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Breakthrough in scalable production of high-quality organoids November 25, 2024 Pohang University of Science & Technology (POSTECH) Introducing the innovative 'UniMat' platform utilizing 3D engineered nanofiber membrane. Facebook Twitter Pinterest LinkedIN Email A research team led by Professor Dong Sung Kim and researcher Dohui Kim from the Department of Mechanical Engineering at POSTECH (Pohang University of Science and Technology) has successfully developed a platform capable of scalable, uniform production of organoids that mimic biological functions. The project was carried out in collaboration with Professor Tae-Eun Park and researcher Hyeonji Lim from the Department of Biomedical Engineering at UNIST (Ulsan National Institute of Science and Technology). This groundbreaking research has recently been published in the online edition of Nature Communications . Organoids are three-dimensional cellular constructs that replicate the functions of human organs, attracting significant attention in the fields of human organ development, disease modeling, and regenerative medicine research. However, the heterogeneity and low reproducibility of organoids present challenges for their scalable production, limiting their practical application in clinical trials and drug development processes. Additionally, current technologies face limitations in producing organoids at scale, falling short of meeting industrial demands. To address these challenges, the research team has developed a platform called UniMat (Uniform and Mature Organoid Culture Platform), which enables the scalable production of mature organoids. This platform is implemented using a three-dimensional engineered membrane made of extremely fine nanofibers -- about 1/200 the width of a human hair -- providing a structural environment that allows for uniform organoid formation while also enhancing nutrient and differentiation factor delivery through material permeability, which is crucial for organoid differentiation and maturation. Using UniMat, the team successfully produced kidney organoids featuring nephron structures and blood vessels similar to those found in human kidneys from human-induced pluripotent stem cells, achieving consistent quality and greatly improving production efficiency. Furthermore, they used UniMat to establish a polycystic kidney disease model, demonstrating the potential for standardized organoid-based disease modeling and drug evaluation. Professor Dong Sung Kim of POSTECH, who led the research, explained the significance of the study: "Through these research outcomes, we not only accelerate organoid-based R&D that requires high reproducibility and reliability, but we also expect to make significant contributions to the development of animal alternative testing methods, which are gaining increasing attention. By addressing both the quality assurance and scalable production challenges of organoids with UniMat, we have laid the foundation for the practical application of organoids in clinical and pharmaceutical industries." This research was supported by the Bio & Medical Technology Development Program, Mid-Career Researcher Program, and Young Researcher Program funded by the National Research Foundation of Korea and the Ministry of Science and ICT, as well as the Alchemist Project funded by the Ministry of Trade, Industry and Energy. Story Source: Materials provided by Pohang University of Science & Technology (POSTECH) . Note: Content may be edited for style and length. Journal Reference : Cite This Page :Significant milestones in life and career of Jimmy Carter
Man United will be very glad they didn't sign £38m flop, left out for four games in a row
Tampa Bay Buccaneers offensive coordinator Liam Coen has been a revelation this year. Coen, in his first year with the team, has done yeoman's work in turning one of the worst running teams in the NFL for years into one of the best in the league in 2024. How well has he done? He's managed to get the Bucs into the top 10 in the league in both rushing and passing offense. That's never been done before in Tampa Bay since the stats became trackable, per FOX Sports' Greg Auman. One thing Liam Coen has brought to the Bucs offense is a rare balance -- Tampa Bay is 10th in rushing yards per game, 10th in passing yards per game. NFL has rankings going back to 1990, and Bucs have never finished in the top 10 in both in same year in that range (likely never). Naturally - and unfortunately for Tampa Bay fans - that's meant Coen has gotten some rumblings throughout the year about being a potential head coaching candidate in the offseason. That didn't stop in the Wednesday column from NFL Network insider Tom Pelissero, who included Coen among his list of coaches who could be getting head coaching looks soon. Pelissero had the following to say about Coen: A former UMass quarterback who still holds school passing records, Coen spent a season in the arena league before going into coaching, where his résumé in recent years has been unique. He had two stints each with the Rams (2018-20, 2022) and the University of Kentucky (2021, 2023) before replacing Panthers head coach Dave Canales as Tampa Bay's OC this past offseason. The Buccaneers' offense has improved statistically, ranking fifth in scoring (27.9 points per game) despite Tampa's ongoing four-game losing streak amidst injuries to its top receivers. Coen has the demeanor and personality for a head job. He may get a look. It's not just the fact that the team has been productive on the field - and they obviously have been. It's been how he's managed to keep dialing up plays and concepts despite losing both of his top wide receivers. Some coordinators might have been satisfied to jam his offense down the throats of whatever reserve players might be stepping in, and that approach sometimes doesn't work. Simply put, some guys can't do what others can, and that's especially the case with stars like Mike Evans and Chris Godwin. However, the Bucs have strong talent elsewhere, particularly with budding star tight end Cade Otton and a room full of talented running backs. The calls made to get them involved in the passing game the last few weeks have been nothing short of genius. They've been effective to keep the offense going and scoring enough points to win some games that the Bucs have lost because of issues on the other side of the ball. Depending on how the 2024 season plays out, the Bucs could have a whale of a decision on their hands. Todd Bowles now has a losing record as a head coach with the Bucs despite the team winning the division the last two years. Coen will likely attract significant interest around the league. The Glazer family and general manager Jason Licht will have to decide if they have had enough of the status quo, or if they're ready to try to hand the reins to their franchise over to an innovative coach on the rise and keep him from leaving the building. This article first appeared on A to Z Sports and was syndicated with permission.Cameron Haffner helps Evansville end five-game skid with 57-40 victory over Missouri StateUS to require passenger vehicles to sound alarms if rear passengers don’t fasten their seat belts
