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Tributes to 'lovely mother and grandmother' who died after accidentPunjab bandh today: From govt offices to bank and rail, road and airport services — what's open, what's closed?Facebook Twitter WhatsApp SMS Email Print Copy article link Save WASHINGTON — American Airlines briefly grounded flights nationwide Tuesday because of a technical problem just as the Christmas travel season kicked into overdrive and winter weather threatened more potential problems for those planning to fly or drive. Government regulators cleared American flights to get airborne about an hour after the Federal Aviation Administration ordered a national ground stop for the airline. The order, which prevented planes from taking off, was issued at the airline's request after it experienced trouble with its flight operating system, or FOS. The airline blamed technology from one of its vendors. As a result, flights were delayed across American's major hubs, with only 36% of the airline's 3,901 domestic and international flights leaving on time, according to Cirium, an aviation analytics company; 51 flights were canceled. People are also reading... York Fire Department responds to Thursday evening structure fire York Fire Department investigating cause of Thursday night blaze 2024 York News-Times All-Area Football Team 2024 York News-Times All-Area Volleyball Team York's housing gap to shrink with new Countryside Estates development Body found in rural Colfax County identified 'Way different numbers': Nebraska's Matt Rhule talks rising costs of players from a year ago 'I can't turn anyone away' — Utica native leads 52-member 4-H club in Columbus Amie Just: National player of the year or not, Lexi Rodriguez has revolutionized libero position Amie Just: Lexi Rodriguez deserved a national title. For her career to end like this? Gutting Gov. Jim Pillen has 7 broken ribs and other injuries after fall from horse Suzanna “Suzie” Jackson Most York restaurants closing early on Christmas Eve Rankings: Nebraska high school boys basketball, Dec. 23 York County deputies arrest Colorado man for possession of drugs, knife An American Airlines employee wearing looks toward quiet check-in counters Tuesday in the American terminal at Miami International Airport in Miami. Dennis Tajer, a spokesperson for the Allied Pilots Association, a union representing American Airlines pilots, said the airline told pilots at 7 a.m. Eastern that there was an outage affecting the FOS system. It handles different types of airline operations, including dispatch, flight planning, passenger boarding, as well as an airplane's weight and balance data, he said. Some components of FOS went down in the past, but a systemwide outage is rare, Tajer said. Hours after the ground stop was lifted, Tajer said the union had not heard about "chaos out there beyond just the normal heavy travel day." He said officials were watching for cascading effects, such as staffing problems. On social media, however, customers expressed frustration with delays that caused them or their family members to miss connecting flights. One person asked if American planned to hold flights for passengers to make connections, while others complained about the lack of assistance they said they received from the airline or gate agents. Travelers wait in line for security checks Tuesday at the Los Angeles International Airport in Los Angeles. Bobby Tighe, a real estate agent from Florida, said he would miss a family Christmas Eve party in New York because his American flight was repeatedly delayed. The delays made him miss a connecting flight, leaving him the choice of going to his destination — Westchester, N.Y. — on Christmas Day or taking another flight to Newark, N.J., scheduled to land Tuesday evening. He chose the latter. "I'm just going to take an Uber or Lyft to the airport I was originally supposed to go to, pick up my rental car and kind of restart everything tomorrow," Tighe said. He said his girlfriend was "going through the same exact situation" on her way from Dallas to New York. Cirium noted the vast majority of flights departed within two hours of their scheduled departure time. A similar percentage — 39% — arrived at their destinations as scheduled. Dallas-Fort Worth, New York's Kennedy Airport and Charlotte, North Carolina, saw the greatest number of delays, Cirium said. Washington, Chicago and Miami experienced considerably fewer delays. Meanwhile, the flight-tracking site FlightAware reported that 4,058 flights entering or leaving the U.S., or serving domestic destinations, were delayed, with 76 flights canceled. The site did not post any American Airlines flights Tuesday morning, but it showed in the afternoon that 961 American flights were delayed. Amid the travel problems, significant rain and snow were expected in the Pacific Northwest at least into Christmas Day. Showers and thunderstorms were developing in the South. Freezing rain was reported in the Mid-Atlantic region near Baltimore and Washington, and snow fell in New York. An American Airlines employee wearing a Santa Claus hat walks through the American terminal Tuesday at Miami International Airport in Miami. Because the holiday travel period lasts weeks, airports and airlines typically have smaller peak days than they do during the rush around Thanksgiving, but the grind of one hectic day followed by another takes a toll on flight crews. And any hiccups — a winter storm or a computer outage — can snowball into massive disruptions. That is how Southwest Airlines stranded 2 million travelers in December 2022, and Delta Air Lines suffered a smaller but significant meltdown after a worldwide technology outage in July caused by a faulty software update from cybersecurity company CrowdStrike. Many flights during the holidays are sold out, which makes cancellations even more disruptive than during slower periods. That is especially true for smaller budget airlines that have fewer flights and fewer options for rebooking passengers. Only the largest airlines, including American, Delta and United, have "interline agreements" that let them put stranded customers on another carrier's flights. This will be the first holiday season since a Transportation Department rule took effect that requires airlines to give customers automatic cash refunds for canceled or significantly delayed flights. Passengers still can ask to get rebooked, which is often a better option than a refund during peak travel periods. That's because finding a last-minute flight on another airline tends to be expensive. American Airlines employees check in travelers Tuesday in the American terminal at Miami International Airport in Miami. An American spokesperson said Tuesday was not a peak travel day for the airline — with about 2,000 fewer flights than the busiest days — so it had somewhat of a buffer to manage the delays. The Transportation Security Administration said it expected to screen 40 million passengers through Jan. 2. About 90% of Americans traveling far from home over the holidays will be in cars, according to AAA. Gasoline prices are similar to last year. The nationwide average Thursday was $3.04 a gallon, down from $3.13 a year ago, according to AAA. Flight nightmare? Here's how to get compensated Flight nightmare? Here's how to get compensated "It's not the