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Gene Therapy to Target GD2 for Oncology is under clinical development by and currently in Phase I for Osteosarcoma. According to GlobalData, Phase I drugs for Osteosarcoma have an 89% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. Gene Therapy to Target GD2 for Oncology overview Gene therapy is under development for the treatment of relapsed or refractory neuroblastoma, osteosarcoma and refractory or metastatic GD2-positive sarcoma. It is administered and constitutes modified natural Killer T cells expressing the third-generation chimeric antigen receptor (CAR) transduced with retroviral vector specific for the disialoganglioside GD2 and the suicide gene inducible caspase 9 (iCasp9). Bristol-Myers Squibb overview (BMS) is a specialty biopharmaceutical company. It is engaged in the discovery, development, licensing and manufacturing, marketing, distribution and sale of medicines and related medical products to patients with serious diseases. Its primary focus is on cancer, immunology, cardiovascular, and fibrotic diseases. The company offers its products across the world to wholesalers, retail pharmacies, medical professionals, hospitals and government entities. The company has an operational presence in the US, Switzerland, Puerto Rico, Ireland, and the Netherlands. The company conducts research to focus on the discovery and development of novel medicines that address diseases in areas of unmet medical need. BMS is headquartered in Princeton, New Jersey, the US. For a complete picture of Gene Therapy to Target GD2 for Oncology’s drug-specific PTSR and LoA scores, This content was updated on 12 April 2024 From Blending expert knowledge with cutting-edge technology, GlobalData’s unrivalled proprietary data will enable you to decode what’s happening in your market. You can make better informed decisions and gain a future-proof advantage over your competitors. , the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article. GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s .Tottenham required a second-half strike by substitute Dejan Kulusevski to earn a 1-1 draw with Rangers in a pulsating Europa League clash at Ibrox . Former Celtic boss Ange Postecoglou was under the spotlight after just one win in seven and his side were more than matched by a combative Gers side amid a terrific atmosphere. The Light Blues took the lead two minutes into the second half through a terrific strike by in-form Moroccan striker Humza Igamane, his fifth goal in five games. Tottenham had to hold on grimly in the face of constant Gers pressure but half-time replacement Kulusevski equalised in the 75th minute with former Parkhead keeper Fraser Forster ending a fine night's work by making a terrific save late the game from Gers substitute Cyriel Dessers to take the point back south. Both sides moved on to 11 points from 18 with two fixtures remaining and still on course for the knockout stages but the Light Blues will take huge confidence from their performance into Sunday's Premier Sports Cup final against Celtic at Hampden Park. After Spurs enjoyed a pre-match huddle in front of their travelling support, both sides went at each other. Forster made fine saves from drives from Nedim Bajrami and Vaclav Cerny, twice, while Gers keeper Jack Butland thwarted Tottenham captain Heung-Min Son and Brennan Johnson, also at close range. Amid an expansive first half, John Souttar had to be replaced by Leon Balogun but the Gers fans were heartened by the interval, where Postocoglou replaced the ineffective Timo Werner with Kulusevski who barely had time to settle before Spurs fell behind. Gers skipper James Tavernier dinked a ball over the Tottenham defence and Igamane drilled the ball behind Forster from just inside the box to send most of Ibrox into raptures. Spurs wobbled and Ibrox rocked as Rangers went for number two with Cerny probing again. In the 53rd minute, as Spurs responded, Pedro Porro fired over the bar as a warning to the home side. Postecoglou took action. Lucas Bergvall, Dominic Solanke and Pape Sarr come on for Rodrigo Bentancur, Johnson and Yves Bissouma and Spurs regrouped, with Butland forced into a save at his near post from a Pedro Porro volley. Connor Barron and Dujon Sterling took over from the tiring Bajrami and Sterling in the 68th minute, just before Dejan Kulusevski drilled a left-footed drive low past Butland following a Solanke cut-back, to finish off a slick Spurs move. The visitors looked more likely to get a second but Rangers fought back again and Forster saved the day for Spurs five minutes from time when he Dessers, on for Igamane and the Gers substitute had the ball in the net moments later, only to be ruled offside.ADBE Earnings: Adobe Sinks as Soft Guidance Overshadows Q4 Beat - TipRanks
