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MGX-001, utilizing a highly specific and efficient MG29-1 nuclease, exhibits no identifiable off-target editing MG29-1 nuclease targeting the albumin safe harbor locus showed no evidence of translocations in primary human hepatocytes Metagenomi Adenine Base Editor (ABE) demonstrates no detectable translocations and no significant genomic base composition differences in primary T-cells EMERYVILLE, Calif., Dec. 11, 2024 (GLOBE NEWSWIRE) -- Metagenomi, Inc. (Nasdaq: MGX), a precision genetic medicines company committed to developing curative therapeutics for patients using its proprietary gene editing toolbox, today presented a talk titled "Specific and efficient genome editing with metagenomics-derived tools for in vivo and ex vivo therapeutic applications” at the Nature Conference: RNA at the Bench and Bedside IV. "We believe the value proposition for single-dose gene editing therapies requires exquisite specificity characterization to ensure safety and efficacy. Today's presentation highlights the precision of Metagenomi's next-generation nucleases and ABEs, discovered through the company's proprietary metagenomics platform and tailored for both in vivo and ex vivo therapeutic applications,” said Alan Brooks, SVP and Head of Preclinical. "MGX-001, Metagenomi's development candidate for hemophilia A, which utilizes the novel nuclease MG29-1, exhibits no identifiable off-target editing using a series of orthogonal assays employed to evaluate potential off-target sites in the genome. The MG29-1 nuclease targeting the albumin safe harbor locus showed no evidence of translocations in primary human hepatocytes. For Metagenomi's novel next-generation ABE for ex vivo cell therapy indications via multiplex editing, the data showed no detectable translocations and no significant genomic base composition differences in primary T-cells when compared to unedited cells. These examples demonstrate our strong capabilities in developing highly specific next-generation gene editing tools and support the company's ability to potentially progress these systems toward the clinic for the benefit of patients.” About Metagenomi Metagenomi is a precision genetic medicines company committed to developing curative therapeutics for patients using its proprietary, comprehensive metagenomics-derived toolbox. Metagenomi is harnessing the power of metagenomics, the study of genetic material recovered from the natural environment, to unlock four billion years of microbial evolution to discover and develop a suite of novel editing tools capable of correcting any type of genetic mutation found anywhere in the genome. Its comprehensive genome editing toolbox includes programmable nucleases, base editors, and RNA and DNA-mediated integration systems (including prime editing systems and clustered regularly interspaced short palindromic repeat associated transposases (CAST)). Metagenomi believes its diverse and modular toolbox positions the company to access the entire genome and select the optimal tool to unlock the full potential of genome editing for patients. For more information, please visit https://​metageno​mi​.co. Cautionary Note Regarding Forward‐​Looking Statements This press release contains ​"forward-looking statements” within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934, each as amended. Such statements, which are often indicated by terms such as ​"anticipate,” ​"believe,” ​"could,” ​"estimate,” ​"expect,” ​"goal,” ​"intend,” ​"look forward to,” ​"may,” ​"plan,” ​"potential,” ​"predict,” ​"project,” ​"should,” ​"will,” ​"would” and similar expressions, include, but are not limited to, any statements relating to our growth strategy and product development programs, including the timing of and our ability to conduct IND-enabling studies, make regulatory filings such as INDs, statements concerning the potential of therapies and product candidates, and any other statements that are not historical facts. Forward-looking statements are based on management's current expectations and are subject to risks and uncertainties that could negatively affect our business, operating results, financial condition, and stock value. Factors that could cause actual results to differ materially from those currently anticipated include: risks relating to our growth strategy; our ability to obtain, perform under, and maintain financing and strategic agreements and relationships; risks relating to the results of research and development activities; risks relating to the timing of starting and completing clinical trials; uncertainties relating to preclinical and clinical testing; our dependence on third party suppliers; our ability to attract, integrate and retain key personnel; the early stage of products under development; our need for substantial additional funds; government regulation; patent and intellectual property matters; competition; as well as other risks described in ​"Risk Factors,” in our most recent Form 10-K and our most recent 10-Qs on file with the Securities and Exchange Commission. We expressly disclaim any obligation or undertaking to release publicly any updates or revisions to any forward-looking statements contained herein to reflect any change in our expectations or any changes in events, conditions or circumstances on which any such statement is based, except as required by law, and we claim the protection of the safe harbor for forward-looking statements contained in the Private Securities Litigation Reform Act of 1995. Contact: Simon Harnest - CIO, SVP Investor Relations IR@​metagenomi.​co8k8k 2 nguoi 。

GAINESVILLE, Fla. — Florida coach Billy Napier exchanged an uncomfortable handshake with Ole Miss counterpart Lane Kiffin, shared a few well-earned hugs and then headed to the northeast corner of the Swamp to join his players singing the school’s alma mater. On a crisp and sunny November day, Napier’s Gators had just done the unexpected, if not the unthinkable, beating the No. 9 Rebels 24-17. Ole Miss was a 10-point favorite Saturday fresh off a bye week after a dominant 28-10 win against Georgia, that positioned the Rebels for a spot in the expanded 12-team College Football Playoff. Instead, the Gators (6-5, 4-4 SEC) stopped the Lane Train in its tracks and dispatched of the Rebels (8-3, 4-3). “These guys have stepped up in a major way,” Napier said. The Gators’ victory marked consecutive wins against ranked teams for the first time since triumphs against Florida State and Alabama during the 2008 national championship season. The last time the unranked Gators beat ranked teams on back-to-back weeks were 2003 wins at LSU and Arkansas. This time, Florida capitalized on the friendly confines of the Swamp. “Just an incredible atmosphere; it doesn’t get much better than that,” Napier said. A pair of interceptions by sophomore safety Bryce Thornton in the final 1:31 iced the game and spurred roaring responses by a sold-out crowd of 89,942 and end-zone celebrations by players and fans. On Senior Day in the Swamp, true freshman quarterback DJ Lagway threw two touchdowns, veteran tailback Montrell Johnson Jr. ran 127 yards in his final home game