destination, it's the journey," said American essayist Ralph Waldo Emerson. Ralph clearly was not among the travellers on one of more than 350 cancelled or 1,400 delayed flights after a worldwide tech outage caused by an update to Crowdstrike's "Falcon Sensor" software in July of 2023. U.S. airlines carried nearly 863 million travellers in 2023, with Canadian carriers accounting for another 150 million, many of whom experienced lost luggage, flight delays, cancellations, or were bumped off their flights. It's unclear how many of them were compensated for these inconveniences. Suffice it to say, posting a crabby rant on social media might temporarily soothe anger, but it won't put wasted money back in pockets. Money.ca shares what to know in order to be compensated for the three most common air travel headaches. Lost Luggage Bags elected to go on a vacay without you? Check off the following: Alert the airline, both in person and in writing, of any missing bags. Remember, the clock starts ticking immediately. After 21 days, the baggage is considered lost and the airline is liable for it and its contents. Contact the U.S. Department of Transportation (DOT) or Canadian Transportation Agency , who will query the airline on your behalf and give them a 30-day deadline to respond. Usually, the airline will resolve the issue, but if it doesn't, or if you're unsatisfied with the offer, the next level is mediation. Beyond that, the case could move to adjudication, a court-like process with a panel deciding on the outcome. On international flights, you have up to two years to file litigation. If you expect a large payout, think again. Tariffs (air carrier contracts) limit the compensation amounts for "loss of, damage to, or the delay in delivery of baggage or other personal property." In the case of Air Canada, the maximum payout is $1,500 per passenger in the currency of the country where the baggage was processed. To raise that limit, purchase a Declaration of Higher Value for each leg of the trip. The charge is $0.50 for each $100, in which case the payout limit is $2,500. For Delta Air Lines, passengers are entitled to up to $3,800 in baggage compensation, though how much you'll receive depends on your flight. Delta will pay up to $2,080 for delayed, lost, and damaged baggage for international travellers, almost half of what U.S. domestic passengers can claim. If your flight is marked delayed for more than 30 minutes, approach the gate agent and politely request food and hotel vouchers to be used within the airport or nearby. Delayed/Cancelled Flights Different air carriers and jurisdictions have their own compensation policies when flights are delayed or cancelled. For example, under European Union rules, passengers may receive up to 600 Euros, even when travelling on a non-EU carrier. Similarly, the DOT states that travellers are entitled to a refund "if the airline cancelled a flight, regardless of the reason, and the consumer chooses not to travel." However, US rules regarding delays are complicated. Some air carriers, such as Air Canada, do not guarantee their flight schedules. They're also not liable for cancellations or changes due to "force majeure" such as weather conditions or labour disruptions. If the delay is overnight, only out-of-town passengers will be offered hotel accommodation. Nevertheless, many airlines do offer some compensation for the inconvenience. If your flight is marked delayed for more than 30 minutes, approach the gate agent and politely request food and hotel vouchers to be used within the airport or nearby. Flight Compensation in the U.S. In terms of cash compensation, what you'll get can differ significantly based on things like departure location, time, carrier, and ticket class. The DOT offers a helpful delay and cancellations dashboard designed to keep travellers informed about their compensation rights. The dashboard is particularly helpful because, as the DOT states on its website, "whether you are entitled to a refund depends on a lot of factors—such as the length of the delay, the length of the flight, and your particular circumstances." Flight Compensation in Canada The Canadian Transportation Agency is proposing air passenger protection regulations that guarantee financial compensation to travellers experiencing flight delays and cancellations, with the level of compensation varying depending on the situation and how much control the air carrier had. The proposed regulations include the following: A plane must return to its gate after three hours on the tarmac. Minimum requirements will be set for procuring food, drink, lavatories, ventilation, and access to electronic communications during the delay. For larger airlines, payouts will range from $400 for a 3-6 hour delay, to $700 for 6-9 hours, and $1,000 for more than nine hours. For smaller carriers, the compensation would be $125, $250, and $500, respectively. Here's the loophole: If the delay is related to the air carrier's maintenance problems, no compensation is required. The airline is obligated to complete the passenger's itinerary. If the new ticket is for a lower class of service, the air carrier would have to refund the cost difference; if the booking is in a higher class of service, passengers cannot be charged extra. If the passenger declines the ticket, the airline must give a full refund, in addition to the prescribed compensation. For overnight delays, the air carrier needs to provide hotel accommodation and transportation free-of-charge. Again, if you are unsatisfied, the Canadian Transportation Agency or Department of Transportation may advocate on your behalf. Bumped Off the Flight Passengers get bumped because airlines overbook. When this happens, the air carrier must compensate you. For international flights in the US, the rate is 200% of your one-way fare to your final destination, with a $675 maximum. If the airline does not make travel arrangements for you, the payout is 400% of your one-way fare to a maximum of $1,350. To qualify, you must check-in by the stated deadline, which on international flights can be up to 3 hours ahead. Keep in mind that if you accept the cash, you are no longer entitled to any further compensation, nor are you guaranteed to be rebooked on a direct flight or similar type of seat. Don't be too quick to give up your boarding pass. Negotiate for the best compensation deal that would include cash, food and hotel vouchers, flight upgrade, lounge passes, as well as mileage points. But avoid being too greedy—if the gate attendant is requesting volunteers and you wait too long, you'll miss the offer. According to Air Canada's tariff, if a passenger is involuntarily bumped, they'll receive $200, in cash or bank draft, for up to a two-hour delay; $400 for a 2-6 hours delay; and $800 if the delay is over six hours. (Air Canada was forced to raise its payouts in 2013 due to passenger complaints.) The new rules would raise the payout significantly: $900 for up to six hours; $1,800 for 6-9; and $2,400 for more than nine hours, all to be paid within 48 hours. Statistically speaking, Delta Airlines is the carrier most likely to bump. A few years ago, Delta raised its payout maximum to $9,950, while United Airlines tops out at $10,000. This story was produced by Money.ca and reviewed and distributed by Stacker. Get local news delivered to your inbox!
SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--Dec 8, 2024-- Genentech, a member of the Roche Group (SIX: RO, ROG; OTCQX: RHHBY), announced today data from a five-year follow-up of the pivotal Phase III POLARIX study evaluating Polivy ® (polatuzumab vedotin-piiq) in combination with Rituxan ® (rituximab), cyclophosphamide, doxorubicin and prednisone (R-CHP) in people with untreated diffuse large B-cell lymphoma (DLBCL). Data were presented in an oral session at the 66th American Society of Hematology (ASH) Annual Meeting and Exposition, December 7-10, 2024 in San Diego, California. This latest analysis conducted after a median follow-up of 60.9 months, includes descriptive data on primary and secondary endpoints, as well as safety results. “POLARIX was the first trial to elevate treatment standards for frontline diffuse large B-cell lymphoma in 20 years and we are additionally encouraged by the five-year follow-up results,” said Levi Garraway, M.D., Ph.D., Genentech’s chief medical officer and head of Global Product Development. “More than 38,000 people worldwide have been treated with Polivy in combination with R-CHP and these data continue to underscore its potential to improve outcomes for people diagnosed with this aggressive lymphoma.” Follow-up exploratory analysis after five-years indicated a positive trend in overall survival (OS) in the intent-to-treat (ITT) population in favor of Polivy in combination with R-CHP compared to Rituxan plus cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP). Results showed a trend in reduction in the risk of death (HR 0.85; 95% CI: 0.63–1.15) for people with previously untreated DLBCL with the Polivy combination, an improvement on the three-year follow-up data (HR 0.94; 95% CI: 0.67–1.33). The five-year analysis of POLARIX indicates that the full difference in OS between treatment arms has yet to be observed and an additional two years of follow-up will continue. “Diffuse large B-cell lymphoma is a notoriously challenging cancer to treat, however, Polivy in combination with R-CHP has shown to be a critical advance for patients by helping to reduce relapse and disease progression,” said Gilles Salles, M.D., Ph.D., chief of Lymphoma Service, Division of Hematological Malignancies, Memorial Sloan Kettering Cancer Center, New York. “The survival trend seen in this follow-up analysis reinforces the potential impact of frontline treatment with Polivy in combination with R-CHP and its role as a standard of care therapy.” In addition to the positive trend in OS, an observational analysis suggested nearly 25% fewer follow-up treatments such as radiation, systemic chemotherapy and CAR-T cell therapy were needed in patients receiving Polivy in combination with R-CHP compared to those treated with R-CHOP (38.3% versus 61.7%). At five years of follow-up, benefits in progression-free survival and disease-free survival with Polivy in combination with R-CHP were maintained, consistent with the three-year follow-up data, reinforcing the potential of Polivy in combination with R-CHP to provide durable and lasting remissions. The latest follow-up data also showed a numerical reduction in death related to patients’ lymphoma in those treated with Polivy in combination with R-CHP compared to those treated with R-CHOP (9.0% versus 11.4%). The safety profile remains consistent with the known profiles of the individual study medicines with no new safety signals observed, reinforcing the positive benefit-risk profile of this Polivy combination. Results from an expanded cohort of 1,000 patients including global and Chinese patients demonstrated comparability to the global ITT population. Polivy in combination with R-CHP is currently approved for the treatment of first-line (1L) DLBCL in more than 90 countries worldwide including the U.S., countries throughout the EU, the U.K., Japan, Canada and China. Genentech continues to work with health authorities around the world to bring this treatment regimen to even more patients. Genentech aims to offer various treatment options for DLBCL that meet the diverse needs of patients and healthcare systems. In an effort to elevate treatment standards even further, Genentech is exploring Polivy in combination with other molecules, including its bispecific antibodies. Studies include the Phase III SUNMO trial evaluating the efficacy and safety of subcutaneously administered Lunsumio ® (mosunetuzumab-axgb) in combination with intravenous (IV) Polivy versus IV Rituxan plus gemcitabine and oxaliplatin (R-GemOx) in second-line or later DLBCL, and the Phase III SKYGLO trial investigating the efficacy of Polivy in combination with R-CHP and Columvi ® (glofitamab-gxbm) versus Polivy in combination with R-CHP in 1L DLBCL. About the POLARIX Study POLARIX [ NCT03274492 ] is an international Phase III, randomized, double-blind, placebo-controlled study evaluating the efficacy, safety and pharmacokinetics of Polivy ® (polatuzumab vedotin-piiq) plus Rituxan ® (rituximab), cyclophosphamide, doxorubicin and prednisone (R-CHP) versus Rituxan, cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP) in people with previously untreated diffuse large B-cell lymphoma (DLBCL). Eight-hundred and seventy-nine patients were randomized 1:1 to receive either Polivy plus R-CHP plus a vincristine placebo for six cycles, followed by Rituxan for two cycles; or R-CHOP plus a Polivy placebo for six cycles, followed by two cycles of Rituxan. The primary outcome measure is progression-free survival as assessed by the investigator using the Lugano Response Criteria for malignant lymphoma. POLARIX is being conducted in collaboration with The Lymphoma Study Association (LYSA) and The Lymphoma Academic Research Organisation (LYSARC). About Diffuse Large B-Cell Lymphoma Diffuse large B-cell lymphoma (DLBCL) is an aggressive (fast-growing) blood cancer and is the most common form of non-Hodgkin’s lymphoma (NHL) in the U.S. While many people with DLBCL are responsive to treatment, the majority of those who relapse or are refractory to subsequent treatments have poor outcomes. DLBCL not otherwise specified is the most common category of large B-cell lymphoma (LBCL) and accounts for about 80% or more of cases. It applies to cases that do not fall into any specific disease subgroups of LBCL. About Polivy ® (polatuzumab vedotin-piiq) Polivy is a first-in-class anti-CD79b antibody-drug conjugate (ADC). The CD79b protein is expressed specifically in the majority of B cells, an immune cell impacted in some types of non-Hodgkin’s lymphoma (NHL), making it a promising target for the development of new therapies. Polivy binds to cancer cells such as CD79b and destroys these B cells through the delivery of an anti-cancer agent, which is thought to minimize the effects on normal cells. Polivy is being developed by Genentech using Pfizer ADC technology and is currently being investigated for the treatment of several types of NHL. Polivy U.S. Indication Polivy is a prescription medicine used with other medicines (a rituximab product, cyclophosphamide, doxorubicin, and prednisone) as a first treatment for adults who have moderate to high