New Delhi: Prime Minister Narendra Modi on Thursday condoled the demise of former Prime Minister Manmohan Singh saying that India mourns the loss of one of its most distinguished leaders. In a post on X, the Prime Minister said that his thoughts are with Dr Manmohan Singh’s family, his friends, and his countless admirers. “India mourns the loss of one of its most distinguished leaders, Dr. Manmohan Singh Ji. Rising from humble origins, he rose to become a respected economist. He also served in various government positions, including as Finance Minister, leaving a strong imprint on our economic policy over the years. His interventions in Parliament were also insightful. As our Prime Minister, he made extensive efforts to improve people’s lives,” he wrote on X. “Dr. Manmohan Singh Ji and I interacted regularly when he was PM and I was the CM of Gujarat. We would have extensive deliberations on various subjects relating to governance. His wisdom and humility were always visible. In this hour of grief, my thoughts are with the family of Dr. Manmohan Singh Ji, his friends and countless admirers. Om Shanti,” PM Modi added. Manmohan Singh passed away on Thursday night at the age of 92 due to age-related medical conditions, AIIMS informed. Bharatiya Janata Party (BJP) President JP Nadda also expressed condolences over former PM Singh’s demise, calling it a loss for the nation. Nadda said that Singh’s legacy will continue to inspire generations in their pursuit of nation-building. “The passing of Former Prime Minister and Economist Shri Manmohan Singh ji is an immense loss for the nation. A visionary statesman and a stalwart of Indian politics, throughout his remarkable career in public service, he consistently voiced for the welfare of the downtrodden. His leadership earned admiration and respect across party lines. Shri Manmohan Singh Ji’s legacy will continue to inspire generations in their pursuit of nation-building. My heartfelt condolences to his family, friends, and admirers. Om Shanti,” JP Nadda. Aam Aadmi Party (AAP) MP Raghav Chadha expressed his deepest condolences to Singh’s family and called him blessed and privileged to have had the opportunity to work alongside him in the Rajya Sabha. “A world-renowned economist and the architect behind the liberalization of the Indian economy, Dr Manmohan Singh Ji steered India through difficult times and into a new era. An Oxford-educated economist, he spearheaded India’s 1991 economic reforms and led the nation as Prime Minister with quiet determination, proving that intellect and integrity can drive transformative change. I join the nation in mourning the passing of one of our most distinguished statesmen. His legacy will endure and inspire generations to come. I consider myself blessed and privileged to have had the opportunity to work alongside him in the Rajya Sabha. My deepest condolences to his family. RIP, Sir. Om Shanti,” the AAP leader posted on X. Singh retired from the Rajya Sabha earlier this year after serving for 33 years in the house. Manmohan Singh, born in Punjab in 1932, served two terms as Prime Minister of India- from 2004 to 2014. He took the oath of office for the first time in 2004, after Congress’ win in the 2004 Lok Sabha election against Atal Bihari Vajpayee-led NDA. He served his second term from 2009 to 2014. He was then succeeded by PM Narendra Modi in 2014.Ohio secures 84-68 win against Robert Morris
Northwest B.C. First Nation Nadleh Whut’en has confirmed the identification of potential unmarked graves at the site of the former Lejac Indian Residential School, located at Tseyaz Bunk’ut near Fraser Lake. Earlier in May, the First Nation had said it would search the residential school site using both ground-penetrating radar (GPR) and magnetometry to detect irregularities underground. Lejac Indian Residential School operated from 1922 to 1976, impacting children from over 70 Nations. Nadleh Whut’en's announcement on November 30 follows nearly two years of geophysical surveys that began after Tk'emlúps te Secwépemc First Nation revealed in 2021 that they had identified around 200 potential burial sites at the former Kamloops Indian Residential School. Nadleh Whut’en said the preliminary findings from GPR and magnetometry surveys at Lejac uncovered geophysical signatures consistent with burials. These results are part of ongoing efforts to locate and honour the children who died while attending residential schools in Canada, the First Nation said. The survey, conducted by the guiding team of the project, which translates to "Let's Look for our Children" in