and another inspired defensive effort led the way. On the game-winning drive, Johnson followed a 41-yard completion from Lagway to a diving Chimere Dike with runs of 12, 5 and 9 yards to give the Gators a 24-17 lead with 7:40 to go — the final run coming out of the wildcat formation. Meanwhile, the SEC’s leading passer and keenest offensive mind failed to capitalize on their chances. The Rebels left Florida’s red zone three times without points. “There’s an understanding you have to play well in the trenches,” Napier said. “I thought we were better on both sides up front. We had a guy step up and make plays.” Twice, the Gators stuffed the Ole Miss jumbo package on fourth-and-1, stopping 6-foot-2, 325-pound defensive tackle JJ Pegues shy of the first down following a direct snap — the second time when trailing 17-14. The other time, Ole Miss dropped three passes, the final one when star receiver Tre Harris, back after a three-game absence, re-injured his leg. Caden Davis then missed a 34-yard field goal with the game tied 14-14. Davis tied the game at 17-17 with 45 seconds left in the third quarter. But Dart, who finished with 394 total yards, and the SEC’s top-scoring attack could not overcome the Gators’ defense or three turnovers. “We took advantage,” Napier said. ©2024 Orlando Sentinel. Visit orlandosentinel.com . Distributed by Tribune Content Agency, LLC.Peacock Pays Up: Macy's Thanksgiving Parade Costs Set To Balloon For Content-Hungry NBC

Second Cup dumps Jewish General Hospital franchisee over video with ‘hateful remarks’

Most Adani shares rebound as six of 10 group companies post gainsMaharashtra Assembly passes prison reforms bill; state govt to build detention centreThe Christmas tradition has become nearly global in scope: Children from around the world track Santa Claus as he sweeps across the earth, delivering presents and defying time. Each year, at least 100,000 kids call into the North American Aerospace Defense Command to inquire about Santa’s location. Millions more , from English to Japanese. On any other night, NORAD is scanning the heavens , such as last year’s . But on Christmas Eve, volunteers in Colorado Springs are fielding questions like, “When is Santa coming to my house?” and, “Am I on the naughty or nice list?” “There are screams and giggles and laughter,” said Bob Sommers, 63, a civilian contractor and NORAD volunteer. Sommers often says on the call that everyone must be asleep before Santa arrives, prompting parents to say, “Do you hear what he said? We got to go to bed early.” NORAD’s annual tracking of Santa has endured since , predating and . Here’s how it began and why the phones keep ringing. The origin story is Hollywood-esque It started with a child’s accidental phone call in 1955. The Colorado Springs newspaper printed a Sears advertisement that encouraged children to call Santa, listing a phone number. A boy called. But he reached the Continental Air Defense Command, now NORAD, a joint U.S. and Canadian effort to spot potential enemy attacks. Tensions were growing with the Soviet Union, along with anxieties about nuclear war. Air Force Col. Harry W. Shoup picked up an emergency-only “red phone” and was greeted by a tiny voice that began to recite a Christmas wish list. “He went on a little bit, and he takes a breath, then says, ‘Hey, you’re not Santa,’” Shoup told The Associated Press in 1999. Realizing an explanation would be lost on the youngster, Shoup summoned a deep, jolly voice and replied, “Ho, ho, ho! Yes, I am Santa Claus. Have you been a good boy?” Shoup said he learned from the boy’s mother that Sears mistakenly printed the top-secret number. He hung up, but the phone soon rang again with a young girl reciting her Christmas list. Fifty calls a day followed, he said. In the pre-digital age, the agency used a 60-by-80 foot (18-by-24 meter) plexiglass map of North America to track unidentified objects. A staff member jokingly drew Santa and his sleigh over the North Pole. The tradition was born. “Note to the kiddies,” began an AP story from Colorado Springs on Dec. 23, 1955. “Santa Claus Friday was assured safe passage into the United States by the Continental Air Defense Command.” In a likely reference to the Soviets, the article noted that Santa was guarded against possible attack from “those who do not believe in Christmas.” Is the origin story humbug? Some grinchy journalists have nitpicked Shoup’s story, questioning whether a misprint or a misdial prompted the boy’s call. In 2014, tech news site Gizmodo from Dec. 1, 1955, about a child’s call to Shoup. Published in the Pasadena Independent, the article said the child reversed two digits in the Sears number. “When a childish voice asked COC commander Col. Harry Shoup, if there was a Santa Claus at the North Pole, he answered much more roughly than he should — considering the season: ‘There may be a guy called Santa Claus at the North Pole, but he’s not the one I worry about coming from that direction,’” Shoup said in the brief piece. In 2015, The Atlantic magazine to the secret line, while noting that Shoup had a flair for public relations. Phone calls aside, Shoup was indeed media savvy. In 1986, he told the Scripps Howard News Service that he recognized an opportunity when a staff member drew Santa on the glass map in 1955. A lieutenant colonel promised to have it erased. But Shoup said, “You leave it right there,” and summoned public affairs. Shoup wanted to boost morale for the troops and public alike. “Why, it made the military look good — like we’re not all a bunch of snobs who don’t care about Santa Claus,” he said. Shoup died in 2009. His children that it was a misprinted Sears ad that prompted the phone calls. “And later in life he got letters from all over the world,” said Terri Van Keuren, a daughter. “People saying ‘Thank you, Colonel, for having, you know, this sense of humor.’” A rare addition to Santa’s story NORAD’s tradition is one of the few modern additions to the centuries-old Santa story that have endured, according to Gerry Bowler, a Canadian historian who spoke to the AP in 2010. Ad campaigns or movies try to “kidnap” Santa for commercial purposes, said Bowler, who wrote “Santa Claus: A Biography.” NORAD, by contrast, takes an essential element of Santa’s story and views it through a technological lens. In a recent interview with the AP, Air Force Lt. Gen. Case Cunningham explained that NORAD radars in Alaska and Canada — known as the northern warning system — are the first to detect Santa. He leaves the North Pole and typically heads for the international dateline in the Pacific Ocean. From there he moves west, following the night. “That’s when the satellite systems we use to track and identify targets of interest every single day start to kick in,” Cunningham said. “A probably little-known fact is that Rudolph’s nose that glows red emanates a lot of heat. And so those satellites track (Santa) through that heat source.” NORAD has an app and website, , that will track Santa on Christmas Eve from 4 a.m. to midnight, Mountain Standard Time. People can call 1-877-HI-NORAD to ask live operators about Santa’s location from 6 a.m. to midnight, mountain time.