risk diffuse large B-cell lymphoma (DLBCL), not otherwise specified (NOS) or high-grade B-cell lymphoma (HGBL). Polivy is a prescription medicine used with other medicines, bendamustine and a rituximab product, to treat DLBCL in adults who have progressed after at least 2 prior therapies. Important Safety Information Possible serious side effects Everyone reacts differently to Polivy therapy, so it’s important to know what the side effects are. Some people who have been treated with Polivy have experienced serious to fatal side effects. Your doctor may stop or adjust your treatment if any serious side effects occur. Be sure to contact your healthcare team if there are any signs of these side effects. Side effects seen most often The most common side effects during treatment were Polivy may lower your red or white blood cell counts and increase uric acid levels. Polivy may not be for everyone. Talk to your doctor if you are These may not be all the side effects. Talk to your healthcare provider for more information about the benefits and risks of Polivy treatment. You may report side effects to the FDA at (800) FDA-1088 or http://www.fda.gov/medwatch . You may also report side effects to Genentech at (888) 835-2555. Please see the full Prescribing Information and visit https://www.Polivy.com for additional Important Safety Information. About Lunsumio ® (mosunetuzumab-axgb) Lunsumio is a first-in-class CD20xCD3 T-cell engaging bispecific antibody designed to target CD20 on the surface of B cells and CD3 on the surface of T cells. This dual targeting activates and redirects a patient’s existing T cells to engage and eliminate target B cells by releasing cytotoxic proteins into the B cells. A robust clinical development program for Lunsumio is ongoing, investigating the molecule as a monotherapy and in combination with other medicines, for the treatment of people with B-cell non-Hodgkin’s lymphomas, including follicular lymphoma and diffuse large B-cell lymphoma, and other blood cancers. Lunsumio U.S. Indication Lunsumio (mosunetuzumab-axgb) is a prescription medicine used to treat adults with follicular lymphoma whose cancer has come back or did not respond to previous treatment, and who have already received two or more treatments for their cancer. It is not known if Lunsumio is safe and effective in children. The conditional approval of Lunsumio is based on response rate. There are ongoing studies to establish how well the drug works. What is the most important information I should know about Lunsumio? Lunsumio may cause Cytokine Release Syndrome (CRS), a serious side effect that is common during treatment with Lunsumio and can also be severe or life-threatening. Get medical help right away if you develop any signs or symptoms of CRS at any time, including: Due to the risk of CRS, you will receive Lunsumio on a “step-up dosing schedule.” Your healthcare provider will check you for CRS during treatment with Lunsumio and may treat you in a hospital if you develop signs and symptoms of CRS. Your healthcare provider may temporarily stop or completely stop your treatment with Lunsumio, if you have severe side effects. What are the possible side effects of Lunsumio? Lunsumio may cause serious side effects, including: Your healthcare provider may temporarily stop or permanently stop treatment with Lunsumio if you develop severe side effects. The most common side effects of Lunsumio include: tiredness, rash, fever, and headache. The most common severe abnormal blood test results with Lunsumio include: decreased phosphate, increased glucose, and increased uric acid levels. Before receiving Lunsumio, tell your healthcare provider about all of your medical conditions, including if you: Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. What should I avoid while receiving Lunsumio? Do not drive, operate heavy machinery, or do other dangerous activities if you develop dizziness, confusion, tremors, sleepiness, or any other symptoms that impair consciousness until your signs and symptoms go away. These may be signs and symptoms of CRS or neurologic problems. These are not all the possible side effects of Lunsumio. Talk to your healthcare provider for more information about the benefits and risks of Lunsumio. You may report side effects to the FDA at (800) FDA-1088 or http://www.fda.gov/medwatch . You may also report side effects to Genentech at (888) 835-2555. Please see Important Safety Information, including Serious Side Effects, as well as the Lunsumio full Prescribing Information and Medication Guide or visit https://www.Lunsumio.com . About Columvi ® (glofitamab-gxbm) Columvi is a CD20xCD3 T-cell engaging bispecific antibody designed to target CD3 on the surface of T cells and CD20 on the surface of B cells. Columvi was designed with a novel 2:1 structural format. This T-cell engaging bispecific antibody is engineered to have one region that binds to CD3, a protein on T cells, a type of immune cell, and two regions that bind to CD20, a protein on B cells, which can be healthy or malignant. This dual-targeting brings the T cell in close proximity to the B cell, activating the release of cancer cell-killing proteins from the T cell. Columvi is part of Genentech’s broad and industry-leading CD20xCD3 T-cell-engaging bispecific antibody clinical development program that also includes Lunsumio ® (mosunetuzumab), which aims to provide tailored treatment options that suit the diverse needs, preferences, and experiences of people with blood cancers and healthcare systems. Genentech is investigating Columvi as a monotherapy and in combination with other medicines for the treatment of diffuse large B-cell lymphoma and mantle cell lymphoma. Columvi U.S. Indication Columvi (glofitamab-gxbm) is a prescription medicine to treat adults with certain types of diffuse large B-cell lymphoma (DLBCL) or large B-cell lymphoma (LBCL) that has come back (relapsed) or that did not respond to previous treatment (refractory), and who have received 2 or more prior treatments for their cancer. It is not known if Columvi is safe and effective in children. The conditional approval of Columvi is based on response rate and durability of response. There are ongoing studies to establish how well the drug works. What is the most important information I should know about Columvi? Columvi can cause Cytokine Release Syndrome (CRS), a serious side effect that is common during treatment with Columvi, and can also be serious and lead to death. Call your healthcare provider or get emergency medical help right away if you develop any signs or symptoms of CRS, including: Due to the risk of CRS, you will receive Columvi on a “step-up dosing schedule”. Your healthcare provider will monitor you for CRS during treatment with Columvi and may treat you in a hospital if you develop signs and symptoms of CRS. Your healthcare provider may temporarily stop or completely stop your treatment with Columvi if you have severe side effects. Carry the Columvi Patient Wallet Card with you at all times and show it to all of your healthcare providers. The Columvi Patient Wallet Card lists the signs and symptoms of CRS