Dakelh, covers a 142,500 square-meter area (about 27 football fields). The research is a response to survivor testimony and archival records that suggest numerous children may have been buried in unmarked graves at Lejac. During its operation, at least 7,850 Indigenous children, including day scholars, attended the residential school, which subjected students to harsh conditions, including forced labor, abuse, and the loss of cultural identity. The school’s cemetery, where some graves are marked, has long been known to survivors. However, the recent surveys suggest there are additional unmarked graves that have not been accounted for. “The work is hard and it takes a long time – and we are bringing information forward as we receive it because survivors have a right to know,” Nadleh Whut’en Chief Beverly Ketlo said about the importance of these findings. The Lejac Indian Residential School has had an active cemetery on the grounds since it was founded in 1922. "We have always known that there were children buried at Lejac because many of their graves are marked in a cemetery. I want you to ask yourself if your elementary school had a cemetery,” Ketlo added. Ketlo said this is not just a thing of the past but the horrors experienced at Lejac are still very real for the survivors who lived through this "genocide.” “Lejac relentlessly taught the children that they were inferior. They were forcibly taken from their families, lands, and cultures, leading them to believe that everything about their identity was wrong,” she said. The geophysical surveys, which were conducted in winter 2023 and spring/summer 2024, used advanced technologies to detect disturbances beneath the surface that could indicate burial sites. GPR sends radar pulses into the ground, revealing underground conditions, while magnetometry detects metal objects and magnetic changes. This data is being analyzed by two independent teams of experts and will guide future steps in the search for missing children. Former Chief Archie Patrick of Stellat’en First Nation, a survivor of Lejac, expressed hope that these efforts would help bring justice to those affected. “Lejac is still with me. I continue to deal with the upheaval of being taken from my parents, and the daily trauma of living at that place. But I am so pleased that the stories of survivors are finally being brought to light.” The findings are part of ongoing work, and no immediate plans for excavation or exhumation have been made. The guiding team, made up of survivors and inter-generational survivors, is overseeing the research and will determine the next steps. The federal government has committed to funding these efforts, and an estimated 20 years of work remain to uncover the full truth about the missing children from residential schools across Canada.Supporting high-performing building codes in Prince Edward Island
(Reuters) – Bitcoin neared $100,000 for the first time on Thursday as the election of Republican Donald Trump as president fuelled expectations that his administration will create a friendly regulatory environment for cryptocurrencies. The world’s biggest and best-known cryptocurrency has more than doubled from this year’s low of $38,505 and is up about 45% in the two weeks since Trump’s sweeping election win. Here are key events in bitcoin’s journey towards $100,000: 2008: Satoshi Nakamoto, the pseudonym used by the cryptocurrency’s presumed developer, introduces the concept of bitcoin 2010: The first retail transaction takes place when a user pays 10,000 bitcoin for two Papa John’s pizzas 2013: As bitcoin’s popularity grows, Cameron and Tyler Winklevoss, co-founders of crypto exchange Gemini, file their first application with the U.S. Securities and Exchange Commission to create a spot bitcoin ETF. Grayscale Investments launches the Bitcoin Investment Trust, an open-ended private bitcoin trust. 2016: The Winklevoss brothers adjust their application numerous times, such as the exchange on which the product would be traded. They also file amendments naming State Street as administrator. Grayscale files with the SEC to convert its bitcoin trust into a spot bitcoin ETF. 2017: The SEC rejects the Winklevoss application on the grounds bitcoin markets were not mature enough. Grayscale withdraws its first attempt to convert its trust into an ETF, saying the regulatory environment was not developed enough. 2018: The SEC rejects the Winklevoss twins’ second application to launch a spot bitcoin ETF, saying cryptocurrency exchanges do not have the necessary controls to prevent manipulation. 