its ability to identify and manage data duplicates across vast networks, significantly reducing storage redundancy. By leveraging sophisticated algorithms, FC 25 pinpoints identical data blocks, allowing developers to store unique content only once, thus minimizing the required storage space. The implications for the gaming industry are profound. As games continue to expand in scope, requiring higher-resolution textures and more intricate character models, storage needs burgeon correspondingly. FC 25 provides a sustainable solution that can extend the life cycle of gaming hardware, reduce costs, and allow players to enjoy smoother, faster gaming experiences without frequent upgrades. Looking ahead, FC 25’s adoption could not only influence game development but also spill over into other sectors reliant on heavy data storage, setting a new standard for efficiency. As it continues to garner attention, its potential to reshape digital landscapes positions it as a pivotal development in the future of gaming technology. How FC 25 Duplicate Storage is Redefining Data Management in Gaming In the realm of gaming technology, the emergence of FC 25 Хранилище Дубликатов (Duplicate Storage) is a game-changer for data management and storage. As games grow increasingly complex and expansive, developers encounter challenges in managing vast volumes of data efficiently. FC 25 offers a revolutionary solution that optimizes the way game data is stored, accessed, and retrieved. Pros and Cons of FC 25 Pros: – Redundancy Reduction: FC 25 significantly reduces data redundancy by identifying and managing duplicates across extensive networks. – Storage Optimization: By storing unique data blocks only once, FC 25 minimizes required storage space. – Cost-Effective: Reducing the need for additional storage hardware can lead to substantial cost savings. – Sustainable: FC 25 extends the lifecycle of gaming hardware by efficiently managing data storage needs. Cons: – Initial Implementation: Integrating FC 25 might require a significant overhaul of existing storage infrastructure. – Learning Curve: Developers may need to familiarize themselves with how FC 25’s algorithms work for optimal utilization. Innovations and Features FC 25 leverages sophisticated algorithms to pinpoint identical data blocks, ensuring that unique content is stored just once. This optimization not only enhances storage efficiency but also provides players with smoother and faster gaming experiences, reducing the necessity for frequent hardware upgrades. Use Cases Beyond Gaming While FC 25 is a boon to the gaming industry, its potential applications extend into sectors that rely heavily on data storage, such as film production, digital design, and cloud computing services. Its capacity to manage large datasets efficiently positions it as a vital tool for any data-intensive industry. Market Insights and Predictions The adoption and integration of FC 25 could herald a shift in how data storage systems are perceived across various industries. As it continues to gain traction, it may become a benchmark for data storage solutions, inspiring more advanced systems developed in its wake. Security Aspects FC 25 ensures data integrity by maintaining secure, non-redundant storage units, which can protect against data loss and unauthorized access. The system’s comprehensive approach to storage management also enhances data retrieval efficiency, further securing sensitive information. For more insights into innovative gaming technologies, visit Electronic Arts .Bob MacIntyre admits Scottie Scheffler is going to be hard to catch, but the Scot is heading into 2025 with his sights on getting as close as he can to the dominant American in the world rankings. Scheffler capped a sensational calendar year by landing his eighth PGA Tour win and ninth in total if you add in his gold medal in the Olympics by successfully defending the Hero World Challenge title in the Bahamas. One behind Justin Thomas heading into the closing circuit at Albany Golf Course, the 28-year-old signed off with a brilliant nine-under-par 63 to win the Tiger Woods-hosted event by six shots as he ended up on 25 under. Korean Tom Kim, who followed his best-of-the week 62 with a closing 68, finished as his closest challenger, with two-time US PGA champion Thomas having to settle for third spot after a signing for a 71 alongside Scheffler. On his debut in the 20-man tournament, MacIntyre finished seventh after a last-day 70 left him on 11 under and, after a short break back home in Oban, he’s relishing the prospect of getting his 2025 campaign underway in Hawaii next month. “I’m delighted with it,” said the left-hander of his week’s work at the end of a fairytale year that saw him win the RBC Canadian Open with dad Dougie caddying for him then became the first home player to win the Genesis Scottish Open since 1999. “Tee to green, this is as good as I ever played.” In a closing stretch of holes that encapsulated how MacIntyre plays the game, he hit the flag from a greenside bunker with an eagle attempt, hit a majestic tee shot to six feet at the short 17th then produced a brilliant recovery shot from close to the water to save par at the last. “That shot into 17 today, for example,” he added of how well he feels his long game is. “It was a 7-iron and it was the perfect golf shot for the conditions. A flat draw that is never getting out of control. It’s always holding the wind and not fighting it. It just felt like that all day and, overall, this week has been superb tee to green.” He did admit, though, that it had been a “stressful week” on the greens. “I know the area I need to work on - there is no point in me keeping on saying it,” he said of his putting. “Yeah, it is letting me down big time.” MacIntyre came into the event sitting 15th in the world rankings and, from start to finish, it was clear that he feels comfortable playing alongside the world’s top players, partnering former FedEx Cup winner Patrick Cantlay, for example, in the final round and outsourcing him by a couple of shots. “I feel like this is where I am meant to be,” he said with a smile. “I’ve got the right team around me and I’m not just sitting here thinking this is great and accepting it. “It’s taken hard work to get here and, in my team, we’ve looked at the stats to try to keep moving forward and get closer to Scheffler. He’s miles ahead of everyone, but No 2 feels as though it is within reach. That’s what is driving me and I’ve just got to keep chasing forward.”