Jake Paul and Mike Tyson have both been suspended by the Texas Department of Licensing and Regulation (TDLR) after their highly-anticipated fight. The two men were given the mandatory minimum of days, which in this case, is a 24-day suspension after their fight in Arlington. TDLR have a stipulation in place where each fighter is required to rest for at least three days per round fought, and because the the YouTuber-turned-boxer and the former undisputed heavyweight champion only fought for eight rounds, they will be suspended for 24 days, according to MMA Junkie . Amanda Serrano and Katie Taylor also will be banned from competing as well. With their fight going the distance, which Taylor won via a unanimous decision, the two stars will also be shelved for more than a month as a result of the fight, with the two being suspended for 45 days. Mike Tyson hid health problems from Jake Paul after fearing he would die before fight Jake Paul issues Mike Tyson fight apology as he makes major world title claim And while Serrano and Taylor's fight proved to be an incredible display of will and strength, Paul and Tyson's main event bout appeared to be anything but that. After a quick flurry from the 58-year-old early in the fight, Tyson appeared to tire quickly, with Paul taking advantage of his opponent's lack of stamina. After eight rounds of lackluster boxing , the 27-year-old was awarded a unanimous decision, with Paul bowing to Tyson in the waning moments of the final round. Speaking to his fans after the fact, Paul apologised for choosing not to knockout Tyson, despite promising he would do so. "I'm sorry I didn't knock him out," Paul began, with those alongside him agreeing he did the respectful move by not knocking down the 58-year-old legend. He also admitted to pulling his punches after he saw Tyson in a weakened state as the fight wore on. "After I'd seen him tired I didn't want to put too much hurt on him, but I wanted the fans to get a good experience," he continued. "But there was a point where my aggression and violence went away when I wasn't getting hit. I love Mike." Paul also added that fighting against Tyson was "different" compared to his previous bouts. In particular, he noted that his approach and being in a better headspace helped him calculate what Tyson was going to do and how to better prepare for what his 58-year-old opponent was going to do. "Fighting in a stadium, it is less personal and less loud so it is less nerve racking," Paul said. "Arenas are harder to fight in. Walk out, I was cool, calm and collected. "First round I was gauging his speed, and I managed to get his time pretty quick, saw how I could tag him up and touch him. The rest was pretty much history, I just out boxed him and had fun." With Paul proving he is one of the biggest draws in the sport, with over 100 million viewers tuning in at one point , the youngster believes he deserves a shot at facing some of the biggest names in the boxing. As a result, Paul believes he could be a champion in the coming years after defeating Tyson . "I think it could happen in the next 24 months. I truly, truly believe in my skills and my ability and my power. And the cruiserweight division is seemingly open for the taking on that timeline," he said.Merus announces First Patient Dosed in Phase 2 Trial of Petosemtamab in 3L+ mCRC
DETROIT (AP) — Starting in September of 2027, all new passenger vehicles in the U.S. will have to sound a warning if rear-seat passengers don’t buckle up. Related Articles National News | Former TV host Carlos Watson gets nearly 10 years in prison in case about failed startup Ozy Media National News | TikTok asks the Supreme Court for an emergency order to block a US ban unless it’s sold National News | Boston police arrest 2 on drones encroaching on Logan Airport National News | Survivors seek a reckoning as FBI investigates child sex abuse in little-known Christian sect National News | Trump migrant deportations could threaten states’ agricultural economies The National Highway Traffic Safety Administration said Monday that it finalized the rule, which also requires enhanced warnings when front seat belts aren’t fastened. The agency estimates that the new rule will save 50 lives per year and prevent 500 injuries when fully in effect, according to a statement. The new rule will apply to passenger cars, trucks, buses except for school buses, and multipurpose vehicles weighing up to 10,000 pounds. Before the rule, seat belt warnings were required only for the driver’s seat. Under the new rule, outboard front-seat passengers also must get a warning if they don’t fasten their belts. Front-center seats will not get a warning because NHTSA found that it wouldn’t be cost effective. The agency said most vehicles already have warnings for the outboard passenger seats. The rule also lengthens the duration of audio and visual warnings for the driver’s seat. The front-seat rules are effective starting Sept. 1 of 2026. Rear passengers consistently use seat belts at a lower rate than front passengers, the agency says. In 2022, front belt use was just under 92%, while rear use dropped to about 82%. About half of automobile passengers who died in crashes two years ago weren’t wearing belts, according to NHTSA data. The seat belt rule is the second significant regulation to come from NHTSA in the past two months. In November the agency bolstered its five-star auto safety ratings to include driver assistance technologies and pedestrian protection. Safety advocates want the Department of Transportation, which includes NHTSA, to finish several more rules before the end of the Biden administration, because President-elect Donald Trump has said he’s against new government regulations. Cathy Chase, president of Advocates for Highway and Auto Safety, urged the department to approve automatic emergency braking for heavy trucks and technology to prevent impaired driving.