2020: Grayscale transforms its trust into an SEC-reporting entity, and its shares begin trading on the pink sheets, for stocks that trade over the counter. Although not an ETF, it is the first publicly traded bitcoin fund in the U.S. 2021: The first spot bitcoin ETF launches in Canada. Gary Gensler replaces Jay Clayton as SEC chair in April. In October, the SEC approves the ProShares Bitcoin Trust listed on the Chicago Mercantile Exchange, noting the CME has a satisfactory mechanism for surveilling abuse in the futures market. It is the first U.S.-listed futures-based bitcoin ETF, accumulating $1 billion in assets within its first days of trading – faster than any other ETF. Also in October, Grayscale again submits an application to the SEC to convert its trust into a spot bitcoin ETF. 2022: The SEC rejects several applications from would-be spot bitcoin ETF issuers, including SkyBridge, Fidelity and Bitwise. The SEC also rejects Grayscale’s application, prompting the company to sue the agency. Amid crashing crypto prices, multiple crypto companies file for bankruptcy, including Three Arrows Capital, Celsius Network and FTX, whose founder Sam Bankman-Fried is also charged with fraud. 2023: May: Cathie Woods’ ARK Investments and CBOE Global Markets file for a spot bitcoin ETF, giving the SEC a maximum of 240 days to approve or reject the application. June: BlackRock files a spot bitcoin ETF application with the SEC, raising industry hopes the agency may approve the product and sending the price of bitcoin to a one-year high. A flurry of other issuers and exchanges, including Fidelity and Invesco, file bitcoin ETF applications in the subsequent weeks and months. August: A federal appeals court in Washington D.C. rules in favor of Grayscale, saying the SEC did not justify why it had rejected its proposal. Europe’s first spot bitcoin ETF begins trading on the Euronext Amsterdam stock exchange. October: The SEC opts not to appeal the court’s ruling in the Grayscale case and is required to reexamine the application. 2024: Jan. 10: The SEC approves 11 proposals from issuers including BlackRock, Fidelity and VanEck, among others, to launch spot bitcoin ETFs. February: Net inflows into the 10 largest ETFs hit $4 billion in the first month, according to LSEG data. March: Bitcoin tops $70,000 for the first time to hit a record high, having doubled in value in the five months. June: Trump pitches himself as a champion for cryptocurrency and slammed Democrats’ attempts to regulate the sector during a San Francisco fundraiser. July: Trump tells a bitcoin conference that, if elected, he will create a strategic national bitcoin stockpile and will ensure the United States is the “crypto capital of the planet.” October: The SEC grants “accelerated approval” to U.S. exchanges to list and trade options tied to 11 spot bitcoin ETFs. Nov 6: Trump is declared winner of the presidential election, sparking a huge rally in a range of assets, with bitcoin being the standout gainer. Nov 12: Total crypto market cap reaches $3 trillion for the first time. Year-to-date ETF net inflows hit $25.8 billion, according to LSEG data. Nov 21: Bitcoin nears $100,000 for the first time in history, driven by a swell of buying from investors in anticipation of Trump dismantling a lot of the regulation around crypto investment. The price has risen by around 40% since the election. (Reporting by Amanda Cooper, Hannah Lang and Suzanne McGee; Editing by Rod Nickel) Disclaimer: This report is auto generated from the Reuters news service. ThePrint holds no responsibilty for its content. var ytflag = 0;var myListener = function() {document.removeEventListener('mousemove', myListener, false);lazyloadmyframes();};document.addEventListener('mousemove', myListener, false);window.addEventListener('scroll', function() {if (ytflag == 0) {lazyloadmyframes();ytflag = 1;}});function lazyloadmyframes() {var ytv = document.getElementsByClassName("klazyiframe");for (var i = 0; i < ytv.length; i++) {ytv[i].src = ytv[i].getAttribute('data-src');}} Save my name, email, and website in this browser for the next time I comment. Δ document.getElementById( "ak_js_1" ).setAttribute( "value", ( new Date() ).getTime() );NASHUA, NH – Despite having lived in Nashua for over a decade, through all of the ’90s, I did not remember the Temple Street Diner when I pulled into their parking lot. I had arranged to meet there with Ed Briand and Chuck Smith, both enthusiastic hunters, to discuss Ed getting his 30th bear at the impressive age of 100 (Ed, not the bear). Chuck lives in Kingston, Ed lives in Nashua, and they figured the diner would be a good spot to meet. Plus, it’s a favorite of Ed’s. This became apparent, when, within minutes of meeting me there, Ed leaned toward me and said, “The girls here, they know me. I razz the shit out of ’em.” A few minutes