'Bashar al-Assad, family in Moscow' after ouster from power Russian news agencies say ousted Syrian president and his family granted asylum on humanitarian grounds MOSCOW: Syria's Bashar al-Assad and his family have arrived in Russia and have been granted asylum by the Russian authorities, Russian news agencies reported on Sunday, citing a Kremlin source. The Interfax news agency quoted the unnamed source as saying: "President Assad of Syria has arrived in Moscow. Russia has granted them (him and his family) asylum on humanitarian grounds." Earlier, two Syrian sources said the disappearance of the Assad’s plane from tracking could indicate it had been shot down, or that it had switched off its transponder. Syria rebel fighters raced into Damascus unopposed on Sunday, overthrowing President Bashar al-Assad and ending nearly six decades of his family's iron-fisted rule after a lightning advance that reversed the course of a 13-year civil war. In one of the most consequential turning points in the Middle East for generations, the fall of Assad's government wiped out a bastion from which Iran and Russia exercised influence across the Arab world. Moscow gave him and his family asylum. His sudden overthrow, at the hands of a Turkish-backed revolt, limits Iran's ability to spread weapons to its allies and could cost Russia its Mediterranean naval base. It also may pave the way for millions of refugees scattered for more than a decade in camps across Turkey, Lebanon and Jordan to finally return home. For Syrians, it brought a sudden unexpected end to a war that had been in deep freeze for years, with hundreds of thousands dead, cities pounded to dust, an economy hollowed out by global sanctions and seemingly no resolution in sight. "How many people were displaced across the world? How many people lived in tents? How many drowned in the seas?" the top rebel commander Abu Mohammed al-Golani told a huge crowd at the medieval Umayyad Mosque in central Damascus, referring to refugees who drowned trying to reach Europe. "A new history, my brothers, is being written in the entire region after this great victory," he said. It would take hard work to build a new Syria which he said would be "a beacon for the Islamic nation". The Assad police state — known since his father seized power in the 1960s as one of the harshest in the Middle East with hundreds of thousands of political prisoners in its gulag — melted away overnight. Bewildered and elated inmates poured out of jails after rebels blasted away the locks on their cells. Reunited families wept and wailed in joy. Newly freed prisoners were filmed at dawn running through the Damascus streets holding up the fingers of both hands to show how many years they had been in prison. "We toppled the regime!" a voice shouted and a prisoner yelled and skipped with delight. As the sun set in Damascus without Assad for the first time, the roads leading into the city were mostly empty, apart from motorcycles carrying armed men and rebel vehicles caked with brownish mud as camouflage. Some men could be seen looting a shopping centre on the road between the capital and the Lebanese border, stuffing goods into plastic bags or into pick-up trucks. The myriad checkpoints lining the road to Damascus were empty. Posters of Assad had been torn at his eyes. A burning Syrian military truck was parked diagonally on the road out of the city. A thick column of black smoke billowed out from the Mazzeh neighbourhood, where Israeli strikes earlier had targeted Syrian state security branches, according to two security sources. Throughout the evening, intermittent gunfire rang out throughout the city in apparent celebration. Shops and restaurants closed early in line with a curfew imposed by the rebels. Just before it came into effect, people could be seen briskly walking home with stacks of bread. Earlier, the rebels said they had entered the capital with no sign of army deployments. Thousands of people in cars and on foot congregated at a main square in Damascus waving and chanting "Freedom". People were seen walking inside the Al-Rawda Presidential Palace, with some leaving carrying furniture from inside. A motorcycle was parked on the intricately-laid parquet floor of a gilded hall. Golani, whose group was once Syria's branch of al Qaeda but has since softened its image to reassure members of minority sects and foreign countries, said there was no room for turning back. "The future is ours," he said in a statement read on state TV. The Syrian rebel coalition said it was working to complete the transfer of power to a transitional governing body with executive powers. "The great Syrian revolution has moved from the stage of struggle to overthrow the Assad regime to the struggle to build a Syria together that befits the sacrifices of its people," it added in a statement. Mohammad Ghazi al-Jalali, prime minister under Assad, called for free elections and said he had been in contact with Golani to discuss the transitional period. Jubilant supporters of the revolt stormed Syrian embassies in a number of cities around the world, lowering red, white and black Assad-era flags and replacing them with the green, white and black flag flown throughout the war by his opponents. Israeli Prime Minister Benjamin Netanyahu said Assad's fall was a direct result of blows Israel had dealt to Iran and its Lebanese ally Hezbollah, once the lynchpin of Assad's security forces but