'I felt like I was walking on eggshells': Family violence 'under-reported, under-prosecuted'ST. SIMONS ISLAND, Ga. (AP) — Maverick McNealy steadied himself after a rugged start Saturday with a 4-under 66 and caught up with Vince Whaley in a wild third round at the RSM Classic in which a half-dozen players had at least a share of the lead. McNealy looked as though he might have the lead when he hit wedge on the final hole that rolled just by the cup and settled 8 feet away. He missed the putt, still in great position to go after his first PGA Tour victory. Javascript is required for you to be able to read premium content. Please enable it in your browser settings.

Fox News Flash top sports headlines are here. Check out what's clicking on Foxnews.com. Roughly two months after barring parents who wore "XX" wristbands during a high school soccer game against a transgender athlete, a school district is confident in its decision to do so. Anthony Foote of Bow, New Hampshire, told the New Hampshire Journal he had received a notice of trespass from Bow and Dunbarton School Districts Superintendent Marcy Kelley after he had worn armbands in support of biological girls-only sports to his daughter’s high school soccer game back in September. Foote, his wife Nicole, Kyle Fellers, and Eldon Rash then filed a federal lawsuit against the Bow School District, Superintendent of Schools Marcy Kelley, Principal Matt Fisk, Athletic Director Mike Desilets, Bow Police Lieutenant Phil Lamy and soccer referee Steve Rossetti several days later. CLICK HERE FOR MORE SPORTS COVERAGE ON FOXNEWS.COM A group of New Hampshire parents sued a school district over their removal from a girls' soccer game for protesting against participation by a transgender player. (Getty Images) The "silent protest" at Bow High School, the lawsuit says, intended to "show solidarity" with the Bow team and oppose a policy that allowed a transgender girl to play on Plymouth's team. Fellers and Foote testified Thursday that they hadn’t intended to harass or otherwise target a transgender player on the opposing team, but the school district said differently. Kelley and Desilets believed that the protest wouldn't stop at just wristbands, saying they had received strongly worded emails from Foote in which he called himself a "real leader" who was prepared to take action. They also said Foote urged others to attend the game on social media. In the days leading up to the game, another parent told school officials that she had overheard others talk about showing up to the game wearing dresses and heckling the transgender player. "When we suspect there’s some sort of threat . . . we don’t wait for it to happen," Kelley said on Friday. The "silent protest" at Bow High School, the lawsuit says, intended to "show solidarity" with the Bow team and oppose a policy that allowed a transgender girl to play on Plymouth's team. PRO SOCCER PLAYER BLASTS MEDIA FOR PRAISING MEGAN RAPINOE WHILE BLASTING CHRISTIAN PULISIC FOR TRUMP DANCE Kelley also pushed back on the idea that the plaintiffs were simply expressing support for their daughters and the girls' teammates in general, noting that they had chosen the one game involving a transgender player to begin wearing the wristbands. "This was organized and targeted," she said. "If we were to allow harassment, we’re liable." A federal judge in the case, Steven McAuliffe, pushed back on the parents for repeatedly referring to the athlete as a boy on Thursday. "You seem to go out of your way to suggest there’s no such thing as a trans girl," McAuliffe said during the hearing. The transgender player in question, Parker Tirrell, and another student athlete are challenging the state law that bans transgender athletes in grades 5 to 12 from playing on teams that align with their gender identity. A federal judge ruled in their case that they can play sports during the ongoing lawsuit that seeks to overturn the law. The Bow School District defended its decision to bar those who wore "XX" wristbands at the game. (Friedemann Vogel/Getty Images) CLICK HERE TO GET THE FOX NEWS APP Gov. Chris Sununu, who signed the Fairness in Women’s Sports Act into law in July, has said that it "ensures fairness and safety in women’s sports by maintaining integrity and competitive balance in athletic competitions." Fox News' Paulina Dedaj, Landon Mion, Jackson Thompson, and The Associated Press contributed to this report. Follow Fox News Digital’s sports coverage on X , and subscribe to the Fox News Sports Huddle newsletter .