later a waitress arrived, glanced at Ed, and said, “I wish I’d known it was THIS troublemaker who was coming!” Ed smiled at me as he said, “Told ‘ya!” A bit later, after his order of scrambled eggs & dry rye toast had been delivered, Ed dumped a container of his medications onto the plate of eggs. Maybe eight pills. I’ve seen people 30 years younger with far more complicated sets of medications. After a few bites Ed looked at me and asked, “So what kind of story we lookin’ for here?” I said, “That’s pretty much up to you.” Ed said, “First of all, I gotta ask, are you anything to do with the Fed?” “You mean the government? Law enforcement? Nope, not me.” “Are you sure?” he said, with the beginnings of a grin. Then I realized he was pulling my leg. That would become a theme in our conversation. On a Friday morning at 9:30, less than half of the diner’s tables are filled. The south wall is nearly all glass, facing the Henry Hanger Mill, which is currently undergoing major renovations to become the “ Hanger Mill Residences .” (They look like they will be impressive.) Ed said he remembered when it was a shoe mill with a shoe store on the ground floor. According to Ed, he worked at the shoe store for a while. In fact, he seemed to have worked at many places in and around Nashua. He explained that his father would get irritated with his habit of changing jobs frequently. “My old man used to get pissed off. I said, ‘Dad, I go there, I learn my limit, then: see ya.'” Forty years ago, Ed was at his last job before retiring, running his own full-service gun shop in Nashua, where he sold and serviced many kinds of guns. At that time Chuck was looking to purchase a gun, and that’s how he med Ed. Chuck bought a gun at Ed’s shop and they became friends, later hunting together often. Ed was born in Nashua in 1924. As a kid he skated on the Merrimack River when it froze over, which he says used to happen far more often than today. He and friends jumped trains in Nashua and rode them further north. Remember, Ed would have been 16 years old in 1940. Later he served briefly in the military during WWII. His service was cut short by an injury during training. Later still, Ed did all of the following: Worked on farms Worked in mills Worked as a Nashua city boiler inspector for a while Drove trucks Did some plumbing Worked in construction Supervised construction crews Dealt with workers gambling on the job Dealt with bookkeepers being overly creative Built from 70 to 100 homes on land he owned near Lincoln Park in Nashua, on streets Edmund Drive, Luke Street, Marie Avenue, Denise Street, among others Fished and hunted north of the arctic circle Worked as a caribou hunting guide in Canada Hunted bear, deer, caribou, moose, plus smaller game Has never eaten bear – but Chuck has Befriended Hells Angels members in Lowell, MA Was subject of article in Hawkeye magazine, regarding NH crossbow hunting regulation change Ed said that while running a construction crew, he once took a vacation, and when he returned, the amount of construction finished during his absence was far less than what he expected. As he asked around, some suspicions began to develop. He had three workers who spoke French but very little English. With the help of a translator he determined that one of the foremen had, in Ed’s absence, taken these French workers into the building and coerced them into gambling with him at cards. Unsurprisingly this guy had also won most of the hands, bilking the French workers out of most of their earnings. Ed questioned the guy, he owned up, Ed told him to get gone and not come back. Later Ed discovered a bookkeeper had been way too creative with the books. The outcome there was much the same – bye bye, bookkeeper. Ed spent some time north of the arctic circle. He visited the town of Hay River on the south shore of Great Slave Lake, in Canada’s Northwest Territories. This is the same lake seen on the History Channel TV show “Ice Road Truckers.” He fished in that lake and did some hunting and guiding in the surrounding territory. At some point Ed became a motorcycle rider and owner, and became acquainted with a few Hells Angels in Lowell, MA. He said that being friends with Hells Angels meant he always had a safe place to park his bike. Today Ed uses a cane for help with walking, is not as nimble as he used to be. He likes pizza and the occasional John Wayne movie. And still enjoys hunting. So how the heck did I learn about a 100-year-old hunter in Nashua, anyway? Earlier in the fall Chuck came to my house to perform a standard annual furnace inspection. Chuck works for Crawford-Vogel & Wenzel Oil Company in Manchester. While chatting he mentioned that he was looking forward to his vacation in a few weeks. I asked what he had planned. “Going bear hunting up north with a friend.” “No kidding? I’ve never been bear hunting.” “Guess how old my friend Ed is.” “No idea.” “In a month he’ll be 100.” I was flabbergasted. “One hundred years old? And he’s still hunting? Hunting bear?” “Yup. If he gets one this year it will be his 30th bear.” “Wow, that’s amazing. 