you should get emergency medical help for right away. What are the possible side effects of Columvi? Columvi may cause serious side effects, including: The most common side effects of Columvi include: CRS, muscle and bone pain, rash, and tiredness. The most common severe abnormal lab test results with Columvi include: decreased white blood cells, decreased phosphate (an electrolyte), increased uric acid levels, and decreased fibrinogen (a protein that helps with blood clotting). Your healthcare provider may temporarily stop or completely stop treatment with Columvi if you develop certain side effects. Before receiving Columvi, tell your healthcare provider about all of your medical conditions, including if you: Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. What should I avoid while receiving Columvi? Do not drive, operate heavy machinery, or do other dangerous activities if you develop dizziness, confusion, shaking (tremors), sleepiness, or any other symptoms that impair consciousness until your signs and symptoms go away. These may be signs and symptoms of neurologic problems. These are not all the possible side effects of Columvi. Talk to your health care provider for more information about the benefits and risks of Columvi. You may report side effects to the FDA at (800) FDA-1088 or http://www.fda.gov/medwatch . You may also report side effects to Genentech at (888) 835-2555. Please see Important Safety Information, including Serious Side Effects , as well as the Columvi full Prescribing Information and Medication Guide or visit https://www.Columvi.com About Genentech in Hematology For more than 20 years, Genentech has been developing medicines with the goal to redefine treatment in hematology. Today, we’re investing more than ever in our effort to bring innovative treatment options to people with diseases of the blood. For more information visit http://www.gene.com/hematology . About Genentech Founded more than 40 years ago, Genentech is a leading biotechnology company that discovers, develops, manufactures and commercializes medicines to treat patients with serious and life-threatening medical conditions. The company, a member of the Roche Group, has headquarters in South San Francisco, California. For additional information about the company, please visit http://www.gene.com . Dr. Salles has financial interests related to Roche and Genentech. View source version on businesswire.com : https://www.businesswire.com/news/home/20241208818007/en/ CONTACT: Media Contact: Kristen Ingram, (650) 467-6800Advocacy Contact: Catherine Creme Henry, (202) 258-8228Investor Contacts: Loren Kalm, (650) 225-3217 Bruno Eschli, 011 41 61 687 5284 KEYWORD: CALIFORNIA UNITED STATES NORTH AMERICA INDUSTRY KEYWORD: BIOTECHNOLOGY HEALTH PHARMACEUTICAL CLINICAL TRIALS ONCOLOGY SOURCE: Genentech Copyright Business Wire 2024. PUB: 12/08/2024 12:30 PM/DISC: 12/08/2024 12:30 PM http://www.businesswire.com/news/home/20241208818007/enOilers' Hyman can still crack Canada's 4 Nations Face-Off team: report
MAN UTD icon Nani has retired from football at the age of 38. The tricky winger announced his decision in an emotional video he shared on social media. Nani captioned the three-minute clip: "The time has come to say goodbye, I have decided to finish my career as a professional player. "It’s been an amazing ride and I wanted to thank every single person who has helped me and supported me through the highs and lows during a career which lasted over 20 years and gave me so many unforgettable memories. "Time to turn a new leaf and focus on new goals and dreams. See you soon!" The wideman's announcement is seemingly a surprise given he was playing his football in his homeland in the top flight for Estrella Amadora. Although the club are in a relegation battle, Nani had appeared 10 times this season and was considered a first team regular. Part of Nani's decision to retire, he revealed in his post, was down to the recent passing of his father. That has forced him to contemplate his future - vowing to spend more with his family. "I want to make the most of my time with my children, my wife, my mother, my siblings, cousins, uncles and aunts. "They also need me, and I need to be with them which is very important." Nani is best remembered on our shores for his time at Man Utd , where he won four Premier League titles, the 2008 Champions League and the League Cup twice. He also helped his country win the Euros in 2016 alongside fellow United alumni Cristiano Ronaldo . Nani turned out 230 times, scoring 40 goals. In 2015, he returned to Portugal on loan with Sporting Lisbon. Then spells at Fenerbahce, Valencia, Lazio, Sporting again, Orlando City, Venezia, Melbourne Victory, Adana Demirspor followed. A hint where his future lies was given in the summer, when Nani bought fourth division side SU Sintrense. Nani said: "I am very happy to be part of this project. I hope to add value to the club. "Sintrense are an opportunity for me to do something interesting. "It is very important for me that they are close to the area where I grew up. I hope it will be a successful project."
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According to Greg Wyshynski of ESPN , the Detroit Red Wings are on the verge of making a coaching change. Following the team’s disappointing 4-0 loss to the St. Louis Blues, with the holiday break giving GM Steve Yzerman some time to think it over, speculation is he’s ready to pull the plug on Derek Lalonde . Hearing whispers that Steve Yzerman is ready for a coaching change in Detroit, however owner Chris Ilitch is hesitant due to the financial impact of a potential buyout. Interesting situation developing... #LGRW The defeat to the Blues has fueled discussions about the team’s long-term direction and performance under its current coaching staff. What may be causing the delay is owner Chris Ilitch’s reluctance to approve a coaching change due to financial concerns. While Yzerman appears dissatisfied with recent results and is eager to make a move, Ilitch is hesitant to pay two coaches. The expenses involved in buying out the current coach’s contract, along with the cost of hiring an experienced replacement, are creating obstacles to approving the change. Do the Red Wings think they can salvage the season? It’s intriguing timing for talk of the coaching chance to surface. There has been chatter most of the year that this might be in the works, but now that the Red Wings are 34 games into the season and seventh in the Atlantic Division, it’s hard to see a scenario where they turn things around. The team is eight points out of the wild-card race , and while a new coach might offer them a bump in terms of improved play, would it be enough? As pressure mounts, Red Wings fans are eager to see whether Yzerman can secure the resources needed to make significant changes and get the team back on track. And, if they do make a change, is the coach they bring in supposed to get this team into the playoff mix? Or, is it about finding a coach to move forward with the team after this year? This article first appeared on NHL Trade Talk and was syndicated with permission.