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Friday, December 20, 2024 Facebook Instagram Twitter WhatsApp Youtube Personal Finance Education Entertainment Jobs Alert Sports Hindi Technology Complaint Redressal. Fact-Checking Policy Correction policy Authors and Team DNPA Code of Ethics Onwership and Funding Cookie Policy Terms of Service Disclaimer Contact US About Us More Search Home Personal Finance New Visa Appointment Rules: US announces new visa appointment rules for Indians... Personal Finance New Visa Appointment Rules: US announces new visa appointment rules for Indians – Details here By Shyamu Maurya December 20, 2024 0 13 Share Facebook Twitter Pinterest WhatsApp Telegram New Visa Appointment Rules: US announces new visa appointment rules for Indians - Details here US Visa Appointment: Getting a US visa is a very challenging task. The main reason behind this is the waiting time for a visa appointment. The visa waiting time at the US embassies in India has exceeded one year, due to which it is taking a long time for Indians to get a visa. US Visa Appointment News: Indians will no longer have to wait long to get a US visa. The US Embassy is implementing new rules in India from January 1, 2025, for taking and rescheduling non-immigrant visa appointments. The US Embassy in India said in a statement, “To ensure that everyone has a fair chance to get a visa appointment interview and to reduce waiting times, we are making some changes.” People can now change their appointment date once without paying any additional fee. However, if you wish to reschedule for the second time or are unable to visit the embassy on the rescheduled date, you will have to take a new appointment and pay the fee again. “These changes will make it easier and faster to get an appointment. We urge people to come on their appointment date to keep the entire process smooth and fair,” Dutawa said. Long wait for visa appointment In fact, a lot of efforts are being made to reduce the waiting time for visa appointments, but it is not showing any benefit. The waiting time for visa appointments for Indian applicants is very long. For B1/B2 visas, one has to wait a long time for appointments at different US embassies in India. You may have to wait for 438 days in Mumbai, 479 days in Chennai, 441 days in Delhi, 436 days in Kolkata and 429 days in Hyderabad. There is some relief for those who can get interview waiver. There is a wait of 21 days for visas with interview waiver in Delhi and only 2 days in Kolkata. This is for those who have already gone to the US. In 2023, the US issued a record 14 lakh visas for Indians. The wait time for visitor visas decreased by 75%. But demand has increased again, putting pressure on the visa system, meaning it is getting harder to get a visa quickly. Join Informal Newz Tags New Visa Appointment Rules Share Facebook Twitter Pinterest WhatsApp Telegram Previous article Saturday Bank Holiday: Banks will remain closed on Saturday? check the list of holidays Shyamu Maurya Shyamu has done Degree in Fine Arts and has knowledge about bollywood industry. He started writing in 2018. Since then he has been associated with Informalnewz. In case of any complain or feedback, please contact me @informalnewz@gmail.com RELATED ARTICLES Personal Finance Saturday Bank Holiday: Banks will remain closed on Saturday? check the list of holidays December 20, 2024 Personal Finance Traffic Challan: Traffic challan will be forgiven, do this work immediately on 20 December December 20, 2024 Personal Finance Credit Card Late fee: Big news for credit card customers! Banks will now be able to charge more late fees from credit card customers,... 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CHRIS DOBEY has issued a grovelling apology for his "absolute s*** show" at the Players Championship. The darts star was thrashed 6-1 by a struggling Nathan Aspinall in the tournament on Friday . Dobey , 34, won one leg in the match to save himself the embarrassment of being whitewashed. The Northumberland-born thrower was 4-0 down in the match before he won his first leg. But it was too little too late as Aspinall won the next two legs to wrap up the match. Dobey was furious with his performance as he had entered the tournament as the top seed. READ MORE ON DARTS He took out his frustration on social media as he apologised to his supporters. He wrote: "That was an absolute s*** show tonight. "I apologise to everyone for making you sit through that, I was abysmal. "Need to seriously get my act together before the worlds. Most read in Darts CASINO SPECIAL - BEST CASINO WELCOME OFFERS "I dunno what’s happened to me, I just can’t seem to play on stage." Plenty of fans did show their backing for Dobey as they reacted on social media. One posted: "You’ll be back Chris, keep your head up." A second wrote: "Try and channel it out. Best wishes for the world’s mate." A third commented: "Chin up. Everyone goes through bad spells. Form is temporary, Class is permanent." A fourth said: "Every player has a blip mate, you’ll be back. We all know what you can do on your day." Another added: "Keep your head up Chris. It’ll come. Keep pushing." Dobey will now have to wait for his return to the oche at the Worlds at Alexandra Palace next month. BELOW is a list of Darts world champions by year. The list does not include winners from the pre-Professional Darts Corporation (PDC) era or BDO world champions. That means Raymond van Barneveld, for example, is only listed once - Barney also won four BDO titles - and none of Eric Bristow's five BDO titles are included. 1994 - Dennis Priestley 1995 - Phil Taylor 1996 - Phil Taylor (2) 1997 - Phil Taylor (3) 1998 - Phil Taylor (4) 1999 - Phil Taylor (5) 2000 - Phil Taylor (6) 2001 - Phil Taylor (7) 2002 - Phil Taylor (8) 2003 - John Part 2004 - Phil Taylor (9) 2005 - Phil Taylor (10) 2006 - Phil Taylor (11) 2007 - Raymond van Barneveld 2008 - John Part (2) 2009 - Phil Taylor (12) 2010 - Phil Taylor (13) 2011 - Adrian Lewis 2012 - Adrian Lewis (2) 2013 - Phil Taylor (14) 2014 - Michael van Gerwen 2015 - Gary Anderson 2016 - Gary Anderson (2) 2017 - Michael van Gerwen (2) 2018 - Rob Cross 2019 - Michael van Gerwen (3) 2020 - Peter Wright 2021 - Gerwyn Price 2022 - Peter Wright (2) 2023 - Michael Smith 2024 - Luke Humphries Most World Titles 14 - Phil Taylor 3 - Michael van Gerwen 2 - John Part, Adrian Lewis, Gary Anderson, Peter Wright 1 - Dennis Priestley, Raymond van Barneveld, Rob Cross, Gerwyn Price, Michael Smith, Luke Humphries