100 years old. I’ll bet he’s got some stories.” Before I knew what was happening, Chuck pulled out his cellphone, punched a button, then was speaking into the phone saying, “Hey this is Chuck, I’ve got a guy here who wants to talk to you” then he handed me the phone, saying, “Here he is, go ahead, talk to him.” Trying to stop sputtering, I took the phone. “Hi, is this Ed?” “Yeah, who’s this?” “Hi, my name’s Jeff, Chuck is here at my house working on the furnace and telling me about his plans to go bear hunting. He says you’re going to join him.” “Yup, planning to.” “He also tells me that you’re about to turn 100.” “Yup, that’s right too.” I said, “Wow, 100 and still hunting bear. That’s pretty impressive.” “Well, it will be if I get one.” “Well, I hope you do. Maybe we can talk more about it after that.” “Sure, that would be great.” “OK, I’ll stay in touch with Chuck and we’ll see how the hunting goes this year.” After that Chuck and I exchanged numbers and I checked in with him periodically to see how the hunt was going. Meanwhile, I had a chance to educate myself about bear hunting in New Hampshire. At least two organizations are fantastic sources of information online. One is the Wildlife Heritage Foundation of NH , and they are the official non-profit partner of the second organization, the NH Fish & Game Department . For bear hunting specifically, Fish & Game has a lot of info at this link . And boy did I learn a lot. Within a single normal year, each hunter is only allowed to take a single bear. (2024 is not normal, more below.) Typically, about a thousand bears per year are killed by hunters in NH. Below are specific counts for years 2018 – 2022. 2018 — 1,053 2019 — 866 2020 — 1,184 2021 — 892 2022 — 1,156 The season typically starts September 01 and ends on November 30, with the bulk of the bear harvest occurring in September. However, the state’s area is divided into 19 “Wildlife Management Units,” or WMUs (see map), and not all units are included in that entire time frame. Those curious should consult the Fish & Game Department website for details. Within the overall bear season, there are three distinct smaller seasons: (1) allows stalking of bear, (2) allows stalking with dogs, (3) allows use of bait to lure bear. For each of these, a bear hunting license is required, and the latter two seasons each require an additional specific license. Furthermore, each of those distinct activities will have its own restrictions as to region (WMUs) where it’s allowed, and specific time periods when it’s allowed. Within a single year, hunters may normally take only one bear statewide. But in 2024 New Hampshire has an oversized population of black bears, currently at 0.64 bears per square mile, with a goal is 0.52. That’s a total of 5,955 bears in the state, where the desired population is 4,838, for an overpopulation state-wide of 1,117 bears. The overpopulation is worst in the White Mountains, at 1.24 bears per square mile, with a goal of 0.80 bears per square mile. At least partially as a result of this overpopulation, National Forest staff have fielded daily calls since July concerning human-bear interactions on the National Forest’s trails. (Those trails include Lincoln Woods, Bondcliff, Franconia Brook, Lincoln Brook, and at the Liberty Springs and Thirteen Falls campsites.) Staff generally want to minimize bear-human interactions. Therefore, as a form of population control, this year NH Fish & Game is allowing hunters to purchase a license for a second bear to be taken in the white mountains region (WMUs C1, D2, E, or F – the green areas on the map). There are 13 stations throughout the state where hunters may perform the legally-required registration of their kills. After educating myself, I checked back in with Chuck, and, sure enough, Ed had gotten a bear, which weighed about 145 lbs., and Chuck got one too. For Ed, this was his 30th bear kill in his lifetime. (BTW, all photos supplied by Chuck, except those of the diner taken be me.) Below are several photos taken during Ed and Chuck’s hunting trips over the years. Finally... Ed and Chuck have plenty of game cameras throughout the area. Below are various images they’ve captured over the years – two bears at night, one bear getting a close-up selfie, a bull moose at night, two cubs, and a lynx or bobcat.