Texas Instruments Inc. stock underperforms Thursday when compared to competitorsNot so long ago, you needed only the major over-the-air networks and a few cable channels to watch virtually any significant sporting event. No longer. Decisions by the NFL, NBA and other leagues have left fans reaching into their pockets to pay for subscriptions to a handful of streaming services, incurring costs they never needed to worry about just three years ago. And, for some, that trend will continue on Christmas, when Netflix will televise NFL games for the first time. The streaming giant, which has more than 270 million subscribers, made a big splash by paying $150 million to acquire rights to two Christmas NFL games: Kansas City-Pittsburgh at 1 p.m. and Baltimore-Houston at 4:30 p.m. CBS will produce both games but Netflix will use announcers from CBS, NBC, Fox, NFL Network and ESPN. Three CBS announcers — Ian Eagle and studio analysts Nate Burleson and J.J. Watt — will call the Chiefs-Steelers game. NBC’s Noah Eagle will call the Ravens-Texans game with Fox’s Greg Olsen. Netflix began dabbling in outside-the-box sports programming earlier this year, including a tennis exhibition between Spain’s two biggest tennis stars, Rafael Nadal and Carlos Alcaraz. A Nov. 14 Mike Tyson-Jake Paul fight was marred by technical errors and freezing, but Netflix has assured the NFL that won’t happen on Christmas. Per the Associated Press, the Tyson bout peaked at 65 million concurrent streams, including 38 million concurrent streams in the United States. Nearly 85,000 viewers logged problems with outages or streaming before and during the fight, per the website Down Detector. Netflix is the nation’s most profitable streaming service; in the first quarter of this year, it reported revenue of $9.4 billion and net income of $2.3 billion. A Netflix standard plan costs $6.99 per month with ads and $15.49 per month without ads. Besides landing two NFL games, Netflix made another big splash this week, landing rights to the 2027 and 2031 Women’s World Cup. Beyond Netflix, an update on what streaming services you’ll need to have access to all major sports between now and the end of next year: Amazon Prime Video — Cost: $14.99 per month or $139 per year. — What’s offered: If you prefer to spend on just one streaming service, this probably has become the most essential one for sports fans. Amazon is carrying a third season of “Thursday Night Football” and also acquired rights to a Saturday wild-card playoff game that streamed on Peacock last season. Amazon will carry Thursday NFL games again next season, including a Christmas night game. Al Michaels, 80 is expected to return on play-by-play. Also, Amazon is spending $1.8 billion annually for an NBA and WNBA package beginning in 2025-26. That Amazon NBA package includes six conference finals over 11 years, the NBA’s in-season tournament, the play-in games, a Friday night double-header and Thursday night games after NFL season ends, plus some exclusive playoff games. Also, Amazon’s NBA deal includes 30 regular-season WNBA games annually, a first-round WNBA playoff series each season, seven semifinals and three WNBA Finals series over 11 years. Beyond the NFL and the NBA, Amazon also has NASCAR races, NHL games in Canada and Champions League soccer in England, Italy and Germany. And at some point in 2025, Amazon will begin streaming FanDuel Sports Network cablecasts of some NBA and MLB teams, including the Heat and Marlins. Everyone, including Amazon subscribers, will be required to pay an additional undetermined fee to access Amazon’s streaming of local NBA and MLB games. Netflix, Amazon and Disney are the only streaming services with more than 200 million subscribers. But many of those subscribers have Amazon subscriptions primarily as a purchase platform, rather than for the programming content. As perspective, 33 million U.S. homes now have cable television and only 13 million have satellite service, mostly DirecTV or Dish Network. ESPN Plus — Cost: $11.99 per month or $119.99 a year. There’s also a bundle of ESPN Plus, Disney Plus and Hulu for $15 a month, with all three streaming services carrying ads in that package. — What’s offered: Many of the marquee events on ESPN Plus also air on ESPN or ABC, but there are exceptions. ESPN had one exclusive NFL game this season: Chargers at Arizona on Oct. 21. ESPN Plus has a full slate of exclusive NHL games and select WNBA games, plus international soccer events including the EFL Championship, U.S. Open Cup and Bundesliga; Ivy League, Big Sky and Atlantic 10 conference sports; some ACC and SEC football and basketball games that aren’t picked up by ABC, ESPN, ESPN2 or ESPNU; and select golf and tennis events. ESPN Plus allows subscribers to purchase UFC play-per-view events and access an extensive archive of on-demand content, including the entire 30 for 30 series and game replays. Apple — Cost: $9.99 per month. — What’s offered: Apple, which produces more original non-sports content than most streamers, owns rights to Major League Soccer and Friday night MLB games. MLS Season Pass — which carries the league’s matches on TVs, phones and other devices — costs $13 per month or $79 for the season if you’re already a subscriber to the Apple TV Plus streaming service. If you don’t subscribe to Apple TV Plus, MLS Season Pass costs $15 a month or $99 for the season. Apple also has carried several sports documentary series, including The Dynasty: New England Patriots; Messi Meets America; Real Madrid: Until the End and Stephen Curry: Underrated. Peacock — Cost: $7.99 per month or $79.99 per year. — What’s offered: Besides simulcasting NBC’s sports coverage (including all its NFL games), the network has acquired enough exclusive sports content to make itself more important for fans. Though NBC’s streaming service won’t have an exclusive NFL playoff game again this season, it had exclusive rights to the Eagles-Packers game from Brazil in Week 1. Meanwhile, NBC’s new NBA deal, which begins in 2025-26, will give Peacock an exclusive Monday night double-header and two Tuesday night NBA games, one of which will air on your local NBC affiliate. On Tuesdays beginning in the 2025-26 season, NBC plans to carry one NBA game at 8 p.m. that will air in the Eastern and Central Time zones on NBC affiliates and one game at 11 p.m. that will air in the Mountain and Western Time zones. Both games also will stream on Peacock, meaning viewers in the East will be able to watch the Western game on Peacock and vice versa. Peacock already owned exclusive rights to one