pounded by Israel over the last two months. French President Emmanuel Macron said "the barbaric state has fallen" and paid tribute to the Syrian people. When the celebrations fade, Syria's new leaders will face the daunting task of trying to deliver stability to a diverse country that will need billions of dollars in aid to rebuild. During the civil war, which erupted in 2011 as an uprising against Assad, his forces and their Russian allies bombed cities to rubble. The refugee crisis across the Middle East was one of the biggest of modern times and caused a political reckoning in Europe when a million people arrived in 2015. President Joe Biden's administration was monitoring developments but has not adjusted the positioning of the US troops, officials told Reuters. The biggest strategic losers were Russia and Iran, which had intervened in the war's early years to rescue Assad, helping him recapture most territory and all major cities. The front lines were frozen four years ago under a deal Russia and Iran reached with Turkey. Even after Assad had fled, Israel continued to strike targets associated with his government and its Iranian-backed allies, including one in Damascus where Israel had previously accused Iran of developing missiles. Netanyahu said the toppling of Assad could make it easier for Israel to reach a ceasefire deal to free hostages in Gaza. On Sunday rebels stormed Iran's embassy, Iran's English-language Press TV reported. Iran's foreign ministry said Syria's fate was the sole responsibility of the Syrian people. Hezbollah had pulled all its remaining forces from Syria on Saturday, two Lebanese security sources said. Syria's insurgency led by former al Qaeda chief Abu Mohammed al-Golani topples Assad’s regime Russia says Assad has left Syria as curfew announced in rebels-taken Damascus World reacts as Assad's 24-year rule ends in Syria Rebels declare end of Assad rule in Syria; prime minister seeks free electionsThe General Assembly on Tuesday adopted the United Nations Convention against Cybercrime, a landmark global treaty aimed at strengthening international cooperation to combat cybercrime and protecting societies from digital threats UNITED NATIONS, (APP - UrduPoint / Pakistan Point News - 25th Dec, 2024) The General on Tuesday adopted the Convention against Cybercrime, a landmark global treaty aimed at strengthening international cooperation to combat cybercrime and protecting societies digital threats. The on the legally binding treaty marked the culmination of a five-year effort by member states, with inputs , information security experts, academia and the private sector. UN Secretary-General Antonio Guterres welcomed the adoption of the Convention – the first international justice treaty to have been negotiated in over 20 years. “This treaty is a demonstration of multilateralism succeeding during difficult times and reflects the collective will of Member States to promote international cooperation to prevent and combat cybercrime,” his spokesperson said in a statement. The statement added that the Convention “creates an unprecedented platform for collaboration” in the of evidence, protection for victims and prevention, while safeguarding human rights online. “The Secretary-General trusts that the new treaty will promote a safe cyberspace and calls on States to join the Convention and to implement it in cooperation with relevant stakeholders.” Philemon Yang, President of the General , highlighted the importance of the new Convention. “We live in a digital , one where information and communications technologies have enormous potential for the development of societies, but also increases the potential threat of cybercrime,” he said. “With the adoption of this Convention, Member States have at hand the tools and means to strengthen international cooperation in preventing and combating cybercrime, protecting people and their rights online. ” The containing the Convention was adopted without a by the 193-member General . Ghada Waly, Executive Director of the Office on and Crime (UNODC), also described the adoption of the treaty as a “major victory” for multilateralism. “It is a crucial step forward in our efforts to address crimes like online child sexual abuse, sophisticated online scams and laundering,” she said. Ms. Waly reiterated the agency’s commitment to support nations in signing, ratifying and implementing the new treaty, as well as providing them with the tools and support they need to protect their economies and safeguard the digital sphere cybercrime. The Convention against Cybercrime acknowledges the significant risks posed by the misuse of information and communications technologies (ICT), which enable activities on an unprecedented scale, speed, and scope. It highlights the adverse impacts such crimes can have on States, enterprises, and the well-being of individuals and society, and focuses on protecting them offenses such as terrorism, human trafficking, drug smuggling and online financial crimes. It also recognizes the growing impact of cybercrime on victims and prioritizes justice, especially for vulnerable groups. It further underscores the need for technical assistance, capacity-building and collaboration among States and other stakeholders. The Convention against Cybercrime will open for signature at a formal ceremony to be hosted in , , in 2025. It will enter into force 90 days after being ratified by the 40th signatory.