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Via TheMindUnleashed.com, The agricultural world is witnessing a remarkable transformation, driven by groundbreaking technology. Among the most fascinating innovations is a farming robot equipped with lasers that can destroy hundreds of thousands of weeds in mere hours. This high-tech solution is not just a marvel of engineering but a timely response to persistent challenges in farming, from labor shortages to the environmental impact of chemical herbicides. By combining artificial intelligence with precision laser technology, companies like Carbon Robotics are reshaping the way farmers tackle one of agriculture’s most labor-intensive tasks. These futuristic machines offer a glimpse into the potential of sustainable farming, where innovation meets efficiency, paving the way for a healthier and more productive future for agriculture. Weeds have been a persistent challenge for farmers , creating a constant battle for resources in the field. These invasive plants not only compete with crops for vital sunlight, nutrients, and water but also provide a safe haven for pests that can wreak havoc on harvests. The presence of weeds significantly reduces crop yields and quality, making effective weed management essential for agricultural success. For centuries, farmers have relied on labor-intensive methods and chemical herbicides to combat this problem, but these approaches are not without their flaws. The use of chemical herbicides , while convenient and effective in the short term, poses serious environmental concerns. These chemicals can seep into water supplies, harming aquatic ecosystems and affecting soil health. Over time, their overuse may lead to the development of herbicide-resistant weeds, further complicating the issue. Meanwhile, manual weeding, though free of chemical drawbacks, is both backbreaking and time-consuming. The agriculture industry’s labor shortages have made this method increasingly impractical, leaving farmers with few viable options. The urgency for a sustainable, efficient solution to weed control cannot be overstated. Modern farming demands innovation that not only solves immediate issues but also protects the environment for future generations. This is where technological advancements, such as farming robots equipped with cutting-edge weed management systems, come into play. By addressing the limitations of traditional methods, these innovations offer a promising alternative to tackle one of agriculture’s oldest dilemmas. In the face of persistent agricultural challenges, technology has emerged as a transformative force, with farming robots leading the way. Carbon Robotics’ Autonomous Weeder is a standout example of how innovation can revolutionize agriculture. This remarkable machine is designed to address the dual problems of labor shortages and environmental damage caused by conventional weed management practices. By combining artificial intelligence with advanced laser technology, the Autonomous Weeder delivers an unprecedented level of precision and efficiency. A post shared by Carbon Robotics (@carbon_robotics) The robot operates with minimal human intervention, scanning rows of crops using 12 high-resolution cameras that detect weeds in real time. Its onboard AI system processes this information, distinguishing weeds from crops with incredible accuracy. Once a weed is identified, carbon dioxide lasers target and destroy it instantly, leaving the surrounding soil undisturbed. This approach eliminates the need for chemical herbicides, reducing environmental harm while preserving soil health. It also alleviates the physical burden of manual weeding, offering farmers a more efficient alternative. Beyond its functional benefits, the introduction of robots like the Autonomous Weeder marks a significant shift in the agricultural sector. These machines demonstrate the potential of integrating AI into farming practices, enabling farmers to achieve more with fewer resources. As the capabilities of such robots continue to expand, they are not only solving immediate issues but also setting the stage for a future defined by sustainable and technologically advanced agriculture. Building on the success of the Autonomous Weeder, Carbon Robotics has introduced a new, more powerful iteration of its technology: the LaserWeeder. This latest innovation reflects the company’s commitment to continually improving its products to meet farmers’ needs. Unlike its predecessor, the LaserWeeder is not autonomous; it is designed as a pull-behind implement that attaches to a tractor. While this adjustment requires a driver, it allows for greater flexibility and compatibility with various farming operations. The LaserWeeder is equipped with three times the lasers of the original model, enabling it to kill up to 200,000 weeds per hour. This incredible efficiency makes it one of the most effective weed management tools available. In just one hour, the LaserWeeder can cover two acres of farmland, a feat that would take human laborers days to achieve. Its precision targeting ensures that only weeds are eliminated, leaving crops unharmed and the soil intact. This targeted approach not only boosts productivity but also supports healthier, more sustainable farming practices. By adapting its design while retaining the core laserweeding technology, Carbon Robotics has ensured that the LaserWeeder meets the practical needs of modern farmers. The machine’s