Notre Dame game and a few Big Ten football games each season; Premier League soccer and select cycling, motorsports, golf, college basketball and rugby events. Peacock also streams some Olympic events that aren’t on NBC or NBC-owned cable networks. YouTube TV — Cost: $82.99 per month. — What’s offered: The streaming service is paying about $2 billion annually for NFL Sunday Ticket, the out-of-market NFL service which was carried on DirecTV before last season. (DirecTV still owns licensing rights for restaurants and sports bars.) YouTube has changed the price of Sunday Ticket depending on the time of year; before the season, it cost $449 for a standalone subscription through YouTube Primetime Channels. For an additional $40, subscribers can add NFL RedZone, which shows highlights from all Sunday NFL games. Next year’s prices haven’t been determined. Paramount Plus — Cost: $8 per month, or $13.00 per month for the Showtime plan, which includes access to Showtime’s live sports coverage, such as boxing and MMA. Those are also available as annual packages for $60 and $120, respectively. — What’s offered: Besides all CBS Sports programming, Paramount exclusively carries than 360 matches per year from Brazil’s Campeonato Brasileiro Serie A soccer league, as well as all matches from the Italian Serie A league. Other exclusive programming includes the UEFA Champions League, UEFA Europa League, UEFA Europa Conference League and soccer matches from the NWSL, FAWSL, and AFA. Paramount Plus also live streams the Masters (including coverage that’s not on CBS), PGA Tour event, the Argentine Primera Division and programming from CBS Sports HQ, which streams sports news content 24 hours per day. Bundle options In May, Comcast (which owns Peacock) announced it would offer its broadband customers a bundle of Peacock, Netflix and Apple Plus for $15 per month. Venu, a new sports streaming joint venture, planned to charge $42.99 per month for access to all sports programming from ABC/ESPN/ESPN Plus, as well as Fox and Turner Sports. But a federal judge blocked the planned launch of Venu, with a trial scheduled for February. Meanwhile, ESPN plans to launch a direct-to-consumer service at some point next year, which will allow viewers to cancel their cable or satellite subscriptions and receive all ESPN programming if they chose. The cost reportedly will be $30 or so a month. ©2024 Miami Herald. Visit miamiherald.com . Distributed by Tribune Content Agency, LLC.
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HEARTBROKEN Kate Cassidy has posted about 'sadness and grief' at Christmas following Liam Payne's tragic death. Former One Direction star Liam, 31 died in October after falling from a hotel balcony while on holiday in Buenos Aires, Argentina. 3 Kate Cassidy has opened up about dealing with 'grief' at Christmas following Liam's death Credit: Getty 3 She took to Instagram to share the message as she wished her followers a 'healthy holiday season' Credit: Instagram 3 Liam tragically died in October His death came just days after girlfriend Kate, 25, returned home to the US following their trip together. Devastated Kate has posted about dealing with grief at Christmas time to her fans. Taking to Instagram, she said: "As the holidays are here, I realize it is a time for happiness and joy, but it is also a time of sadness and grief for so many. "Be gentle with those around you this time of year, as the holidays can feel different for everyone." more on liam payne her angel Liam Payne's girlfriend Kate Cassidy reveals new tattoo following star's death PAL'S SILENCE Major update in Liam Payne death probe as pal 'refuses to answer questions' She continued: "Sending all my love to those carrying grief this holiday. I hope the seasons bring you comfort and peace. "Wishing everyone a love-filled and healthy holiday season this year." Kate recently shared her new tattoo with fans as a tribute to Liam, which is on her middle and index fingers. Its design features an angel wing on each digit, with Kate posting the snap along with a love heart. Most read in Celebrity REFFIN' HELL KMI panel reveals FIVE more VAR blunders including THREE mistakes in one game ON PAR Ex-Rangers star 'in line' to take charge of his last club's bitter rivals TRAGIC LOSS Olympic snowboarder Sophie Hediger dead aged 26 after being caught in avalanche IN THE DOCK Suspect appears in court charged with murder of man near Scots nightclub Meanwhile, last week it was reported that a close friend of tragic Liam has refused to answer questions over his death. Zayn Malik pays poignant tribute to Liam Payne as he performs first gig since ex-One Direction bandmate’s tragic death Rogelio ‘Roger’ Nores declined to testify and will submit a written statement to the investigating judge. He has denied claims he abandoned Liam before he fell from his balcony at the CasaSur Palermo Hotel . Liam Payne's sad death On October 16, 2024, Liam Payne sadly died, leaving family, friends and fans devastated. Here we take you through the biggest stories to unfold since his tragic passing: Liam's death is announced. The star's family release a heartbreaking statement . Liam's cause of death revealed after he fell from a balcony. The singer's One Direction bandmates pay tribute. Cheryl Cole describes ‘earth shattering’ agony following the death of son's father. Mourners gather at vigils around the world to honour the late star. Liam's girlfriend Kate Cassidy makes an emotional tribute . Liam's body is flown back to the UK with his family. Zayn Malik reschedules his tour dates due to ‘unforeseen circumstances’ following Liam's death. Liam's family announce his funeral .Palamu man held for killing mother-in-law over ‘witchcraft’