US House passes defense bill banning gender care for minorsRitholtz Wealth Management’s Josh Brown created a new index that tracks the most popular stocks in some of the hottest themes of the market . What To Know: Last Tuesday on " The Compound & Friends " podcast, Brown set the stage for unveiling the “Degen Dow.” “I think that if we were to make a list of the biggest themes of 2024, one of those themes would have been degeneracy,” Brown said. It’s tough to say precisely how the word “degen” came to be, but some believe it originates from the term “degenerate gambler” in sports betting and gambling culture, according to The Wall Street Journal. It’s also used by crypto traders and meme-stock traders who often make risky short-term bets based on momentum and steer clear of traditional ways of assessing investments. Brown put together a list of the top stocks used as trading vehicles by “degen” traders using platforms such as Robinhood, Stocktwits and Reddit’s WallStreetBets . The list includes high beta Bitcoin BTC/USD -related names, gaming and gambling companies, AI names, space theme plays, Cathie Wood favorites and president-elect Donald Trump -related stocks. “All the major degen food groups are represented,” Brown said. Here’s a look at all of the stocks that made it into the “Degen Dow.” Archer Aviation Inc ACHR AMC Entertainment Holdings Inc AMC Applovin Corp APP Coinbase Global Inc COIN Carvana Co CVNA Trump Media & Technology Group Corp DJT DraftKings Inc DKNG Flutter Entertainment Plc FLUT Geo Group Inc GEO GameStop Corp GME Hims & Hers Health, Inc HIMS Robinhood Markets, Inc HOOD Lucid Group, Inc LCID MARA Holdings, Inc MARA MicroStrategy Inc MSTR NVIDIA Corp NVDA PagerDuty, Inc PD Palantir Technologies Inc PLTR Roblox Corp RBLX Reddit, Inc RDDT Riot Platforms, Inc RIOT Rivian Automotive, Inc RIVN Rocket Lab USA, Inc RKLB Rumble Inc RUM Super Micro Computer Inc SMCI SoFi Technologies, Inc SOFI SoundHound AI, Inc SOUN Tesla, Inc TSLA Unity Software Inc U Vistra Corp VST Why It Matters: Brown equal-weighted the basket of stocks in the index to track performance. The index actually declined more than 80% from the highs in late 2021, but it has formed a base and appears to be breaking out to the upside with gains of nearly 50% since the start of the year. “Look how it’s like turning up ... this thing is ripping into year-end,” Brown said, to which his co-host Michael Batnick replied, “I want to get long.” Brown noted Nvidia and Reddit are the only two names on the list he currently owns. Read Next: GameStop Q3 Earnings: Revenue Miss, $4B+ Cash, No More Offerings Planned In Fiscal Year Photo: Shutterstock © 2024 Benzinga.com. Benzinga does not provide investment advice. All rights reserved.