performance and ease of use make it an invaluable addition to farm operations, especially for larger-scale growers. As this technology becomes more widely adopted, it is poised to redefine weed management and set new standards for agricultural efficiency. For many farmers, the introduction of the LaserWeeder has been nothing short of transformative. This technology addresses one of the most labor-intensive tasks on the farm, dramatically reducing the time and effort required to manage weeds. By automating this critical process, the LaserWeeder not only frees up labor for other essential tasks but also provides a level of consistency that is difficult to achieve manually. Farmers who have incorporated the machine into their operations report noticeable improvements in both productivity and crop health. The environmental benefits of the LaserWeeder are equally significant. By eliminating the need for herbicides, it helps maintain healthier soil and reduces the risk of water contamination. This shift toward chemical-free farming practices aligns with the growing demand for sustainable agriculture, offering farmers an opportunity to meet consumer expectations while improving their bottom line. Additionally, the LaserWeeder’s precision ensures that crops are not damaged during the weeding process, further enhancing yield quality and quantity. Economically, the LaserWeeder is a sound investment. While the initial cost may seem substantial, its ability to cut weeding expenses by up to 80% means that the machine pays for itself within two to three years. This rapid return on investment, combined with its labor-saving capabilities, makes it a practical choice for farms of all sizes. As more farmers experience its benefits firsthand, the LaserWeeder is solidifying its place as a vital tool for modern agriculture. The LaserWeeder is just one example of how technology is reshaping the agricultural landscape. Its success signals a broader shift toward more sustainable and efficient farming practices. By reducing reliance on chemical herbicides and manual labor, machines like the LaserWeeder are not only addressing immediate challenges but also paving the way for long-term solutions. The environmental benefits of laser technology, such as reduced soil contamination and healthier ecosystems, cannot be overstated. A post shared by Carbon Robotics (@carbon_robotics) As innovation continues, the potential applications of laser-equipped robots in agriculture are vast. Future iterations could handle a variety of tasks, from planting and fertilizing to harvesting, creating an integrated system that maximizes efficiency and minimizes waste. These advancements could also help address global food security challenges by enabling farmers to produce more with fewer resources. The combination of AI, robotics, and precision technology holds the promise of revolutionizing the industry, making it more resilient in the face of climate change and population growth. Ultimately, the integration of laser technology into farming represents a hopeful vision for the future. By embracing these advancements, farmers can tackle long-standing challenges while contributing to a more sustainable and productive agricultural system. As tools like the LaserWeeder gain traction, they are not just changing how farms operate—they are redefining what is possible in agriculture. The rise of laser-equipped robots is not just changing how weeds are managed—it’s transforming the very role of farmers. Traditionally, farmers have had to spend countless hours manually overseeing labor-intensive tasks like weeding, often diverting their attention from other crucial aspects of their operations. With the LaserWeeder and similar technologies, much of this burden is lifted, allowing farmers to focus on higher-level planning and crop optimization. These machines are empowering farmers to adopt precision agriculture, a method that uses data and technology to make farming more efficient and sustainable. By automating repetitive tasks, robots enable farmers to analyze crop health, soil quality, and weather patterns in real time, helping them make informed decisions that maximize yield and conserve resources. The time saved by automating weeding can now be invested in improving the overall health of the farm, ensuring long-term success. Moreover, the integration of advanced tools like the LaserWeeder is making farming more appealing to younger generations. With agriculture becoming more tech-driven, it opens doors for a new wave of tech-savvy individuals who are eager to bring innovation to the industry. This blend of tradition and technology is redefining what it means to be a farmer, ensuring that agriculture remains a vital and dynamic field in the modern world. The introduction of laser-equipped farming robots like the LaserWeeder is reshaping agriculture in ways once thought impossible. By combining advanced technology with practical farming needs, these machines address age-old challenges with a level of precision and efficiency that is hard to match. They eliminate weeds without harming the environment, reduce dependency on manual labor, and make farms more sustainable and productive. More than just tools, these robots symbolize a shift toward innovation-driven agriculture. They allow farmers to embrace environmentally conscious practices without sacrificing productivity. With benefits ranging from healthier soil to significant cost savings, the LaserWeeder represents a win for both farmers and the planet. Its rapid adoption by farmers across the industry underscores its value as a game-changing solution. As this technology evolves, it has the potential to go beyond weeding, shaping the future of farming for generations to come. From addressing global food demands to fostering a greener planet, laser-equipped robots are setting a new standard in agriculture. This is just the beginning of a farming revolution, where cutting-edge technology meets the age-old art of cultivation.