By CHRIS MEGERIAN and COLLEEN LONG WASHINGTON (AP) — In the two weeks since Donald Trump won the presidency, he’s tried to demonstrate his dominance by naming loyalists for top administration positions, even though many lack expertise and some face sexual misconduct accusations. It often seems like he’s daring Congress to oppose his decisions. But on Thursday, Trump’s attempt to act with impunity showed a crack as Matt Gaetz , his choice for attorney general, withdrew from consideration. Trump had named Gaetz, a Florida congressman, to be the country’s top law enforcement official even though he was widely disliked by his colleagues, has little legal experience and was accused of having sex with an underage girl, an allegation he denied. After being plagued by investigations during his first presidency, Trump wanted a devoted ally in charge of the Justice Department during his second. However, it was never obvious that Gaetz could win enough support from lawmakers to get confirmed as attorney general. Trump chose for a replacement Pam Bondi, a former Florida attorney general who defended him during his first impeachment trial and supported his false claims of voter fraud. Now the question is whether Gaetz was uniquely unpalatable, or if Trump’s other picks might exceed his party’s willingness to overlook concerns that would have sunk nominees in a prior political era. The next test will likely be Pete Hegseth, who Trump wants to lead the Pentagon despite an allegation of sexual assault that he’s denied. So far, Republicans are rallying around Hegseth , an Army veteran and former Fox News host. Sen. Thom Tillis, a North Carolina Republican who serves on the Senate Judiciary Committee, said the controversy over Gaetz would have little bearing on Trump’s other choices. He said they would be considered “one at a time.” Sen. Richard Blumenthal, a Connecticut Democrat, suggested otherwise, claiming “the dominoes are falling.” “The drip drip of evidence and truth is going to eventually doom some others,” he said. Trump’s election victory was a sign that there may not be many red lines left in American politics. He won the presidential race despite authoritarian, racist and misogynist rhetoric, not to mention years of lies about election fraud and his role in sparking the Jan. 6, 2021, attack on the U.S. Capitol. He was also criminally convicted of falsifying business records to pay hush money, and he was found liable for sexual abuse in a civil case. Empowered by voters who looked past his misconduct and saw him as a powerful agent of change, Trump has shown no deference to Washington norms while working to fill his second administration . The transition team hasn’t pursued federal background checks for Trump’s personnel choices. While some of his selections have extensive experience in the areas they’ve been chosen to lead, others are personal friends and Fox News personalities who have impressed and flattered Trump over the years. Several have faced allegations involving sexual misconduct . Hegseth is facing the most scrutiny after Gaetz. Once Trump announced Hegseth as his nominee for Pentagon chief, allegations emerged that he sexually assaulted a woman in California in 2017. The woman said he took her phone, blocked the door to the hotel room and refused to let her leave, according to a police report made public this week. Hegseth told police at the time that the encounter had been consensual and denied any wrongdoing, the report said. However, he paid the woman a confidential settlement in 2023. Hegseth’s lawyer said the payment was made to head off the threat of a baseless lawsuit. Trump’s choice for secretary of health and human Services, Robert F. Kennedy Jr., has faced allegations of misconduct too. A woman who babysat for him and his second wife told Vanity Fair magazine that Kennedy groped her in the late 1990s, when she was 23. Kennedy did not deny the allegation and texted an apology to the woman after the article was published. That isn’t the only hurdle for Kennedy; he’s spent years spreading misinformation and conspiracy theories about vaccines, raising fears about making him a top health official in the new administration. Linda McMahon, chosen by Trump to be education secretary, is fighting a lawsuit connected to her former company, World Wrestling Entertainment. She’s accused of knowingly enabling sexual exploitation of children by an employee as early as the 1980s, and she denies the allegations. Tulsi Gabbard is another person who could face a difficult confirmation battle, but for very different reasons. The former Democratic representative from Hawaii has been a vocal Trump ally, and he chose her to be national intelligence director. But there’s grave concern by lawmakers and national security officials over Gabbard’s history of echoing Russian propaganda. Critics said she would endanger relationships with U.S. allies. Gaetz was investigated by federal law enforcement for sex trafficking, but the case was closed without charges and Republicans have blocked the release of a related report from the House Ethics Committee. However, some allegations leaked out, including that Gaetz paid women for sex. One of the women testified to the committee that she saw Gaetz having sex with a 17-year-old girl, according to a lawyer for the woman. As Gaetz met with senators this week, it became clear that he would face stubborn resistance from lawmakers who were concerned about his behavior and believed he was unqualified to run the Justice Department. “While the momentum was strong, it is clear that my confirmation was unfairly becoming a distraction,” Gaetz wrote on social media when announcing his withdrawal. Sen. Mike Braun, an Indiana Republican, said he believed there were four to six members of the caucus who would have voted against Gaetz, likely dooming his nomination, and “the math got too hard.” He said some of the issues and allegations around Gaetz were “maybe beyond the pale.” “I think there were just too many things, it was like a leaky dike, and you know, it broke,” Braun said. Trump thanked Gaetz in a post on Truth Social, his social media website, without addressing the substance of the allegations against him. “He was doing very well but, at the same time, did not want to be a distraction for the Administration, for which he has much respect,” Trump wrote. Associated Press writers Mary Clare Jalonick, Stephen Groves and Lisa Macaro contributed from Washington. Jill Colvin in New York and Adriana Gomez Licon in Fort Lauderdale, Florida, also contributed.
Jimmy Carter, former US president who won Nobel Peace Prize, dies aged 100
Stock market today: Wall Street rallies ahead of ChristmasLouisiana agreed to terms on a new five-year deal with Ragin' Cajuns football coach Michael Desormeaux, ESPN reported Monday. The contract keeps Desormeaux, 39, in Lafayette through the 2029 season. Financial terms were not reported. Desormeaux was named the Sun Belt Coach of the Year this season and guided the Ragin' Cajuns (10-3, 7-1) to the conference title game. Louisiana will face TCU (8-4) in the New Mexico Bowl on Saturday in Albuquerque. Desormeaux is 23-17 as the head coach at his alma mater since taking over as the interim coach for the New Orleans Bowl to conclude the 2021 season. He replaced Billy Napier, who left Louisiana to take over as head coach at Florida. --Field Level Media
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