Kremlin falsely claims Trump’s report of 600,000 Russian casualties in Ukraine came from Kyiv
Over the last couple of months, there have been recalls of millions of pounds of meat for listeria concerns and of carrots for potential E. coli contamination . Searches for “recalled ground beef” are trending on Google while some on social media are claiming that hundreds of thousands of pounds of ground beef have been recalled. THE QUESTION Is there a ground beef recall for potential E. coli contamination? THE SOURCES U.S. Food Safety and Inspection Service (FSIS) Minnesota Department of Health Centers for Disease Control and Prevention (CDC) THE ANSWER Yes, there is a ground beef recall for potential E. coli contamination, but the recalled meat was not sold in grocery stores. WHAT WE FOUND Wolverine Packing Co. is recalling about 167,277 pounds of ground beef products due to potential E. coli contamination, according to a Nov. 20 announcement from the U.S. Food Safety and Inspection Service (FSIS) . The recalled beef is not sold in stores. The FSIS says the beef was shipped to restaurant locations nationwide. The FSIS did not name the restaurants where the beef was distributed. Restaurants can identify the recalled beef by looking for establishment number “EST. 2574B” inside the USDA mark of inspection. Fresh products have a “use by” date of 11/14/2024, and frozen products have a production date of 10 22 24. The FSIS has shared a list of product labels for the recalled beef. The FSIS says the problem was discovered after the Minnesota Department of Agriculture notified them of a group of people who reported eating ground beef before becoming sick. On Nov. 15, the Minnesota Department of Health urged people to contact their healthcare provider if they ate a hamburger at a table-service restaurant anytime after Oct. 31 and developed diarrhea, particularly bloody diarrhea. At the time, the Minnesota Department of Health reported that infected people ate the contaminated meat between Oct. 31 and Nov. 7. The FSIS said all 15 reported infections so far have been in Minnesota. E. coli is a kind of bacteria that can be found in many places, including the intestines of people and animals. Most kinds of E. coli are harmless and part of a healthy intestinal tract, but some E. coli can make people sick with diarrhea, urinary tract infections, pneumonia, sepsis and other illnesses, according to the Centers for Disease Control and Prevention (CDC) . The kind of E. coli found in the contaminated beef can cause dehydration, stomach cramps that last two to eight days and diarrhea that is often bloody, according to the FSIS, although the Minnesota Department of Health also notes that patients usually have no fever or a low-grade fever. Most people recover in five to 10 days, but about 5% of infections lead to hemolytic uremic syndrome (HUS), a severe complication that involves acute kidney failure, the Minnesota Department of Health says. HUS can occur to people of any age, but is most common in older adults and children under 5 years old, the FSIS says. Symptoms include easy bruising, pale skin and decreased urine output. People who experience these symptoms should immediately seek emergency medical care. Related Articles Yes, there is a carrot recall following an E. coli outbreak Yes, some black plastics in kitchen utensils, toys are made from recycled electronics Yes, the average Thanksgiving meal this year is more affordable than last year The VERIFY team works to separate fact from fiction so that you can understand what is true and false. Please consider subscribing to our daily newsletter , text alerts and our YouTube channel . You can also follow us on Snapchat , Instagram , Facebook and TikTok . Learn More » Follow Us YouTube Snapchat Instagram Facebook TikTok Want something VERIFIED? Text: 202-410-8808Gene Therapy to Target GD2 for Oncology is under clinical development by and currently in Phase I for Osteosarcoma. According to GlobalData, Phase I drugs for Osteosarcoma have an 89% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. Gene Therapy to Target GD2 for Oncology overview Gene therapy is under development for the treatment of relapsed or refractory neuroblastoma, osteosarcoma and refractory or metastatic GD2-positive sarcoma. It is administered and constitutes modified natural Killer T cells expressing the third-generation chimeric antigen receptor (CAR) transduced with retroviral vector specific for the disialoganglioside GD2 and the suicide gene inducible caspase 9 (iCasp9). Bristol-Myers Squibb overview (BMS) is a specialty biopharmaceutical company. It is engaged in the discovery, development, licensing and manufacturing, marketing, distribution and sale of medicines and related medical products to patients with serious diseases. Its primary focus is on cancer, immunology, cardiovascular, and fibrotic diseases. The company offers its products across the world to wholesalers, retail pharmacies, medical professionals, hospitals and government entities. The company has an operational presence in the US, Switzerland, Puerto Rico, Ireland, and the Netherlands. The company conducts research to focus on the discovery and development of novel medicines that address diseases in areas of unmet medical need. BMS is headquartered in Princeton, New Jersey, the US. For a complete picture of Gene Therapy to Target GD2 for Oncology’s drug-specific PTSR and LoA scores, This content was updated on 12 April 2024 From Blending expert knowledge with cutting-edge technology, GlobalData’s unrivalled proprietary data will enable you to decode what’s happening in your market. You can make better informed decisions and gain a future-proof advantage over your competitors. , the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article. GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s .Brian Odom has made an impact in a short time at UNT, which is turning to him to save year as DC
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