USA News Group Commentary Issued on behalf of Oncolytics Biotech Inc. VANCOUVER, BC , Dec. 20, 2024 /PRNewswire/ -- USA News Group News Commentary – The American Cancer Society has published its Advances in Oncology – 2024 Research Highlights , underscoring major strides in cancer research and ongoing innovation. However, the optimism is tempered by a troubling finding: a significant global rise in early-onset colorectal cancer cases . This unsettling trend comes as the medical community grapples with the lingering effects of the COVID-19 pandemic. A recent Nature article revealed how disruptions in cancer care—particularly delays in screenings, diagnoses, and treatments—have likely exacerbated the progression of advanced disease, diminished survival rates, and complicated long-term data analysis. Still, the oncology field continues to push forward with promising developments emerging from key innovators like O ncolytics Biotech Inc. (NASDAQ: ONCY) (TSX: ONC), Cardiff Oncology, Inc. (NASDAQ: CRDF), Personalis, Inc. (NASDAQ: PSNL), Tempus AI, Inc. (NASDAQ: TEM), and Checkpoint Therapeutics, Inc. (NASDAQ: CKPT). The article continued: Additionally, the American Cancer Society has spotlighted an alarming rise in cancer incidence and mortality among younger age groups. Analysts at Exactitude Consultancy anticipate that the global Cancer Immunotherapy Market will expand at a robust 12.84% CAGR, reaching $258.22 billion by 2031 —a clear indicator of oncology's rapid growth and critical importance. Oncolytics Biotech® to Present Promising Pelareorep Data in Pancreatic and Anal Cancers at ASCO GI Symposium Oncolytics Biotech Inc. (NASDAQ: ONCY) (TSX: ONC), a leading clinical-stage company specializing in immunotherapy for oncology, today announced the presentation of two data sets through two abstracts showcasing pelareorep's potential in difficult-to-treat gastrointestinal cancers, which were accepted and will be presented at the 2025 American Society of Clinical Oncology (ASCO) Gastrointestinal Cancers Symposium in San Francisco January 23-25, 2025 . "We are enthusiastic about pelareorep's applicability across multiple gastrointestinal cancer indications, including pancreatic and anal cancer," said Tom Heineman , M.D., Ph.D., Chief Medical Officer of Oncolytics . "Pelareorep engages patients' immune systems to help make commonly used chemotherapies and checkpoint inhibitors, such as atezolizumab, more effective in fighting cancer. This offers the promise of delaying disease progression and improving survival in patients with these devasting diseases. Given the versatility of pelareorep, we see multiple clinical and regulatory options for bringing this promising medicine to patients." Oncolytics will present two key data sets from the GOBLET study, with preliminary safety and tumor response results for the relapsed anal carcinoma cohort treated with pelareorep and atezolizumab presented in Poster Session C on January 25, 2025 , from 7:00 to 7:55 a.m. PT . Additionally, results from the safety run-in phase for first-line metastatic pancreatic ductal adenocarcinoma patients treated with pelareorep, modified FOLFIRINOX, with and without atezolizumab will be presented in Poster Session B on January 24, 2025 , from 11:30 a.m. to 1:00 p.m. PT . Both abstracts will be available on the ASCO Gastrointestinal Cancers Symposium website at 5:00 p.m. ET on January 21, 2025 . CONTINUED... Read this and more news for Oncolytics Biotech at: https://usanewsgroup.com/2023/10/02/the-most-undervalued-oncolytics-company-on-the-nasdaq/ In other recent industry developments and happenings in the market include: Cardiff Oncology, Inc. (NASDAQ: CRDF), a clinical-stage biotechnology company leveraging PLK1 inhibition to develop novel therapies across a range of cancers, recently announced positive initial data from CRDF-004, a randomized, Phase 2 clinical trial evaluating onvansertib in combination with standard-of-care (SoC) in patients with first-line RAS-mutated metastatic colorectal cancer (mCRC). Efficacy and safety data are for all evaluable patients as of a November 26, 2024 , data cut-off date, and all efficacy data are determined by a blinded, independent central review (BICR) of each patient's tumor scan. "We are highly encouraged by the robust efficacy signal and favorable safety profile observed with onvansertib plus standard-of-care from the first 30 evaluable patients in our randomized first-line RAS-mutated mCRC CRDF-004 trial," said Fairooz Kabbinavar, MD, FACP, Chief Medical Officer of Cardiff Oncology . "Our data shows an objective response rate of 64% in patients receiving the 30 mg dose of onvansertib in combination with standard of care, significantly higher than the 33% objective response rate observed in the control arms of standard of care alone. In addition, as can be seen in the spider plots, we are observing deeper tumor response in patients receiving the 30mg dose of onvansertib compared to those receiving the 20mg dose with similar safety profiles for both doses." Personalis, Inc. (NASDAQ: PSNL), a developer of advanced cancer genomic tests and analytics, and Tempus AI, Inc. (NASDAQ: TEM), an AI-powered healthcare technology company, recently announced they've expanded their commercial relationship. Both companies agreed in November 2023 to collaborate and bring ultra-sensitive MRD testing to market and launched their efforts at the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting. Tempus is serving as the exclusive commercial diagnostic partner for Personalis' ultra-sensitive tumor-informed MRD product, NeXT Personal® Dx, for broad patient adoption in breast and lung cancers, and for immunotherapy monitoring across all solid tumors. "While we already offer NeXT Personal through our own biopharma channel, we are pleased to leverage Tempus' integrated platform as well for these biopharma customers who desire to combine NeXT Personal with other Tempus products," said Chris Hall , CEO of Personalis . "We believe the expansion of the relationship with Tempus will accelerate market penetration of our leading ultra-sensitive MRD platform and allow us to better capitalize on the opportunity." Under this expanded relationship, Tempus will be enabled to offer Personalis' NeXT Personal MRD product to pharmaceutical and biotech customers who wish to bundle MRD testing with other Tempus offerings in a given study. Checkpoint Therapeutics, Inc. (NASDAQ: CKPT), a commercial-stage immunotherapy and targeted oncology company focused on novel treatments for patients with solid tumor cancers, recently announced that the FDA approved its UNLOXCYTTM (cosibelimab-ipdl) for the treatment of adults with metastatic cutaneous squamous cell carcinoma (cSCC) or locally advanced cSCC who are not candidates for curative surgery or curative radiation. UNLOXCYT is the first and only programmed death ligand-1 (PD-L1) blocking antibody to receive FDA marketing approval for this indication. "[This] FDA approval of UNLOXCYT – the first marketing approval for our company – is a significant milestone both for Checkpoint and for patients with advanced cSCC," said James Oliviero , President and CEO of Checkpoin t. "This approval marks Checkpoint's transformation to a commercial-stage