PARIS: Newly restored Notre Dame Cathedral held its first mass on Sunday, with Christians celebrating the return of the French capital’s most famous place of worship after a historic re-opening ceremony. The beloved Paris monument nearly burned down in 2019, but has been fully renovated inside and fitted with a new roof and spire during a frenzied five-year refit. The inaugural mass was led by Paris archbishop Laurent Ulrich with 150 bishops and more than 100 priests from the capital in attendance, as well as French President Emmanuel Macron. The archbishop led prayers and consecrated a new altar which replaced the old one that was destroyed five years ago. “Whether you are here in person in the cathedral or in front of a screen, including perhaps under the rain, I greet you with intense emotion,” Ulrich told the congregation, referring to the small rain-drenched crowds outside watching events on public screens. In a nod to France’s ongoing political turmoil, he added that he “prayed also for our country that is looking to the future with worry.” A second mass in the evening at 6:30 pm will be open to the public, with roughly 2,500 people who secured free tickets this week expected to attend. The cathedral will open fully to visitors on December 16 via an online reservation system. ‘For Jesus’ During a re-opening service on Saturday attended by world leaders including US President-elect Donald Trump, Macron expressed the “gratitude of the French nation” for the restoration work since 2019. “We have rediscovered what great nations can do—achieve the impossible,” he said. Macron is under intense political pressure having called snap elections in June that led to a hung parliament, with the main parties now struggling to form a stable government. One of the most moving moments on Saturday came when firefighters in their protective gear walked through the congregation to thunderous applause as the word “Merci” (“Thank you”) was beamed on the intricate facade and famous belltowers of the Gothic masterpiece. The architectural wonder had been in danger of collapsing during the April 2019 blaze and was saved only by firefighters pumping vast quantities of water onto the flames from the nearby River Seine. Groups of worshippers huddled under umbrellas on Sunday beyond a strict security perimeter set up outside Notre Dame. “Beyond the reconstruction work, it’s beautiful because it shows that the church still has a role, discreet and small, but it still has a role to play in France,” 21-year-old engineering student Jacques told AFP. Monique Kashale, a 75-year-old from the Democratic Republic of Congo, said she was “very cold but for Jesus Christ I can put up with it, for the Virgin Mary it is bearable.” Trump in Paris Saturday’s re-opening service began with the archbishop Ulrich, dressed in brightly colored new vestments designed by fashion designer Jean-Charles de Castelbajac, knocking on the doors of the cathedral three times. Trump was placed on the front row as guest of honor next to Macron, with invitees marveling at the freshly cleaned walls, new furniture and state-of-the-art lighting installed as part of the overhaul. The reconstruction effort cost around 700 million euros ($750 million), financed from donations, with the five-year re-opening deadline met despite predictions it could take decades. Part of the cathedral’s lead roofing base still needs to be finished and the statues of the apostles and saints, removed before the fire to allow for their restoration, will only be reinstalled in the first half of 2025. The exact cause of the 2019 blaze has never been identified despite a forensic investigation by prosecutors, who believe an accident such as an electrical fault was the most likely reason. Notre Dame welcomed around 12 million visitors a year before the fire, but expects to receive an even higher figure of “14 to 15 million” after the reopening, according to the church authorities. Meanwhile, US president-elect Donald Trump Saturday met the UK’s Prince William on the sidelines of the reopening of Notre Dame in Paris, hailing the heir to the British throne as a “good man” who was doing a “fantastic job”. The elder son of King Charles III attended the reopening of the cathedral, restored after a 2019 fire, on behalf of the UK. The Prince of Wales was among some 40 heads of state and government in the French capital for the ceremony on Saturday. The last time William met Trump was in 2019, when the then-US president was on a state visit to the UK. “A good man, this one!” Trump told reporters, gesturing to William as they met in Paris at the residence of the UK ambassador to France after the ceremony. “He’s doing a fantastic job,” he added as William laughed. The prince’s last official trip to Paris was in 2017, when he visited with his wife, Princess Catherine, for a two-day trip in the aftermath of the Brexit result. He was not accompanied this time by Kate, who has been gradually resuming public duties after being diagnosed with cancer earlier this year. King Charles III is currently undergoing cancer treatment. William joined his father and other heads of state in Normandy for D-Day commemorations earlier this year, which were also attended by Jill Biden, wife of US President Joe Biden. - AFP

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