New Locations in Collegeville and Malvern Mark Entry into Pennsylvania Market PHILADELPHIA , Dec. 10, 2024 /PRNewswire/ -- Options Medical Weight Loss, the nation's premier medical weight loss clinic, is excited to announce its expansion into the Philadelphia Metro area with the opening of two new clinics in Collegeville and Malvern . These state-of-the-art facilities mark the company's entry into Pennsylvania , advancing its mission to end obesity, one patient at a time through medically supervised, customized weight loss solutions. The grand opening celebrations will kick off at the Collegeville Options Medical Weight Loss clinic at 50 National Ave, Suite 200, Collegeville, PA 19355, on Tuesday, December 17 , from 4:00–6:00 p.m., with a ribbon-cutting ceremony hosted by the Montgomery County Chamber of Commerce at 4:30 p.m. The festivities continue at the Malvern Options Medical Weight Loss clinic, located at 50 National Ave, Suite 200, Malvern, PA 19355, on Wednesday, December 18 , from 4:00–6:00 p.m., with a ribbon cutting officiated by the Greater West Chester Chamber of Commerce at 4:30 p.m. "We are thrilled to bring Options Medical Weight Loss to the Philadelphia Metro area, offering two state-of-the-art clinics to meet the needs of this dynamic community," said Kristy Kaloyanides , chief operating officer. "This expansion reinforces our commitment to delivering compassionate, personalized care to people seeking safe, effective, medically supervised weight loss solutions." Grand Opening Highlights Include: Serving communities such as Collegeville , Malvern , Phoenixville , Radnor , and King of Prussia , both clinics offer tailored programs featuring board-certified obesity medicine specialists, one-on-one coaching, and advanced tools like the InBody scale for detailed progress tracking. Clinic Hours and Special Offers: The clinics will operate Tuesday through Thursday from 8:00 a.m. to 7:00 p.m. and Friday and Saturday from 8:00 a.m. to 2:00 p.m. During their grand opening weeks, local residents are invited to stop by for a FREE weight loss snapshot using the InBody scale, along with a consultation with certified health coaches. "At Options, we're dedicated to empowering patients to lead healthier lives by addressing the physical, emotional, and mental aspects of weight loss," said Dr. Katrina Mattingly , chief medical officer. "We're proud to bring our transformative care to a new market, helping the Philadelphia community achieve lasting health and confidence." These new clinics bring Options Medical Weight Loss's footprint to 39 locations nationwide, further solidifying its position as a leader in personalized, medically supervised weight loss care. To start a weight loss journey, sign up for a free consultation and metabolic scan at the Malvern or Collegeville location, or call 888-405-LOSE (5673). For more information about the weight loss program, visit OptionsMedicalWeightLoss.com or follow along on Facebook , Instagram , LinkedIn and YouTube . About Options Medical Weight Loss Options Medical Weight Loss is the nation's premier medical weight loss clinic. The company incorporates medically backed solutions, one-on-one health coaching, and innovative technology designed to track progress and help drive positive patient outcomes that far exceed the industry average. The practice has pioneered positive weight loss experiences for more than 50,000 patients since its founding in Chicago in 2014, and currently operates 37 full-service clinics throughout the U.S., including Illinois , Ohio , Florida , Arizona , Indiana , Michigan and Georgia . Visit OptionsMedicalWeightLoss.com for more information. About Thurston Group Thurston Group is a private equity firm that focuses on building industry-leading companies in the healthcare and business services sectors. Thurston has an extensive track record of partnering with physicians and building fast-growing healthcare businesses, including Smile Doctors, US Endo Partners, US Oral Surgery Management, South Georgia Dental Management, Gen4 Dental Partners, ARC Health, Options Medical Weight Loss and U.S. Orthopaedic Partners. Over its 35-year history, Thurston Group has returned more than $4B of invested capital. For additional information about Thurston Group, please visit Thurston Group's website at www.thurstongroup.com . View original content to download multimedia: https://www.prnewswire.com/news-releases/options-medical-weight-loss-brings-state-of-the-art-clinics-to-philadelphia-metro-area-302328089.html SOURCE Options Medical Weight Loss
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