company, with the opportunity to compete in a U.S. market estimated to exceed $1 billion annually, where we believe UNLOXCYT offers a differentiated treatment option versus available therapies by binding to PD-L1, rather than programmed death receptor-1 (PD-1), to release the inhibitory effects of PD-L1 on the anti-tumor immune response. Additionally, UNLOXCYT has demonstrated the ability to induce antibody-dependent cell-mediated cytotoxicity (ADCC), another potential differentiating feature of the drug compared to existing marketed therapies for patients with cSCC." Source: https://usanewsgroup.com/2024/09/21/is-oncolytics-biotech-the-markets-most-undervalued-cancer-opportunity/ CONTACT: USA NEWS GROUP info@usanewsgroup.com (604) 265-2873 DISCLAIMER: Nothing in this publication should be considered as personalized financial advice. We are not licensed under securities laws to address your particular financial situation. No communication by our employees to you should be deemed as personalized financial advice. Please consult a licensed financial advisor before making any investment decision. This is a paid advertisement and is neither an offer nor recommendation to buy or sell any security. We hold no investment licenses and are thus neither licensed nor qualified to provide investment advice. The content in this report or email is not provided to any individual with a view toward their individual circumstances. USA News Group is a wholly-owned subsidiary of Market IQ Media Group, Inc. ("MIQ"). MIQ has been paid a fee for Oncolytics Biotech Inc. advertising and digital media from the company directly. There may be 3rd parties who may have shares of Oncolytics Biotech Inc., and may liquidate their shares which could have a negative effect on the price of the stock. This compensation constitutes a conflict of interest as to our ability to remain objective in our communication regarding the profiled company. Because of this conflict, individuals are strongly encouraged to not use this publication as the basis for any investment decision. The owner/operator of MIQ own shares of Oncolytics Biotech Inc. which were purchased in the open market, and reserve the right to buy and sell, and will buy and sell shares of Oncolytics Biotech Inc. at any time without any further notice commencing immediately and ongoing. We also expect further compensation as an ongoing digital media effort to increase visibility for the company, no further notice will be given, but let this disclaimer serve as notice that all material, including this article, which is disseminated by MIQ has been approved by Oncolytics Biotech Inc.; this is a paid advertisement, we currently own shares of Oncolytics Biotech Inc. and will buy and sell shares of the company in the open market, or through private placements, and/or other investment vehicles. While all information is believed to be reliable, it is not guaranteed by us to be accurate. Individuals should assume that all information contained in our newsletter is not trustworthy unless verified by their own independent research. Also, because events and circumstances frequently do not occur as expected, there will likely be differences between the any predictions and actual results. Always consult a licensed investment professional before making any investment decision. Be extremely careful, investing in securities carries a high degree of risk; you may likely lose some or all of the investment. View original content: https://www.prnewswire.com/news-releases/oncology-advancements-accelerate-amid-rising-early-onset-cancer-diagnoses-302337555.html SOURCE USA News Group

LOS ANGELES (AP) — The Biden administration plans on reducing part of Intel's $8.5 billion in federal funding for computer chip plants around the country, according to three people familiar with the grant who spoke on the condition of anonymity to discuss private conversations. Read this article for free: Already have an account? To continue reading, please subscribe: * LOS ANGELES (AP) — The Biden administration plans on reducing part of Intel's $8.5 billion in federal funding for computer chip plants around the country, according to three people familiar with the grant who spoke on the condition of anonymity to discuss private conversations. Read unlimited articles for free today: Already have an account? LOS ANGELES (AP) — The Biden administration plans on reducing part of Intel’s $8.5 billion in federal funding for computer chip plants around the country, according to three people familiar with the grant who spoke on the condition of anonymity to discuss private conversations. The reduction is largely a byproduct of the $3 billion that Intel is also receiving to provide computer chips to the military. President Joe Biden announced the agreement to provide Intel with up to $8.5 billion in direct funding and $11 billion in loans in March. The changes to Intel’s funding are not related to the company’s financial record or milestones, the people familiar with the grant told The Associated Press. In August, the chipmaker announced that it would cut 15% of its workforce — about 15,000 jobs — in an attempt to turn its business around to compete with more successful rivals like Nvidia and AMD. Unlike some of its rivals, Intel manufactures chips in addition to designing them. Two years ago, President Biden hailed Intel as a job creator with its plans to open a new plant near Columbus, Ohio. The president praised the company for plans to “build a workforce of the future” for the $20 billion project, which he said would generate 7,000 construction jobs and 3,000 full-time jobs set to pay an average of $135,000 a year. The California-based tech giant’s funding is tied to a sweeping 2022 law that President Biden has celebrated and which is designed to revive U.S. semiconductor manufacturing. Known as the CHIPS and Science Act, the $280 billion package is aimed at sharpening the U.S. edge in military technology and manufacturing while minimizing the kinds of supply disruptions that occurred in 2021, after the start of the coronavirus pandemic, when a shortage of chips stalled factory assembly lines and fueled inflation. The Biden administration helped shepherd the legislation following pandemic-era concerns that the loss of access to chips made in Asia could plunge the U.S. economy into recession. When pushing for the investment, lawmakers expressed concern about efforts by China to control Taiwan, which accounts for more than 90% of advanced computer chip production. In August, the administration pledged to provide up to $6.6 billion so that a Taiwanese semiconductor giant could expand the facilities it is already building in Arizona and better ensure that the most advanced microchips are produced domestically for the first time. The Commerce Department said the funding for Taiwan Semiconductor Manufacturing Co. meant the company could expand on its existing plans for two facilities in Phoenix and add a third, newly announced production hub. The administration has promised tens of billions of dollars to support construction of U.S. chip foundries and reduce reliance on Asian suppliers, which Washington sees as a security weakness. _____ Boak reported from Washington. Advertisement